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Calx, a sodium/calcium exchanger, may affect lifespan in Drosophila melanogaster.

Jung-Wan Mok, Hyunglok Chung, Kwang-Wook Choi,

(microPublication biology)
[2020, 2020:]

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Precision medicine in localized bladder cancer: Personalizing therapies to improve outcomes.

Roberto Carando, Giuseppe Mario Ludovico, Michele Zazzara, Stefania Zamboni, Luca Afferi, Claudio Simeone, Wojciech Krajewski, Marco Moschini,

In the last decades, only few improvements have been made in the comprehension of bladder cancer tumor leading to few improvements in the development of new diagnostic and therapeutic approaches.However, in the last years several step forwards in the field of precision medicine have been made. In this review we ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2021, 73(10):1016-1022]

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[Bladder cancer immunological background and biomarkers.]

Mar Valés-Gómez, Gloria Esteso, María José Felgueres, Jorge Huete-Carrasco,

Bladder cancer was one of the first to have a successful treatment based on immune system stimulation, recognized by patient survival and tumor recurrence data. In addition, bladder tumors are now known to have high antigenic load and are therefore considered to be susceptible to respond well to new immunotherapies. ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2021, 73(10):895-905]

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Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.

Sigrun Lange,

Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes, including in the central nervous system. Peptidylarginine deiminases cause post-translational deimination/citrullination, leading to changes in structure and function of a wide range of target proteins. Deimination can facilitate protein moonlighting, modify protein-protein interaction, cause ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):934-938]

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Strategies to prevent and detect intraoperative spinal cord ischemia during complex aortic surgery: from drainages and biomarkers.

Alexander Gombert, Florian Simon,

Neural Regen Res (Neural regeneration research)
[2021, 16(4):678-679]

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Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke.

Xing-Yong Chen, Ming Fu, Shao-Fen Wan, Xu Zhang, Yin-Zhou Wang,

Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment (PSCI), but no biomarkers are widely used in clinical practice. The purpose of this study was to investigate the association between the plasma immunoproteasome and patients' 90-day prognosis after first-ever acute ischemic stroke. In our prospective, single-center study, 259 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(4):790-795]

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Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients: a crossover design study.

Viviane Rostirola Elsner, Lucieli Trevizol, Isadora de Leon, Marcos da Silva, Thayná Weiss, Milena Braga, Daniela Pochmann, Amanda Stolzenberg Blembeel, Caroline Dani, Elenice Boggio,

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of stroke. Thus, strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these patients. Physical exercise has been ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):805-812]

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MicroRNAs as diagnostic and prognostic biomarkers of age-related macular degeneration: advances and limitations.

Bridget Martinez, Philip V Peplow,

A main cause of vision loss in the elderly is age-related macular degeneration (AMD). Among the cellular, biochemical, and molecular changes linked to this disease, inflammation and angiogenesis appear as being crucial in AMD pathogenesis and progression. There are two forms of the disease: dry AMD, accounting for 80-90% of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):440-447]

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Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model.

Hongzhi Wang, Emily W Baker, Abhyuday Mandal, Ramana M Pidaparti, Franklin D West, Holly A Kinder,

Traumatic brain injury (TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments; however, identification of specific magnetic resonance imaging (MRI) biomarkers that are most reflective of injury severity ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(2):338-344]

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An integrative multivariate approach for predicting functional recovery using magnetic resonance imaging parameters in a translational pig ischemic stroke model.

Erin E Kaiser, J C Poythress, Kelly M Scheulin, Brian J Jurgielewicz, Nicole A Lazar, Cheolwoo Park, Steven L Stice, Jeongyoun Ahn, Franklin D West,

Magnetic resonance imaging (MRI) is a clinically relevant, real-time imaging modality that is frequently utilized to assess stroke type and severity. However, specific MRI biomarkers that can be used to predict long-term functional recovery are still a critical need. Consequently, the present study sought to examine the prognostic value of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):842-850]

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Multiplexed Protein Biomarker Detection with Microfluidic Electrochemical Immunoarrays.

Abby Jones, Patricia Czarnecki, Lasangi Dhanapala, James F Rusling,

Electrochemistry is a multidisciplinary field encompassing the study of analytes in solution for detection and quantification. For the medical field, this brings opportunities to the clinical practice of disease detection through measurements of disease biomarkers. Specifically, panels of biomarkers offer an important future option that can enable physicians' access to ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2237:69-82]

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Using Antibody Arrays for Biomarker Discovery.

Shuhong Luo, Yunbiao Ling, Li-Pai Chen, Ruo-Pan Huang,

Biomarkers for diseases are important for the development of clinical diagnostic tests and can provide early intervention for cancer or cardiovascular patients. Over the past decade, antibody array technology has achieved significant technological improvement in the quantitative measurement of more than a thousand proteins simultaneously and has been utilized to ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2237:237-245]

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Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers.

Lorenzo Gaetani, Nicola Salvadori, Elena Chipi, Lucia Gentili, Angela Borrelli, Lucilla Parnetti, Massimiliano Di Filippo,

Cognitive impairment is a common clinical manifestation of multiple sclerosis, but its pathophysiology is not completely understood. White and grey matter injury together with synaptic dysfunction do play a role. The measurement of biomarkers in the cerebrospinal fluid and the study of their association with cognitive impairment may provide interesting ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(1):36-42]

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Neonatal opioid exposure: public health crisis and novel neuroinflammatory disease.

Vikram Vasan, Yuma Kitase, Jessie C Newville, Shenandoah Robinson, Gwendolyn Gerner, V Joanna Burton, Lauren L Jantzie,

Substance use, specifically the use of prescription and non-prescription opioids among pregnant women, is a major public health issue and chief contributor to the opioid crisis. The prevalence of Neonatal Opioid Withdrawal Syndrome has risen 5-fold in the past decade, and is a well-recognized consequence of perinatal opioid exposure. By ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):430-432]

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Future Directions in Sports-Related Concussion Management.

Hamish Kerr, Bjørn Bakken, Gregory House,

This article focuses on 3 concepts that continue to be investigated in the search for the holy grail of concussion-a valid diagnostic test. Imaging advances are discussed with optimism that functional MRI and diffusion tensor imaging may be available clinically. Biomarkers and the use of genetic tests are covered. Sideline ... Read more >>

Clin Sports Med (Clinics in sports medicine)
[2021, 40(1):199-211]

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Antiretroviral therapy reduces but does not normalize immune and vascular inflammatory markers in adults with chronic HIV infection in Kenya.

Tecla M Temu, Jerry S Zifodya, Stephen J Polyak, Jessica Wagoner, Celestine N Wanjalla, Sarah Masyuko, Jerusha Nyabiage, John Kinuthia, Gerald S Bloomfield, Stephanie T Page, Carey Farquhar,

<b>Introduction: </b>Markers of monocyte/macrophage activation and vascular inflammation are associated with HIV-related cardiovascular diseases (CVD) and mortality. We compared these markers among African people living with HIV (PLWH) and HIV-negative adults, and examined risk factors associated with elevated biomarkers (>75th percentile) in PLWH on antiretroviral therapy (ART).<br><br><b>Design: </b>Cross-sectional study.<br><br><b>Methods: </b>We ... Read more >>

AIDS (AIDS (London, England))
[2021, 35(1):45-51]

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Animal Models and Renal Biomarkers of Diabetic Nephropathy.

Laura Pérez-López, Mauro Boronat, Carlos Melián, Yeray Brito-Casillas, Ana M Wägner,

Diabetes mellitus (DM) is the first cause of end stage chronic kidney disease (CKD). Animal models of the disease can shed light on the pathogenesis of the diabetic nephropathy (DN) and novel and earlier biomarkers of the condition may help to improve diagnosis and prognosis. This review summarizes the most ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1307:521-551]

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Functional neuroimaging biomarkers of resilience in major depressive disorder.

Adina S Fischer, Kelsey E Hagan, Ian H Gotlib,

PURPOSE OF REVIEW:In this review we provide an overview of definitions and determinants of resilience in the context of neuroimaging research in major depressive disorder (MDD). We summarize emerging literature on functional neuroimaging biomarkers of resilience in MDD and discuss their clinical relevance and implications for future research. RECENT FINDINGS:Resilience ... Read more >>

Curr Opin Psychiatry (Current opinion in psychiatry)
[2021, 34(1):22-28]

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Possible role of glial cell line-derived neurotrophic factor for predicting cognitive impairment in Parkinson's disease: a case-control study.

Ming-Yu Shi, Cheng-Cheng Ma, Fang-Fang Chen, Xiao-Yu Zhou, Xue Li, Chuan-Xi Tang, Lin Zhang, Dian-Shuai Gao,

Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the protection of dopaminergic neurons, but there are few reports of the relationship between GDNF and its precursors (α-pro-GDNF and β-pro-GDNF) and cognitive impairment in Parkinson's disease. This study aimed to investigate the relationship between the serum levels of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):885-892]

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[Prognostic and predictive methylation biomarkers in HNSCC : Epigenomic diagnostics for head and neck squamous cell carcinoma (HNSCC)].

A Franzen, F Bootz, D Dietrich,

BACKGROUND:Prognostic and predictive biomarkers for personalized treatment management in head and neck squamous cell carcinoma (HNSCC) are of great clinical interest. OBJECTIVE:DNA methylation is an epigenetic process involved in gene regulation and could be a source of potential prognostic and predictive biomarkers. METHODS:This study comprises literature research in PubMed and own ... Read more >>

HNO (HNO)
[2020, 68(12):911-915]

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Rheumatology in the era of precision medicine: synovial tissue molecular patterns and treatment response in rheumatoid arthritis.

Amit Lakhanpal, Melanie H Smith, Laura T Donlin,

PURPOSE OF REVIEW:A critical unmet need in rheumatoid arthritis (RA) is the identification of biomarkers that predict which of the available medications will be most effective for an individual in order to lower disease activity sooner than is afforded by the current treat-to-target approach. Here we will discuss recent reports ... Read more >>

Curr Opin Rheumatol (Current opinion in rheumatology)
[2021, 33(1):58-63]

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The Citrullinated and MMP-degraded Vimentin Biomarker (VICM) Predicts Early Response to Anti-TNFα Treatment in Crohn's Disease.

Joachim H Mortensen, Wouter T van Haaften, Morten A Karsdal, Anne-Christine Bay-Jensen, Peter Olinga, Henning Grønbæk, Christian L Hvas, Tina Manon-Jensen, Gerard Dijkstra, Anders Dige,

<b>Background: </b>In Crohn's disease (CD), 10% to 40% of patients do not respond to anti-tumor necrosis factor-α (TNFα) treatment. Currently, there are no biomarkers with adequate sensitivity to separate responders from nonresponders at an early stage.<br><br><b>Aim: </b>The aim of this study was to investigated whether early changes in the VICM ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, 55(1):59-66]

Cited: 1 time

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Circular RNAs: Promising Biomarkers for Age-related Diseases.

Yan-Hong Pan, Wei-Peng Wu, Xing-Dong Xiong,

Aging is a complex biological process closely linked with the occurrence and development of age-related diseases. Despite recent advances in lifestyle management and drug therapy, the late diagnosis of these diseases causes severe complications, usually resulting in death and consequently impacting social economies. Therefore, the identification of reliable biomarkers and ... Read more >>

Aging Dis (Aging and disease)
[2020, 11(6):1585-1593]

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High day-to-day and diurnal variability of oxidative stress and inflammation biomarkers in people with type 2 diabetes mellitus and healthy individuals.

Alistair R Mallard, Siri Marte Hollekim-Strand, Charlotte Björk Ingul, Jeff S Coombes,

Objective: Assess the variability and differences in oxidative stress, antioxidant, and inflammatory biomarkers in people with type 2 diabetes mellitus (T2D) and healthy controls. Methods:: Ten men and women diagnosed with T2D and ten healthy matched controls (CON) were recruited. Participants had venous blood taken at six different time points ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2020, 25(1):64-69]

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Computational identification of biomarker genes for lung cancer considering treatment and non-treatment studies.

Mona Maharjan, Raihanul Bari Tanvir, Kamal Chowdhury, Wenrui Duan, Ananda Mohan Mondal,

<b>Background: </b>Lung cancer is the number one cancer killer in the world with more than 142,670 deaths estimated in the United States alone in the year 2019. Consequently, there is an overreaching need to identify the key biomarkers for lung cancer. The aim of this study is to computationally identify ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2020, 21(Suppl 9):218]

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