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Full Text Journal Articles about
Bronchiectasis

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Adult outcomes of childhood bronchiectasis.

Dawn Sibanda, Rosalyn Singleton, John Clark, Christine Desnoyers, Ellen Hodges, Gretchen Day, Gregory Redding,

Recent literature has highlighted the importance of transition from paediatric to adult care for children with chronic conditions. Non-cystic fibrosis bronchiectasis is an important cause of respiratory morbidity in low-income countries and in indigenous children from affluent countries; however, there is little information about adult outcomes of childhood bronchiectasis. We ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1731059]

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Mutation on lysX from Mycobacterium avium hominissuis impacts the host-pathogen interaction and virulence phenotype.

Greana Kirubakar, Hubert Schäfer, Volker Rickerts, Carsten Schwarz, Astrid Lewin,

The lysX gene from Mycobacterium avium hominissuis (MAH) is not only involved in cationic antimicrobial resistance but also regulates metabolic activity. An MAH lysX deficient mutant was shown to exhibit a metabolic shift at the extracellular state preadapting the bacteria to the conditions inside host-cells. It further showed stronger growth ... Read more >>

Virulence (Virulence)
[2020, 11(1):132-144]

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Managing and preventing exacerbation of bronchiectasis.

Hani Abo-Leyah, James D Chalmers,

PURPOSE OF REVIEW:Pulmonary exacerbations are key events in the natural history of bronchiectasis given their impact on quality of life, prognosis, and their contribution to healthcare costs. Preventing and managing exacerbations is a priority for clinicians and in this review, we discuss measures that should be utilized to achieve this ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):189-196]

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Alpha-1-Antitrypsin Deficiency and Bronchiectasis: A Concomitance or a Real Association?

Alessandro Sanduzzi, Emanuele Ciasullo, Ludovica Capitelli, Stefano Sanduzzi Zamparelli, Marialuisa Bocchino,

Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes' predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are a cough, sputum production and frequent respiratory exacerbations. In the literature, there are many papers concerning ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(7):]

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Association between physical activity and risk of hospitalisation in bronchiectasis.

V Alcaraz-Serrano, E Gimeno-Santos, G Scioscia, A Gabarrús, A Navarro, B Herrero-Cortina, R Amaro, L Fernández-Barat, A Torres,

BACKGROUND:Patients with bronchiectasis have a less active lifestyle than healthy peers, but the association with hospital admission has not been explored. The aim of this study was to investigate the association between (i) any physical activity (PA) variable and (ii) sedentary time with hospitalisation due to exacerbation in adults with ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, :]

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Effectiveness of two high frequency chest wall oscillation techniques in patients with bronchiectasis: a randomized controlled preliminary study.

Antonello Nicolini, Bruna Grecchi, Paolo Banfi,

BACKGROUND:Chest physiotherapy is an important tool in the treatment of bronchiectasis. High frequency chest wall oscillation (HFCWO) is a technique designed to create a global percussion of the lung which moves secretions and probably clears the peripheral bronchial tree. We propose the comparison between an existing device (SmartVest) and a ... Read more >>

Panminerva Med (Panminerva medica)
[2020, :]

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INCREASED CHITOTRIOSIDASE IS ASSOCIATED WITH ASPERGILLUS AND FREQUENT EXACERBATIONS IN SOUTH-EAST ASIANS WITH BRONCHIECTASIS.

Tuang Yeow Poh, Pei Yee Tiew, Albert Yick Hou Lim, Kai Xian Thng, Nur A'tikah Binte Mohamed Ali, Jayanth Kumar Narayana, Micheál Mac Aogáin, Zhijun Tien, Wui Mei Chew, Adrian Kwok Wai Chan, Holly R Keir, Alison J Dicker, Tidi Maharani Hassan, Huiying Xu, Augustine K H Tee, Thun How Ong, Mariko Siyue Koh, John Arputhan Abisheganaden, James D Chalmers, Sanjay H Chotirmall,

BACKGROUND:and Research Question: Chitinase activity is an important innate immune defence mechanism against infection including fungi. The two human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase) are associated to allergy, asthma and chronic obstructive pulmonary disease (COPD), however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO) is unknown STUDY ... Read more >>

Chest (Chest)
[2020, :]

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Impact of mannose-binding lectin 2 gene polymorphisms on disease severity in noncystic fibrosis bronchiectasis in children.

Deniz Dogru, Sanem E Polat, Çağman Tan, İlhan Tezcan, Sıddıka S Yalçın, Eda Utine, Berna Oğuz, İsmail Yaz, Nagehan Emiralioğlu, Mina Hızal, Ebru Yalçın, Uğur Özçelik, Deniz Çağdaş, Nural Kiper,

BACKGROUND:Mannose-binding lectin (MBL) is a complement protein involved in the innate immune system, and is associated with some chronic respiratory diseases including noncystic fibrosis (non-CF) bronchiectasis in adults. The aim of this study was to investigate the frequency of MBL2 gene polymorphisms in children with non-CF bronchiectasis, and the effect ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, :]

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Happy Birthday, Bronchiectasis: 200 Years of Targeting Mucus.

James D Chalmers, Oriol Sibila,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(6):639-640]

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Honeycomb lung-like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis.

Michiru Sawahata, Noriharu Shijubo, Takeshi Johkoh, Koichi Hagiwara, Satoshi Konno, Tetsuo Yamaguchi,

Gene expression profiles of patients with progressive sarcoidosis, most of whom had evidence of fibrosis on imaging, have been reported to be similar to those of patients with inflammatory hypersensitivity pneumonitis, while expression profiles in progressive sarcoidosis did not resemble those of idiopathic pulmonary fibrosis. However, it is not known ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(3):e00539]

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Assessment of Bronchiectasis in HIV Patients among an Urban Population.

Veena Dronamraju, Navneet Singh, Justin Poon, Sachi Shah, Joseph Gorga, Hector Ojeda-Martinez, Samy McFarlane,

Bronchiectasis is characterized by permanent destruction of the airways that presents with productive cough, as well as bronchial wall thickening and luminal dilatation on computed tomographic (CT) scan of the chest; it is associated with high mortality. Accumulating data suggests higher rates of bronchiectasis among the HIV-positive population. This case ... Read more >>

Case Rep Pulmonol (Case reports in pulmonology)
[2020, 2020:8903809]

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Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis.

Kathryn A Ramsey, Alice C H Chen, Giorgia Radicioni, Rohan Lourie, Megan Martin, Amy Broomfield, Yong H Sheng, Sumaira Z Hasnain, Graham Radford-Smith, Lisa A Simms, Lucy Burr, David J Thornton, Simon D Bowler, Stephanie Livengood, Agathe Ceppe, Michael R Knowles, Peadar G Noone, Scott H Donaldson, David B Hill, Camille Ehre, Brian Button, Neil E Alexis, Mehmet Kesimer, Richard C Boucher, Michael A McGuckin,

Rationale: Non-cystic fibrosis bronchiectasis is characterized by airway mucus accumulation and sputum production, but the role of mucus concentration in the pathogenesis of these abnormalities has not been characterized.Objectives: This study was designed to: 1) measure mucus concentration and biophysical properties of bronchiectasis mucus; 2) identify the secreted mucins contained ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(6):661-670]

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Understanding Primary Ciliary Dyskinesia: Experience From a Mediterranean Diagnostic Reference Centre.

Miguel Armengot-Carceller, Ana Reula, Manuel Mata-Roig, Jordi Pérez-Panadés, Lara Milian-Medina, Carmen Carda-Batalla,

BACKGROUND:Due to the lack of a gold standard diagnostic test, reference centres with experienced personnel and costly procedures are needed for primary ciliary dyskinesia (PCD) diagnostics. Diagnostic flowcharts always start with clinical symptoms. Therefore, the aim of this work is to define differential clinical criteria so that only patients clinically ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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Deviations of body functions and structure, activity limitations, and participation restrictions of the International Classification of Functioning, Disability, and Health model in children with cystic fibrosis and non-cystic fibrosis bronchiectasis.

Melike Ozipek, Hulya Arikan, Ebru Calik-Kutukcu, Mintaze Kerem-Gunel, Melda Saglam, Deniz Inal-Ince, Naciye Vardar-Yagli, Ayse Livanelioglu, Cemile Bozdemir-Ozel, Aslihan Cakmak, Hazal Sonbahar-Ulu, Nagehan Emiralioglu, Ugur Ozcelik,

BACKGROUND:To the best of our knowledge, there is no study in the literature investigating the extrapulmonary outcomes of children with non-cystic fibrosis (CF) bronchiectasis and CF under the framework of the International Classification of Functioning, Disability, and Health (ICF) model. The purpose of the present study is to evaluate the ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, :]

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Etiology and characteristics of patients with bronchiectasis in Taiwan: a cohort study from 2002 to 2016.

Hung-Yu Huang, Fu-Tsai Chung, Chun-Yu Lo, Horng-Chyuan Lin, Yu-Tung Huang, Chih-Hsin Yeh, Chang-Wei Lin, Yu-Chen Huang, Chun-Hua Wang,

BACKGROUND:Bronchiectasis is a chronic infectious respiratory disease with diverse causes and ethnic or geographic differences. However, few large-scale studies of its etiology have been conducted in Asia. This study aimed to determine the etiology and clinical features of bronchiectasis in Taiwan. METHODS:This longitudinal cohort study investigated the etiology and clinical ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):45]

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Aberrant Epithelial Cell Proliferation in Peripheral Airways in Bronchiectasis.

Yang Peng, Ai-Ru Xu, Shi-Ying Chen, Yan Huang, Xiao-Rong Han, Wei-Jie Guan, De-Yun Wang, Nan-Shan Zhong,

Dilation of bronchi and bronchioles caused by destruction and excessive epithelial remodeling is a characteristic feature of bronchiectasis. It is not known how epithelial progenitor cells contribute to these pathologic conditions in peripheral airways (bronchioles) in bronchiectasis. We aimed to explore the expression levels of signature airway progenitor cells in ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:88]

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Acute Appendicitis in Patients with Kartagener Syndrome.

Pedro Nogarotto Cembraneli, Gabriel Ambrogi, Julia Brasileiro de Faria Cavalcante, Raphael Raphe, Rafael Luís Luporini,

Situs inversus totalis is a congenital syndrome characterized by a total left-right transposition of all abdominal and thoracic organs. It may be associated with chronic respiratory conditions such as sinusitis and bronchiectasis, composing the Kartagener syndrome. If not detected, this condition may compromise the early diagnosis of surgical emergencies such ... Read more >>

Case Rep Surg (Case reports in surgery)
[2020, 2020:8716474]

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"Can't Stop the Feeling": Symptoms as the Key to Trial Success in Bronchiectasis?

Pierre-Régis Burgel, Sanjay H Chotirmall,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, :]

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Validity of Self-rating Screening Scales for the Diagnosis of Depression and Anxiety in Adult Patients With Bronchiectasis.

Natalia Colomo, Casilda Olveira, Javier Hernández-Pedrosa, Trinidad Bergero, Julia Fábrega-Ruz, Nuria Porras, María Victoria Girón, Luis Fernández de Rota, Gabriel Olveira,

BACKGROUND:There are no previous studies aimed at assessing the validity of the screening scales for depression and anxiety in adult patients with bronchiectasis. AIMS:To analyze the psychometric properties of Hospital Anxiety and Depression Scale (HADS), Beck Depression Inventory (BDI) and Hamilton Anxiety Scale and to evaluate the concordance for the ... Read more >>

Arch. Bronconeumol. (Archivos de bronconeumologia)
[2020, :]

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Sphingosine signaling dysfunction in airway cells as a potential contributor to progression from protracted bacterial bronchitis to bronchiectasis in children.

Sandra Hodge, Matthew Macowan, Hong Liu, Rhys Hamon, Alice C-H Chen, Julie M Marchant, Susan J Pizzutto, John W Upham, Anne B Chang,

AIM:Protracted bacterial bronchitis (PBB) is considered a potential precursor to bronchiectasis (BE) in some children. We previously showed that alveolar macrophages (AM) from children with PBB or BE have a similar significant defect in phagocytic capacity, with proinflammatory associations. We hypothesized that the mechanisms responsible for this defect involve dysregulation ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, :]

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Bubble-positive expiratory pressure device and sputum clearance in bronchiectasis: A randomised cross-over study.

Mary D Santos, Maree A Milross, David K McKenzie, Jennifer A Alison,

OBJECTIVES:The bubble-positive expiratory pressure (PEP) device may be used for sputum clearance in people with daily sputum production. However, this device has never been studied in people with bronchiectasis. Hence, the objective of this study was to compare the effect of bubble-PEP device, the active cycle of breathing technique (ACBT) ... Read more >>

Physiother Res Int (Physiotherapy research international : the journal for researchers and clinicians in physical therapy)
[2020, :e1836]

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Translation and linguistic validation of the Bronchiectasis Health Questionnaire (BHQ) into Danish.

Tina N Gissel, Mikkel Hvass, Jette Fly, Kristine Børsting, Surinder S Birring, Arietta Spinou, Ulla Møller Weinreich,

INTRODUCTION:Patients with bronchiectasis suffer from breathlessness, cough and sputum production, which impairs quality of life. The Bronchiectasis Health Questionnaire (BHQ), a short and disease-specific questionnaire, has previously been developed and validated in English. The aim of this study was to translate and validate the BHQ in Danish, using established cross-cultural ... Read more >>

Dan Med J (Danish medical journal)
[2020, 67(3):]

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High Flow Nasal Therapy Use in Patients with Acute Exacerbation of COPD and Bronchiectasis: A Feasibility Study.

Claudia Crimi, Alberto Noto, Andrea Cortegiani, Raffaele Campisi, Enrico Heffler, Cesare Gregoretti, Nunzio Crimi,

The efficacy and feasibility of high flow nasal therapy (HFNT) use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and bronchiectasis is unknown. We performed a single-center, single-arm prospective observational study in patients with AECOPD, documented bronchiectasis, pH ≥ 7.35, respiratory rate (RR) ≥ 26 breaths/minute despite ... Read more >>

COPD (COPD)
[2020, :1-7]

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Vitamin D Deficiency and Radiological Findings in Adult Non-Cystic Fibrosis Bronchiectasis.

Elif Yelda Niksarlıoğlu, Lütfiye Kılıç, Deniz Bilici, Burcu Yiğitbaş, M Atilla Uysal, Güngör Çamsarı,

OBJECTIVES:Vitamin D may play an important role in immunity and its deficiency has been related to increased respiratory infections. The aim of this study was to detect the prevalence of vitamin D deficiency and to investigate the relationship between radiological and clinical effects on adult bronchiectasis (BR) patients. MATERIALS AND ... Read more >>

Turk Thorac J (Turkish thoracic journal)
[2020, 21(2):87-92]

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Is out-patient based treatment of bronchiectasis exacerbations in children comparable to inpatient based treatment?

Claudia O'Rourke, Sandra Schilling, Rebecca Martin, Patrick Joyce, Anne Bernadette Chang, Nitin Kapur,

BACKGROUND AND OBJECTIVE:Children with bronchiectasis have recurrent exacerbations and may require hospitalization. "Hospital in the home (HITH)" is used as an alternative to hospitalization for children with cystic fibrosis (CF) but to date, there is no published data on children without CF. We describe our experience of HITH (intravenous [IV] ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(4):994-999]

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