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Brain Metastasis

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Silencing hsa_circ_PVT1 (circPVT1) suppresses the growth and metastasis of glioblastoma multiforme cells by up-regulation of miR-199a-5p.

Guonan Chi, Fuwei Yang, Donghui Xu, Weiming Liu,

Background: Glioblastoma multiforme (GBM) is one of the most prevailing primary brain tumours among adults and most aggressive cancers. Despite multiple developments in medical and surgical treatments, GBM is still a deadly disease with a high mortality rate. Here, this study was performed to investigate the function of circPVT1 on ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):188-196]

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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.

Qinghua Wu, Wenda Wu, Vesna Jacevic, Tanos C C Franca, Xu Wang, Kamil Kuca,

c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein functions in a cell context- and cell type-specific manner to affect signal pathways ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):574-583]

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Carbonic anhydrase IX as a novel candidate in liquid biopsy.

Ozen Ozensoy Guler, Claudiu T Supuran, Clemente Capasso,

Among the diagnostic techniques for the identification of tumour biomarkers, the liquid biopsy is considered one that offers future research on precision diagnosis and treatment of tumours in a non-invasive manner. The approach consists of isolating tumor-derived components, such as circulating tumour cells (CTC), tumour cell-free DNA (ctDNA), and extracellular ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):255-260]

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An Instrument to Guide Physicians when Estimating the Survival of Elderly Patients With Brain Metastasis from Gynecological Cancer.

Dirk Rades, Trang Nguyen, Stefan Janssen, Steven E Schild,

BACKGROUND/AIM:For treatment personalization in elderly cancer patients, survival prognoses should be considered. We developed an instrument to estimate survival of elderly patients with brain metastasis from gynecological cancer. PATIENTS AND METHODS:In 15 patients, whole-brain radiotherapy regimen, tumor site, age, Karnofsky performance score (KPS), number of brain metastases, extra-cerebral metastases and ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(4):2257-2260]

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Remaining Lifespan of Patients Aged ≥65 Years Receiving Whole-brain Irradiation for Metastases from Cancer of Unknown Primary.

Dirk Rades, Trang Nguyen, Mai Trong Khoa, Stefan Janssen, Steven E Schild,

BACKGROUND/AIM:Personalized therapies may improve outcomes in elderly patients with brain metastases from cancer of unknown primary (CUP). To contribute to this strategy, an instrument for judging their survival time was designed. PATIENTS AND METHODS:This retrospective study included 53 patients, aged ≥65 years and treated with whole-brain irradiation (WBI) for brain ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(4):2261-2264]

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The potential of an optical surface tracking system in non-coplanar single isocenter treatments of multiple brain metastases.

Ans C C Swinnen, Michel C Öllers, Chin Loon Ong, Frank Verhaegen,

To evaluate the accuracy of a commercial optical surface tracking (OST) system and to demonstrate how it can be implemented to monitor patient positioning during non-coplanar single isocenter stereotactic treatments of brain metastases. A 3-camera OST system was used (Catalyst HD™, C-RAD) on a TruebeamSTx with a 6DoF couch. The ... Read more >>

J Appl Clin Med Phys (Journal of applied clinical medical physics)
[2020, :]

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Outcomes and the Role of Primary Histology Following LINAC-based Stereotactic Radiation for Sarcoma Brain Metastases.

Austin J Sim, Kamran A Ahmed, Andrew Keller, Nicholas B Figura, Daniel E Oliver, Siriporn Sarangkasiri, Timothy J Robinson, Peter A S Johnstone, Hsiang-Hsuan Michael Yu, Arash O Naghavi,

OBJECTIVES:The brain is a rare site for sarcoma metastases. Sarcoma's radioresistance also makes standard whole-brain radiotherapy less appealing. We hypothesize that stereotactic radiation techniques (stereotactic radiosurgery [SRS]/stereotactic fractionated radiotherapy [FSRT]) may provide effective local control. MATERIALS AND METHODS:This single-institution retrospective analysis evaluated our experience with linear acceleator-based SRS/FSRT for sarcoma ... Read more >>

Am. J. Clin. Oncol. (American journal of clinical oncology)
[2020, :]

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Brain Metastases From Gynecologic Malignancies: Prevalence and Management.

Dimitrios Nasioudis, Anitra Persaud, Neil K Taunk, Nawar A Latif,

OBJECTIVE:The objective of this study was to investigate the prevalence, clinicopathologic characteristics, management, and outcomes of patients with brain metastasis (BM) from gynecologic malignancies in a large hospital-based database. MATERIALS AND METHODS:The National Cancer Database (NCDB) was accessed and patients with ovarian, uterine, or cervical cancer and BM were identified. ... Read more >>

Am. J. Clin. Oncol. (American journal of clinical oncology)
[2020, :]

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Challenges in the treatment of breast cancer brain metastases: evidence, unresolved questions, and a practical algorithm.

I Meattini, N Andratschke, A M Kirby, G Sviri, B V Offersen, P Poortmans, O Kaidar Person,

Breast cancer is the leading cause of brain metastases in women. Large randomized clinical trials that have evaluated local therapies in patients with brain metastases include patients with brain metastases from a variety of cancer types. The incidence of brain metastases in the breast cancer population continues to grow, which ... Read more >>

Clin Transl Oncol (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico)
[2020, :]

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External Validation of a Prognostic Score for Patients with Brain Metastases: Extended Diagnosis-Specific Graded Prognostic Assessment.

Carsten Nieder, Sebastian Hess, Victor Lewitzki,

PURPOSE:The aim of our study was the external validation of an extended variant of the four-tiered diagnosis-specific graded prognostic assessment (DS-GPA) that includes more information about extracranial disease burden and blood test results, and predicts survival of patients with brain metastases. The extracranial DS-GPA (EC-GPA) includes serum albumin, lactate dehydrogenase, ... Read more >>

Oncol Res Treat (Oncology research and treatment)
[2020, :1-6]

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Single-fraction radiosurgery versus fractionated stereotactic radiotherapy in patients with brain metastases: a comparative study.

Maxime Loo, Yvan Pin, Alicia Thierry, Jean-Baptiste Clavier,

To compare the local control and brain radionecrosis in patients with brain metastasis primarily treated by single-fraction radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (HFSRT). Between January 2012 and December 2017, 179 patients with only 1-3 brain metastases (total: 287) primarily treated by SRS (14 Gy) or HFSRT (23.1 Gy in 3 fractions ... Read more >>

Clin. Exp. Metastasis (Clinical & experimental metastasis)
[2020, :]

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Tyrosine Kinase Inhibitor Therapy for Brain Metastases in Non-Small-Cell Lung Cancer: A Primer for Radiologists.

C Dodson, T J Richards, D A Smith, N H Ramaiya,

Treatment options for patients who develop brain metastases secondary to non-small-cell lung cancer have rapidly expanded in recent years. As a key adjunct to surgical and radiation therapy options, systemic therapies are now a critical component of the oncologic management of metastatic CNS disease in many patients with non-small-cell lung ... Read more >>

AJNR Am J Neuroradiol (AJNR. American journal of neuroradiology)
[2020, :]

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Papillary thyroid microcarcinoma presenting as a metastasis to the brain.

M Shawky, I Proctor, T Kurzawinski, T Abdel-Aziz,

The brain is a particularly rare site of metastasis from papillary microcarcinoma, with only few cases described in the literature. We present a case of 59-year-old man who presented with seizures and dysphasia due to left frontal lobe cystic mass, which was excised and turned out on histopathology to be ... Read more >>

Ann R Coll Surg Engl (Annals of the Royal College of Surgeons of England)
[2020, :e1-e4]

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Computer-aided Detection of Brain Metastases in T1-weighted MRI for Stereotactic Radiosurgery Using Deep Learning Single-Shot Detectors.

Zijian Zhou, Jeremiah W Sanders, Jason M Johnson, Maria K Gule-Monroe, Melissa M Chen, Tina M Briere, Yan Wang, Jong Bum Son, Mark D Pagel, Jing Li, Jingfei Ma,

Background Brain metastases are manually identified during stereotactic radiosurgery (SRS) treatment planning, which is time consuming and potentially challenging. Purpose To develop and investigate deep learning (DL) methods for detecting brain metastasis with MRI to aid in treatment planning for SRS. Materials and Methods In this retrospective study, contrast material-enhanced ... Read more >>

Radiology (Radiology)
[2020, :191479]

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Study protocol: watchful observation of patients with limited small cell lung cancer instead of the PCI-prospective, multi-center one-arm study.

Sergiusz Nawrocki, Anna Sugajska,

BACKGROUND:Prophylactic cranial irradiation (PCI) is a current standard of care after confirmed response to radical chemoradiotherapy for limited disease small cell lung cancer (LD-SCLC). This standard is mostly based on results of old randomized studies when brain imaging with magnetic resonance (MRI) was not available. Survival benefit of PCI in ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):231]

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Melanoma Radiological Surveillance: A Review of Current Evidence and Clinical Challenges.

Matthew David Howard,

Melanoma is a common cancer in both young and older populations in many western countries. Rates of melanoma diagnosis worldwide are increasing. With the introduction of both targeted and immunotherapies there have been dramatic improvements in the care of patients with metastatic melanoma. With these new therapies being increasingly offered ... Read more >>

Yale J Biol Med (The Yale Journal of Biology and Medicine)
[2020, 93(1):207-213]

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Systemic Therapies for Melanoma Brain Metastases: A Primer for Radiologists.

Cassidy Dodson, Daniel A Smith, Tyler J Richards, Robert R Devita, Christopher J Hoimes, Nikhil H Ramaiya,

OBJECTIVE:The purpose of this article is to provide a primer for radiologists outlining the modern systemic therapies used in melanoma brain metastases, including tyrosine kinase inhibitors and immune checkpoint inhibitors. The role of radiologic treatment response evaluation will be discussed from the standpoint of both modern systemic therapies and more ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2020, :]

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New insights into patterns of first metastatic sites influencing survival of patients with hormone receptor-positive, HER2-negative breast cancer: a multicenter study of 271 patients

Jun Yamamura, Shunji Kamigaki, Junya Fujita, Hiroki Osato, Hironobu Manabe, Yumiko Tanaka, Wataru Shinzaki, Yukihiko Hashimoto, Yoshifumi Komoike,

<title>Abstract</title> <p> Background: The initial therapeutic strategy for hormone receptor-positive (HR+), HER2-negative (HER2-) breast cancer is based on the first metastatic site, but little evidence is available regarding the influence of metastatic distribution patterns of first metastatic sites on prognosis. In this study, we aimed to identify the ... Read more >>

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Primary Brain Rhabdomyosarcoma Causing Extracranial Metastases. Case Report with Narrative Review of Atypical Presentations and Their Diagnostic Challenges.

Charles-Henry Mallereau, Mario Ganau, Julien Todeschi, Hélène Cebula, Marie-Des-Neiges Santin, Guillaume Virbel, Raoul Pop, Benoit Lhermitte, Francois Proust, Salvatore Chibbaro,

BACKGROUND:Rhabdomyosarcoma (RMS) is a rare malignant tumour originating from striated muscle cells; it accounts for only 3% of all soft tissue sarcomas in adults and its metastases can also reach the central nervous system. Only sporadic cases of primary brain RMS (PBRMS) have been reported so far. CASE PRESENTATION:We discuss ... Read more >>

World Neurosurg (World neurosurgery)
[2020, :]

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Risk Factors for Brain Metastases in Patients with Renal Cell Carcinoma.

Zhi-Bin Ke, Shao-Hao Chen, Ye-Hui Chen, Yu-Peng Wu, Fei Lin, Xue-Yi Xue, Qing-Shui Zheng, Ning Xu, Yong Wei,

Background:Patients with brain metastases (BM) from renal cell carcinoma (RCC) were considered to experience a poor prognosis. However, there is little knowledge on the risk factors for BM from RCC at diagnosis. This study was aimed at exploring the risk factors for patients with BM from RCC and the interaction ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:6836234]

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Case report: cranial angiosarcoma with multiple hemorrhagic brain metastasis in a child.

Vanessa Lee, Dominic Gessler, Oguz Cataltepe,

BACKGROUND AND IMPORTANCE:Angiosarcoma is a rare malignant tumor with an aggressive course and poor prognosis. It is typically seen in adults but very rarely seen in children. Angiosarcoma of the skull with brain metastasis is exceptionally rare. Due to the rare nature of these tumors, much is left unknown about ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :]

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Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.

Fangqiu Fu, Yang Zhang, Zhendong Gao, Yue Zhao, Zhexu Wen, Han Han, Yuan Li, Haiquan Chen,

One of the most common sites of extra-thoracic distant metastasis of nonsmall-cell lung cancer is the brain. Our study was performed to discover genes associated with postoperative brain metastasis in operable lung adenocarcinoma (LUAD). RNA seq was performed in specimens of primary LUAD from seven patients with brain metastases and ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

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Synergistic Chemotherapy for Breast Cancer and Breast Cancer Brain Metastases via Paclitaxel-Loaded Oleanolic Acid Nanoparticles.

Youmei Bao, Shenqi Zhang, Zeming Chen, Ann T Chen, Junning Ma, Gang Deng, Weiguo Xu, Jiangbing Zhou, Zhi-Qiang Yu, Guangyu Yao, Jianjun Chen,

Breast cancer is the most common type of cancer in women. About 12% of all women in the United States will be diagnosed with breast cancer over their lifetimes. At the same time, incidences of brain metastases (BMs) are increasing and represent an emerging health threat. However, there is no ... Read more >>

Mol. Pharm. (Molecular pharmaceutics)
[2020, :]

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Brain metastases from differentiated thyroid cancer occurring during and after radioactive iodine therapy: a report of four cases and literature review

Noriko Takata, Yasushi Hamamoto, Masao Miyagawa, Kenji Makita, Hirofumi Ishikawa, Shintaro Tsuruoka, Kei Nagasaki, Teruhito Mochizuki,

<title>Abstract</title> <p> Background Brain metastases from differentiated thyroid cancer are uncommon, and the prognosis of patients with them is poor. To explore the optimal treatment for this entity, we retrospectively investigated incidence and features of brain metastases from differentiated thyroid cancer that appeared during and after radioactive iodine ... Read more >>

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Stereotactic radiosurgery combined with anlotinib for limited brain metastases with perilesional edema in non-small cell lung cancer: Rvision-001 study protocol.

Yuxia Wang, Xin Wang, Yun Guan, Yongchun Song, Hongqing Zhuang, Enmin Wang,

INTRODUCTION:About 50% of patients with non-small cell lung cancers (NSCLC) are diagnosed with brain metastases during treatment, and stereotactic radiosurgery (SRS) is an important treatment for brain oligometastasis. Some patients with brain metastases have cerebral edema before treatment, and radiation therapy may also cause, or aggravate brain edema. Vascular endothelial ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, :]

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