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Bradycardia

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Vascular smooth muscle cell loss underpins the accelerated atherosclerosis in Hutchinson-Gilford progeria syndrome.

Magda R Hamczyk, Vicente Andrés,

Lamin A, a product of the LMNA gene, is an essential nuclear envelope component in most differentiated cells. Mutations in LMNA have been linked to premature aging disorders, including Hutchinson-Gilford progeria syndrome (HGPS). HGPS is caused by progerin, an aberrant form of lamin A that leads to premature death, typically ... Read more >>

Nucleus (Nucleus (Austin, Tex.))
[2019, 10(1):28-34]

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Kv1.1 channel subunits in the control of neurocardiac function.

Edward Glasscock,

Voltage-gated Kv1.1 potassium channel α-subunits are broadly expressed in the nervous system where they act as critical regulators of neuronal excitability. Mutations in the KCNA1 gene, which encodes Kv1.1, are associated with the neurological diseases episodic ataxia and epilepsy. Studies in mouse models have shown that Kv1.1 is important for ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2019, 13(1):299-307]

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Augmented fear bradycardia in rats with heart failure.

Satoshi Koba, Ichiro Hisatome, Tatsuo Watanabe,

In congestive heart failure (CHF), while resting parasympathetic activity becomes reduced, parasympathetically-mediated responses to stressors have not been described. This study aimed to (1) elucidate the effect of CHF on fear bradycardia, a parasympathetically-mediated response, and (2) examine if brain oxidative stress of CHF mediates fear bradycardia. White noise sound ... Read more >>

J Physiol Sci (The journal of physiological sciences : JPS)
[2019, :]

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Swallow syncope: a case report and review of literature.

Kelvin Shenq Woei Siew, Maw Pin Tan, Ida Normiha Hilmi, Alexander Loch,

BACKGROUND:Swallow or deglutition syncope is an unusual type of neurally-mediated syncope associated with life-threatening bradyarrhythmia and hypotension. It is a difficult condition to diagnose with commonly delayed diagnosis and management. There is lack of review articles that elucidate the basic demographics, clinical characteristics and management of this rare condition. This ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2019, 19(1):191]

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Inhibitory effects of sulfur dioxide within the nucleus tractus solitarii of rats: involvement of Calcium Ion channels, Adenine nucleoside triphosphate-sensitive potassium channels, and the nitric oxide/cyclic Guanine trinucleotide phosphate pathway.

Bin Li, Ming-Xia Gao, Wei-Lin Yang, Chen Chai, Deng-Xia Zhang, Hong-Yan Cai, Jian Liu, Yan Lu,

This study was designed to investigate the cardiovascular effects of sulfur dioxide within the nucleus tractus solitarii. Sulfur dioxide or artificial cerebrospinal fluid was unilaterally applied into the nucleus tractus solitarii of rats, and the effects on blood pressure, heart rate, and arterial baroreflex sensitivity (ABR) were determined. To explore ... Read more >>

Neuroreport (Neuroreport)
[2019, 30(13):914-920]

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Trimethoprim/Sulfamethoxazole-Induced Bradycardia, Renal Failure, AV-Node Blockers, Shock and Hyperkalemia Syndrome.

Nnaemeka Diribe, Jacqueline Le,

BRASH (bradycardia, renal failure, atrioventricular-node blockers, shock, and hyperkalemia) syndrome is a recently coined term for a condition that describes the severe bradycardia and shock associated with hyperkalemia in patients on atrioventricular (AV)-node blocking agents. The proposed pathophysiology involves a precipitating event that exacerbates renal dysfunction with resulting AV-node blocker ... Read more >>

Clin Pract Cases Emerg Med (Clinical practice and cases in emergency medicine)
[2019, 3(3):282-285]

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Randomized Controlled Trial on the Effects of Morning versus Evening Primary Vaccination on Episodes of Hypoxemia and Bradycardia in Very Preterm Infants.

Stefan Gottlob, Christian Gille, Christian F Poets,

BACKGROUND:Hypoxemia and bradycardia occur frequently in preterm infants, but are incompletely understood. They are more prevalent during infections and following immunization. Data on adults suggested an increased immune response if subjects slept following vaccination, suggesting an interaction between circadian rhythm and the immune system. Whether this holds true for preterm ... Read more >>

Neonatology (Neonatology)
[2019, :1-6]

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NAVA-synchronized compared to nonsynchronized noninvasive ventilation for apnea, bradycardia, and desaturation events in VLBW infants.

Christa R Tabacaru, Russell R Moores, Joseph Khoury, Henry J Rozycki,

Neurally adjusted ventilatory assistance (NAVA) can overcome technical difficulties with synchronizing noninvasive ventilation breaths with the patient, a modality often used in very low birthweight infants (VLBW) with apnea of prematurity (AOP). This study is a retrospective single-center investigation into whether NAVA-synchronized noninvasive (niNAVA) ventilation is better than nonsynchronized (nasal intermittent positive ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2019, :]

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Sinus Bradycardia as a Rare and Unusual Presentation of Partial Empty Sella Syndrome: A Case Report.

Nabil Braiteh, Nour Breiteh, Hisham E Kashou,

BACKGROUND Empty sella syndrome (ESS) occurs when the pituitary gland becomes flattened or shrinks, which leads to filling of the sella turcica with cerebrospinal fluid. This causes the appearance of empty sella on imaging. ESS is often diagnosed after the workup of pituitary disorders, or as an incidental finding after ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:1071-1074]

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Bradycardia and Asystole in Patients Undergoing Symptomatic Chronically Occluded Internal Carotid Artery Recanalization.

Joseph S Hudson, Mario Zanaty, Victoria Wadman, Daichi Nakagawa, Daizo Ishii, Jorge A Roa, Sami Al Kasab, Kaustubh Limaye, James D Rossen, Pascal Jabbour, Harold P Adams, Edgar A Samaneigo, David M Hasan,

BACKGROUND:Reports have emerged describing the successful endovascular recanalization of chronically occluded cervical internal carotid arteries (COICA). The impact this restoration of flow has on the sensitive carotid sinus baroreceptors has not been previously described. In this manuscript we present the largest COICA surgical series to date, with a specific focus ... Read more >>

World Neurosurg (World neurosurgery)
[2019, :]

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Evaluating and managing bradycardia.

Sunjeet Sidhu, Joseph E Marine,

Bradycardia is a commonly observed arrhythmia and a frequent occasion for cardiac consultation. Defined as a heart rate of less than 50-60 bpm, bradycardia can be observed as a normal phenomenon in young athletic individuals, and in patients as part of normal aging or disease (Table 1). Pathology that produces bradycardia ... Read more >>

Trends Cardiovasc. Med. (Trends in cardiovascular medicine)
[2019, :]

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Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions.

Alicia D'Souza, Tariq Trussell, Gwilym M Morris, Halina Dobrzynski, Mark R Boyett,

Athletes are prone to supraventricular rhythm disturbances including sinus bradycardia, heart block, and atrial fibrillation. Mechanistically, this is attributed to high vagal tone and cardiac electrical and structural remodeling. Here, we consider the supporting evidence for these three pro-arrhythmic mechanisms in athletic human cohorts and animal models, featuring current controversies, ... Read more >>

Physiology (Bethesda) (Physiology (Bethesda, Md.))
[2019, 34(5):314-326]

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Cardiac Arrhythmias and Acute Cerebrovascular Events: A Case of QT Prolongation and Torsades de Pointes Early After Right Insular Stroke.

Ilaria Jane Romano, Antonio Lippolis, Margherita D'Anna, Francesco Gentile,

Stroke involving some areas of the cerebral hemisphere, such as insula, amygdala, and lateral hypothalamus, may cause changes in autonomic control of cardiac function. A 58-year-old woman presented to the emergency department for acute onset of left facial-brachial-crural hemiparesis and dysarthria. A brain CT scan showed subacute ischemic lesion with ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2019, :104308]

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Bradyarrhythmias for the Internist.

Noha Elbanhawy, Shajil Chalil, Khalid Abozguia,

In this article, the authors review the different types of sinus node and atrioventricular node diseases that lead to bradyarrhythmias with their associated symptoms, the diagnostic investigations needed to assess the degree of disease, and the therapeutic management, including the indications for permanent pacing. ... Read more >>

Med. Clin. North Am. (The Medical clinics of North America)
[2019, 103(5):897-912]

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To pace or not to pace…that is not the (only) question: A transition from managing devices to managing disease states in the latest bradycardia guidelines.

Keith R Oken,

Trends Cardiovasc. Med. (Trends in cardiovascular medicine)
[2019, :]

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Hypoxemia, Bradycardia, and Multiple Laryngoscopy Attempts during Anesthetic Induction in Infants: A Single-center, Retrospective Study.

Jorge A Gálvez, Samuel Acquah, Luis Ahumada, Lingyu Cai, Marcia Polanski, Lezhou Wu, Allan F Simpao, Jonathan M Tan, Jack Wasey, John E Fiadjoe,

WHAT WE ALREADY KNOW ABOUT THIS TOPIC:Successful tracheal intubation of an infant may be a challenging skill to acquire due to differing anatomy and physiology compared to older children and adultsMultiple intubation attempts may be associated with increased complications WHAT THIS ARTICLE TELLS US THAT IS NEW: In a quaternary ... Read more >>

Anesthesiology (Anesthesiology)
[2019, :]

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β-blockers in the treatment of periocular infantile hemangioma.

Christiane Al-Haddad, Nasrine Anais El Salloukh, Zeinab El Moussawi,

PURPOSE OF REVIEW:To evaluate the medical literature on the use of β-blockers, through different routes, for the treatment of periorbital infantile hemangiomas and to summarize the recommendations available on dosage and monitoring. RECENT FINDINGS:β-blockers for the treatment of infantile hemangioma are now considered to be first-line treatment. Growing literature on ... Read more >>

Curr Opin Ophthalmol (Current opinion in ophthalmology)
[2019, 30(5):319-325]

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Physiological instability after respiratory pauses in preterm infants.

Andrew P Marshall, Kathleen Lim, Sanoj K Ali, Timothy J Gale, Peter A Dargaville,

BACKGROUND:The factors influencing the severity of apnea-related hypoxemia and bradycardia are incompletely characterized, especially in infants receiving noninvasive respiratory support. OBJECTIVES:To identify the frequency and predictors of physiological instability (hypoxemia-oxygen saturation (SpO2 ) <80%, or bradycardia-heart rate (HR) < 100 bpm) following respiratory pauses in infants receiving noninvasive respiratory support. METHODS:Respiratory pause duration, ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2019, :]

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A unique case of bradycardia recognized by wearable technology as first presentation of complete heart block.

Daniel L Overbeek, Emily M Hogikyan, Mallory Davis, Daniel C McGillicuddy,

Wearable technology has advanced significantly, and the proposed health benefits have been widely touted. Most of the discussion has been surrounding the identification and diagnosis of asymptomatic atrial fibrillation. However, the heart monitoring functions of the wearable technology can also identify other abnormalities as well. We present the first case ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2019, :158357]

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Recovery from bradycardia and desaturation events at 32 weeks corrected age and NICU length of stay: an indicator of physiologic resilience?

V Peter Nagraj, Robert A Sinkin, Douglas E Lake, J Randall Moorman, Karen D Fairchild,

BACKGROUND:Preterm very low birth weight (VLBW) infants experience physiologic maturation and transitions off therapies from 32 to 35 weeks postmenstrual age (PMA), which may impact episodic bradycardia and oxygen desaturation. We sought to characterize bradycardias and desaturations from 32 to 35 weeks PMA and test whether events at 32 weeks ... Read more >>

Pediatr. Res. (Pediatric research)
[2019, :]

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Crataegus mexicana (Tejocote) Exposure Associated with Cardiotoxicity and a Falsely Elevated Digoxin Level.

Katherine G Palmer, Jacob A Lebin, Michael T Cronin, Suzan S Mazor, Rebekah A Burns,

INTRODUCTION:A species of hawthorn, Crataegus mexicana (tejocote), has been marketed as a weight-loss supplement that is readily available for purchase online. While several hawthorn species have shown clinical benefit in the treatment of heart failure owing to their positive inotropic effects, little is known about hawthorn, and tejocote in particular, ... Read more >>

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[2019, :]

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Uterine hypertonus and fetal bradycardia occurred after combined spinal-epidural analgesia during induction of labor with oxytocin infusion: A case report.

Lingyun Yang, Li Wan, Han Huang, Xiaorong Qi,

RATIONALE:Pain management is an essential part of good obstetrical care. The rapid onset of pain relief after combined spinal-epidural (CSE) analgesia may cause a transient imbalance in maternal catecholamine level, leading to uterine hyperactivity and fetal heart rate (FHR) abnormalities. How to manage the uterine basal tone and FHR abnormalities ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(28):e16282]

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Investigation of associations between preoperative acepromazine or dexmedetomidine administration and development of arterial hypotension or bradycardia in dogs undergoing ovariohysterectomy.

Manuel Martin-Flores, Monika M Mostowy, Ella Pittman, Daniel M Sakai, Hussni O Mohammed, Robin D Gleed, Luis Campoy,

OBJECTIVE To evaluate potential associations between preanesthetic administration of acepromazine or dexmedetomidine and development of arterial hypotension or bradycardia in isoflurane-anesthetized dogs undergoing ovariohysterectomy. ANIMALS 341 dogs. PROCEDURES Medical records were searched to identify dogs that underwent ovariohysterectomy between January 2009 and December 2010 and received hydromorphone with acepromazine or ... Read more >>

J. Am. Vet. Med. Assoc. (Journal of the American Veterinary Medical Association)
[2019, 255(2):193-199]

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Role of baseline 12‑lead ECG in predicting syncope caused by arrhythmia in patients investigated using an implantable loop recorder.

Emma Sandgren, Cecilia Rorsman, Nils Edvardsson, Johan Engdahl,

Aim:To evaluate the role of baseline 12‑lead ECG in predicting the syncope mechanism during continuous monitoring using an implantable loop recorder (ILR). Methods:Consecutive patients with syncope implanted with an ILR were enrolled. Baseline 12‑lead ECG were related to ECG diagnosis derived from ILR tracings recorded at the time of syncope ... Read more >>

Int J Cardiol Heart Vasc (International Journal of Cardiology. Heart & Vasculature)
[2019, 24:100386]

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Ganglionated Plexi Ablation to Treat Patients with Refractory Neurally Mediated Syncope and Severe Vagal-Induced Bradycardia.

Mauricio Scanavacca, Denise Hachul,

Arq. Bras. Cardiol. (Arquivos brasileiros de cardiologia)
[2019, 112(6):709-712]

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