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Paternal mitochondria from an rmd-2, rmd-3, rmd-6 triple mutant are properly positioned in the C. elegans zygote.

Iris Y Juanico, Christina M Meyer, John E McCarthy, Ting Gong, Francis J McNally,

RMD-1,2,3,6 (regulator of microtubule dynamics) is a family of homologous proteins conserved between humans and <i>C. elegans</i>. Human RMD-3/PTPIP51 is a mitochondrial protein that tethers mitochondria to the endoplasmic reticulum. <i>C. elegans</i> RMD-2, 3, and 6 are expressed in sperm. To test whether paternal RMD-2, 3, 6 might redundantly tether ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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MFP1/MSD-1 and MFP2/NSPH-2 co-localize with MSP during C. elegans spermatogenesis.

Kayleigh N Morrison, Christopher M Uyehara, James Matthew Ragle, Jordan D Ward, Diane C Shakes,

Until recently, the only verified component of Fibrous Bodies (FBs) within <i>Caenorhabditis elegans</i> spermatocytes was the Major Sperm Protein (MSP), a nematode-specific cytoskeletal element. Earlier studies in the pig parasite <i>Ascaris suum</i> had identified accessory proteins that facilitate MSP polymerization and depolymerization within the pseudopod of crawling spermatozoa. In this ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The conserved MASRPF motif in the Attractin homolog, Distracted, is required for association with Drosophila E3-ligase Mgrn1.

Vindhya Nawaratne, Sirisha Kudumala, Priyanka Prakash Kakad, Tanja A Godenschwege,

In rodents, all three paralogs of the Attractin (Atrn) transmembrane protein family exhibit strong phenotypic overlap and are implicated in the regulation of the same G-protein coupled receptors (GPCR) as E3-ligase Mahogunin ring finger 1 (Mgrn1). Recently it was shown that the highly conserved intracellular MASRPF motif in mammal Multiple ... Read more >>

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[2021, 2021:]

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Drosophila yakuba - Tsc1.

Bailey Lose, Abigail Myers, Savanah Fondse, Ian Alberts, Joyce Stamm, James J Youngblom, Chinmay P Rele, Laura K Reed,

Gene Model for <i>Tsc1</i> in the <i>Drosophila yakuba</i>'s DyakCAF1 assembly (GCA_000005975.1). ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Swimming exercise reduces native ⍺-synuclein protein species in a transgenic C. elegans model of Parkinson's disease.

Minna Y Schmidt, Manish Chamoli, Gordon J Lithgow, Julie K Andersen,

Exercise has been historically recommended to prevent many disease conditions. Intense exercise in particular, has been shown to be beneficial for Parkinson's disease (PD) - stopping and even reversing symptoms in some patients. Recent research in mammalian animal models of Parkinson's have shown that exercise affects ⍺-synuclein aggregate species, considered ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Effects of blunt force injuries in third-instar Drosophila larvae persist through metamorphosis and reduce adult lifespan.

Jorgo Lika, Rebeccah J Katzenberger, Barry Ganetzky, David A Wassarman,

Blunt force injuries are a significant cause of disability and death worldwide. Here, we describe a <i>Drosophila melanogaster</i> model of blunt force injury that can be used to investigate cellular and molecular mechanisms that underlie the short-term and long-term effects of injuries sustained at a juvenile stage of development. Injuries ... Read more >>

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[2021, 2021:]

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Acute exposure of Nicotine during Drosophila puncture injury activates an epidermal wound response reaction.

Chrissy Cherenfant, Michelle T Juarez,

Epidermal wound reaction after injury can be visualized in <i>Drosophila melanogaster</i> embryos by transgenic fluorescent wound reporters. A "local" reaction is limited to the epidermal cells surrounding a wound site occurs in <i>wildtype</i> embryos. A "global" reaction extends beyond the wound site to all epidermal cells occurs in immune response ... Read more >>

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[2021, 2021:]

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Transcriptional Response to a Dauer-Inducing Ascaroside Cocktail in Late L1 in C. elegans.

Sarah M Cohen, Jessica J Sun, Frank C Schroeder, Paul W Sternberg,

The dauer diapause stage in <i>C. elegans</i> is a non-feeding alternative to the L3 larval stage that is highly resistant to harsh environmental conditions. The decision to enter dauer is a two-step process. First, L1 larvae encounter adverse conditions such as lack of food or overcrowding and decide to enter ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Creation of a functional unc-11/PICALM GFP knock-in by CRISPR.

Maria Gallegos, Alex Hermes, Debjani Patra,

<i>unc-11</i> is the only <i>C. elegans</i> ortholog of mammalian PICALM/AP180, paralogs that play an important role in Clathrin-Mediated Endocytosis (CME) and the recycling of a subset of SNAREs, the vesicle-associated membrane proteins (VAMPs). In this publication we report the creation of a new <i>unc-11</i> allele that is endogenously-tagged with GFP ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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SIMR foci are found in the progenitor germ cells of C. elegans embryos.

Celja J Uebel, Kevin I Manage, Carolyn M Phillips,

RNA interference is a widely conserved mechanism of gene regulation and silencing across eukaryotes. In <i>C. elegans</i>, RNA silencing is coordinated through perinuclear nuage containing at least four granules: P granules, Z granules, <i>Mutator</i> foci, and SIMR foci. Embryonic localization of these granules is known for all except SIMR foci. ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Differential effects on neuromuscular physiology between Sod1 loss-of-function mutation and paraquat-induced oxidative stress in Drosophila.

Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu,

Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of <i>Superoxide dismutase 1</i> (<i>Sod1</i>) and by paraquat (PQ) feeding in <i>Drosophila</i>. We demonstrated alterations in <i>Sod1</i> mutants; the larval neuromuscular junction displayed supernumerary discharges and the ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Drosophila grimshawi - Rheb.

Chinmay P Rele, Jared Williams, Laura K Reed, James J Youngblom, Wilson Leung,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Mutating two putative phosphorylation sites on ZHP-3 does not affect its localization or function during meiotic chromosome segregation.

Anna E Russo, Christian R Nelson, Needhi Bhalla,

Meiotic chromosome segregation depends on crossover recombination to link homologous chromosomes together and promote accurate segregation in the first meiotic division. In <i>Caenorhabditis elegans</i>, a conserved RING finger protein, ZHP-3, is essential for meiotic recombination and localizes to sites of crossover formation. Whether ZHP-3 is regulated to promote recombination remains ... Read more >>

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[2021, 2021:]

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Mutations in the Physcomitrium patens gene encoding Aminodeoxychorismate Synthase confer auxotrophic phenotypes.

Michael J Prigge, Yingluo Wang, Mark Estelle,

To facilitate genetic mapping of developmental mutants of <i>Physcomitrium patens</i>, we produced a genetic marker that combines recessive auxotrophy with dominant positive selection. We first identified the gene affected by the <i>pabB4</i> auxotrophic mutation and then replaced it with a cassette that confers antibiotic resistance. This strain may be used ... Read more >>

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[2021, 2021:]

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Conserved missense variant in ALDH1A3 ortholog impairs fecundity in C. elegans.

Wan-Rong Wong, Shayda Maher, Jun Young Oh, Katherine I Brugman, Shahla Gharib, Paul W Sternberg,

Accumulating evidence demonstrates that mutations in <i>ALDH1A3</i> (the aldehyde dehydrogenase 1 family, member A3) are associated with developmental defects. The ALDH1A3 enzyme catalyzes retinoic acid biosynthesis and is essential to patterning and neuronal differentiation in the development of embryonic nervous system. Several missense mutations in <i>ALDH1A3</i> have been identified in ... Read more >>

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[2021, 2021:]

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Worms avoid a cat sensed repellent.

Brianna Ramos, Gareth Harris,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Glutamatergic transmission regulates locomotory behavior on a food patch in C. elegans.

Trevor Wolf, Ariana Perez, Gareth Harris,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Variation between nematodes in a multi-sensory behavioral assay.

Renae Ellis, Gareth Harris,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Zebrafish Trak proteins 1a and 2 localize to the mitochondria.

Kelsey A Oonk, Lauren B Bienvenu, Paxton S Sickler, Christine Martin, Emily Nickoloff-Bybel, Albert Matthew Volk, Douglas C Weiser, Susan Walsh,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Expression of a FRET-based ATP Biosensor in the C. elegans Intestine.

Jose Soto, Madeline Rivera, Gina Broitman-Maduro, Morris F Maduro,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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In vitro screening methods for parasites: the wMicroTracker & the WormAssay.

Emma Gunderson, Christina Bulman, Mona Luo, Judy Sakanari,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 1 time

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The muscarinic agonist arecoline suppresses motor circuit hyperactivity in C. elegans.

Katherine A McCulloch, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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A null mutation of C. elegans vwa-8.

Ming Zhu, Andrew D Chisholm, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Novel actions of arecoline in the C. elegans motor circuit.

Katherine A McCulloch, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Kavain suppresses human Aβ-induced paralysis in C. elegans.

Manish Chamoli, Shankar J Chinta, Julie K Andersen, Gordon J Lithgow,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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