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Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity.

Chaomin Li, Jing Li, Fang He, Kun Li, Xu Li, Yan Zhang,

Objective Matrix Gla protein (MGP) is a potent calcification inhibitor. Mgp-/- mice display increased proportion of brown adipose tissue. However, whether MGP is involved in fat metabolism remains unclear. This study aims to investigate the involvement. Methods Expression of adipocyte differentiation markers was examined by RT-qPCR. Adipocyte formation was assessed ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):68-76]

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Impact of sunshine on the risk of gestational diabetes mellitus in primiparous women.

Merja K Laine, Hannu Kautiainen, Mika Gissler, Pirjo Pennanen, Johan G Eriksson,

There is a lack of data about the influence of sunshine hours on the prevalence for gestational diabetes mellitus (GDM). The aim of this study was to evaluate whether the prevalence of GDM varied according to hours of daily sunshine during the first trimester. The study cohort (N = 6189) ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1703882]

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The personal motif in naturalistic case study research: developing "innerstandings" in woman's compulsive behaviour.

Tineke A Abma, Andrea Ruissen, Ellen den Oude, Petra Verdonk,

Purpose: The purpose of this article is to show case study research focused on persons as a case and our personal engagement with the case can improve our innerstandings and understanding of person-centred care. Method: We present the methodology and epistemology of naturalistic case study research and illuminate this approach ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1730552]

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The London Patient.

Timothy Ray Brown,

AIDS Res. Hum. Retroviruses (AIDS research and human retroviruses)
[2020, :]

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AIDSImpact special issue - broadening the lens: recommendations from rehabilitation in chronic disease to advance healthy ageing with HIV.

Kelly K O'Brien, Darren A Brown, Colin Corbett, Nick Flanagan, Patricia Solomon, Jaime H Vera, Rachel Aubry, Richard Harding,

People living with HIV are ageing with a combination of physical, mental and social health challenges, known as disability. Although rehabilitation can address disability, the field is still emerging. Our aim was to identify similar disability experiences across complex chronic conditions and establish recommendations for future rehabilitation research and practice ... Read more >>

AIDS Care (AIDS care)
[2020, :1-9]

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Multilevel Barriers to Engagement in the HIV Care Continuum Among Residents of the State of Rhode Island Living with HIV.

Matthew J Mimiaga, D August Oddleifson, Stephen C Meersman, Annie Silvia, Jaclyn M W Hughto, Stewart Landers, Emily Brown, Paul Loberti,

An estimated 1.2 million people in the United States are living with HIV. Of those living with HIV, only 40% are engaged in HIV care, 37% are prescribed antiretroviral therapy (ART), and 30% are virally suppressed. Individual-, interpersonal-, and structural-level factors that represent barriers to engagement along the HIV care ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, 24(4):1133-1150]

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A Call to Action: Ethics Committee Roundtable Recommendations for Addressing Burnout and Moral Distress in Oncology.

Fay J Hlubocky, Lynne P Taylor, Jonathan M Marron, Rebecca A Spence, Molly M McGinnis, Richard F Brown, Daniel C McFarland, Eric D Tetzlaff, Colleen M Gallagher, Abby R Rosenberg, Beth Popp, Konstantin Dragnev, Linda D Bosserman, Denise M Dudzinski, Sonali Smith, Monica Chatwal, Manali I Patel, Merry J Markham, Kathryn Levit, Eduardo Bruera, Ronald M Epstein, Marie Brown, Anthony L Back, Tait D Shanafelt, Arif H Kamal,

Oncologist well-being is critical to initiating and maintaining the physician-patient relationship, yet many oncologists suffer from symptoms of burnout. Burnout has been linked to poor physical and mental health, as well as increased medical errors, patient dissatisfaction, and workforce attrition. In this Call to Action article, we discuss causes of ... Read more >>

JCO Oncol Pract (JCO oncology practice)
[2020, :JOP1900806]

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Broaching the Topic of HIV Self-testing with Potential Sexual Partners Among Men and Transgender Women Who Have Sex with Men in New York and Puerto Rico.

Cody Lentz, Sarah Iribarren, Rebecca Giguere, Donaldson F Conserve, Curtis Dolezal, Javier Lopez-Rios, Iván C Balán, Alan Z Sheinfil, Christine Tagliaferri Rael, William Brown, Catherine Cruz Torres, Raynier Crespo, Irma Febo, Alex Carballo-Diéguez,

Men who have sex with men (MSM) and transgender women (TGW) are highly affected by HIV and need novel prevention strategies. Using HIV self-testing (HIVST) kits to screen sexual partners may represent a viable risk-reduction alternative; however, more research is needed on effective strategies for broaching HIVST with partners. In ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, :]

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Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System-a Call for Epidemiologic Investigations.

Thomas C Hanff, Michael O Harhay, Tyler S Brown, Jordana B Cohen, Amir M Mohareb,

Mortality from coronavirus disease 2019 (COVID-19) is strongly associated with cardiovascular disease, diabetes, and hypertension. These disorders share underlying pathophysiology related to the renin-angiotensin system (RAS) that may be clinically insightful. In particular, activity of the angiotensin-converting enzyme 2 (ACE2) is dysregulated in cardiovascular disease, and this enzyme is used ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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PEBRA trial - effect of a peer-educator coordinated preference-based ART service delivery model on viral suppression among adolescents and young adults living with HIV: protocol of a cluster-randomized clinical trial in rural Lesotho.

Thabo Ishmael Lejone, Mathebe Kopo, Nadine Bachmann, Jennifer Anne Brown, Tracy Renée Glass, Josephine Muhairwe, Tebatso Matsela, Ramona Scherrer, Lebohang Chere, Tilo Namane, Niklaus Daniel Labhardt, Alain Amstutz,

BACKGROUND:Despite tremendous progress in controlling the HIV epidemic in sub-Saharan Africa, HIV-related mortality continues to increase among adolescents and young people living with HIV (AYPLHIV). Globally, sub-Saharan Africa accounts for 85% of the AYPLHIV. Overall outcomes along the HIV care cascade are worse among AYPLHIV as compared to all other ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):425]

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Effects of Frailty on Outcomes and 30-day Readmissions After Surgical Mitral Valve Replacement.

Amit Iyengar, Nicholas Goel, John J Kelly, Jason Han, Chase R Brown, Fabliha Khurshan, Zehang Chen, Nimesh Desai,

BACKGROUND:Frailty is increasingly recognized as an important prognostic marker in surgical populations. The effects of frailty on outcomes after mitral valve replacement (MVR) is less clear given the inherent complexity of this patient population. We evaluated the influences of frailty on outcomes and readmission rates after MVR. METHODS:Adult patients undergoing ... Read more >>

Ann. Thorac. Surg. (The Annals of thoracic surgery)
[2020, 109(4):1120-1126]

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Information and Motivation Predict HIV-Serostatus Among a Population of High-Risk Men and Transgender Women Who Have Sex with Men.

Alan Z Sheinfil, Rebecca Giguere, Curtis Dolezal, Javier Lopez-Rios, Sarah Iribarren, William Brown, Christine Rael, Cody Lentz, Ivan Balán, Timothy Frasca, Catherine Cruz Torres, Raynier Crespo, Irma Febo, Alex Carballo-Diéguez,

Two constructs from the information-motivation-behavioral skills model were used to predict HIV-serostatus among a sample of men and transgender women who have sex with men. Hypotheses were that lower levels of HIV knowledge and lower levels of motivation to remain HIV-negative would be associated with an increased likelihood of receiving ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, :]

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The Impact of Clinic Policy Attendance and the Ryan White HIV/AIDS Medical Case Management Program on HIV Clinical Outcomes: A Retrospective Longitudinal Study.

Julia D López, Enbal Shacham, Tawnya Brown,

Clinic appointment attendance is a significant determinant of improved HIV health outcomes. A retrospective longitudinal analysis from 2009 to 2015 examined the relationship of clinic policy attendance with and without medical case management (MCM) on HIV clinical outcomes. Clinical parameters were abstracted across the study years and latent growth models ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, 24(4):1161-1169]

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Convergence excess consecutive esotropia associated with 0.01% atropine eye drops usage in patients operated for intermittent exotropia.

Mihir Kothari, Mohini Modak, Heena Khan, Shairin Jahan, Meghna Solanki, Vivek Rathod,

To report convergence excess esotropia (CEET) following 0.01% atropine eye drops (Low dose atropine [LDA]). Children who developed CEET that resolved promptly after discontinuation of LDA are described. Three myopes aged 5.3 ± 1.2 years and mean sphere -4.5D were included. All were operated for intermittent exotropia earlier. Mean esotropia ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2020, 68(4):653-656]

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Diagnostic value of Anthropometric Measurements for Familial Partial Lipodystrophy, Dunnigan variety.

Chandna Vasandani, Xilong Li, Hilal Sekizkardes, Beverley Adams-Huet, Rebecca J Brown, Abhimanyu Garg,

CONTEXT:Familial partial lipodystrophy, Dunnigan variety (FPLD2) is a rare autosomal dominant disorder due to LMNA causal variants, which is characterized by loss of subcutaneous fat from the extremities and predisposition to metabolic complications. The diagnostic value of various anthropometric measurements for FPLD2 remains unknown. OBJECTIVE:To determine specificity and sensitivity of ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, :]

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Treatment and compliance with virtual reality and anaglyph-based training programs for convergence insufficiency.

Mei Ying Boon, Lisa J Asper, Peiting Chik, Piranaa Alagiah, Malcolm Ryan,

BACKGROUND:Convergence insufficiency may be treated by visual exercises designed to increase convergence while maintaining single, clear, binocular vision. However, compliance with treatment is problematic, as patients often cease treatment when symptoms start to improve and before treatment is complete. The purpose of the present study was to assess the feasibility ... Read more >>

Clin Exp Optom (Clinical & experimental optometry)
[2020, :]

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PAMPs of the Fungal Cell Wall and Mammalian PRRs.

Remi Hatinguais, Janet A Willment, Gordon D Brown,

Fungi are opportunistic pathogens that infect immunocompromised patients and are responsible for an estimated 1.5 million deaths every year. The antifungal innate immune response is mediated through the recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). PRRs are immune receptors that ensure the internalisation and ... Read more >>

Curr. Top. Microbiol. Immunol. (Current topics in microbiology and immunology)
[2020, :]

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Does Patient Frailty Status Influence Recovery Following Spinal Fusion for Adult Spinal Deformity?: An Analysis of Patients With 3-Year Follow-up.

Katherine E Pierce, Peter G Passias, Haddy Alas, Avery E Brown, Cole A Bortz, Renaud Lafage, Virginie Lafage, Christopher Ames, Douglas C Burton, Robert Hart, Kojo Hamilton, Michael Kelly, Richard Hostin, Shay Bess, Eric Klineberg, Breton Line, Christopher Shaffrey, Praveen Mummaneni, Justin S Smith, Frank A Schwab, ,

STUDY DESIGN:Retrospective review of a prospective database. OBJECTIVE:The aim of this study was to evaluate postop clinical recovery among adult spinal deformity (ASD) patients between frailty states undergoing primary procedures SUMMARY OF BACKGROUND DATA.: Frailty severity may be an important determinant for impaired recovery after corrective surgery. METHODS:It included ASD ... Read more >>

Spine (Spine)
[2020, 45(7):E397-E405]

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Recreational Use of HIV Antiretroviral Medication and Implications for HIV Pre-exposure Prophylaxis and Treatment.

Caroline Kuo, Danielle Giovenco, Teresa DeAtley, Jackie Hoare, Kristen Underhill, Millicent Atujuna, Catherine Mathews, Dan J Stein, Larry K Brown, Don Operario,

Diversion of antiretroviral therapy (ART) for recreational use is concerning for countries with high HIV prevalence. This paper presents reports of recreational use of ART among adolescents from two HIV prevention studies in South Africa: (1) a cross-sectional survey of N = 200 adolescents and (2) a qualitative study of pre-exposure prophylaxis ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, :]

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An evaluation and review of English language pre-exposure prophylaxis websites and YouTube videos.

Laura Whiteley, Meredith G Healy, Ashley Lowery, Kayla K Haubrick, Larry K Brown,

Int J STD AIDS (International journal of STD & AIDS)
[2020, :956462420905271]

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Impact of etonogestrel implant use on T-cell and cytokine profiles in the female genital tract and blood.

Lisa B Haddad, Alison Swaims-Kohlmeier, C Christina Mehta, Richard E Haaland, Nakita L Brown, Anandi N Sheth, Hsin Chien, Kehmia Titanji, Sharon L Achilles, Davis Lupo, Clyde E Hart, Igho Ofotokun,

BACKGROUND:While prior epidemiologic studies have suggested that injectable progestin-based contraceptive depot medroxyprogesterone acetate (DMPA) use may increase a woman's risk of acquiring HIV, recent data have suggested that DMPA users may be at a similar risk for HIV acquisition as users of the copper intrauterine device and levonorgestrel implant. Use ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230473]

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Safety, feasibility and preliminary efficacy of single agent combretastatin A1 diphosphate (OXi4503) in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes.

Christopher R Cogle, Bradley Collins, Daniel Turner, Leslie C Pettiford, Raphael Bossé, Kimberly E Hawkins, Zackary Beachamp, Elizabeth Wise, Christina Cline, William S May, Jan S Moreb, Jack Hsu, John Hiemenz, Randall Brown, Maxim Norkin, John R Wingard, Fatih Uckun,

Br. J. Haematol. (British journal of haematology)
[2020, :]

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Social network intervention to increase pre-exposure prophylaxis (PrEP) awareness, interest, and use among African American men who have sex with men.

Jeffrey A Kelly, Yuri A Amirkhanian, Jennifer L Walsh, Kevin D Brown, Katherine G Quinn, Andrew E Petroll, Broderick M Pearson, A Noel Rosado, Thom Ertl,

In the U.S., HIV incidence is highest among Black men who have sex with men (MSM) but PrEP uptake is low, in part due to lack of normative support for using PrEP. This research pilot tested a social network-level intervention designed to increase PrEP use willingness, interest, and peer supports ... Read more >>

AIDS Care (AIDS care)
[2020, :1-7]

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Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats.

Ryan du Preez, Stephen Wanyonyi, Peter Mouatt, Sunil K Panchal, Lindsay Brown,

Saskatoon berry (Amelanchier alnifolia) is a potential functional food containing anthocyanins and flavonols, as well as ellagitannins and phenolic acids. We have determined the potential therapeutic effects of Saskatoon berry in diet-induced metabolic syndrome. Nine- to ten-week-old male Wistar rats were randomly assigned to four groups. Two groups were fed ... Read more >>

Nutrients (Nutrients)
[2020, 12(4):]

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Effect of the deuterium on efficiency and type of adipogenic differentiation of human adipose-derived stem cells in vitro.

Alona V. Zlatska, Roman G. Vasyliev, Inna M. Gordiienko, Anzhela E. Rodnichenko, Maria A. Morozova, Maria A. Vulf, Dmytro O. Zubov, Svitlana N. Novikova, Larisa S. Litvinova, Tatiana V. Grebennikova, Igor A. Zlatskiy, Anton V. Syroeshkin,

In this study, we performed an adipogenic differentiation of human adipose-derived stem cells (ADSCs) in vitro with different deuterium content (natural, low and high) in the culture medium during differentiation process with parallel analysis of the gene expression, metabolic activity and cell viability/toxicity. After ADSCs differentiation into adipocytes we have ... Read more >>

Sci Rep (Scientific reports)
[2020, 10:]

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