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Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells in vitro.

Ewa Grabowska, Magdalena Czerniecka, Urszula Czyżewska, Aneta Zambrzycka, Zenon Łotowski, Adam Tylicki,

Oxythiamine (OT) and 3-deazathiamine (DAT) are the antimetabolites of thiamine. The aim of study was to compare the effects of OT and DAT pyrophosphates (-PP) on the kinetics of mammalian pyruvate dehydrogenase complex (PDHC) and the in vitro culture of HeLa cells. The kinetic study showed that 3-deazathiamine pyrophosphate (DATPP) was ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):122-129]

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Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.

Sigrun Lange,

Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes, including in the central nervous system. Peptidylarginine deiminases cause post-translational deimination/citrullination, leading to changes in structure and function of a wide range of target proteins. Deimination can facilitate protein moonlighting, modify protein-protein interaction, cause ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):934-938]

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Serum total prostate-specific antigen (tPSA): correlation with diagnosis and grading of prostate cancer in core needle biopsy.

Nina Čamdžić, Suada Kuskunović-Vlahovljak, Mirsad Dorić, Svjetlana Radović, Edina Lazović Salčin, Mirsad Babić,

Aim To investigate the impact of pre-treatment serum total prostate-specific antigen (PSA) level on prevalence of prostate carcinoma detection in prostate core needle biopsy, and its correlation with established prognostic factors. Methods Prostate needle biopsy samples of 115 patients with available pre-treatment serum total PSA (tPSA) level were analysed. For ... Read more >>

Med Glas (Zenica) (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina)
[2021, 18(1):]

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Recent Advances and Current Role of Transperineal Prostate Biopsy.

Yasin Bhanji, Mathew J Allaway, Michael A Gorin,

"Approximately 1 million prostate biopsies are performed each year in the United States. This procedure has traditionally been performed using a transrectal approach, which is associated with a significant risk of infectious complications including sepsis. In recent years, transperineal prostate biopsy has been increasingly adopted due to its lower associated ... Read more >>

Urol Clin North Am (The Urologic clinics of North America)
[2021, 48(1):25-33]

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Effect of Tracer Staining Technology Based on Nano-Carbon Suspension on Patients with Oral Squamous Cell Carcinoma.

Tongwu Wang, Hongyu Yang, Dong Liang, Rahim Kacimi, Alain Pegatoquet,

Oral squamous cell carcinoma has the characteristics of high malignancy, strong invasiveness and special anatomical location. The prognosis of patients is generally poor. Invasion and metastasis of oral squamous cell carcinoma is a complex process involving multiple levels and factors. In order to explore the value of sentinel lymph node ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):995-1000]

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Assessing the effect of physeal biopsy on angular deformity in a rabbit model.

Peter Stevens, Richard T Epperson, Nicholas B Taylor, Mary Dickerson, Dustin L Williams,

Obtaining a biopsy of the physis in a pediatric/juvenile could provide the ability to diagnose and manage children with physeal abnormalities. However, it has not yet been determined whether a physeal biopsy procedure affects angular deformity. We employed a rabbit model to collect biopsies of the distal femoral and proximal ... Read more >>

J Pediatr Orthop B (Journal of pediatric orthopedics. Part B)
[2021, 30(1):93-100]

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Management of High-Risk Breast Lesions.

Manisha Bahl,

High-risk breast lesions (HRLs) are a group of heterogeneous lesions that can be associated with a synchronous or adjacent breast cancer and that confer an elevated lifetime risk of breast cancer. Management of HRLs after core needle biopsy may include close imaging and clinical follow-up or excisional biopsy to evaluate ... Read more >>

Radiol Clin North Am (Radiologic clinics of North America)
[2021, 59(1):29-40]

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Role of Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection in the Management of Barrett's Related Neoplasia.

Esther A Nieuwenhuis, Oliver Pech, Jacques J G H M Bergman, Roos E Pouw,

Endoscopic resection has been proven to be safe and highly effective for removing early neoplastic lesions in Barrett esophagus. It enables accurate histopathological assessment and is therefore considered as the cornerstone in the endoscopic work-up for patients with Barrett neoplasia. Various techniques are available to perform endoscopic resection. Multiband mucosectomy ... Read more >>

Gastrointest Endosc Clin N Am (Gastrointestinal endoscopy clinics of North America)
[2021, 31(1):171-182]

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Diagnostic significance of cytomegalovirus DNA quantitation in gastrointestinal biopsies: comparison with histopathological data and blood cytomegalovirus DNA.

Sema Alacam, Nuran Karabulut, Ayfer Bakir, Mustafa Onel, Melek Buyuk, Mine Gulluoglu, Ali Agacfidan,

<b>Objectives:</b>This study aims to improve the diagnosis of gastrointestinal (GI) cytomegalovirus (CMV) disease. It presents the results of a novel study in which CMV blood viral load (BVL), tissue viral load (TVL) determined by PCR and hematoxylin-eosin (HE)/immunohistochemistry (IHC) results of GI biopsies are examined comparatively.<br><br><b>Methods:</b>CMV DNA was investigated by ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(1):40-45]

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Blastomere removal affects homeostatic control leading to obesity in male mice.

Magdalena Kotlarska, Dawid Winiarczyk, Wiesława Florek, Marta Ziętek, Jolanta Pęczkowicz-Szyszka, Adrian Mateusz Stankiewicz, Rafał Radosław Starzyński, Roberta Arena, Gaspare Drago, Silvestre Sampino, Jacek Andrzej Modlinski,

Preimplantation embryos are particularly vulnerable to environmental perturbations, including those related to assisted reproductive technologies. Invasive embryo manipulations, such as blastomere biopsy, are applied worldwide in clinical settings for preimplantation genetic testing. Mouse models have previously shown that blastomere biopsy may be associated with altered phenotypes in adult offspring. The ... Read more >>

Reproduction (Reproduction (Cambridge, England))
[2021, 161(1):61-72]

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Aspiration Biopsy Versus Dilatation and Curettage for Endometrial Hyperplasia Prior to Hysterectomy

Woo Yeon Hwang, Dong Hoon Suh, Kidong Kim, Jae Hong No, Yong Beom Kim,

Abstract Background: To compare the diagnostic accuracy of aspiration biopsy and dilatation and curettage (D&C) in patients diagnosed with endometrial hyperplasia prior to hysterectomy. Methods: We retrospectively reviewed medical records of 250 patients diagnosed with endometrial hyperplasia by endometrial sampling between July 2003 and March 2020. Endometrial sampling was performed ... Read more >>

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Carbonic anhydrase IX as a novel candidate in liquid biopsy.

Ozen Ozensoy Guler, Claudiu T Supuran, Clemente Capasso,

Among the diagnostic techniques for the identification of tumour biomarkers, the liquid biopsy is considered one that offers future research on precision diagnosis and treatment of tumours in a non-invasive manner. The approach consists of isolating tumor-derived components, such as circulating tumour cells (CTC), tumour cell-free DNA (ctDNA), and extracellular ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):255-260]

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The First Case of Metastatic Pancreatic Leiomyosarcoma Derived from the Urinary Bladder Diagnosed Using an Endoscopic Ultrasound-guided Fine-needle Biopsy.

Ayana Ishizaki, Kosuke Okuwaki, Mitsuhiro Kida, Hiroshi Imaizumi, Tomohisa Iwai, Hiroshi Yamauchi, Toru Kaneko, Rikiya Hasegawa, Hironori Masutani, Masayoshi Tadehara, Kai Adachi, Masafumi Watanabe, Takahiro Kurosu, Akihiro Tamaki, Wasaburo Koizumi,

We herein report the first case of metastatic pancreatic leiomyosarcoma derived from the urinary bladder diagnosed by an endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) in a 65-year-old woman. The patient had undergone total cystectomy for bladder leiomyosarcoma. Four years thereafter, a nodule was observed in her left lung on chest computed ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2020, :]

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The usefulness of a target sample check illuminator in the detection of target specimens in endoscopic ultrasound-guided fine-needle biopsy samples: A multicenter prospective study.

Kazuya Matsumoto, Kazuo Hara, Ichiro Yasuda, Takao Itoi, Hiroki Kurumi, Shimpei Matsumoto, Shinpei Doi, Mitsuyoshi Honjo, Yohei Takeda, Jin Shibuya, Hisashi Noma, Hajime Isomoto,

OBJECTIVES:Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) uses a thin needle, rendering unclear whether the collected sample contains pathological evidence. We examined the usefulness of our target sample check illuminator (TSCI) through a multicenter prospective trial. METHODS:We included 52 consecutive patients. After assessing EUS-FNB samples by conventional (visual observation) and TSCI methods, ... Read more >>

Dig Endosc (Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society)
[2020, :]

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Transthoracic needle biopsy: How to Maximize diagnostic accuracy and Minimize complications.

Chaeuk Chung, Yoonjoo Kim, Dongil Park,

While the transthoracic needle biopsy (TTNB) was introduced for lung biopsy about 40 years ago, it is still mainstay of pathologic diagnosis in lung cancer, because it is relatively inexpensive and has the advantage of obtaining tissue regardless of tumor-bronchus relationship. With several technological advances, clinicians can perform TTNB more ... Read more >>

Tuberc Respir Dis (Seoul) (Tuberculosis and respiratory diseases)
[2020, :]

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Cost-Benefit Analysis of Routine Bone Biopsy During Augmentation of Osteoporotic Vertebral Compression Fractures.

Oded Hershkovich, Edward Bayley, Oren Rudik, Vitaly Alexandrovsky, Alon Friedlander, Efrat Daglen, Raphael Lotan,

STUDY DESIGN:Multi-center prospective study. OBJECTIVE:To analyze the cost of routine biopsy during augmentation of osteoporotic vertebral compression fractures (VCF) and the affect it has on further treatment. SUMMARY OF BACKGROUND DATA:Vertebroplasty (VP) and Balloon Kyphoplasty (BKP) are accepted treatments for VCF. Bone biopsy is routinely performed during every VCF surgery ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2020, 45(23):1634-1638]

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CT-guided transthoracic needle biopsy of pulmonary lesions: comparison between the cutting needle and aspiration needle.

Zhen-Guo Huang, Hong-Liang Sun, Cun-Li Wang, Bao-Xiang Gao, He Chen, Min-Xing Yang, Xiao-Liang Chen,

OBJECTIVES:To compare CT-guided transthoracic cutting needle biopsy (TCNB) with transthoracic aspiration needle biopsy (TANB) for pulmonary lesions with respect to the diagnostic accuracy and complication rate. METHODS:Of the 859 cases that underwent consecutive CT-guided biopsy of pulmonary lesions, 713 cases confirmed by surgical pathology or clinical follow-up were enrolled. Of ... Read more >>

Br J Radiol (The British journal of radiology)
[2020, :20190930]

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Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl.

Xia Wu, Gangfeng Yan, Shuzhen Han, Yingzi Ye, Xunjia Cheng, Hairong Gong, Hui Yu,

Balamuthia amoebic encephalitis has a subacute-to-chronic course and is almost invariably fatal owing to delayed diagnosis and a lack of effective therapy. Here, we report a 13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of tests and was suspected as having tuberculosis. She was ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1379-1387]

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Clinical comparisons between previously diagnosed SLE and newly diagnosed SLE by kidney biopsy.

Pantipa Tonsawan, Kittisak Sawanyawisuth,

<b>Background:</b>Lupus nephritis is a type of major organ involvement in systemic lupus erythematosus (SLE) patients that leads to higher rates of morbidity and mortality and may present initially in 28% of SLE patients. However, there are limited data available on clinical differences or predictors for biopsy-proven lupus nephritis in established ... Read more >>

Auto Immun Highlights (Auto- immunity highlights)
[2020, 11(1):18]

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Utilization and outcomes of sentinel lymph node biopsy in patients with early stage vulvar cancer.

Catherine E Hermann, Dimitrios Nasioudis, Spyridon A Mastroyannis, Nawar A Latif, Ashley F Haggerty, Robert L Giuntoli Ii, Lori Cory, Sarah H Kim, Mark A Morgan, Emily M Ko,

OBJECTIVE:A retrospective cohort study comparing survival and perioperative outcomes of patients with early vulvar cancer who underwent sentinel lymph node biopsy versus standard lymphadenectomy METHODS: Patients diagnosed between January 2012 and December 2015 with vulvar squamous cell carcinoma of less than 4 cm in size, with invasion of at least 1 mm, ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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Cerebrospinal fluid circulating tumour DNA as a liquid biopsy for central nervous system malignancies.

Laura Escudero, Francisco Martínez-Ricarte, Joan Seoane,

PURPOSE OF REVIEW:The molecular characterization of central nervous system (CNS) malignancies is crucial for obtaining the correct diagnosis and prognosis, and to guide the optimal therapeutic approach. However, obtaining surgical specimens can be challenging because of the anatomical location of the tumour and may limit the correct characterization of these ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2020, 33(6):736-741]

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Delivering Clinical impacts of the MRI diagnostic pathway in prostate cancer diagnosis.

Ivo G Schoots, Anwar R Padhani,

Pre-biopsy multiparametric MRI is now recommended by multiple guidelines, not only for men with persistent suspicion of prostate cancer after prior negative systematic biopsy, but also at initial screening before the first biopsy. The major benefit of pre-biopsy MRI in the diagnostic work-up is to promote individualized risk-adapted approaches for ... Read more >>

Abdom Radiol (NY) (Abdominal radiology (New York))
[2020, 45(12):4012-4022]

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[What's new liquid biopsy-PIK3CA testing in breast cancer].

Claudia Vollbrecht,

The impact of liquid biopsies on the analysis of molecular alterations of circulating tumor DNA (ctDNA) has recently increased. PIK3CA is one of the most frequently mutated genes in breast cancer and the expected approval of targeted PIK3CA therapy based on the results of the SOLAR1 trial is likely to ... Read more >>

Pathologe (Der Pathologe)
[2020, :]

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Long term safety and efficacy of breast biopsy markers in clinical practice.

Sharon Smith, Clayton R Taylor, Estella Kanevsky, Stephen P Povoski, Jeffrey R Hawley,

OBJECTIVE:: Percutaneous breast and axillary core biopsy followed by marker placement are integral parts of a breast imager's practice benefiting both patients and clinicians. Marker placement is the standard to facilitate future care. The purpose of this study is to characterize safety and performance of MammoMARK, CorMARK, and HydroMARK biopsy ... Read more >>

Expert Rev Med Devices (Expert review of medical devices)
[2020, :]

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Atypical and incomplete pulmonary hypertrophic osteoarthropathy in the left distal femur: a case report.

Gang Xu, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Yuta Taniguchi, Yoshihiro Araki, Hirotaka Yonezawa, Sei Morinaga, Hiroyuki Tsuchiya,

BACKGROUND:Pulmonary hypertrophic osteoarthropathy (PHO) is a rare paraneoplastic syndrome that mainly occurs in patients with lung cancer. Most symptoms occur symmetrically, and unilateral symptoms without clubbing are infrequent. This report presents the case of a rare atypical symptom that was highly suspected of being PHO. CASE PRESENTATION:A 77-year-old woman with swelling ... Read more >>

BMC Surg (BMC surgery)
[2020, 20(1):293]

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