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Bipolar Affective Disorder

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An exploration of medical student attitudes towards disclosure of mental illness.

Ian Fletcher, Michael Castle, Aaron Scarpa, Orrin Myers, Elizabeth Lawrence,

Background: Medical students are reluctant to access mental health services, despite having high rates of anxiety and depression. This reluctance persists through residency and into practice. Physicians and trainees who are unwell deliver lower quality patient care, behave less professionally, communicate less effectively and are at an increased risk for ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1727713]

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Abnormal brain activity in adolescents with Internet addiction who attempt suicide: an assessment using functional magnetic resonance imaging.

Yan Huang, Lu Xu, Li Kuang, Wo Wang, Jun Cao, Mu-Ni Xiao,

Internet addiction is associated with an increased risk of suicidal behavior and can lead to brain dysfunction among adolescents. However, whether brain dysfunction occurs in adolescents with Internet addiction who attempt suicide remains unknown. This observational cross-sectional study enrolled 41 young Internet addicts, aged from 15 to 20 years, from ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1554-1559]

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Targeting the P2X7 receptor in microglial cells to prevent brain inflammation.

Lin-Hua Jiang, Sébastien Roger,

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1245-1246]

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Estimation of lithium clearance in patients with bipolar disorder.

Saeed Alqahtani, Noha Aljuma'ah, Norah Bin Aydan, Abdullah Alsultan, Emad Alsarhani, Yousif Asiri,

Lithium is an effective agent approved for the treatment of bipolar disorder. It has narrow therapeutic window and significant variability in its pharmacokinetic. The aim of this study is to determine the population pharmacokinetics of lithium in patients with bipolar disorder in Saudi Arabia and to identify the factors that ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2020, 35(3):157-162]

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Older Age Bipolar Disorder.

Annemiek Dols, Aartjan Beekman,

Further understanding of older age bipolar disorder (OABD) may lead to more specific recommendations for treatment adjusted to the specific characteristics and needs caused by age-related somatic and cognitive changes. Late-onset mania has a broad differential diagnosis and requires full psychiatric and somatic work-up, including brain imaging. Research on pharmacotherapy ... Read more >>

Clin. Geriatr. Med. (Clinics in geriatric medicine)
[2020, 36(2):281-296]

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Evaluation of cariprazine in the treatment of bipolar I and II depression: a randomized, double-blind, placebo-controlled, phase 2 trial.

Lakshmi N Yatham, Eduard Vieta, Willie Earley,

This double-blind placebo-controlled, fixed/flexible-dose phase 2 trial assessed the efficacy, safety, and tolerability of cariprazine vs. placebo for depressive episodes associated with bipolar I or II disorder. Primary endpoint was change in Montgomery-Åsberg Depression Rating Scale (MADRS) total scores (baseline to week 8), and secondary endpoint was mean Clinical Global ... Read more >>

Int Clin Psychopharmacol (International clinical psychopharmacology)
[2020, 35(3):147-156]

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The Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP): Changes in preferred treatment strategies and medications over 16 years and five editions.

Duk-In Jon, Young Sup Woo, Jeong-Seok Seo, Jung Goo Lee, Jong-Hyun Jeong, Won Kim, Young Chul Shin, Kyung Joon Min, Bo-Hyun Yoon, Won-Myong Bahk,

OBJECTIVES:The Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) is based on expert consensus and has been revised five times since 2002. The present study evaluated the changes in treatment strategies advocated by the KMAP-BP over time. METHODS:The five editions of the KMAP-BP were reviewed, and the recommendations of the ... Read more >>

Bipolar Disord (Bipolar disorders)
[2020, :]

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Principal Diagnoses in Psychiatric Outpatients With Posttraumatic Stress Disorder: Implications for Screening Recommendations.

Reina Kiefer, Iwona Chelminski, Kristy Dalrymple, Mark Zimmerman,

In this study, we examined the prevalence of posttraumatic stress disorder (PTSD) in 3800 psychiatric outpatients with different principal diagnoses. For all disorders identified as a principal diagnosis, we compared patients' odds ratios of PTSD to all other patients in the sample. Approximately one-sixth of the sample (n = 663, ... Read more >>

J. Nerv. Ment. Dis. (The Journal of nervous and mental disease)
[2020, 208(4):283-287]

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Bipolar disorder and musical obsessions.

Michael Thomson, Verinder Sharma,

Although not listed in the DSM-5, musical obsessions (also known as stuck song syndrome) are generally considered a symptom of obsessive-compulsive disorder. Occurring alone or concurrently with other symptoms of obsessive-compulsive disorder, musical obsessions may be common in bipolar disorder. Due to the lack of awareness and availability of proper ... Read more >>

Bipolar Disord (Bipolar disorders)
[2020, :]

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HDAC inhibitors reverse mania-like behavior and modulates epigenetic regulatory enzymes in an animal model of mania induced by Ouabain.

Roger B Varela, Wilson R Resende, Gustavo C Dal-Pont, Fernanda F Gava, Susannah J Tye, João Quevedo, Samira S Valvassori,

BACKGROUND:The etiology of bipolar disorder (BD) is multifactorial, involving both environmental and genetic factors. Current pharmacological treatment is associated with several side effects, which are the main reason patients discontinue treatment. Epigenetic alterations have been studied for their role in the pathophysiology of BD, as they bridge the gap between ... Read more >>

Pharmacol. Biochem. Behav. (Pharmacology, biochemistry, and behavior)
[2020, :172917]

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Thalamocortical Anatomical Connectivity in Schizophrenia and Psychotic Bipolar Disorder.

Julia M Sheffield, Anna S Huang, Baxter P Rogers, Monica Giraldo-Chica, Bennett A Landman, Jennifer Urbano Blackford, Stephan Heckers, Neil D Woodward,

BACKGROUND:Anatomical connectivity between the thalamus and cortex, including the prefrontal cortex (PFC), is abnormal in schizophrenia. Overlapping phenotypes, including deficits in executive cognitive abilities dependent on PFC-thalamic circuitry, suggest dysrupted thalamocortical anatomical connectivity may extend to psychotic bipolar disorder. We tested this hypothesis and examined the impact of illness stage ... Read more >>

Schizophr Bull (Bp) (Schizophrenia bulletin)
[2020, :]

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Cognitive outcomes of the bipolar depression electrical treatment trial (BETTER): a randomized, double-blind, sham-controlled study.

Gabriel Tortella, Bernardo Sampaio-Junior, Marina L Moreno, Adriano H Moffa, Adriano Fernandes da Silva, Beny Lafer, Paulo Andrade Lotufo, Wagner Gattaz, Lucas Borrione, Rodrigo Machado-Vieira, Stephan Goerigk, Isabela M Benseñor, Andre R Brunoni,

Bipolar depression is associated with marked cognitive deficits. Pharmacological treatments for this condition are limited and may aggravate depressive and cognitive symptoms. Therefore, therapeutic interventions that preserve adequate cognitive functioning are necessary. Our previous results demonstrated significant clinical efficacy of transcranial direct current stimulation (tDCS) in the Bipolar Depression Electrical ... Read more >>

Eur Arch Psychiatry Clin Neurosci (European archives of psychiatry and clinical neuroscience)
[2020, :]

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Cognitive and clinical predictors of community functioning across the psychoses.

Kathryn E Lewandowski, Talia R Cohen, Dost Ongur,

Schizophrenia, bipolar disorder, and related psychotic illnesses are common, serious mental disorders that are often associated with functional impairments and poor quality of life, even after clinical recovery. Cognitive dysfunction is a strong predictor of functional impairment; however, findings regarding relative impairments in functioning and cognition across diagnoses have been ... Read more >>

Psych J (PsyCh journal)
[2020, :]

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Lithium treatment in the era of personalized medicine.

Janusz K Rybakowski,

In 1949, an Australian psychiatrist, John Cade, reported on the antimanic efficacy of lithium carbonate, which is regarded as an introduction of lithium into contemporary psychiatry. Since the 1960s, lithium has been a precursor of mood stabilizers and has become first-choice drug for the prevention of affective episodes in mood ... Read more >>

Drug Dev. Res. (Drug development research)
[2020, :]

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Managing bipolar disorder during pregnancy and the postpartum period: a critical review of current practice.

Verinder Sharma, Priya Sharma, Sapna Sharma,

Introduction: Despite increased interest in the pharmacotherapy of bipolar disorder during pregnancy and the postpartum period, management of the disorder during these critical periods in a woman's life remains challenging.Areas covered: The authors review the effect of pregnancy and the postpartum period on the course of bipolar disorder, describe adverse ... Read more >>

Expert Rev Neurother (Expert review of neurotherapeutics)
[2020, :1-11]

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Olfactory Memory in Depression: State and Trait Differences between Bipolar and Unipolar Disorders.

François Kazour, Sami Richa, Chantale Abi Char, Boriana Atanasova, Wissam El-Hage,

: Background: Changes in olfactory recognition memory may constitute sensory markers in depression. Significant differences may exist between unipolar and bipolar depression. Our study compares olfactory memory between control, unipolar, and bipolar patients in depressed and euthymic states in order to identify potential markers of depression. METHODS:176 participants were recruited ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(3):]

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An Extended Swedish National Adoption Study of Bipolar Disorder Illness and Cross-Generational Familial Association With Schizophrenia and Major Depression.

Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist,

Importance:Information about how risk for bipolar disorder is transmitted across generations and how parental risk for bipolar disorder relates to their children's risk for schizophrenia and major depression is limited. Objective:To evaluate the sources of parent-offspring transmission of bipolar disorder and its familial cross-generational association with schizophrenia and major depression. ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, :]

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Patients with borderline personality disorder and bipolar disorder: a descriptive and comparative study.

Mark Zimmerman, Caroline Balling, Iwona Chelminski, Kristy Dalrymple,

BACKGROUND:Bipolar disorder and borderline personality disorder (BPD) are each significant public health problems. It has been frequently noted that distinguishing BPD from bipolar disorder is challenging. Consequently, reviews and commentaries have focused on differential diagnosis and identifying clinical features to distinguish the two disorders. While there is a burgeoning literature ... Read more >>

Psychol Med (Psychological medicine)
[2020, :1-12]

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Functional analysis of an R311C variant of Ca2+ -calmodulin dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder.

Naomi Xy Ling, Christopher G Langendorf, Ashfaqul Hoque, Sandra Galic, Kim Loh, Bruce E Kemp, Andrew L Gundlach, Jonathan S Oakhill, John W Scott,

OBJECTIVES:Loss-of-function mutations in the gene encoding the calcium-calmodulin (Ca2+ -CaM) dependent protein kinase kinase-2 (CaMKK2) enzyme are linked to bipolar disorder. Recently, a de novo arginine to cysteine (R311C) mutation in CaMKK2 was identified from a whole exome sequencing study of bipolar patients and their unaffected parents. The aim of ... Read more >>

Bipolar Disord (Bipolar disorders)
[2020, :]

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Glial and neuronal markers in bipolar disorder: A meta-analysis testing S100B and NSE peripheral blood levels.

Francesco Bartoli, Błażej Misiak, Cristina Crocamo, Giuseppe Carrà,

S100 calcium-binding protein B (S100B) and neuron-specific enolase (NSE) might be peripheral markers reflecting glia and neuronal abnormalities in subjects with bipolar disorder. We carried out a systematic review and meta-analysis, searching for studies indexed in main electronic databases, to clarify whether S100B and NSE blood levels might be increased ... Read more >>

Prog. Neuropsychopharmacol. Biol. Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2020, 101:109922]

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Effect of Slope Grain on Mechanical Properties of Different Wood Species.

Przemysław Mania, Filip Siuda, Edward Roszyk,

The aim of the presented study is to determine the relationship between mechanical parameters of selected wood species (Carya sp., Fagus sylvatica L., Acer platanoides L., Fraxinus excelsior L., Ulmus minor Mill.) used for the production of hand tools and drumsticks and the grain deviation angle from the rectilinear pattern. ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2020, 13(7):]

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Resting state networks activity in euthymic Bipolar Disorder.

Marcella Bellani, Pietro Bontempi, Niccolò Zovetti, Maria Gloria Rossetti, Cinzia Perlini, Nicola Dusi, Letizia Squarcina, Veronica Marinelli, Giada Zoccatelli, Franco Alessandrini, Elisa Francesca Maria Ciceri, Andrea Sbarbati, Paolo Brambilla,

OBJECTIVES:Bipolar disorder (BD) is a psychiatric condition causing shifts in mood, energy and activity levels severely altering the quality of life of the patients even in the euthymic phase. Although widely accepted, the neurobiological bases of the disorder in the euthymic phase remain elusive. This study aims at characterizing resting ... Read more >>

Bipolar Disord (Bipolar disorders)
[2020, :]

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Delirious mania as a frequent and recognizable neuropsychiatric syndrome in patients with anti-NMDAR encephalitis.

Miguel Restrepo-Martinez, Jesus Ramirez-Bermudez, Leo Bayliss, Mariana Espinola-Nadurille,

BACKGROUND:Previous case reports showed that delirious mania could be one of the many neuropsychiatric presentations of Anti-N-methyl-d-aspartate receptor encephalitis (ANMDARE). OBJECTIVE:To evaluate the frequency of delirious mania and its associated factors in ANMDARE. METHOD:A prospective study, including all patients with ANMDARE admitted to the National Institute of Neurology and Neurosurgery ... Read more >>

Gen Hosp Psychiatry (General hospital psychiatry)
[2020, 64:50-55]

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Diet and Neurocognition in Mood Disorders - an Overview of the Overlooked.

Vicent Balanzá-Martínez, Flavio Milman Shansis, Amparo Tatay-Manteiga, Pilar López-García,

Bipolar disorder and major depression are associated with significant disability, morbidity, and reduced life expectancy. People with mood disorders have shown higher ratios of unhealthy lifestyle choices, including poor diet quality and suboptimal nutrition. Diet and nutrition impact on brain /mental health, but cognitive outcomes have been less researched in ... Read more >>

Curr. Pharm. Des. (Current pharmaceutical design)
[2020, :]

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Valproic Acid-Induced Hyperammonemic Encephalopathy in a Patient with Bipolar Disorder: A Case Report.

Meng-Yu Wu, Fang-Yu Chang, Jian-Yu Ke, Chien-Sheng Chen, Po-Chen Lin, Tzong-Shi Wang,

Valproic acid (VPA) is widely used to control various seizure disorders and psychiatric disorders. Valproic acid-induced hyperammonemic encephalopathy (VHE) is a rare but dangerous complication of VPA-induced toxicity. For this case report, several risk factors were identified, including young age, polytherapy regimens, VPA overdose, poor liver function, and carnitine deficiency. ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(3):]

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