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Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing.

Dillon E King, A Clare Sparling, Rashmi Joglekar, Joel N Meyer, Susan K Murphy,

DNA methylation is an important epigenetic mechanism involved in proper genome function. Bisulfite pyrosequencing (PSQ) is a commonly used technique to quantify DNA methylation. Although very accurate, bisulfite pyrosequencing can be expensive and time consuming for large-scale quantitative DNA methylation analysis at the single nucleotide level. High throughput DNA methylation ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Calx, a sodium/calcium exchanger, may affect lifespan in Drosophila melanogaster.

Jung-Wan Mok, Hyunglok Chung, Kwang-Wook Choi,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Circulating extracellular vesicles: friends and foes in neurodegeneration.

Anna Picca, Flora Guerra, Riccardo Calvani, Hélio José Coelho-Junior, Cecilia Bucci, Emanuele Marzetti,

Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):534-542]

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Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers: a randomized controlled trial.

Steven McGuigan, Lisbeth Evered, David A Scott, Brendan Silbert, Henrik Zetterberg, Kaj Blennow,

General anesthesia and surgery are associated with an increase in neural injury biomarkers. Elevations of these neural injury biomarkers in the perioperative period are associated with postoperative delirium. Xenon has been shown to be protective against a range of neurological insults in animal models. It remains to be seen if ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(1):10-17]

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Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis.

Qian-Qian Wei, Yan-Bing Hou, Ling-Yu Zhang, Ru-Wei Ou, Bei Cao, Yong-Ping Chen, Hui-Fang Shang,

The neutrophil-to-lymphocyte ratio (NLR) is considered a robust prognostic biomarker for predicting patient survival outcomes in many diseases. However, it remains unclear whether it can be used as a biomarker for amyotrophic lateral sclerosis (ALS). To correlate NLR with disease progression and survival in sporadic ALS, 1030 patients with ALS ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):875-880]

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Toward future adaptive deep brain stimulation for Parkinson's disease: the novel biomarker - narrowband gamma oscillation.

Hao Ding, Sergiu Groppa, Muthuraman Muthuraman,

Neural Regen Res (Neural regeneration research)
[2022, 17(3):557-558]

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Urinary calprotectin, NGAL, and KIM-1 in the differentiation of primarily inflammatory vs. non-inflammatory stable chronic kidney diseases.

Felix S Seibert, Maximilian Sitz, Jürgen Passfall, Martin Haesner, Peter Laschinski, Martin Buhl, Frederic Bauer, Benjamin Rohn, Nina Babel, Timm H Westhoff,

<h4>Introduction</h4>It has been demonstrated that urinary neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin are helpful biomarkers in the differentiation of intrinsic and prerenal acute kidney injury.<h4>Objective</h4>The present cross-sectional study investigates, whether urinary biomarkers are able to differentiate primarily inflammatory from non-inflammatory entities in chronic kidney disease (CKD).<h4>Methods</h4>Urinary calprotectin, NGAL, and kidney ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):417-424]

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Metabolomic assessment of mechanisms underlying anti-renal fibrosis properties of petroleum ether extract from Amygdalus mongolica.

Chen Gao, Wan-Fu Bai, Hong-Bing Zhou, Hai-Mei Hao, Ying-Chun Bai, Quan-Li Liu, Hong Chang, Song-Li Shi,

<h4>Context</h4>The petroleum ether extract (PET) of <i>Amygdalus mongolica</i> (Maxim.) Ricker (Rosaceae) has an ameliorative effect on renal fibrosis (RF).<h4>Objective</h4>To evaluate the antifibrotic effects of <i>A. mongolica</i> seeds PET on RF by serum metabolomics, biochemical and histopathological analyses.<h4>Materials and methods</h4>Sixty male Sprague-Dawley rats were randomly divided into the sham-operated, RF model, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):565-574]

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MicroRNA expression profile and identification of novel microRNA biomarkers for metabolic syndrome.

Guanzhi Liu, Yutian Lei, Sen Luo, Zhuo Huang, Chen Chen, Kunzheng Wang, Pei Yang, Xin Huang,

The lack of efficient biomarkers is the main reason for the inaccurate early diagnosis and poor treatment outcomes of patients with metabolic syndrome (MetS). The current study aimed to identify several novel microRNA (miRNA) biomarkers for metabolic syndrome via high-throughput sequencing and comprehensive bioinformatics analysis. Through high-throughput sequencing and differentially ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3864-3872]

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Development of molecular tools for diagnosis of Alzheimer's disease that are based on detection of amyloidogenic proteins.

Konstantin Y Kulichikhin, Sergei A Fedotov, Maria S Rubel, Natalia M Zalutskaya, Anastasia E Zobnina, Oksana A Malikova, Nikolay G Neznanov, Yury O Chernoff, Aleksandr A Rubel,

Alzheimer's disease (AD) is the most common form of dementia that usually occurs among older people. AD results from neuronal degeneration that leads to the cognitive impairment and death. AD is incurable, typically develops over the course of many years and is accompanied by a loss of functional autonomy, making ... Read more >>

Prion (Prion)
[2021, 15(1):56-69]

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Identification of fibronectin 1 (FN1) and complement component 3 (C3) as immune infiltration-related biomarkers for diabetic nephropathy using integrated bioinformatic analysis.

Yuejun Wang, Mingming Zhao, Yu Zhang,

Immune cell infiltration (ICI) plays a pivotal role in the development of diabetic nephropathy (DN). Evidence suggests that immune-related genes play an important role in the initiation of inflammation and the recruitment of immune cells. However, the underlying mechanisms and immune-related biomarkers in DN have not been elucidated. Therefore, this ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5386-5401]

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A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis.

Hong Chang, Hong-Yu Meng, Wan-Fu Bai, Qing-Gang Meng,

<h4>Context</h4>Baicalin, a major flavonoid extracted from <i>Scutellaria baicalensis</i> Georgi (Lamiaceae), has been shown to exert therapeutic effects on pulmonary fibrosis (PF).<h4>Objective</h4>To use serum metabolomics combined with biochemical and histopathological analyses to clarify anti-PF mechanisms of baicalin on metabolic pathways and the levels of potential biomarkers.<h4>Materials and methods</h4>Forty male Sprague-Dawley rats ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1016-1025]

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The screening of immune-related biomarkers for prognosis of lung adenocarcinoma.

Zhonghui Liu, Dan Sun, Qing Zhu, Xinmin Liu,

Lung adenocarcinoma (LUAD) accounts for a frequently seen non-small cell lung cancer (NSCLC) histological subtype, and it is associated with dismal prognostic outcome. However, the benefits of traditional treatment are still limited, and the efficacies of immunotherapy are quite different. Therefore, it is of great significance to identify novel immune-related ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1273-1285]

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Diagnostic value of TWEAK for predicting active lupus nephritis in patients with systemic lupus erythematosus: a systematic review and meta-analysis.

Hao-Yang Ma, Shuang Chen, Wei-Dong Cao, Cui-Ting Min,

<h4>Purpose</h4>Accumulative studies showed that tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) was up-regulated in the blood and urine from patients diagnosed with lupus nephritis (LN) and that it might be used as a novel biomarker for active LN. This meta-analysis aimed to determine the diagnostic value of TWEAK ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):20-31]

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Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.

Jiayu Zhang, Rongguo Yu, Xiaoyu Guo, Yuanxia Zou, Sixuan Chen, Kai Zhou, Yi Chen, YongRong Li, Su Gao, Yifei Wu,

This study aims to explore biomarkers associated with vitiligo and analyze the pathological role of immune cell infiltration in the disease. We used the robust rank aggregation (RRA) method to integrate three vitiligo data sets downloaded from gene expression omnibus database, identify the differentially expressed genes (DEGs) and analyze the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2214-2227]

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Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada).

Thierry Comlan Marc Medehouenou, Cynthia Roy, Pierre-Yves Tremblay, Audray St-Jean, Salma Meziou, Gina Muckle, Pierre Ayotte, Michel Lucas,

In contrast to most Indigenous people in Canada, Inuit appeared until recently to have been protected from type 2 diabetes (T2D) related to obesity. We assessed the associations of metabolites (amino acids, acylcarnitines) with adiposity and biomarkers of T2D in school-aged Inuit children of Nunavik (Canada). Concentrations of metabolite were measured ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1858605]

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Identification of four key biomarkers and small molecule drugs in nasopharyngeal carcinoma by weighted gene co-expression network analysis.

Xi Pan, Jian-Hao Liu,

Nasopharyngeal carcinoma (NPC) is a heterogeneous carcinoma whose underlying molecular mechanisms involved in tumor initiation, progression, and migration are largely unclear. The aim of the present study was to identify key biomarkers and small-molecule drugs for screening, diagnosing, and treating NPC via gene expression profile analysis. Raw microarray data was ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3647-3661]

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Profile of gut microbiota in patients with traumatic thoracic spinal cord injury and its clinical implications: a case-control study in a rehabilitation setting.

Binbin Yu, Huaide Qiu, Shupeng Cheng, Feng Ye, Jiahui Li, Sijing Chen, Li Zhou, Yumei Yang, Caiyun Zhong, Jianan Li,

Gut microbiota are the candidate biomarkers for neurogenic bowel dysfunction (NBD) in patients with spinal cord injury (SCI). We aimed to identify the common features between patients with varying degree of thoracic SCI and healthy individuals and subpopulations of microbiota correlated with the serum biomarkers. Twenty-one patients with complete thoracic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4489-4499]

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Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas.

Dandan Zou, Yang Wang, Meng Wang, Bo Zhao, Fei Hu, Yanguo Li, Bingming Zhang,

Soft tissue sarcomas (STSs) are rare, heterogeneous mesenchymal neoplasias. Understanding the tumor microenvironment (TME) and identifying potential biomarkers for prognosis associated with the TME of STS might provide effective clues for immune therapy. We evaluated the immune scores and stromal scores of STS patients by using the RNA sequencing dataset ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):496-506]

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Long noncoding RNA PR11-387H17.6 as a potential novel diagnostic biomarker of atherosclerotic renal artery stenosis.

Wenxia Fu, Xiaoxiang Tian, Liwen Liu, Xiaolin Zhang, Xiaozeng Wang,

<h4>Background</h4>Atherosclerotic renal artery stenosis (ARAS) is frequently related to ischemic nephropathy, secondary hypertension, and end-stage renal failure. Thus, this study aimed to explore whether certain circulating long noncoding RNAs (lncRNAs) may be used as potential specific ARAS biomarkers.<h4>Methods</h4>In the present study, a microarray analysis was performed to screen for lncRNAs ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):1188-1197]

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Prognostic value of circulating clonal plasma cells in newly diagnosed multiple myeloma.

Wenmin Han, Yuanyuan Jin, Min Xu, Si-Shu Zhao, Qinglin Shi, Xiaoyan Qu, Run Zhang, Jianyong Li, Yujie Wu, Lijuan Chen,

<h4>Objectives</h4>Multiple myeloma (MM) involves a clinically and biologically heterogeneous malignancy of plasma cells. It is difficult to predict the prognosis of MM. The presence of circulating clonal plasma cells (CPC) has been associated with a worse prognosis in patients with MM.<h4>Methods</h4>This study retrospectively analysed CPC in 108 newly diagnosed MM ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):510-517]

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Construction of a immune-associated genes based prognostic signature in bladder cancer.

Chengquan Shen, Liping Wang, XueCheng Yang, Jing Liu, Qingbo Yang, Xuemei Ding, Haitao Niu, Yonghua Wang,

Current studies indicated that immune-associated genes (IAGs) have important roles in the occurrence and development of bladder cancer (BC). The current work aims to identify the prognostic values of IAGs in BC and establish a prognostic signature based on IAGs. RNA sequencing data and protein expression data were used to ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):108-119]

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Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome.

Javier Toro-Pérez, Ramón Rodrigo,

<h4>Background</h4>The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):35-44]

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Four specific biomarkers associated with the progression of glioblastoma multiforme in older adults identified using weighted gene co-expression network analysis.

Yushi Yang, Liangzhao Chu, Zhirui Zeng, Shu Xu, Hua Yang, Xuelin Zhang, Jun Jia, Niya Long, Yaxin Hu, Jian Liu,

Glioblastoma multiforme (GBM) is the most common primary intracranial malignancy in adults. Owing to individual tolerance and tumor heterogeneity, the therapy methods for young adults do not apply to older adults. The present study aimed to identify specific biomarkers for GBM in older adults using weighted gene co-expression network analysis ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6643-6654]

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Neuron-specific enolase in cerebrospinal fluid as a biomarker of brain damage in infants with hypoxic-ischemic encephalopathy.

Alfredo Garcia-Alix, Juan Arnaez,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):318-319]

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