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FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm.

Jane Norman, Andrew Shennan, Bo Jacobsson, Sarah J Stock, ,

For women with a singleton or a multiple pregnancy in situations where active neonatal care is appropriate, and for whom preterm birth is anticipated between 24 and 34 weeks of gestation, one course of prenatal corticosteroids should ideally be offered 18 to 72 h before preterm birth is expected to improve outcomes ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):26-30]

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Beyond-Mild Psoriasis: A Consensus Statement on Calcipotriol and Betamethasone Dipropionate Foam for the Topical Treatment of Adult Patients.

Roland Aschoff, Anthony Bewley, Annunziata Dattola, Clara De Simone, Mourad Lahfa, Mar Llamas-Velasco, Antonio Martorell, Mira Pavlovic, Michael Sticherling,

<h4>Introduction</h4>There are clear treatment options for mild psoriasis where topical therapies are the mainstay, and for severe psoriasis where systemic therapy (biologic or non-biologic) is necessary. However, there is less clarity in the 'grey zone' of patients in the moderate or so-called 'beyond-mild' segment. There are frequent delays to the ... Read more >>

Dermatol Ther (Heidelb) (Dermatology and therapy)
[2021, :]

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Topical corticosteroid wet wrap treatment and adrenal suppression: An Auckland perspective.

Jenny G Chung, Harriet Cheng, Michael Croxson, Karen Agnew, Jane Alsweiler, Steven Lamb,

JAAD Int (JAAD international)
[2021, 5:66-68]

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Clinical efficacy and safety of using calcipotriol-betamethasone compounding agent for psoriasis treatment: a systematic review and meta-analysis.

Junrong Ren, Qi Zhu, Siyao Wang, Xiaolong Li, Zhen Sun, Nan Li, Jian Feng, Haining Ding, Sitong Dong, Hongmei Wang,

The main objective is to evaluate clinical efficacy and safety of using calcipotriol-betamethasone compounding agent for psoriasis treatment through a systematic review and meta-analysis. We searched MEDLINE, Embase, The Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), and WanFang Data from inception till July 31, 2020. ... Read more >>

Arch Dermatol Res (Archives of dermatological research)
[2021, :]

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Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment.

Amanda Vrselja, J Jane Pillow, M Jane Black,

Preterm birth coincides with a key developmental window of cardiac growth and maturation, and thus has the potential to influence long-term cardiac function. Individuals born preterm have structural cardiac remodelling and altered cardiac growth and function by early adulthood. The evidence linking preterm birth and cardiovascular disease in later life ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(17):]

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Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation.

Darina Czamara, Linda Dieckmann, Simone Röh, Sarah Kraemer, Rebecca C Rancourt, Sara Sammallahti, Eero Kajantie, Hannele Laivuori, Johan G Eriksson, Katri Räikkönen, Wolfgang Henrich, Andreas Plagemann, Elisabeth B Binder, Thorsten Braun, Sonja Entringer,

<h4>Background</h4>Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects of antenatal sGCs have been reported, but their effects on placental epigenetic characteristics have never been systematically studied in humans.<h4>Results</h4>We ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2021, 13(1):165]

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Development and validation of a RP-UPLC method for the determination of betamethasone dipropionate impurities in topical formulations using a multivariate central composite design.

Siva Krishna Muchakayala, Kommera Pavithra, Naresh Kumar Katari, Vishnu M Marisetti, Thirupathi Dongala, Raju V K Vegesna,

The current study presents a specific, accurate, simple, and rapid UPLC method for the determination of impurities present in cream and ointment formulations of betamethasone dipropionate (BMD). The analytical method was optimized using central composite design (CCD) prior to the method validation. Critical Process Parameters (CPPs) and Critical Quality Attributes ... Read more >>

Anal Methods (Analytical methods : advancing methods and applications)
[2021, 13(33):3705-3723]

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Short-Term Effects of Dexamethasone versus Betamethasone on Ultrasonic Measures of Fetal Well-Being: Cohort from a Blinded, Randomized Trial.

Amanda Henry, Aditi Mahajan, Caroline A Crowther, Anne Lainchbury, Lynne Roberts, Antonia W Shand, Alec W Welsh,

<h4>Introduction</h4>Maternal corticosteroid administration for anticipated preterm birth is common; however, the corticosteroid effect on fetal ultrasound and cardiotocograph (CTG) remains contested. This study aimed to evaluate short-term ultrasound and CTG impact of (a) dexamethasone versus betamethasone (b) pooled corticosteroid effect.<h4>Methods</h4>Substudy of blinded randomized trial of dexamethasone versus betamethasone (given <34 ... Read more >>

Fetal Diagn Ther (Fetal diagnosis and therapy)
[2021, 48(7):526-540]

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Antenatal Betamethasone Induces Increased Surfactant Proteins and Decreased Foxm1 Expressions in Fetal Rabbit Pups.

Yong-Sung Choi, Chae-Young Kim, Hye Kyung Chang, Young Joo Lee, Sung-Hoon Chung,

<b>Introduction:</b> Antenatal steroid improves respiratory distress syndrome in preterm infants. The molecular mechanism of the process is not well established. The aim of this study is to investigate the possible association between antenatal steroid and fetal Forkhead box M1(Foxm1) expression. <b>Materials and methods:</b> An animal study using mated pregnant New ... Read more >>

Int J Med Sci (International journal of medical sciences)
[2021, 18(15):3367-3372]

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Patient-reported outcomes with calcipotriol/betamethasone aerosol foam in patients with plaque psoriasis in Greece. Results from the CELSUS study.

D Rigopoulos, E Lazaridou, E Papadavid, S Georgiou, V Chasapi, K Sfaelos, G Cheliotis, D Ioannides,

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Physiologically based pharmacokinetic modelling in pregnancy: Model reproducibility and external validation.

Larissa L Silva, Rebecca M Silvola, David M Haas, Sara K Quinney,

<h4>Aims</h4>Physiologically based pharmacokinetic (PBPK) models have been previously developed for betamethasone and buprenorphine for pregnant women. The goal of this work was to replicate and reassess these models using data from recently completed studies.<h4>Methods</h4>Betamethasone and buprenorphine PBPK models were developed in Simcyp V19 based on prior publications using V17 and ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2021, :]

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Calcipotriene Plus Betamethasone Dipropionate Foam for Mild Psoriasis: Pooled Results from Three Randomized Trials.

Karen A Veverka, Jes B Hansen, Maria Yaloumis, Leon Kircik, Linda Stein Gold,

<h4>Background</h4>Psoriasis vulgaris is not easy to manage, even when mild. Knowledge of the efficacy of most topical therapies in this population is limited.<h4>Objective</h4>To assess the efficacy of calcipotriene 0.005% plus betamethasone dipropionate 0.064% (Cal/BD) foam in patients with mild psoriasis.<h4>Methods</h4>Post hoc analysis was performed on pooled data for subjects with ... Read more >>

J Drugs Dermatol (Journal of drugs in dermatology : JDD)
[2021, 20(8):822-828]

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Long-Term Proactive Treatment of Plaque Psoriasis with Calcipotriene/Betamethasone Dipropionate Foam Prolongs Remission and Reduces Relapses Irrespective of Patient Baseline Characteristics.

Mark G Lebwohl, Kim A Papp, Marie Holst Mørch, Marie Y Jablonski Bernasconi, Richard B Warren,

<h4>Introduction</h4>The phase 3 PSO LONG study (NCT02899962) demonstrated superior efficacy of proactive (PM) versus reactive management (RM) using calcipotriene 0.005%/betamethasone dipropionate 0.064% (Cal/BD) foam in adults with psoriasis. Here, we evaluated whether certain baseline parameters had an effect on time to first relapse (TTFR), number of relapses, and assessed interactions ... Read more >>

Dermatol Ther (Heidelb) (Dermatology and therapy)
[2021, :]

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A potential role of mesenchymal stem cells derived from human umbilical cord blood in ameliorating psoriasis-like skin lesion in the rats.

S S Attia, M Rafla, N E El-Nefiawy, H F Abdel Hamid, M A Amin, M A Fetouh,

<h4>Background</h4>Psoriasis is a common autoimmune inflammatory skin disease, with no clear cause, treated with topical agents and phototherapy to conventional immunosuppressant drugs and biologic agents. Stem cell therapy has showed significant interest in regenerative medicine. The aim of this study was to use mesenchymal stem cell (MSC) therapy compared to ... Read more >>

Folia Morphol (Warsz) (Folia morphologica)
[2021, :]

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Successful Prediction of Human Fetal Exposure to P-gp Substrate Drugs Using the Proteomics-informed Relative Expression Factor Approach and PBPK Modeling and Simulation.

Olena Anoshchenko, Flavia Storelli, Jashvant D Unadkat,

Many women take drugs during their pregnancy to treat a variety of clinical conditions. To optimize drug efficacy and reduce fetal toxicity, it is important to determine or predict fetal drug exposure throughout pregnancy. Previously, we developed and verified a maternal-fetal physiologically based pharmacokinetic (m-f PBPK) model to predict fetal ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2021, :]

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Anterior Scleritis Manifesting After Coronavirus Disease 2019: A Report of Two Cases.

Sepehr Feizi, Aidin Meshksar, Ali Naderi, Hamed Esfandiari,

<h4>Purpose</h4>The purpose of this study was to report 2 patients with anterior scleritis manifesting after coronavirus disease 2019 (COVID-19).<h4>Methods</h4>The patients with confirmed COVID-19 developed anterior scleritis after their systemic symptoms were markedly improved. A thorough systemic workup identified no underlying autoimmune diseases. Ocular characteristics and safety and efficacy of systemic ... Read more >>

Cornea (Cornea)
[2021, 40(9):1204-1206]

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Dosage escalation of antenatal steroids in preterm twin pregnancies does not improve long-term outcome.

Thorsten Braun, Vivien Filleböck, Boris Metze, Christoph Bührer, Andreas Plagemann, Wolfgang Henrich,

<h4>Objectives</h4>To analyze long-term effects of antenatal betamethasone (≤16 mg, =24 mg and >24 mg) in preterm twins on infant and childhood morbidity.<h4>Methods</h4>Retrospective cohort study among 198 preterm twins. Three follow up time points, including a total of 84 outcomes, were evaluated: first neonatal examination after birth and in the neonatal period up to ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2021, :]

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Antenatal dexamethasone use and respiratory distress in late preterm infants: results from first Vietnamese matched cohort study.

Tran Tuan Hung Ho, Quang Vinh Truong, Thi Kim Anh Nguyen, Minh Tam Le, Vu Quoc Huy Nguyen,

<h4>Background</h4>Respiratory distress syndrome (RDS) is one of the leading causes of early neonatal morbidity and mortality in late preterm infants (LPIs) worldwide. This matched cohort study aimed to assess how the antenatal dexamethasone use affect the respiratory distress (RD) proportion in preterm newborns between 34 0/7 weeks and 36 6/7 weeks of ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):546]

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Society for Maternal-Fetal Medicine Consult Series #58: Use of antenatal corticosteroids for individuals at risk for late preterm delivery: Replaces SMFM Statement #4, Implementation of the use of antenatal corticosteroids in the late preterm birth period in women at risk for preterm delivery, August 2016.

, Uma M Reddy, Uma Deshmukh, Annie Dude, Lorie Harper, Sarah S Osmundson,

The administration of antenatal corticosteroids has been widely adopted as the standard of care in the management of pregnancies at risk for preterm delivery before 37 weeks of gestation, with the primary goal of reducing neonatal morbidity. However, the long-term risks associated with antenatal corticosteroid use remain uncertain. The purpose ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

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Updates in the Diagnosis and Management of Linear IgA Disease: A Systematic Review.

Leah Shin, Jeffrey T Gardner, Harry Dao,

<i>Background and Objectives:</i> Linear IgA disease (LAD) is a rare autoimmune blistering disease with linear IgA deposits along the basement membrane zone. Direct immunofluorescence remains the gold standard for diagnosis, but other diagnostic measures reported in recent literature have proven useful in the setting of inconclusive preliminary results. Dapsone is ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2021, 57(8):]

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Effectiveness of corticosteroids to treat severe COVID-19: A systematic review and meta-analysis of prospective studies.

Han Li, Bingdi Yan, Rong Gao, Jin Ren, Junling Yang,

<h4>Objectives</h4>To assess the effects of corticosteroid therapy for patients with severe coronavirus disease 2019 (COVID-19).<h4>Methods</h4>We comprehensively searched articles published in the Cochrane Library, PubMed, Embase, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases from January 1, 2019, to March 20, 2021.<h4>Results</h4>A total of 6771 patients ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2021, 100:108121]

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Would High-Dose Corticosteroid Adjuvant To Multimodal Cocktail Periarticular Injection Contribute To Prolonged Pain Control and Better Recovery After Total Knee Arthroplasty?: Study Protocol for a Double-Blinded, Randomized, and Placebo-Controlled Trial

Chengfan Zhong, Rong He, Xiaomin Lu, Lilun Zhong, Ding-Kun Lin, Jun Liu, Guo Da,

<h4>Background: </h4> Enhanced recovery after total knee arthroplasty (TKA) has been suggested to enhance postoperative recovery. The use of multimodal cocktail periarticular injection (MCPI) to control the pain of TKA has gained wide acceptance. MCPI containing corticosteroids is believed to be an effective solution because of its local anti-inflammatory effects ... Read more >>

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Patient satisfaction with calcipotriol/betamethasone dipropionate cutaneous foam for the treatment of plaque psoriasis: The LION real-life multicenter prospective observational cohort study.

Anna Campanati, Laura Atzori, Concetta Potenza, Giovanni Damiani, Luca Bianchi, Monica Corazza, Rossana Tiberio, Francesca Prignano, Giuseppe Argenziano, Maria Concetta Fargnoli, Luca Stingeni, Annamaria Mazzotta, Ornella De Pità, Carlo Mazzatenta, Claudio Feliciani, Massimo Donini, Annamaria Offidani, Ketty Peris, ,

Topical treatment is the mainstay for mild or moderate psoriasis, but patients are generally little satisfied. Calcipotriol/betamethasone dipropionate (Cal/BD) cutaneous foam has shown to improve signs and symptoms in plaque psoriasis patients. This study assessed patient's satisfaction with Cal/BD foam in a real-life Italian dermatological clinical practice. A multicenter, 4-week ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2021, :e15077]

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Steroids and Olfactory Training for Postviral Olfactory Dysfunction: A Systematic Review.

Fan Yuan, Tianhao Huang, Yongxiang Wei, Dawei Wu,

<b>Background:</b> Postviral olfactory dysfunction (PVOD) is a clinical challenge due to limited therapeutic options and poor prognosis. Both steroids and olfactory training have been proved to be effective for olfactory dysfunction with varied etiologies. We sought to perform a systematic review to summarize the evidence of steroids or olfactory training ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2021, 15:708510]

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Do maternal demographics and prenatal history impact the efficacy of betamethasone therapy for threatened preterm labor?

Mary T Kinney, Sara K Quinney, Hayley K Trussell, Larissa L Silva, Sherrine A Ibrahim, David M Haas,

<h4>Background</h4>Betamethasone (BMZ) is used to accelerate fetal lung maturation in women with threatened preterm birth, but its efficacy is variable and limited by the lack of patient individualization in its dosing and administration. To determine sources of variability and potential opportunities for individualization of therapy, the objective of this study ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):442]

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