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Blood Dyscrasias and Stroke

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Surrogate Markers of Neutrophil Extracellular Trap Formation are Associated with Ischemic Outcomes and Platelet Activation after Peripheral Angioplasty and Stenting.

Svitlana Demyanets, Stefan Stojkovic, Lisa-Marie Mauracher, Christoph W Kopp, Johann Wojta, Johannes Thaler, Simon Panzer, Thomas Gremmel,

Neutrophil extracellular traps (NETs) are supposed to play a central role in atherothrombosis. We measured circulating citrullinated histone H3 (H3Cit) and cell-free DNA (cfDNA), which serve as surrogate markers of NET formation, in 79 patients with peripheral artery disease (PAD) following infrainguinal angioplasty with stent implantation. Analysis of cfDNA and ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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α-Hydroxybutyrate dehydrogenase is associated with atherothrombotic events following infrainguinal angioplasty and stenting.

Silvia Lee, Renate Koppensteiner, Christoph W Kopp, Thomas Gremmel,

Besides clinical characteristics, easy-accessible laboratory markers could be of value to refine risk stratification in peripheral artery disease. In the current study, we investigated whether α-hydroxybutyrate dehydrogenase (HBDH) is associated with atherothrombotic events in 83 stable patients undergoing infrainguinal angioplasty and stenting. The primary endpoint was defined as the composite ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18200]

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Plasma Levels of snoRNAs are Associated with Platelet Activation in Patients with Peripheral Artery Disease.

Anne Yaël Nossent, Neda Ektefaie, Johann Wojta, Beate Eichelberger, Christoph Kopp, Simon Panzer, Thomas Gremmel,

In addition to supervised walking therapy, antithrombotic therapy and the management of risk factors, the treatment of peripheral artery disease (PAD) is limited to endovascular and surgical interventions, i.e., angioplasty with stent implantation and bypass surgery, respectively. Both are associated with a high restenosis rate. Furthermore, patients with PAD often ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(23):]

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Coexistence of aortic valve stenosis and cardiac amyloidosis: echocardiographic and clinical significance.

Gergely Peskó, Zsigmond Jenei, Gergely Varga, Astrid Apor, Hajnalka Vágó, Sándor Czibor, Zoltán Prohászka, Tamás Masszi, Zoltán Pozsonyi,

BACKGROUND:Left ventricular hypertrophy and diastolic dysfunction are common echocardiographic features of both aortic valve stenosis (AS) and cardiac amyloidosis (CA). These two different entities therefore may mask each other. From recent years, there is a growing body of evidence about the relatively high incidence of wild-type transthyretin (wtTTR) amyloidosis in ... Read more >>

Cardiovasc Ultrasound (Cardiovascular ultrasound)
[2019, 17(1):32]

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POEMS syndrome: a rare cause of adrenal insufficiency in a young male.

Joanna Prokop, João Estorninho, Sara Marote, Teresa Sabino, Aida Botelho de Sousa, Eduardo Silva, Ana Agapito,

Summary:POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes) is a rare multisystemic disease. Clinical presentation is variable, the only mandatory criteria being polyneuropathy and monoclonal gammapathy in association with one major and one minor criterion. Primary adrenal insufficiency is rarely reported. We describe a case of a 33-year-old ... Read more >>

Endocrinol Diabetes Metab Case Rep (Endocrinology, diabetes & metabolism case reports)
[2019, 2019:]

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Ischemic and Bleeding Outcomes in Patients With Atrial Fibrillation and Contraindications to Oral Anticoagulation.

Benjamin A Steinberg, Nicholas G Ballew, Melissa A Greiner, Steven J Lippmann, Lesley H Curtis, Emily C O'Brien, Manesh R Patel, Jonathan P Piccini,

OBJECTIVES:This study sought to describe clinical outcomes among patients with atrial fibrillation (AF) and contraindications to oral anticoagulation (OAC). BACKGROUND:Treatment with OAC prevents stroke and death in patients with AF, but may be contraindicated among patients at high bleeding risk. METHODS:This was an observational, longitudinal analysis of a nationally representative ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2019, 5(12):1384-1392]

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Cardiac amyloidosis: the need for early diagnosis.

M I F J Oerlemans, K H G Rutten, M C Minnema, R A P Raymakers, F W Asselbergs, N de Jonge,

Amyloidosis is a collection of systemic diseases characterised by misfolding of previously soluble precursor proteins that become infiltrative depositions, thereby disrupting normal organ structure and function. In the heart, accumulating amyloid fibrils lead to progressive ventricular wall thickening and stiffness, resulting in diastolic dysfunction gradually progressing to a restrictive cardiomyopathy. The main ... Read more >>

Neth Heart J (Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation)
[2019, 27(11):525-536]

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The role of complement in kidney disease.

Jamie Willows, Matthew Brown, Neil S Sheerin,

While the complement cascade is an important component of the innate immune system, uncontrolled activation can cause severe disease. This concept is illustrated by the prototypical complement-mediated renal disease atypical haemolytic uraemic syndrome (aHUS), which causes renal failure if untreated but when managed with the complement inhibitor eculizumab leaves the ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(2):156-160]

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Rationale and design of "Can Very Low Dose Rivaroxaban (VLDR) in addition to dual antiplatelet therapy improve thrombotic status in acute coronary syndrome (VaLiDate-R)" study : A randomised trial modulating endogenous fibrinolysis in patients with acute coronary syndrome.

Ying X Gue, Rahim Kanji, David M Wellsted, Manivannan Srinivasan, Solange Wyatt, Diana A Gorog,

Impaired endogenous fibrinolysis is novel biomarker that can identify patients with ACS at increased cardiovascular risk. The addition of Very Low Dose Rivaroxaban (VLDR) to dual antiplatelet therapy has been shown to reduce cardiovascular events but at a cost of increased bleeding and is therefore not suitable for all-comers. Targeted ... Read more >>

J. Thromb. Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 49(2):192-198]

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Endoscopic treatment modalities and outcomes in nonvariceal upper gastrointestinal bleeding.

Benjamin Cherng Hann Yip, Hossain Sayeed Sajjad, Jie-Xun Wang, Constantinos P Anastassiades,

BACKGROUND:In nonvariceal upper gastrointestinal bleeding (NVUGIB), the optimal volume of adrenaline, the optimal number of hemoclips, and the application of thermal coagulation in determining patient outcomes have not been well studied. AIM:To demonstrate a dose-response relationship between the commonly used endoscopic modalities for the treatment of non-variceal upper gastrointestinal bleeding ... Read more >>

World J Gastrointest Endosc (World journal of gastrointestinal endoscopy)
[2020, 12(2):72-82]

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Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age.

Davide Diena, Maria Messina, Consuelo De Biase, Fabrizio Fop, Edoardo Scardino, Maura M Rossetti, Antonella Barreca, Aldo Verri, Luigi Biancone,

BACKGROUND:Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. METHODS:This study investigated the impact of post transplant proteinuria in the first year in 1127 kidney transplants analyzing the ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):443]

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Adaptation of potentially preventable medication-related hospitalisation indicators for Indigenous populations in Australia using a modified Delphi technique.

Jean Marie Spinks, Lisa M Kalisch Ellett, Geoffrey Spurling, Theo Theodoros, Daniel Williamson, Amanda J Wheeler,

OBJECTIVES:One of the outcomes of a medication review service is to identify and manage medication-related problems (MRPs). The most serious MRPs may result in hospitalisation, which could be preventable if appropriate processes of care were adopted. The aim of this study was to update and adapt a previously published set ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e031369]

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Risks, Benefits, and the Optimal Time to Resume Deep Vein Thrombosis Prophylaxis in Patients with Intracranial Hemorrhage.

Saman Farr, Harjyot Toor, Tye Patchana, Stacey Podkovik, James G Wiginton, Raed Sweiss, Margaret Rose Wacker, Dan E Miulli,

Introduction It is common to start all patients on chemical prophylaxis for deep vein thrombosis (DVT) in order to decrease the risk of venous thromboembolism (VTE) and the associated adverse effects, including the potential for fatal pulmonary embolism (PE). There is no consensus in the literature on the optimal time ... Read more >>

Cureus (Cureus)
[2019, 11(10):e5827]

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Variants in matrix metalloproteinase-9 gene are associated with hemorrhagic transformation in acute ischemic stroke patients with atherothrombosis, small artery disease, and cardioembolic stroke.

Xingyang Yi, Guo Sui, Qiang Zhou, Chun Wang, Jing Lin, Zhenxiao Chai, Ju Zhou,

OBJECTIVE:The potential effect of matrix metalloproteinase-9 (MMP-9) variants and these variants interactions on hemorrhagic transformation (HT) risk after ischemic stroke (IS) remain unclear. The aims of present study were to investigate the associations of six variants in MMP-9 with HT, and these variants interactions whether related to increased HT risk. ... Read more >>

Brain Behav (Brain and behavior)
[2019, 9(6):e01294]

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Left ventricular global function index by magnetic resonance imaging - a novel marker for differentiating cardiac amyloidosis from hypertrophic cardiomyopathy.

Shan Huang, Hua-Yan Xu, Kai-Yue Diao, Ke Shi, Yong He, Sen He, Yi Zhang, Yue Gao, Meng-Ting Shen, Ying-Kun Guo, Zhi-Gang Yang,

Differentiating cardiac amyloidosis (CA) from hypertrophic cardiomyopathy (HCM) remains a clinical challenge, particularly in those with preserved left ventricular ejection fraction (LVEF) and similar hypertrophy. This study aimed to use left ventricular global function index (LVGFI) and myocardial contraction fraction (MCF) to discriminate CA from HCM without using contrast agents ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4707]

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Atrial Fibrillation in the Elderly: The Role of Sub-Clinical Isolated Cardiac Amyloidosis.

Darshan Krishnappa, Richard Dykoski, Ilknur Can, Mackenzie Mbai, Inder S Anand, Viorel Florea, Y S Chandrashekar, Jian-Ming Li, Venkatakrishna N Tholakanahalli,

Amyloid infiltration of the atrium is described in patients with valvular heart disease and is associated with an increased risk for atrial fibrillation(AF) while amyloid deposits in the ventricles is increasingly being diagnosed in patients with HFpEF. The role of amyloid deposits in patients with AF without valvular heart disease, ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):16584]

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The spectrum of malignancies presenting with neurological manifestations: A prospective observational study.

Dhruv Batra, Hardeep S Malhotra, Ravindra K Garg, Kiran P Malhotra, Neeraj Kumar, Madan L Brahma Bhatt, Rajesh Verma, Praveen K Sharma, Imran Rizvi,

Introduction:A neurological consultation is needed in nearly 45% of patients suffering from cancer. The present study was planned to evaluate the clinical, radiological and histopathological spectrum of patients with an underlying malignancy and presenting with a neurological complaint. Materials and Methods:We prospectively evaluated all patients provisionally diagnosed either with a ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2019, 8(11):3726-3735]

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High-dose Clozapine Withdrawal: A Case Report and Timeline of a Single Potential Withdrawal Seizure.

Megan K Skelly, Tammie Lee Demler, Claudia Lee,

Clozapine, a second-generation antipsychotic (SGA), is known for its superior efficacy in the treatment of refractory schizophrenia. Clozapine's hallmark side effects are well-known, including, but not limited to, drug-induced seizures associated with daily goal doses greater than 600mg and rapid dose escalation, which can also contribute to significant risk of ... Read more >>

Innov Clin Neurosci (Innovations in clinical neuroscience)
[2019, 16(7-08):22-24]

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Early continuous ultrafiltration in Chinese patients with congestive heart failure (EUC-CHF): study protocol for an open-label registry-based prospective clinical trial.

Ying Yang, Chao Shen, Jiangting Lu, Fen Xu, Jinshan Tong, Jiangfen Jiang, Guosheng Fu,

BACKGROUND:Conventional pharmacologic therapies aim to reduce fluid overload in advanced heart failure (HF) represented by intravenous (IV) loop diuretics (LDs) have sometimes not so efficacious and been reported to have side effects such as unpredictable removal of water and sodium and electrolyte disturbance. It is not certain whether early ultrafiltration ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2019, 19(1):249]

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Diagnosis and treatment of heart failure in hereditary transthyretin amyloidosis.

Gisela D Puig-Carrion, Alex Reyentovich, Stuart D Katz,

Amyloidosis describes a family of related disease states associated with the extracellular tissue deposition of fibrils composed of low-molecular-weight subunits of a variety of proteins circulating as constituents of plasma. Depending on the disease subtype, fibrillar deposits in a several organs including the heart, kidney, liver, and peripheral nerves cause ... Read more >>

Clin. Auton. Res. (Clinical autonomic research : official journal of the Clinical Autonomic Research Society)
[2019, 29(Suppl 1):45-53]

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Cardiac Amyloidosis: Updates in Imaging.

Liza Chacko, Raffaele Martone, Francesco Cappelli, Marianna Fontana,

PURPOSE OF REVIEW:We summarize key features pertaining to the two most commonly encountered types of cardiac amyloidosis (CA), monoclonal immunoglobulin light chain (AL) and transthyretin type (ATTR), expanding upon the clinical application and utility of various imaging techniques in diagnosing CA. RECENT FINDINGS:Advances in imaging have led to earlier identification, ... Read more >>

Curr Cardiol Rep (Current cardiology reports)
[2019, 21(9):108]

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Acute Stroke in Diabetes Mellitus: A Prospective Observational Study Evaluating the Course and Short-Term Outcome in Basrah, Southern Iraq.

Mahmood Thamer Altemimi, Ali Raheem Hashim,

Introduction Stroke and diabetes mellitus (DM) are distinct conditions with many aspects in common. Both conditions are prevalent and associated with various vascular risk factors such as dyslipidemia and hypertension. This study was conducted to evaluate the association between stroke and DM regarding the course (i.e., type, recurrence, aspirin failure, ... Read more >>

Cureus (Cureus)
[2019, 11(10):e6017]

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Myocardial fibrosis: why image, how to image and clinical implications.

Rong Bing, Marc Richard Dweck,

Heart (Heart (British Cardiac Society))
[2019, 105(23):1832-1840]

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Focus on Clozapine Withdrawal- and Misuse-Related Cases as Reported to the European Medicines Agency (EMA) Pharmacovigilance Database.

Stefania Chiappini, Fabrizio Schifano, John Martin Corkery, Amira Guirguis,

BACKGROUND:Clozapine is of high clinical relevance for the management of both treatment-resistant schizophrenia and psychotic disturbances with concurrent drug misuse. Although the molecule presents with a range of well-known side-effects, its discontinuation/withdrawal syndrome has been only anecdotally described. AIMS:the 2005-2018 European Medicines Agency (EMA) dataset of Adverse Drug Reactions (ADRs) ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(2):]

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Spotlight on Spironolactone Oral Suspension for the Treatment of Heart Failure: Focus on Patient Selection and Perspectives.

Antonis A Manolis, Theodora A Manolis, Helen Melita, Antonis S Manolis,

Spironolactone, an antagonist of aldosterone, initially used as a potassium-sparing diuretic, was subsequently shown to be a very effective adjunctive agent in the treatment of patients with heart failure with reduced ejection fraction, by halting the disease progression, with significant beneficial effects on both morbidity and mortality. Other uses comprise ... Read more >>

Vasc Health Risk Manag (Vascular health and risk management)
[2019, 15:571-579]

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