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Barotrauma and Mechanical Ventilation

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Validation of neuromuscular blocking agent use in acute respiratory distress syndrome: a meta-analysis of randomized trials.

Wei Chang, Qin Sun, Fei Peng, Jianfeng Xie, Haibo Qiu, Yi Yang,

BACKGROUND:We aimed to synthesize up-to-date trials to validate the effects of neuromuscular blocking agent (NMBA) use in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). METHODS:Several databases including PubMed, EMBASE, Web of Science, and Cochrane Central Register were searched up to November 14, 2019. All randomized trials investigating the use ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):54]

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Neuromuscular blockade in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials.

An Thi Nhat Ho, Setu Patolia, Christophe Guervilly,

Background:Neuromuscular blocking agent (NMBA) has been proposed by medical guidelines for early severe acute respiratory distress syndrome (ARDS) because of its survival benefits. However, new studies have provided evidence contradicting these results. Method:A search was performed of the Pubmed, Scopus, Clinicaltrials.gov, and Virtual Health Library databases for randomized controlled trials ... Read more >>

J Intensive Care (Journal of Intensive Care)
[2020, 8:12]

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Development of a tension pneumomediastinum during mechanical ventilation of a young Irish Wolfhound.

Kristin M Zersen, Jenica L Haraschak, Lauren A Sullivan,

OBJECTIVE:To report the development of a tension pneumomediastinum during mechanical ventilation of a young Irish Wolfhound with aspiration pneumonia. CASE SUMMARY:A 9-month-old intact female Irish Wolfhound was presented for clinical signs consistent with aspiration pneumonia. Evaluation of her pedigree and clinical signs prompted suspicion of Irish Wolfhound rhinitis bronchopneumonia syndrome ... Read more >>

J Vet Emerg Crit Care (San Antonio) (Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001))
[2020, :]

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Mechanical ventilation weaning issues can be counted on the fingers of just one hand: part 2.

Luigi Vetrugno, Alessandro Brussa, Giovanni Maria Guadagnin, Daniele Orso, Francesco De Lorenzo, Gianmaria Cammarota, Erminio Santangelo, Tiziana Bove,

Assessing heart and diaphragm function constitutes only one of the steps to consider along the weaning path. In this second part of the review, we will deal with the more systematic evaluation of the pulmonary parenchyma-often implicated in the genesis of respiratory failure. We will also consider the other possible ... Read more >>

Ultrasound J (The ultrasound journal)
[2020, 12(1):15]

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Neuromuscular blockers in the acute respiratory distress syndrome: A meta-analysis.

Yusi Hua, Xiaofeng Ou, Qian Li, Tao Zhu,

BACKGROUND:The effects of neuromuscular blocking agents (NMBAs) on adult patients with acute respiratory distress syndrome (ARDS) remain unclear. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate its effect on mortality. METHODS:We searched the Cochrane (Central) database, Medline, Embase, the Chinese Biomedical Literature Database (SinoMed), WanFang data and ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0227664]

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Supraglottic jet oxygenation and ventilation - A novel ventilation technique.

Sushan Gupta,

Supraglottic jet oxygenation and ventilation (SJOV) is a novel minimally invasive supraglottic technique of jet ventilation which has shown superior results in maintaining oxygenation without any major complications. Theoretically, it could maintain PaO2 and PaCO2 within physiological limits for as long as required, the maximum duration reported till now is ... Read more >>

Indian J Anaesth (Indian journal of anaesthesia)
[2020, 64(1):11-17]

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Inflammatory and microbiological associations with near-fatal asthma requiring extracorporeal membrane oxygenation.

Sunil Patel, Neeraj M Shah, Akanksha M Malhotra, Christopher Lockie, Luigi Camporota, Nicholas Barrett, Brian D Kent, David J Jackson,

Patients with near-fatal asthma requiring ECMO are more likely to be younger and female and are also likely to have positive viral and fungal isolates on bronchoalveolar lavage when compared to those receiving conventional mechanical ventilation http://bit.ly/2S38SaC. ... Read more >>

ERJ Open Res (ERJ open research)
[2020, 6(1):]

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Neuromuscular blocking agents for acute respiratory distress syndrome: an updated meta-analysis of randomized controlled trials.

Zhongjun Zheng, Libing Jiang, Song Zhang, Christophe Guervilly, Mao Zhang, Xia Feng, Jianbo Ding,

BACKGROUNDS:The aim of this study is investigating the benefits and harms of neuromuscular blocking agents (NMBAs) in patients with acute respiratory distress syndrome (ARDS). METHODS:We comprehensively searched PubMed, EMBASE, and Cochrane library for randomized controlled trials comparing NMBAs to any other comparator. We pooled data using relative risk (RR) for ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21(1):23]

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[The effect of a breathing trainer on relieving airway pressure caused by active cough in patients with mechanical ventilation].

S S Yao, F Yang, Z G Zheng, Y F Cao, M Zhong, Q X Zeng, H Dong, N Liu, J Y Hu, R C Chen,

Objective: To explore the effect of a breathing trainer on relieving the peak airway pressure caused by forced exhalation at the end of deep inspiration, gentle coughing at the end of calm inspiration and forced coughing at the end of deep inspiration in patients undergoing mechanical ventilation. Methods: From July ... Read more >>

Zhonghua Jie He He Hu Xi Za Zhi (Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases)
[2020, 43(2):136-139]

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Patient self-inflicted lung injury and positive end-expiratory pressure for safe spontaneous breathing.

Takeshi Yoshida, Domenico L Grieco, Laurent Brochard, Yuji Fujino,

PURPOSE OF REVIEW:The potential risks of spontaneous effort and their prevention during mechanical ventilation is an important concept for clinicians and patients. The effort-dependent lung injury has been termed 'patient self-inflicted lung injury (P-SILI)' in 2017. As one of the potential strategies to render spontaneous effort less injurious in severe ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2020, 26(1):59-65]

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Pulmonary Barotrauma Following Nasal High-Flow Therapy in a Patient with Bronchiolitis Obliterans Syndrome.

Tsuyoshi Ito, Tomoko Suzuki, Matsuyoshi Maeda, Shotaro Iwamoto, Masahiro Hirayama, Yasuharu Yamada, Eiichi Azuma,

BACKGROUND Pulmonary barotrauma is considered as complication of the use of positive-pressure ventilations. Nasal high-flow therapy is increasingly being used as an alternative to them. Nasal high-flow therapy rarely causes pulmonary barotrauma probably because airway pressures are lower when compared with invasive mechanical ventilation. Bronchiolitis obliterans syndrome after allogenic hematopoietic ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:1619-1622]

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Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP). A Phase II, Multicenter Randomized Controlled Clinical Trial.

Carol L Hodgson, D James Cooper, Yaseen Arabi, Victoria King, Andrew Bersten, Shailesh Bihari, Kathy Brickell, Andrew Davies, Ciara Fahey, John Fraser, Shay McGuinness, Lynne Murray, Rachael Parke, Eldho Paul, David Tuxen, Shirley Vallance, Meredith Young, Alistair Nichol,

Rationale: Open lung ventilation strategies have been recommended in patients with acute respiratory distress syndrome (ARDS).Objectives: To determine whether a maximal lung recruitment strategy reduces ventilator-free days in patients with ARDS.Methods: A phase II, multicenter randomized controlled trial in adults with moderate to severe ARDS. Patients received maximal lung recruitment, ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 200(11):1363-1372]

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Spontaneous breathing in patients with severe acute respiratory distress syndrome receiving prolonged extracorporeal membrane oxygenation.

Jingen Xia, Sichao Gu, Min Li, Donglin Liu, Xu Huang, Li Yi, Lijuan Wu, Guohui Fan, Qingyuan Zhan,

BACKGROUND:The use of extracorporeal membrane oxygenation (ECMO) in awake, spontaneously breathing and non-intubated patients (awake ECMO) may be a novel therapeutic strategy for severe acute respiratory distress syndrome (ARDS) patients. The purpose of this study is to assess the feasibility and safety of awake ECMO in severe ARDS patients receiving ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2019, 19(1):237]

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Air Leak Syndrome: Pneumoperitoneum in a Ventilated Neonate.

Chandana Ravikumar, Dawn McDaniel, Amy Quinn,

Air leak syndrome has several manifestations and is common in neonates with meconium aspiration syndrome (MAS) due to air trapping. While pneumoperitoneum is classically a result of intestinal perforation, intra-abdominal free air may be a less common presentation of air leak syndrome. In the ventilated neonate, there is insufficient clinical ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2019, 2019:4238601]

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Early neuromuscular blockade in acute respiratory distress syndrome: to personalize or paralyze?

Ken Kuljit S Parhar, Kevin Solverson, Vasileios Zochios,

J Thorac Dis (Journal of Thoracic Disease)
[2019, 11(12):5701-5705]

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Evone® Flow-Controlled Ventilation During Upper Airway Surgery: A Clinical Feasibility Study and Safety Assessment.

Jeroen Meulemans, Alexander Jans, Kristien Vermeulen, Johan Vandommele, Pierre Delaere, Vincent Vander Poorten,

Introduction: During upper airway surgery in a narrowed airway due to tumor or stenosis, safe ventilation, good laryngotracheal exposure, and preservation of an adequate surgical working space are of paramount importance. This can be achieved by small-lumen ventilation such as High Frequency Jet Ventilation (HFJV). However, this technique has major ... Read more >>

Front Surg (Frontiers in Surgery)
[2020, 7:6]

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Monitoring Patient Respiratory Effort During Mechanical Ventilation: Lung and Diaphragm-Protective Ventilation.

Michele Bertoni, Savino Spadaro, Ewan C Goligher,

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901. ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):106]

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Early neuromuscular blockade in moderate to severe acute respiratory distress syndrome: do not throw the baby out with the bathwater!

Sunghoon Park, Matthieu Schmidt,

J Thorac Dis (Journal of thoracic disease)
[2019, 11(11):E231-E234]

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The Ventrain Device: A Future Role in Difficult Airway Algorithms?

Stuart Morrison, Sophie Aerts, Vera Saldien,

The Ventrain is a small, manually operated, single-use, inspiratory flow-adjustable ventilation device that generates positive pressure during inspiration and, through a Bernoulli effect within the device, active suction during expiration. It was designed to provide emergency ventilation during airway obstruction via narrow-bore cannulae. The device has been used successfully in ... Read more >>

A A Pract (A&A practice)
[2019, 13(9):362-365]

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Acute exacerbation of chronic obstructive pulmonary disease treated by extracorporeal carbon dioxide removal.

Min Li, Si-Chao Gu, Jin-Gen Xia, Qing-Yuan Zhan,

Chin. Med. J. (Chinese medical journal)
[2019, 132(20):2505-2507]

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Ventilatory support and mechanical properties of the fibrotic lung acting as a "squishy ball".

Alessandro Marchioni, Roberto Tonelli, Giulio Rossi, Paolo Spagnolo, Fabrizio Luppi, Stefania Cerri, Elisabetta Cocconcelli, Maria Rosaria Pellegrino, Riccardo Fantini, Luca Tabbì, Ivana Castaniere, Lorenzo Ball, Manu L N G Malbrain, Paolo Pelosi, Enrico Clini,

Protective ventilation is the cornerstone of treatment of patients with the acute respiratory distress syndrome (ARDS); however, no studies have yet established the best ventilatory strategy to adopt when patients with acute exacerbation of interstitial lung disease (AE-ILD) are admitted to the intensive care unit. Due to the severe impairment ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):13]

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Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial.

Kyeong Tae Kim, Sophie Morton, Sarah Howe, Yeong Shiong Chiew, Jennifer L Knopp, Paul Docherty, Christopher Pretty, Thomas Desaive, Balazs Benyo, Akos Szlavecz, Knut Moeller, Geoffrey M Shaw, J Geoffrey Chase,

BACKGROUND:Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. The Clinical utilisation of respiratory elastance (CURE) trial is a two-arm, randomised controlled trial (RCT) investigating the performance of PEEP selected at an objective, ... Read more >>

Trials (Trials)
[2020, 21(1):130]

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Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial.

Jesús Villar, Carlos Ferrando, Domingo Martínez, Alfonso Ambrós, Tomás Muñoz, Juan A Soler, Gerardo Aguilar, Francisco Alba, Elena González-Higueras, Luís A Conesa, Carmen Martín-Rodríguez, Francisco J Díaz-Domínguez, Pablo Serna-Grande, Rosana Rivas, José Ferreres, Javier Belda, Lucía Capilla, Alec Tallet, José M Añón, Rosa L Fernández, Jesús M González-Martín, ,

BACKGROUND:There is no proven specific pharmacological treatment for patients with the acute respiratory distress syndrome (ARDS). The efficacy of corticosteroids in ARDS remains controversial. We aimed to assess the effects of dexamethasone in ARDS, which might change pulmonary and systemic inflammation and result in a decrease in duration of mechanical ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(3):267-276]

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Airway Pressure Release Ventilation in Adult Patients With Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-Analysis.

Jolene Lim, Edward Litton,

OBJECTIVES:To evaluate the efficacy and safety of airway pressure release ventilation in critically ill adults with acute hypoxemic respiratory failure. DATA SOURCES:A systematic literature search of MEDLINE via PUBMED, EMBASE, the Cochrane Library, published conference proceedings and abstracts, reference lists of eligible studies and review articles, and hand searches of ... Read more >>

Crit. Care Med. (Critical care medicine)
[2019, 47(12):1794-1799]

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Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study.

Helene Haeberle, Stefanie Prohaska, Peter Martus, Andreas Straub, Alexander Zarbock, Gernot Marx, Manola Zago, Martin Giera, Michael Koeppen, Peter Rosenberger,

BACKGROUND:Acute respiratory distress syndrome (ARDS) is caused by rapid-onset (within hours) acute inflammatory processes in lung tissue, and it is a life-threatening condition with high mortality. The treatment of ARDS to date is focused on the prevention of further iatrogenic damage of the lung rather than the treatment of the ... Read more >>

Trials (Trials)
[2020, 21(1):242]

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