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Systemic lupus erythematosus with autoimmune neurological manifestations in a carrier of chronic granulomatous disease - a rare presentation.

Nandita Prabhat, Kamalesh Chakravarty, Shiv Narayan Pattnaik, Aastha Takkar, Sucharita Ray, Vivek Lal,

Chronic granulomatous disease (CGD) is an uncommon genetic immunodeficiency disorder affecting neutrophil function, characterized by recurrent bacterial and fungal infections. X-linked carriers of CGD have an increased risk of autoimmune disorders, in particular lupus like disorders. We describe the case of a 37 years old female carrier of X-linked CGD, who ... Read more >>

J. Neuroimmunol. (Journal of neuroimmunology)
[2020, 343:577229]

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Immunological biomarkers in neuropsychiatric systemic lupus erythematosus: a comparative cross-sectional study from a tertiary care center in South India.

G Seth, A Sundaresh, C M Mariaselvam, G Kumar, K G Chengappa, M B Adarsh, R Tamouza, V S Negi,

INTRODUCTION:The prevalence of various immunological biomarkers in neuropsychiatric systemic lupus erythematosus (NPSLE) differs among various patients with varied neuropsychiatric manifestations and different populations. We studied the prevalence of these biomarkers; especially the neuron specific autoantibodies in patients with systemic lupus erythematosus (SLE) and compared them among patients with and without ... Read more >>

Lupus (Lupus)
[2020, :961203320908940]

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Convective forces increase rostral delivery of intrathecal antisense oligonucleotides in the cynomolgus monkey nervous system

Jenna Sullivan, Curt Mazur, Daniel Wolf, Laura Horky, Nicolas Currier, Bethany Fitzsimmons, Jacob Hesterman, Rachel Pauplis, Scott Haller, Berit Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly Kordasiewicz, Eric Swayze, Ajay Verma,

ABSTRACT Background The intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood-brain barrier and gain direct access to the CNS. We evaluated the use of convective forces acting on the cerebrospinal fluid as a means for increasing rostral delivery of IT dosed radioactive tracer molecules ... Read more >>

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Optic neuritis at the nexus of peripheral autoimmunity and central nervous system demyelination: a nationwide cohort study

Wei-Sheng Lin, Ho-Min Chen, Chih-Chao Yang, Ta-Ching Chen, Jou-Wei Lin, Wang-Tso Lee,

<title>Abstract</title> <p> Background Long-term course of optic neuritis is heterogeneous and varies across populations. We aim to investigate immune-related determinants that predict conversion of optic neuritis (ON) to multiple sclerosis (MS) or neuromyelitis optica (NMO) in a nationwide cohort. Methods We conducted the population-based cohort ... Read more >>

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[Clinical features and follow-up results of boys and girls with systemic lupus erythematosus: a comparative analysis].

Wei-Na Chen, Xiu Luo, You-Hua Si, Cai-Qi Xu, Li-Jun Liang,

OBJECTIVE:To compare the clinical features and follow-up results of systemic lupus erythematosus (SLE) between boys and girls. METHODS:A retrospective analysis was performed for the clinical data of 79 children (18 boys and 61 girls), aged ≤14 years, who were diagnosed with SLE from 2008 to 2018. The boys and the ... Read more >>

Zhongguo Dang Dai Er Ke Za Zhi (Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics)
[2020, 22(2):164-170]

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Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study.

Ahmed Yamany, Mervat E Behiry, Sahar A Ahmed,

Purpose:Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement. Hyponatremia is common in inflammatory diseases such as meningitis. Also, it has been found to be strongly associated with the degree of inflammation. However, it has not been fully evaluated in lupus. This study aimed to assess the inflammatory ... Read more >>

Open Access Rheumatol (Open access rheumatology : research and reviews)
[2020, 12:29-34]

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Treatment resistant opioid use disorder (TROUD): Definition, rationale, and recommendations.

David A Patterson Silver Wolf, Mark Gold,

The opioid overdose epidemic kills about 130 people a day in the United States and it is estimated that there are about 2.1 million people who suffer from an opioid use disorder (OUD). Academic neuroscientists, psychiatrists and the National Institute of Drug Abuse have spent the last forty-years establishing the ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2020, 411:116718]

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Reader response: SYNGAP1 encephalopathy: A distinctive generalized developmental and epileptic encephalopathy.

Peter Wolf, Celina von Stülpnagel, Till Hartlieb, Rikke S Møller, Gerhard J Kluger,

Neurology (Neurology)
[2020, 94(8):368-369]

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Central Nervous System Systemic Lupus Erythematosus (CNS-SLE) Vasculitis Mimicking Lewy Body Dementia: A Case Report Emphasizing the Role of Imaging With an Analysis of 33 Comparable Cases From the Scientific Literature.

Peter Abraham, Ian Neel, Steven Bishay, Daniel D Sewell,

INTRODUCTION:Neuropsychiatric symptoms occur in 30% to 40% of patients living with systemic lupus erythematosus (SLE). Brain imaging may play a pivotal role in determining the etiology as it did for the case presented here. METHODS:A new case of central nervous system (CNS) SLE is presented along with an analysis of ... Read more >>

J Geriatr Psychiatry Neurol (Journal of geriatric psychiatry and neurology)
[2020, :891988720901788]

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Congenital nephrotic syndrome as a complication of whooping cough: a case report.

Ayah Kouli, Sana Sheikh Trab, Shahed Alshaghel, Mohamad Bassel Mouti, Hiba Hamdoun,

Bordetella organisms are responsible for whooping cough, which is an extremely contagious respiratory illness with substantial morbidity in infants. It is also considered one of the 10 predominant reasons for childhood decease globally, particularly before vaccination was available. Congenital nephrotic syndrome (CNS) presents within the first 3 months of life. It ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2020, 2020(2):omaa007]

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Tubercular meningitis in patients with systemic lupus erythematosus: clinical characteristics, risk factors, and outcomes of 10 patients.

Wenya Lin, Peirong Chen,

Tubercular meningitis (TBM) is a rare condition in patients with systemic lupus erythematosus (SLE). The aim of this study is to describe the clinical characteristics, possible risk factors, and outcomes of SLE patients with TBM. We systematically reviewed medical records from10 SLE patients with TBM admitted to our hospital from ... Read more >>

Clin. Rheumatol. (Clinical rheumatology)
[2020, :]

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Chemokine CXCL13 in serum, CSF and blood-CSF barrier function: evidence of compartment restriction.

Georg Pilz, Irma Sakic, Peter Wipfler, Jörg Kraus, Elisabeth Haschke-Becher, Wolfgang Hitzl, Eugen Trinka, Andrea Harrer,

BACKGROUND AND PURPOSE:Elevation of the chemokine CXCL13 in CSF frequently occurs during active and acute CNS inflammatory processes and presumably is associated with B cell-related immune activation. Elevation levels, however, vary a lot and "leaking" of CXCL13 from blood across dysfunctional brain barriers is a possible source. The aim was ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2020, 17(1):7]

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Isolated Area Postrema Syndrome Presenting as Intractable Nausea and Vomiting.

Vasuki Dandu, Suman Siddamreddy, Sreenath Meegada, Vijayadershan Muppidi, Tejo Challa,

Neuromyelitis optica (NMO) is a disease of central nervous system, characterized by demyelination and axonal damage mostly involving optic nerves and spinal cord. Usually these patients present with symptoms related to optic neuritis or myelitis with a typical relapsing course. Some patients present with less common symptoms involving brain stem ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7058]

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Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature.

Amna Ahmed, Alejandro Granillo, Ethan Burns, Kerri Glassner, Nishath Naseem, Christopher Force, Suzanne M Crumley, Ashley Drews,

Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. Patients typically present with a nonspecific clinical picture that often delays diagnosis and treatment, contributing to the high mortality rate. We ... Read more >>

Case Rep Med (Case Reports in Medicine)
[2020, 2020:8613840]

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From illness perceptions to illness reality? Perceived consequences and emotional representations relate to handicap in patients with vertigo and dizziness.

Johannes Wolf, Heribert Sattel, Karina Limburg, Claas Lahmann,

OBJECTIVE:Vertigo and dizziness (VD) are frequent symptoms that can occur due to various structural pathologies or due to functional impairment. Independent of their aetiology, the symptoms are often associated with physical and psychological burden which manifests in severe handicap in more than half of the patients. It is suggested that ... Read more >>

J Psychosom Res (Journal of psychosomatic research)
[2020, 130:109934]

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Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice.

Atsushi Nomura, Daisuke Noto, Goh Murayama, Asako Chiba, Sachiko Miyake,

BACKGROUND:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the absence of apparent inflammation in the central nervous system (CNS), but the mechanisms involved remain unknown. Innate immune-mediated inflammation has attracted attention as a pathogenic mechanism ... Read more >>

Arthritis Res. Ther. (Arthritis research & therapy)
[2019, 21(1):303]

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Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: Clinical and Radiological Considerations.

Fabio Pilato, Marisa Distefano, Rosalinda Calandrelli,

Posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) are relatively uncommon neurological disorders, but their detection has been increasing mainly due to clinical awareness and spreading of magnetic resonance imaging (MRI). Because these syndromes share some common clinical and radiologic features and occasionally occur in the same ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:34]

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Vasculitis and the ear: a literature review.

Torsten Rahne, Stefan Plontke, Gernot Keyßer,

PURPOSE OF REVIEW:Systemic vasculitides as a group of inflammatory disorders of blood vessels may show clinical manifestations in the ear. This article reviews the recent literature about vasculitis of the ear or the cochleovestibular system, focusing on giant-cell arteritis, Takayasu's arteritis, polyarteritis nodosa, Kawasaki disease, microscopic polyangiitis, granulomatosis with polyangiitis ... Read more >>

Curr Opin Rheumatol (Current opinion in rheumatology)
[2020, 32(1):47-52]

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Clinicopathological and Immunological Profile of Patients with Cutaneous Manifestations and their Relationship with Organ Involvement in Systemic Lupus Erythematosus Attending a Tertiary Care Center of Eastern India.

Arghya P Ghosh, Falguni Nag, Saugato Biswas, Raghavendra Rao, Abhishek De,

Background:Lupus erythematosus (LE) is an autoimmune disorder with diverse clinical manifestations ranging from mild cutaneous disorder to life-threatening systemic illness and associated with varying immunological parameters. Aim:We conducted a study in a tertiary care center of eastern India to determine the clinical pattern, immunological profile of patients with cutaneous manifestations ... Read more >>

Indian J Dermatol (Indian journal of dermatology)
[2020, 65(1):22-28]

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Structural dynamics of inosine triphosphate pyrophosphatase (ITPA) protein and two clinically relevant mutants: molecular dynamics simulations.

Yao Houndonougbo, Bethany Pugh, Kandise VanWormer, Caitlin April, Nicholas Burgis,

The inosine triphosphate pyrophosphatase (ITPA) protein is responsible for removing noncanonical purine nucleoside triphosphates from intracellular nucleotide pools. Absence of ITPA results in genomic instability and increased levels of inosine in DNA and RNA. The proline to threonine substitution at position 32 (P32T) affects roughly 15% of the global population ... Read more >>

J. Biomol. Struct. Dyn. (Journal of biomolecular structure & dynamics)
[2020, :1-12]

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A Rare Cause of Optic Neuropathy.

Isabel O Cruz, Sara Alves Pereira, Bruna Vieira, Inês Chora, Paulo Coelho,

Lyme disease is a multisystem infection caused by Borrelia burgdorferi that mainly affects the joints, the heart, and the nervous system. Neurological complications usually manifest in untreated patients and present as meningitis, cranial neuropathies, and radiculoneuritis. The authors present the case of a 48-year-old male who developed loss of vision ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6906]

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Contribution of astrocytes and macrophage migration inhibitory factor to immune-mediated canine encephalitis caused by the distemper virus.

Tatianna F S De Nardo, Paulo H L Bertolo, Priscila A Bernardes, Danísio P Munari, Gisele F Machado, Luciana S Jardim, Pamela R R Moreira, Mayara C Rosolem, Rosemeri O Vasconcelos,

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that is produced by many cell types in situations of homeostasis or disease. One of its functions is to act as a proinflammatory molecule. In humans, several studies have shown that MIF levels become elevated in the serum, urine, cerebrospinal fluid ... Read more >>

Vet. Immunol. Immunopathol. (Veterinary immunology and immunopathology)
[2020, 221:110010]

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Neuroprotective effect of microglia against impairments of auditory steady-state response induced by anti-P IgG from SLE patients in naïve mice.

Xuejiao Wang, Yingzhuo Li, Zijie Li, Jinhong Li, Jingyi Xu, Pingting Yang, Ling Qin,

OBJECTIVE:Autoantibodies against ribosomal P proteins (anti-P antibodies) are strongly associated with the neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE). The present study was designed to assess whether anti-P antibodies can induce abnormal brain electrical activities in mice and investigate the potential cytopathological mechanism. METHODS:Affinity-purified human anti-ribosomal P antibodies were injected ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2020, 17(1):31]

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Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?

Vijaya Iragavarapu-Charyulu, Ewa Wojcikiewicz, Alexandra Urdaneta,

The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in vascular development and autoimmune diseases. Recent studies indicate that while some of ... Read more >>

Front Immunol (Frontiers in Immunology)
[2020, 11:346]

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Fatal Disseminated Aspergillosis in a Patient with Systemic Lupus Erythematosus.

Rochelle Hardie, Tracian James-Goulbourne, Monsoon Rashid, Jeremy Sullivan, Yamen Homsi,

Patients with systemic lupus erythematosus (SLE) are at increased risk for infection including opportunistic infections. Fungal infection in particular can be difficult to diagnose and treat and often can be life-threatening in the immunocompromised patient. We present a case in which a patient with SLE presented to the hospital with ... Read more >>

Case Rep Infect Dis (Case reports in infectious diseases)
[2020, 2020:9623198]

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