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Inheritance of pheromone profiles from aged D. melanogaster.

Samuel G Brown, Dova B Brenman-Suttner, Abigail G McInnes, Katlynn Lew, Amanda J Moehring, Johannes H Bauer, Anne F Simon,

Through aging, <i>D. melanogaster</i> males and females change their social spacing. Flies are initially more social, but reduce sociability as they grow older. This preferred social space is inherited in their progeny. Here, we report that in females, the profiles of cuticular hydrocarbons (CHC), which are known to promote social ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing.

Dillon E King, A Clare Sparling, Rashmi Joglekar, Joel N Meyer, Susan K Murphy,

DNA methylation is an important epigenetic mechanism involved in proper genome function. Bisulfite pyrosequencing (PSQ) is a commonly used technique to quantify DNA methylation. Although very accurate, bisulfite pyrosequencing can be expensive and time consuming for large-scale quantitative DNA methylation analysis at the single nucleotide level. High throughput DNA methylation ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Calx, a sodium/calcium exchanger, may affect lifespan in Drosophila melanogaster.

Jung-Wan Mok, Hyunglok Chung, Kwang-Wook Choi,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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The emerging world of subcellular biological medicine: extracellular vesicles as novel biomarkers, targets, and therapeutics.

Leon G Coleman,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1020-1022]

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COVID-19 is more dangerous for older people and its severity is increasing: a case-control study.

Cuma Mertoglu, Mehmet Tahir Huyut, Hasan Olmez, Mustafa Tosun, Mecit Kantarci, Taha Abdulkadir Coban,

Coronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and inflammatory biomarkers between March 10, 2020, and November 30, 2020 from 3969 COVID-19 patients (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(2):51-54]

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Preliminary examination of early neuroconnectivity features in the R6/1 mouse model of Huntington's disease by ultra-high field diffusion MRI.

Rodolfo G Gatto, Carina Weissmann,

During the last decades, advances in the understanding of genetic, cellular, and microstructural alterations associated to Huntington's disease (HD) have improved the understanding of this progressive and fatal illness. However, events related to early neuropathological events, neuroinflammation, deterioration of neuronal connectivity and compensatory mechanisms still remain vastly unknown. Ultra-high field ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):983-986]

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Circulating extracellular vesicles: friends and foes in neurodegeneration.

Anna Picca, Flora Guerra, Riccardo Calvani, Hélio José Coelho-Junior, Cecilia Bucci, Emanuele Marzetti,

Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):534-542]

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Toward future adaptive deep brain stimulation for Parkinson's disease: the novel biomarker - narrowband gamma oscillation.

Hao Ding, Sergiu Groppa, Muthuraman Muthuraman,

Neural Regen Res (Neural regeneration research)
[2022, 17(3):557-558]

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Comparison of Non-Invasive Clinical Algorithms for Liver Fibrosis in Patients With Chronic Hepatitis B to Reduce the Need for Liver Biopsy: Application of Enhanced Liver Fibrosis and Mac-2 Binding Protein Glycosylation Isomer.

Mina Hur, Mikyoung Park, Hee-Won Moon, Won Hyeok Choe, Chae Hoon Lee,

<h4>Background</h4>Non-invasive clinical algorithms for the detection of liver fibrosis (LF) can reduce the need for liver biopsy (LB). We explored the implementation of two serum biomarkers, enhanced liver fibrosis (ELF) and Mac-2 binding protein glycosylation isomer (M2BPGi), in clinical algorithms for LF in chronic hepatitis B (CHB) patients.<h4>Methods</h4>Two clinical algorithms ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):249-257]

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Biomarker Rule-in or Rule-out in Patients With Acute Diseases for Validation of Acute Kidney Injury in the Emergency Department (BRAVA): A Multicenter Study Evaluating Urinary TIMP-2/IGFBP7.

Hyun Suk Yang, Mina Hur, Kyeong Ryong Lee, Hanah Kim, Hahn Young Kim, Jong Won Kim, Mui Teng Chua, Win Sen Kuan, Horng Ruey Chua, Chagriya Kitiyakara, Phatthranit Phattharapornjaroen, Anchalee Chittamma, Thiyapha Werayachankul, Urmila Anandh, Sanjeeva Herath, Zoltan Endre, Andrea Rita Horvath, Paola Antonini, Salvatore Di Somma, ,

<h4>Background</h4>Urine tissue inhibitor of metalloproteinases-2/insulin-like growth factor-binding protein 7 (TIMP-2/IGFBP7) (NephroCheck, Ortho Clinical Diagnostics, Raritan, NJ, USA) is a US Food and Drug Administration-approved biomarker for risk assessment of acute kidney injury (AKI) in critically ill adult patients in intensive care units; however, its clinical impact in the emergency department ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):178-187]

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Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis.

Qian-Qian Wei, Yan-Bing Hou, Ling-Yu Zhang, Ru-Wei Ou, Bei Cao, Yong-Ping Chen, Hui-Fang Shang,

The neutrophil-to-lymphocyte ratio (NLR) is considered a robust prognostic biomarker for predicting patient survival outcomes in many diseases. However, it remains unclear whether it can be used as a biomarker for amyotrophic lateral sclerosis (ALS). To correlate NLR with disease progression and survival in sporadic ALS, 1030 patients with ALS ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):875-880]

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Prediction of diagnosis and prognosis of COVID-19 disease by blood gas parameters using decision trees machine learning model: a retrospective observational study.

Mehmet Tahir Huyut, Hilal Üstündağ,

The coronavirus disease 2019 (COVID-19) epidemic went down in history as a pandemic caused by corona-viruses that emerged in 2019 and spread rapidly around the world. The different symptoms of COVID-19 made it difficult to understand which variables were more influential on the diagnosis, course and mortality of the disease. ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(2):60-66]

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Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers: a randomized controlled trial.

Steven McGuigan, Lisbeth Evered, David A Scott, Brendan Silbert, Henrik Zetterberg, Kaj Blennow,

General anesthesia and surgery are associated with an increase in neural injury biomarkers. Elevations of these neural injury biomarkers in the perioperative period are associated with postoperative delirium. Xenon has been shown to be protective against a range of neurological insults in animal models. It remains to be seen if ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(1):10-17]

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Exploring the Alzheimer's disease neuroepigenome: recent advances and future trends.

Haolin Zhang, Felice Elefant,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):325-327]

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Neuron-specific enolase in cerebrospinal fluid as a biomarker of brain damage in infants with hypoxic-ischemic encephalopathy.

Alfredo Garcia-Alix, Juan Arnaez,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):318-319]

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Amyotrophic lateral sclerosis, a neurodegenerative motor neuron disease with retinal involvement.

Ana I Ramirez, Rosa de Hoz, Pilar Rojas, Juan J Salazar,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1011-1012]

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N-glycan Characterization by Liquid Chromatography Coupled with Fluorimetry and Mass Spectrometry.

Richard A Gardner, Paulina A Urbanowicz, Daniel I R Spencer,

Human blood plasma and serum have been a source of biomarkers for the indication and progression of many diseases for a few decades now. Human blood plasma is also an excellent source material to enable patients to monitor their health, with a multitude of biomarkers detectable for the assessment of ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2370:267-280]

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Lectin Affinity Chromatography for the Discovery of Novel Cancer Glycobiomarkers: A Case Study with PSA Glycoforms and Prostate Cancer.

Esther Llop, Rosa Peracaula,

Many clinical biomarkers in cancer are glycoproteins, but the majority of them only consider the protein levels. Indeed, only alfa-fetoprotein (AFP) in hepatocarcinoma and CA15-3 in breast cancer are clinically monitored for their glycoforms. Aberrant glycosylation occurs frequently in many of the glycoproteins synthesized by tumor cells and often produce ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2370:301-313]

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Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer.

Rong Liao, Qi-Zhi Ma, Cong-Ya Zhou, Jun-Jun Li, Ning-Na Weng, Yang Yang, Qing Zhu,

Colorectal cancer (CRC) is one of the most common tumors, ranking second in the global cause of death from cancer. The prognosis of advanced patients is still very poor. In this study, hub modules with the highest association with tumor-infiltrating immune cells were identified by weighted gene co-expression network analysis ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1676-1688]

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Epigenetics: The Key to Future Diagnostics and Therapeutics of Lung Cancer

Gaurav Jha, Sabeen Azhar, Usman Rashid, Hasan Khalaf, Noor Alhalabi, Deepthi Ravindran, Rawaha Ahmad,

Lung cancer is still the major cause of cancer-related mortality around the globe. The interplay of permanent genetic and dynamic epigenetic changes leads to the onset and progression of lung cancer. The diagnosis is often made at an advanced stage when the prognosis is dismal and therapy choices are restricted. ... Read more >>

Cureus (Cureus)
[0, 13(11):]

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MicroRNA expression profile and identification of novel microRNA biomarkers for metabolic syndrome.

Guanzhi Liu, Yutian Lei, Sen Luo, Zhuo Huang, Chen Chen, Kunzheng Wang, Pei Yang, Xin Huang,

The lack of efficient biomarkers is the main reason for the inaccurate early diagnosis and poor treatment outcomes of patients with metabolic syndrome (MetS). The current study aimed to identify several novel microRNA (miRNA) biomarkers for metabolic syndrome via high-throughput sequencing and comprehensive bioinformatics analysis. Through high-throughput sequencing and differentially ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3864-3872]

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Metabolomic assessment of mechanisms underlying anti-renal fibrosis properties of petroleum ether extract from Amygdalus mongolica.

Chen Gao, Wan-Fu Bai, Hong-Bing Zhou, Hai-Mei Hao, Ying-Chun Bai, Quan-Li Liu, Hong Chang, Song-Li Shi,

<h4>Context</h4>The petroleum ether extract (PET) of <i>Amygdalus mongolica</i> (Maxim.) Ricker (Rosaceae) has an ameliorative effect on renal fibrosis (RF).<h4>Objective</h4>To evaluate the antifibrotic effects of <i>A. mongolica</i> seeds PET on RF by serum metabolomics, biochemical and histopathological analyses.<h4>Materials and methods</h4>Sixty male Sprague-Dawley rats were randomly divided into the sham-operated, RF model, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):565-574]

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Development of molecular tools for diagnosis of Alzheimer's disease that are based on detection of amyloidogenic proteins.

Konstantin Y Kulichikhin, Sergei A Fedotov, Maria S Rubel, Natalia M Zalutskaya, Anastasia E Zobnina, Oksana A Malikova, Nikolay G Neznanov, Yury O Chernoff, Aleksandr A Rubel,

Alzheimer's disease (AD) is the most common form of dementia that usually occurs among older people. AD results from neuronal degeneration that leads to the cognitive impairment and death. AD is incurable, typically develops over the course of many years and is accompanied by a loss of functional autonomy, making ... Read more >>

Prion (Prion)
[2021, 15(1):56-69]

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A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis.

Hong Chang, Hong-Yu Meng, Wan-Fu Bai, Qing-Gang Meng,

<h4>Context</h4>Baicalin, a major flavonoid extracted from <i>Scutellaria baicalensis</i> Georgi (Lamiaceae), has been shown to exert therapeutic effects on pulmonary fibrosis (PF).<h4>Objective</h4>To use serum metabolomics combined with biochemical and histopathological analyses to clarify anti-PF mechanisms of baicalin on metabolic pathways and the levels of potential biomarkers.<h4>Materials and methods</h4>Forty male Sprague-Dawley rats ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1016-1025]

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The screening of immune-related biomarkers for prognosis of lung adenocarcinoma.

Zhonghui Liu, Dan Sun, Qing Zhu, Xinmin Liu,

Lung adenocarcinoma (LUAD) accounts for a frequently seen non-small cell lung cancer (NSCLC) histological subtype, and it is associated with dismal prognostic outcome. However, the benefits of traditional treatment are still limited, and the efficacies of immunotherapy are quite different. Therefore, it is of great significance to identify novel immune-related ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1273-1285]

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