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LOC496300 is expressed in the endoderm of developing Xenopus laevis embryos.

Maria Stewart, Kelsey Donahue, Elizabeth Wilke, Emily Shifley,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Prediction of bladder cancer outcome by identifying and validating a mutation-derived genomic instability-associated long noncoding RNA (lncRNA) signature.

Hao Wu, Zi-Yi Zhang, Ze Zhang, Xin-Ying Xiao, Sheng-Lin Gao, Chao Lu, Li Zuo, Li-Feng Zhang,

Bladder cancer is one of the most common malignant tumors worldwide. Accordingly, its incidence and mortality are high. One of the characteristics of cancer is genomic instability. New studies suggest that long non-coding RNAs (lncRNAs) play an important role in maintaining genomic instability. This study aimed to identify a genomic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1725-1738]

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The role of telomerase reverse transcriptase (TERT) promoter mutations in prognosis in bladder cancer.

Song Wan, Xuan Liu, Wei Hua, Ming Xi, Yulin Zhou, Yueping Wan,

Telomerase reverse transcriptase (TERT) promoter mutations have been recognized as a common genetic event in bladder cancer (BC). Many studies have found the high TERT promoter mutations' prevalence in BC recurrence patients which may make the TERT promoter mutations become a potential prognosis prediction of BC. We performed a systematic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1495-1504]

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Construction of a immune-associated genes based prognostic signature in bladder cancer.

Chengquan Shen, Liping Wang, XueCheng Yang, Jing Liu, Qingbo Yang, Xuemei Ding, Haitao Niu, Yonghua Wang,

Current studies indicated that immune-associated genes (IAGs) have important roles in the occurrence and development of bladder cancer (BC). The current work aims to identify the prognostic values of IAGs in BC and establish a prognostic signature based on IAGs. RNA sequencing data and protein expression data were used to ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):108-119]

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Signatures and Prognostic Values of N6-methyladenosine (m6A) - related Immune Genes in Bladder Cancer.

Gaoteng Lin, Jianwei Zhang, Yuqi Wu, Shimiao Zhu, Gang Li,

In recent years, genes associated with N6-methyladenosine (m6A) modification were found to participate in modulation of multiple tumor biological processes. Concomitantly, the significantly complicated dual effects of tumor microenvironment have been observed on cancer progression. The present study aims to investigate m6A-related immune genes (m6AIGs) for their signatures and prognostic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2649-2663]

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Multi-omics reveals novel prognostic implication of SRC protein expression in bladder cancer and its correlation with immunotherapy response.

Wenhao Xu, Aihetaimujiang Anwaier, Chunguang Ma, Wangrui Liu, Xi Tian, Maierdan Palihati, Xiaoxin Hu, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye,

<h4>Purpose</h4>This study aims to identify potential prognostic biomarkers of bladder cancer (BCa) based on large-scale multi-omics data and investigate the role of SRC in improving predictive outcomes for BCa patients and those receiving immune checkpoint therapies (ICTs).<h4>Methods</h4>Large-scale multi-comic data were enrolled from the Cancer Proteome Atlas, the Cancer Genome Atlas ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):596-610]

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Longitudinal assessment of B-RAF V595E levels in the peripheral cell-free tumor DNA of a 10-year-old spayed female Korean Jindo dog with unresectable metastatic urethral transitional cell carcinoma for monitoring the treatment response to a RAF inhibitor (sorafenib).

Jung-Hyun Kim, Dana Hyunjung Ahn, Je-Sung Moon, Hyun-Jung Han, Kieun Bae, Kyong-Ah Yoon,

Transitional cell carcinoma (TCC) is the most common malignant tumor of the canine urinary tract. In this case study, a dog with metastatic urethral TCC was treated with sorafenib. The tumor expression levels of receptor tyrosine kinase genes, including <i>VEGFR-1, VEGFR-2, PDGFR-α, PDGFR-β, ALK, EGFR, ErbB2</i>, and <i>B-RAF</i>, were analyzed. ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):153-162]

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PD-1 inhibitors for urothelial cancer: combination or sequential therapy? - Authors' reply.

Matthew D Galsky, Enrique Grande,

Lancet (Lancet (London, England))
[2021, 396(10267):1977-1978]

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Clinical signs and symptoms associated with WHO severe dengue classification: a systematic review and meta-analysis.

Tha Pyai Htun, Zhonghui Xiong, Junxiong Pang,

<b>ABSTRACT</b>The World Health Organization (WHO) introduced the new dengue classification in 2009. We aimed to assess the association of clinical signs and symptoms with WHO severe dengue classification in clinical practice. A systematic literature search was performed using the databases of PubMed, Embase, and Scopus between 2009 and 2018 according ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1116-1128]

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High turnover renal osteodystrophy due to secondary hyperparathyroidism diagnosed by 18F-Fluorocholine combined with 18F-NaF PET/CT.

Lin Xiong, Weihua Wu, Yue Chen, Liang Cai, Santao Ou,

Ren Fail (Renal failure)
[2021, 43(1):882-885]

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Anticancer active trifluoromethylated fused triazinones are safe for early-life stages of zebrafish (Danio rerio) and reveal a proapoptotic action.

Małgorzata Sztanke, Jolanta Rzymowska, Krzysztof Sztanke,

The main purpose of this investigation was to evaluate the effect of anticancer active compounds (<b>I-VIII</b>) on zebrafish development in order to select the safest molecules. Larval mortality, embryo hatchability and malformations were end-points used to assess the acute toxicity among embryos and larvae from compounds-/pemetrexed-treated and control groups. LC<sub>50</sub> ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):336-344]

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Acid-sensing ion channel 3: An analgesic target.

Jasdip Singh Dulai, Ewan St John Smith, Taufiq Rahman,

Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation by extracellular protons mediate a transient inward current inducing cellular excitability. ASIC subunits exhibit differential tissue ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):94-127]

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The clinical and immunological features of the post-extracorporeal shock wave lithotripsy anti-glomerular basement membrane disease.

Beining Wang, Jia Xiaoyu, Xiaojuan Yu, Zhao Cui, Minghui Zhao,

<h4>Introduction</h4>Extracorporeal shock wave lithotripsy (ESWL) is a noninvasive modality to treat urolithiasis, with complications including tissue damage and hematoma of kidney parenchyma. Anti-glomerular basement membrane (GBM) disease is suggested to be a rare complication of ESWL since it was reported in several cases to occur after ESWL. However, the clinical ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):149-155]

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Clinical profile of a Polish cohort of children and young adults with cystinuria.

Marcin Tkaczyk, Katarzyna Gadomska-Prokop, Iga Załuska-Leśniewska, Kinga Musiał, Jan Zawadzki, Katarzyna Jobs, Tadeusz Porowski, Anna Rogowska-Kalisz, Anna Jander, Meritrafat Kirolos, Adam Haliński, Aleksandra Krzemień, Agnieszka Sobieszczańska-Droździel, Katarzyna Zachwieja, Bodo B Beck, Przemysław Sikora, Marcin Zaniew,

<h4>Background</h4>Cystinuria is an inherited disorder that results in increased excretion of cystine in the urine. It accounts for about 1-2% of pediatric kidney stones. In this study, we sought to identify the clinical characteristics of patients with cystinuria in a national cohort.<h4>Methods</h4>This was a retrospective study involving 30 patients from ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):62-70]

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A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection.

Ying Li, Yousheng Yin, Xiaomei Peng, Hongguang Zheng, Fajun Fu, Zhenxiang Liu, Xiongfei Wu, Xiaoyan Wu, Song Zheng, Nan Chen, Leye He, Laicheng Ren, Zhaohui Ni, Detian Li, Peiyu Liang, Xiaoju Lv, Yingyuan Zhang,

<h4>Purpose</h4>To evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated urinary tract infection (UTI) or complicated UTI.<h4>Methods</h4>In this randomized, active-controlled clinical trial, the patients with acute uncomplicated UTI were randomized to receive sitafloxacin 100-mg once-daily (qd) or levofloxacin 500-mg qd orally for 3-5 days. ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):217-226]

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Phylogenetic Group B2 Expressed Significant Biofilm Formation among Drug Resistant Uropathogenic Escherichia coli.

Saima Javed, Zulfiqar Ali Mirani, Zaid Ahmed Pirzada,

Biofilm is an important virulent marker attributed to the development of urinary tract infections (UTIs) by uropathogenic <i>E. coli</i> (UPEC). Drug-resistant and biofilm-producing UPEC are highly problematic causing catheter-associated or recurrent UTIs with significant morbidity and mortality. The aim of the current study was to investigate the prevalence of biofilm ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2021, 16(1):1845444]

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High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission.

Igor Morozov, Thomas P Monath, David A Meekins, Jessie D Trujillo, Sun-Young Sunwoo, Kinga Urbaniak, In Joong Kim, Sanjeev K Narayanan, Sabarish V Indran, Wenjun Ma, William C Wilson, Cassandra O'Connor, Sheri Dubey, Sean P Troth, Beth-Ann Coller, Richard Nichols, Brian K Martin, Heinz Feldmann, Juergen A Richt,

<b>ABSTRACT</b>The recent impact of Ebola virus disease (EVD) on public health in Africa clearly demonstrates the need for a safe and efficacious vaccine to control outbreaks and mitigate its threat to global health. ERVEBO® is an effective recombinant Vesicular Stomatitis Virus (VSV)-vectored Ebola virus vaccine (VSV-EBOV) that was approved by ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):651-663]

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Fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury.

Long Ma, Jing-Yuan Tang, Jin-Yong Zhou, Chen Zhu, Xin Zhang, Ping Zhou, Qiu Yu, Yan Wang, Xiao-Jian Gu,

After spinal cord injury, the upward conduction of the spinal cord is lost, resulting in the loss of micturition control, which manifests as detrusor sphincter dyssynergia and insufficient micturition. Studies have shown that serotonergic axons play important roles in the control of the descending urination tract. In this study, mouse ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(10):2093-2098]

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Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.

Yanling Jin, Wei Liu, Fengxia Wang, Min Wang, Kai Xu, Aijun Yang, Chenyu Wang, Lihan Zhang, Fangfang Zhang, Min Li,

Tissue factor (TF) has been extensively studied for tumor metastasis, but its role in mediating cancer cell adhesion to vasculature remains unknown. This study aimed to measure the ability of TF to mediate the adhesion of breast cancer cells to human umbilical vein endothelial cells (HUVECs). MDA-MB-231 cells expressed the ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2021, 15(1):74-83]

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Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade.

Shaydee J Budel, Marloes M Penning, Louis C Penning,

The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus. It has a crucial role in processes such as embryogenesis, organ size control, homeostasis and tissue regeneration, where mechanosensing and/or cell-cell ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):172-180]

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Breaking the patientification process - through co-creation of care, using old arctic survival knowledge.

Ulrika Sandén, Lars Harrysson, Hans Thulesius, Fredrik Nilsson,

<h4>Purpose</h4>Cancer research and connected innovation processes often lack a major component; patient participation. We revisit three studies (a-c) in order to explore how Momentary contentment theory may be used to improve patient participation and psychosocial health.<h4>Method</h4>We revisited data from the initial (a) classic grounded theory study on Momentary contentment, based ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2021, 16(1):1926052]

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A bibliometric analysis and review of recent researches on Piezo (2010-2020).

Lifu Wang, Xuening Liu, Kun Zhang, Zhongcheng Liu, Qiong Yi, Jin Jiang, Yayi Xia,

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):310-321]

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Analysis of sinking death using video images of the swimming performance of Pacific Bluefin tuna (Thunnus orientalis) larvae

Y Ina, T Takagi, S Miyashita, M Kurata, T Honryo, Y Sawada, H Fukuda, S Torisawa,

In this study, we aimed to clarify the mechanism of sinking death during the larval stage of Pacific Bluefin tuna Thunnus orientalis by investigating the effects of swimming performance on sinking death, using a behavioral approach. Swimming performance was examined 3–9 days after hatching (DAH) under day and night light ... Read more >>

(Aquacultural engineering.)
[2021, 90:Not Available]

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Health-related quality of life in bladder cancer patients: bladder cancer-specific instruments and domains. Part 2.

Kristin Zimmermann, Hadi Mostafaei, Axel Heidenreich, Hans U Schmelz, Shahrokh F Shariat, Keiichiro Mori,

<h4>Purpose of review</h4>Several instruments have been designed to evaluate health-related quality of life (HRQoL) in patients with bladder cancer (BC). However, they vary in purpose, domains, and quality. To identify QoL instruments that have been validated for BC patients and to critically assess their domains and limitations.<h4>Recent findings</h4>Of the 11 ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):304-314]

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Bladder-preserving strategies for Bacillus Calmette-Guérin unresponsive non-muscle invasive bladder cancer; where are we and what will be expected?: Erratum.

Curr Opin Urol (Current opinion in urology)
[2021, 31(4):436]

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