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GPN-1/glypican and UNC-52/perlecan do not appear to function in BMP signaling to pattern the C. elegans postembryonic mesoderm.

Melisa S DeGroot, Robert Greer, Jun Liu,

Heparan sulfate proteoglycans (HSPGs) are diverse macromolecules consisting of a protein core modified with glycosaminoglycan (GAG) chains. HSPGs, including glypicans and perlecans, have been implicated in shaping the extracellular matrix (ECM) to affect growth factor signaling. Here, we tested if GPN-1/glypicanor UNC-52/perlecan plays a role in the bone morphogenetic protein ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Saul-Wilson Syndrome Missense Allele Does Not Show Obvious Golgi Defects in a C. elegans Model.

Isabella Zafra, Benjamin Nebenfuehr, Andy Golden,

Saul-Wilson Syndrome is an ultra-rare skeletal syndrome caused by a mutation in the COG4 gene resulting in a glycine-to-arginine substitution at amino acid position 516. The COG4 gene encodes one of 8 subunits of the conserved oligomeric Golgi complex. Using CRISPR-Cas9, our lab generated a <i>C. elegans</i> model for Saul-Wilson ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The S1A protease family members CG10764 and CG4793 regulate cellular immunity in Drosophila.

Pooja Kr, Jonathan Lee, Nathan T Mortimer,

In nature, <i>Drosophila melanogaster</i> larvae are infected by parasitoid wasps and mount a cellular immune response to this infection. Several conserved signaling pathways have been implicated in coordinating this response, however our understanding of the integration and regulation of these pathways is incomplete. Members of the S1A serine protease family ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress.

Veronica H Ryan, Anne C Hart,

Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between <i>sym-2</i>, the gene encoding an ortholog of hnRNPF and hnRNPH, and <i>hrpa-1</i>, the ortholog of of the gene encoding hnRNPA2, which when mutated ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Affordable Caenorhabditis elegans tracking system for classroom use.

Nicholas Leonard, Andrés G Vidal-Gadea,

For decades the nematode <i>C. elegans</i> has served as an outstanding research organism owing to its unsurpassed experimental amenability. This advantage has also made this tiny worm an attractive vehicle for science instruction across higher learning institutions. However, the prohibitive cost associated with the automated behavioral assessment of these animals ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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tmem-258 is dispensable for both nuclear anchorage and migration in C. elegans.

Ellen Gregory, Daniel Starr,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Caspar SUMOylation regulates Drosophila lifespan.

Bhagyashree Kaduskar, Deepti Trivedi, Girish S Ratnaparkhi,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Characterizing Dynein's Role in P-cell Nuclear Migration using an Auxin-Induced Degradation System.

Jamie Ho, Venecia A Valdez, Linda Ma, Daniel A Starr,

MicroPubl Biol (microPublication biology)
[2018, 2018:]

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Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head.

Jie Ma, Xu-Yun Hua, Mou-Xiong Zheng, Jia-Jia Wu, Bei-Bei Huo, Xiang-Xin Xing, Sheng-Yi Feng, Bo Li, Jian-Guang Xu,

Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the cortex. However, most studies are volume-based which may lead to inaccurate anatomical positioning of functional data. The methods that work on the cortical surface may be ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):806-811]

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Microglia regulation of synaptic plasticity and learning and memory.

Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zhou,

Microglia are the resident macrophages of the central nervous system. Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and survey neuronal and synaptic activity. Through the C1q, C3 and CR3 "Eat Me" and CD47 and SIRPα ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):705-716]

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Bone Ingrowth Around an Uncemented Femoral Implant Using Mechanoregulatory Algorithm: A Multiscale Finite Element Analysis.

Basil Mathai, Sanjay Gupta,

The primary fixation and long-term stability of a cementless femoral implant depend on bone ingrowth within the porous coating. Although attempts were made to quantify the peri-implant bone ingrowth using the finite element (FE) analysis and mechanoregulatory principles, the tissue differentiation patterns on a porous-coated hip stem have scarcely been ... Read more >>

J Biomech Eng (Journal of biomechanical engineering)
[2022, 144(2):]

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Influence of Porosity on Fracture Toughness and Fracture Behavior of Antibiotic-Loaded PMMA Bone Cement.

Sunjung Kim, Caroline Baril, Shiva Rudraraju, Heidi-Lynn Ploeg,

Aseptic loosening is the most common reason for the long-term revision of cemented arthroplasties with fracture of the cement being a postulated cause or contributing factor. In our previous studies we showed that adding an antibiotic to a polymethylmethacrylate (PMMA) bone cement led to detrimental effects on various mechanical properties ... Read more >>

J Biomech Eng (Journal of biomechanical engineering)
[2022, 144(1):]

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3D Biofabricated In Vitro Models of Vascularized and Mineralized Bone Tissues.

Maria Vittoria Colombo, Simone Bersini, Chiara Arrigoni, Matteo Moretti,

This protocol describes a comprehensive practical guide for the biofabrication of 3D in vitro models of vascularized and mineralized bone Minitissues. These models give the possibility to study the contribution of physical and biochemical parameters on bone vascularization, as well as the osteoblast/osteoclast mediated matrix remodeling. Based on the specific ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2373:283-296]

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High turnover renal osteodystrophy due to secondary hyperparathyroidism diagnosed by 18F-Fluorocholine combined with 18F-NaF PET/CT.

Lin Xiong, Weihua Wu, Yue Chen, Liang Cai, Santao Ou,

Ren Fail (Renal failure)
[2021, 43(1):882-885]

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Ficus deltoidea promotes bone formation in streptozotocin-induced diabetic rats.

Nurdiana Samsulrizal, Yong-Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal'ain Azmi, Noor Syaffinaz NoorMohamad Zin, Mahdi Ebrahimi,

<h4>Context</h4>Diabetes mellitus increases the risk of bone diseases including osteoporosis and osteoarthritis. We have previously demonstrated that <i>Ficus deltoidea</i> Jack (Moraceae) is capable of reducing hyperglycaemia. However, whether <i>F. deltoidea</i> could protect against diabetic osteoporosis remains to be determined.<h4>Objective</h4>The study examines the effect of <i>F. deltoidea</i> on bone histomorphometric parameters, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):66-73]

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Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway.

Wudi Wei, Chuanyi Ning, Jiegang Huang, Gang Wang, Jingzhen Lai, Jing Han, Jinhao He, Hong Zhang, Bingyu Liang, Yanyan Liao, Thuy Le, Qiang Luo, Zhen Li, Junjun Jiang, Li Ye, Hao Liang,

Little is known about how <i>Talaromyces marneffei</i>, a thermally dimorphic fungus that causes substantial morbidity and mortality in Southeast Asia, evades the human immune system. Polarization of macrophages into fungal-inhibiting M1-like and fungal-promoting M2-like types has been shown to play an important role in the innate immune response against fungal ... Read more >>

Virulence (Virulence)
[2021, 12(1):1997-2012]

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Influence of different incision designs on bone increment of guided bone regeneration (Bio-Gide collagen membrane +Bio-OSS bone powder) during the same period of maxillary anterior tooth implantation.

Genying Zhuang, Jianshui Mao, Guoli Yang, Huiming Wang,

Exploring the influence of different incision designs on bone increment of guided bone regeneration [Bio-Gide collagen membrane +Bio-OSS bone powder (carbonate apatite crystal extracted from bovine bones), Bio-OSS bone meal was placed on the surface of the bone defect and then covered with a Bio-Gide membrane to close the wound] ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2155-2163]

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In vivo characterization of carbon dots-bone interactions: toward the development of bone-specific nanocarriers for drug delivery.

Rachel DuMez, Esmail H Miyanji, Lesly Corado-Santiago, Bryle Barrameda, Yiqun Zhou, Sajini D Hettiarachchi, Roger M Leblanc, Isaac Skromne,

Current treatments for osteoporosis and other bone degenerative diseases predominately rely on preventing further bone erosion rather than restoring bone mass, as the latter treatments can unintentionally trigger cancer development by undiscriminatingly promoting cell proliferation. One approach to circumvent this problem is through the development of novel chemical carriers to ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):1281-1289]

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Inhibitory effect of Astragalus Membranaceus on osteoporosis in SAMP6 mice by regulating vitaminD/FGF23/Klotho signaling pathway.

Yihui Chai, Xiang Pu, Yongzhen Wu, Xingzhong Tian, Qian Li, Fanyong Zeng, Jing Wang, Jie Gao, Huaqian Gong, Yunzhi Chen,

Spontaneous senile osteoporosis severely threatens the health of the senior population which has emerged as a severe issue for society. A SAMP6 mouse model was utilized to estimate the impact of intragastrically administered Astragalus Membranaceus (AR) on spontaneous senile osteoporosis. Bone mineral density (BMD) and bone microstructure were measured using ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4464-4474]

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N-acetyl cysteine ameliorates aortic fibrosis by promoting M2 macrophage polarization in aging mice.

Qing-Yi Zhu, Shi Tai, Liang Tang, Yi-Chao Xiao, Jian-Jun Tang, Ya-Qin Chen, Li Shen, Jia He, Ming-Qi Ouyang, Sheng-Hua Zhou,

<b>Background:</b> Vascular fibrosis is a universal phenomenon associated with aging, and oxidative stress plays an important role in the genesis of vascular damage in line with the aging process. However, whether antioxidants can ameliorate vascular fibrosis remains unclear.<b>Objectives:</b> The present study was to determine antioxidant N-acetylcysteine (NAC) could ameliorates aortic ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):170-175]

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Using standard X-ray images to create 3D digital bone models and patient-matched guides for aiding implant positioning and sizing in total knee arthroplasty.

Vincent Massé, Raju S Ghate,

X-Atlas™ is a new imaging technology intended to advance the state of the art in patient-specific instrumentation. It uses standard AP and lateral radiographs instead of CT or MRI scans to create 3D bone models, which can be used to perform pre-operative surgical planning and fabricate TKA personalized guides. The ... Read more >>

Comput Assist Surg (Abingdon) (Computer assisted surgery (Abingdon, England))
[2021, 26(1):31-40]

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LncRNA MEG8 sponging miR-181a-5p contributes to M1 macrophage polarization by regulating SHP2 expression in Henoch-Schonlein purpura rats.

Mingyu Jiang, Jicheng Dai, Mingying Yin, Chunming Jiang, Mingyong Ren, Lin Tian,

<h4>Background</h4>Long noncoding RNAs (LncRNAs) are regulatory molecules that play important roles in various biological and pathological processes. Herein, we aimed to explore whether maternally expressed gene 8 (MEG8) promotes M1 macrophage polarization among Henoch-Schonlein purpura (HSP) rats, and to investigate the underlying mechanism.<h4>Methods</h4>Relative mRNA expression of MEG8, miR-181a-5p and suppressor ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1576-1588]

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Circular RNA_0062582 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via regulation of microRNA-145/CBFB axis.

Feng Li, Hao Wu, Guoyou Zou, Dingwei Cang, Yixin Shen,

Osteoporosis poses a threat to human health worldwide. To date, there have been few studies regarding targeted treatment of osteoporosis. We aimed to identify the possible molecular mechanism of circular RNA (circ)_0062582 in osteogenic differentiation, and the interactions among circ_0062582, microRNA-145 (miR-145) and core-binding factor subunit β (CBFB). The proliferation ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1952-1963]

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Downregulation of a novel flagellar synthesis regulator AsiR promotes intracellular replication and systemic pathogenicity of Salmonella typhimurium.

Shuangshuang Ma, Lingyan Jiang, Jingting Wang, Xiaoqian Liu, Wanwu Li, Shuai Ma, Lu Feng,

The intracellular pathogen <i>Salmonella enterica</i> serovar Typhimurium (<i>S</i>. Typhimurium) exploits host macrophage as a crucial survival and replicative niche. To minimize host immune response stimulated by flagellin, the expression of flagellar genes is downregulated during <i>S</i>. Typhimurium growth within host macrophages. However, the underlying mechanisms are largely unknown. In this ... Read more >>

Virulence (Virulence)
[2021, 12(1):298-311]

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Hematopoietic stem cell transplantation for inherited bone marrow failure syndromes: alternative donor and disease-specific conditioning regimen with unmanipulated grafts.

Yue Lu, Min Xiong, Rui-Juan Sun, Yan-Li Zhao, Jian-Ping Zhang, Xing-Yu Cao, De-Yan Liu, Zhi-Jie Wei, Jia-Rui Zhou, Dao-Pei Lu,

<i>Objective</i>: The outcomes of alternative donor hematopoietic stem cell transplantation (HSCT) with unmanipulated grafts for Inherited bone marrow failure syndromes (IBMFS) are discouraging. Our study is to demonstrate that IBMFS with disease-specific characteristics requires a tailored conditioning regimens to enhance engraftment and reduce regimen related toxicities. <i>Methods</i>: We retrospectively analyzed ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):134-143]

Cited: 1 time

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