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Bronchitis Organism Specific Therapy

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Aetiology of Canine Infectious Respiratory Disease Complex and Prevalence of its Pathogens in Europe.

M.J. Day, S. Carey, C. Clercx, B. Kohn, F. MarsilIo, E. Thiry, L. Freyburger, B. Schulz, D.J. Walker,

SummaryThe canine infectious respiratory disease complex (CIRDC) is an endemic worldwide syndrome involving multiple viral and bacterial pathogens. Traditionally, Bordetella bronchiseptica (Bb), canine adenovirus type 2 (CAV-2), canine distemper virus (CDV), canine herpesvirus (CHV) and canine parainfluenza virus (CPiV) were considered the major causative agents. Lately, new pathogens have been ... Read more >>

J. Comp. Pathol. (Journal of Comparative Pathology)
[2020, 176:86-108]

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Developing a core outcome set for children with protracted bacterial bronchitis.

Francis J Gilchrist, Imran Ali, Malcolm Brodlie, Will D Carroll, Bridget Kemball, James Walker, Ian Sinha,

Background:Protracted bacterial bronchitis (PBB) is a chronic endobrochial infection and a leading cause of chronic wet cough in children. There is an urgent need for a randomised controlled trial to investigate the optimal treatment but there is no core outcome set (COS) to inform choice of outcomes. A COS is ... Read more >>

ERJ Open Res (ERJ open research)
[2020, 6(1):]

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Severe community acquired adenovirus pneumonia in an immunocompetent host successfully treated with IV Cidofovir.

Joseph Zhao, Ashton Yap, Eric Wu, Chian Yong Low, Jane Yap,

Adenovirus is a common cause of acute febrile respiratory infection in children and are generally self-limiting although pneumonia can occur in neonates and adults with compromised immunity. However, severe adenovirus pneumonia in healthy adults has been rarely described. Here, we report a case of severe community-acquired adenovirus pneumonia in a ... Read more >>

Respir Med Case Rep (Respiratory medicine case reports)
[2020, 30:101037]

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1767. Incidence of Respiratory Syncytial Virus Infection among Adults Undergoing Hematopoietic Stem Cell Transplantation: A Prospective Study from India.

Sameer Abdul Samad, Lalit Dar, Lalit Kumar, Megha Brijwal, Aashish Choudhary, Animesh Ray, Jyoti Jethani,

AbstractBackground Respiratory Syncytial Virus (RSV) is an important cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients; progression from Upper Respiratory Tract Infection (URI) to Lower Respiratory Tract Infection (LRTI) may occur in 30%–40% of transplant recipients with associated high fatality. Data on disease burden due to ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S651-S651]

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Pneumocystis jirovecii colonization and its association with pulmonary diseases: a multicenter study based on a modified loop-mediated isothermal amplification assay.

Ting Xue, Zhuang Ma, Fan Liu, Weiqin Du, Li He, Jinyan Wang, Chunli An,

BACKGROUND:Pneumocystis jirovecii (P. jirovecii) is an opportunistic fungal pathogen and the role of its colonization in pulmonary diseases has become a popular focus in recent years. The aim of this study was to develop a modified loop-mediated isothermal amplification (LAMP) assay for detection of Pneumocystis jirovecii (P. jirovecii) DNA amongst ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):70]

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Effects of vaccination on acute-phase protein response in broiler chicken.

Arash Janmohammadi, Nariman Sheikhi, Hadi Haghbin Nazarpak, Gholamreza Nikbakht Brujeni,

Broiler chickens experience an acute-phase response (APR) through vaccination, which reflects the innate immunity and stress related to immunization. It is also considered that APR can modulate adaptive immunity and response to infection. As biomarkers for APR, assessing the acute-phase proteins (APPs) function and their levels in response to immunization ... Read more >>

PLoS ONE (PloS one)
[2020, 15(2):e0229009]

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Evaluation of Bronchoscopy and Bronchoalveolar Lavage Findings in Cats With Aelurostrongylus abstrusus in Comparison to Cats With Feline Bronchial Disease.

Paolo E Crisi, Lynelle R Johnson, Angela Di Cesare, Francesca De Santis, Morena Di Tommaso, Simone Morelli, Stefania Pantaleo, Alessia Luciani, Roland Schaper, Fabrizio Pampurini, Andrea Boari,

The cat lungworm Aelurostrongylus abstrusus is a cause of lower respiratory tract disease worldwide. Bronchoscopy and bronchoalveolar lavage (BAL) are important tools for diagnosing respiratory diseases in cats. Therefore, the aim of the study was to investigate the usefulness of bronchoscopy and BAL in the diagnosis of A. abstrusus. Findings ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2019, 6:337]

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Three Amino Acid Changes in Avian Coronavirus Spike Protein Allow Binding to Kidney Tissue.

Kim M Bouwman, Lisa M Parsons, Alinda J Berends, Robert P de Vries, John F Cipollo, Monique H Verheije,

Infectious bronchitis virus (IBV) infects ciliated epithelial cells in the chicken respiratory tract. While some IBV strains replicate locally, others can disseminate to various organs, including the kidney. Here, we elucidate the determinants for kidney tropism by studying interactions between the receptor-binding domain (RBD) of the viral attachment protein spike ... Read more >>

J. Virol. (Journal of virology)
[2020, 94(2):]

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High resolution metagenomic characterization of complex infectomes in paediatric acute respiratory infection.

Ci-Xiu Li, Wei Li, Jun Zhou, Bing Zhang, Yan Feng, Chang-Ping Xu, Yi-Yu Lu, Edward C Holmes, Mang Shi,

The diversity of pathogens associated with acute respiratory infection (ARI) makes diagnosis challenging. Traditional pathogen screening tests have a limited detection range and provide little additional information. We used total RNA sequencing ("meta-transcriptomics") to reveal the full spectrum of microbes associated with paediatric ARI. Throat swabs were collected from 48 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3963]

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Procalcitonin: A promising tool or just another overhyped test?

Robin Paudel, Prerna Dogra, Ashley A Montgomery-Yates, Angel Coz Yataco,

Sepsis is the leading cause of death worldwide. Timely administration of antibiotics is recognized as the cornerstone in the management of sepsis. However, inappropriate use of antibiotics may lead to adverse effects and the selection of drug-resistant pathogens. Microbiological cultures remain the gold standard to diagnose infection despite their low ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2020, 17(3):332-337]

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Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens.

Christine Tedijanto, Yonatan H Grad, Marc Lipsitch,

The relationship between antibiotic stewardship and population levels of antibiotic resistance remains unclear. In order to better understand shifts in selective pressure due to stewardship, we use publicly available data to estimate the effect of changes in prescribing on exposures to frequently used antibiotics experienced by potentially pathogenic bacteria that ... Read more >>

Elife (eLife)
[2020, 9:]

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CD151 in Respiratory Diseases.

Amanda H Wong, Thai Tran,

The tetraspanin, Cluster of Differentiation 151 (CD151), is ubiquitously expressed in adult tissue, especially in the lungs where it has been implicated in lung cancer, asthma, influenza, and idiopathic pulmonary fibrosis (IPF). CD151 interacts with laminin-binding integrins and growth factor receptors, and is reported in cancer-promoting processes such as tumor ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:64]

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Surgical wound dehiscence complicated by methicillin-resistant Staphylococcus aureus infection in a diabetic patient with femorotibial vascular bypass occlusion.

Enrico M Zardi, Nunzio Montelione, Rossella C Vigliotti, Camilla Chello, Domenico M Zardi, Francesco Spinelli, Francesco Stilo,

Diabetic patients with critical limb ischaemia may be affected by severe wound and skin ulcer infections. We report a case of a patient with bilateral femorotibial occlusion and methicillin-resistant Staphylococcus aureus infection. The patient was treated with femoroperoneal vascular bypass, debridement of wound dehiscence and targeted antimicrobial therapy for symptom ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(1):98-100]

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Comprehensive clinical and immunological features of 62 adult patients with selective primary IgM deficiency.

Dayna Lee Lucuab-Fegurgur, Sudhir Gupta,

Selective IgM Deficiency (SIgMD) is a recently incorporated disorder in the classification of primary immunodeficiency diseases. The purpose of this study was to present detailed clinical and immunological features in a cohort of 62 adult patients with SIgMD. A retrospective chart review of 62 patients between 2009 and 2017 with ... Read more >>

Am J Clin Exp Immunol (American journal of clinical and experimental immunology)
[2019, 8(6):55-67]

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Wet Cough and Nasal Symptoms in Children: Can We Do Better?

Fernando M de Benedictis, Ines Carloni, Pasquale Comberiati, Michael D Shields, Andrew Bush, Anne B Chang,

The causes of chronic cough in children are mainly dependent on the setting and age of the child. Protracted bacterial bronchitis is a frequent cause of morbidity in childhood, and antibiotic treatment is beneficial. Prompt recognition and early treatment is important both to prevent inappropriate use of asthma medications and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:459]

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Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design.

Mengjia Zhang, Wan Li, Peng Zhou, Dejian Liu, Rui Luo, Anan Jongkaewwattana, Qigai He,

Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus that causes severe diarrhea, resulting in high mortality in neonatal piglets. Despite widespread outbreaks in many countries, no effective PDCoV vaccines are currently available. Here, we generated, for the first time, a full-length infectious cDNA clone of PDCoV. We further manipulated the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):20-31]

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An exceptional case report of disseminated cryptococcosis in a hitherto immunocompetent patient.

Tatjana Adzic-Vukicevic, Muge Cevik, Jasmina Poluga, Jelena Micic, Salvatore Rubino, Bianca Paglietti, Aleksandra Barac,

Cryptococcosis is an opportunistic fungal infection causes significant disease predominantly in immunocompromised patients. Here we present an excepcional case of disseminated cryptococcosis with pulmonary and cerebral involvement in an immunocompetent patient with no apparent predisposing factors at the time of hospital admission. We described a case of an apparently immunocompetent ... Read more >>

Rev. Inst. Med. Trop. Sao Paulo (Revista do Instituto de Medicina Tropical de São Paulo)
[2020, 62:e3]

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Antimicrobial prescriptions and adherence to prudent use guidelines for selected canine diseases in Switzerland in 2016.

Bérénice Lutz, Claudia Lehner, Kira Schmitt, Barbara Willi, Gertraud Schüpbach, Meike Mevissen, Ruth Peter, Cedric Müntener, Hanspeter Naegeli, Simone Schuller,

Background:Antimicrobial resistance is an increasing problem in human and veterinary medicine and is closely linked to the use of antimicrobials. The objective of this study was to describe antimicrobial prescriptions for selected canine diseases in Switzerland during 2016. Methods:Dogs presented to two university hospitals and 14 private practices for acute ... Read more >>

Vet Rec Open (Veterinary record open)
[2020, 7(1):e000370]

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Assessment of Bronchiectasis in HIV Patients among an Urban Population.

Veena Dronamraju, Navneet Singh, Justin Poon, Sachi Shah, Joseph Gorga, Hector Ojeda-Martinez, Samy McFarlane,

Bronchiectasis is characterized by permanent destruction of the airways that presents with productive cough, as well as bronchial wall thickening and luminal dilatation on computed tomographic (CT) scan of the chest; it is associated with high mortality. Accumulating data suggests higher rates of bronchiectasis among the HIV-positive population. This case ... Read more >>

Case Rep Pulmonol (Case reports in pulmonology)
[2020, 2020:8903809]

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Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006-2016).

Lynelle R Johnson, Eric G Johnson, Sean E Hulsebosch, Jonathan D Dear, William Vernau,

BACKGROUND:Eosinophilic lung disease is a poorly understood inflammatory airway disease that results in substantial morbidity. OBJECTIVE:To describe clinical findings in dogs with eosinophilic lung disease defined on the basis of radiographic, bronchoscopic, and bronchoalveolar lavage fluid (BAL) analysis. Categories included eosinophilic bronchitis (EB), eosinophilic granuloma (EG), and eosinophilic bronchopneumopathy (EBP). ... Read more >>

J. Vet. Intern. Med. (Journal of veterinary internal medicine)
[2019, 33(5):2217-2226]

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Saprochaete Capitata Infection in an 80-Year Old Chronic Obstructive Pulmonary Disease (COPD) Patient: A Case Report.

Pham Ngoc Duan, Nguyen Nhu Hung, Phong Tran Nhu, Chu Dinh Thien, Quang Canh Tran,

BACKGROUND:The fungal disease caused by invasive fungus Saprochaete capitata is becoming an increasingly popular infection. Fungal pathogens mainly occur in patients with immunocompromised disorders such as hematologic malignancies, acute myeloid leukemia, transplant patients. CASE REPORT:In this study, we presented a COPD patient infected with S. capitata. At the first check, ... Read more >>

Open Access Maced J Med Sci (Open access Macedonian journal of medical sciences)
[2019, 7(24):4329-4332]

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Adverse childhood experiences and chronic lung diseases in adulthood: a systematic review and meta-analysis.

Samuel Lopes, Jaime Eduardo Cecilio Hallak, João Paulo Machado de Sousa, Flávia de Lima Osório,

Background: Adverse childhood experiences (ACE) affect physical and mental health and may appear as risk factors for the development of different conditions in adult life. Objective: To perform a literature review and meta-analysis on risk indicators for the development of chronic lung diseases in adulthood associated with ACE. Method: We ... Read more >>

Eur J Psychotraumatol (European journal of psychotraumatology)
[2020, 11(1):1720336]

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Influence of the Lung Microbiota Dysbiosis in Chronic Obstructive Pulmonary Disease Exacerbations: The Controversial Use of Corticosteroid and Antibiotic Treatments and the Role of Eosinophils as a Disease Marker.

Domenico Maurizio Toraldo, Luana Conte,

Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease associated with loss of lung function, poorer quality of life, co-morbidities, significant mortality, and higher health care costs. Frequent acute exacerbations of COPD are sudden worsening of symptoms, the nature of which is associated with bacterial or viral infections. However, ... Read more >>

J Clin Med Res (Journal of clinical medicine research)
[2019, 11(10):667-675]

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First Reported Case of Candida dubliniensis Endocarditis Related to Implantable Cardioverter-Defibrillator.

Nooraldin Merza, John Lung, Taryn B Bainum, Assad Mohammedzein, Shanna James, Mazin Saadaldin, Tarek Naguib,

A 36-year-old male presented to the ED with acute chronic hyponatremia found on routine weekly lab work with one-week history of generalized weakness, confusion, nausea/vomiting, and diarrhea. The patient has nonischemic cardiomyopathy of unknown etiology diagnosed in his teens with an AICD device placed 8 years ago and receiving milrinone ... Read more >>

Case Rep Cardiol (Case reports in cardiology)
[2020, 2020:6032873]

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16S rRNA gene sequencing reveals an altered composition of the gut microbiota in chickens infected with a nephropathogenic infectious bronchitis virus.

Puzhi Xu, Yan Shi, Ping Liu, Yitian Yang, Changming Zhou, Guyue Li, Junrong Luo, Caiying Zhang, Huabin Cao, Guoliang Hu, Xiaoquan Guo,

Infectious bronchitis virus (IBV), a member of the Coronaviridae family, causes serious losses to the poultry industry. Intestinal microbiota play an important role in chicken health and contribute to the defence against colonization by invading pathogens. The aim of this study was to investigate the link between the intestinal microbiome ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3556]

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