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Full Text Journal Articles about
Bacterial Pneumonia

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Adult outcomes of childhood bronchiectasis.

Dawn Sibanda, Rosalyn Singleton, John Clark, Christine Desnoyers, Ellen Hodges, Gretchen Day, Gregory Redding,

Recent literature has highlighted the importance of transition from paediatric to adult care for children with chronic conditions. Non-cystic fibrosis bronchiectasis is an important cause of respiratory morbidity in low-income countries and in indigenous children from affluent countries; however, there is little information about adult outcomes of childhood bronchiectasis. We ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1731059]

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Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.

Zhouxin Ren, Jiansheng Li, Junling Shen, Haibin Yu, Xiaofeng Mei, Peng Zhao, Zhenya Xiao, Wanliu Wu,

Context: Clinical reports showed sildenafil beneficial therapy on severe chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) patients.Objective: The study investigated therapeutic effects of silenafil on pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.Materials and methods: Female Sprague-Dawley rats (200-250 g) were divided into control group ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):116-123]

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Wza gene knockout decreases Acinetobacter baumannii virulence and affects Wzy-dependent capsular polysaccharide synthesis.

Tianshui Niu, Lihua Guo, Qixia Luo, Kai Zhou, Wei Yu, Yunbo Chen, Chen Huang, Yonghong Xiao,

To investigate the virulence of capsular polysaccharide export protein (Wza) in carbapenem-resistant Acinetobacter baumannii and its effect on capsule formation.wza gene knockout and complementation strains were constructed, and changes in bacterial virulence were observed using in vitro adhesion, antiserum complement killing, anti-oxidation experiments, and infections in Galleria mellonella and mice. ... Read more >>

Virulence (Virulence)
[2020, 11(1):1-13]

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Mutation on lysX from Mycobacterium avium hominissuis impacts the host-pathogen interaction and virulence phenotype.

Greana Kirubakar, Hubert Schäfer, Volker Rickerts, Carsten Schwarz, Astrid Lewin,

The lysX gene from Mycobacterium avium hominissuis (MAH) is not only involved in cationic antimicrobial resistance but also regulates metabolic activity. An MAH lysX deficient mutant was shown to exhibit a metabolic shift at the extracellular state preadapting the bacteria to the conditions inside host-cells. It further showed stronger growth ... Read more >>

Virulence (Virulence)
[2020, 11(1):132-144]

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Viral respiratory infections: a cause of community-acquired pneumonia or a predisposing factor?

Forest W Arnold, Joshua L Fuqua,

PURPOSE OF REVIEW:A cause for community-acquired pneumonia (CAP) is only identified in ∼50% of cases. Nasopharyngeal PCR panels contain more viruses than previously. The problem then becomes determining the relevance of the organisms identified rather than figuring out which virus is present. This review addresses how to distinguish between viral ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):208-214]

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Lefamulin: A Novel Semisynthetic Pleuromutilin Antibiotic for Community-Acquired Bacterial Pneumonia.

Richard R Watkins, Thomas M File,

Community-acquired bacterial pneumonia (CABP) remains a significant cause of morbidity and mortality worldwide. Antimicrobial resistance, including in pathogens that cause CABP, continues to spread at an alarming rate. Because of these factors, the development of new antibiotic classes is urgently needed. Lefamulin, previously known as BC-3781, is a semisynthetic pleuromutilin ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Plasma amino acid levels in individuals with bacterial pneumonia and healthy controls

HIDEKI IKEDA,

<title>Abstract</title> <p> Background: Amino acids play an important role in immune responses and as neurotransmitters. During the course of a bacterial pneumonia (BP) episode, from the onset to the recovery phase, immune responses dramatically change, as does the metabolism of amino acids, a concept referred to as immuno-nutrition. ... Read more >>

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Deep Learning-Based Recognizing COVID-19 and other Common Infectious Diseases of the Lung by Chest CT Scan Images

Min Fu, Shuang-Lian Yi, Yuanfeng Zeng, Feng Ye, Yuxuan Li, Xuan Dong, Yan-Dan Ren, Linkai Luo, Jin-Shui Pan, Qi Zhang,

Purpose: COVID-19 has become global threaten. CT acts as an important method of diagnosis. However, human-based interpretation of CT imaging is time consuming. More than that, substantial inter-observer-variation cannot be ignored. We aim at developing a diagnostic tool for artificial intelligence (AI)-based classification of CT images for recognizing COVID-19 and ... Read more >>

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Clinical factors influencing the performance of bacterial multiplex polymerase chain reaction in patients with community-onset pneumonia.

Ga Eun Park, Kyong Ran Peck, Jae-Hoon Ko, Cheol-In Kang, Sun Young Cho, Doo Ryeon Chung, Nam Yong Lee,

The etiologic diagnostic yield of community-onset pneumonia (COP) using conventional methods is low. Bacterial multiplex polymerase chain reaction (mPCR) has been shown to be more sensitive than conventional methods. This study assessed the clinical factors influencing bacterial mPCR results in patients with COP. Patients with COP admitted to a tertiary ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2020, :]

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Evaluation of variation in D-dimer levels among COVID-19 and bacterial pneumonia: a retrospective analysis

Bilian Yu, Xin Li, Jin Chen, Mingqi Ouyang, Hong Zhang, Xinge Zhao, Liang Tang, Qin Luo, Min Xu, Lizhen Yang, Guxiang Huang, Xianling Liu, Jianjun Tang,

<title>Abstract</title> <p> <bold>Background:</bold>In the recent outbreak of novel coronavirus infection worldwide, the risk of thrombosis and bleeding should be concerned. <bold>Objectives: </bold>We aimed to observe the dynamic changes of D-dimer levels during disease progression to evaluate their value for thrombosis. <bold>Methods:</bold> In this study, we report the clinical ... Read more >>

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The Origin of the Idea That Herpes Labialis Is of Prognostic Importance in Bacterial Meningitis.

Peter J Koehler,

OBJECTIVE:The aim of the work was to study the origin of the idea that herpes labialis (HL) in patients with pneumonia and meningitis was believed to be of prognostic importance. BACKGROUND:HL is caused by a primary infection or reactivation of herpes simplex type I. In the past, it has been ... Read more >>

Eur. Neurol. (European neurology)
[2020, :1-6]

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Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) infection during late pregnancy: A Report of 18 patients from Wuhan, China

Jing Yang, Lu Zhang, Lan Dong, Lei Ming, Min Wei, Jun Li, Ruheng Hu,

<title>Abstract</title> <p> Background Compared with Severe Acute Respiratory Syndrome(SARS) and Middle East Respiratory Syndrome(MESR), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of ... Read more >>

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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

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S-nitroso-N-acetylpenicillamine (SNAP) Impregnated Endotracheal Tubes for Prevention of Ventilator-Associated Pneumonia.

Katie H Homeyer, Priyadarshini Singha, Marcus J Goudie, Hitesh Handa,

The chances of ventilator-associated pneumonia (VAP) increases 6- to 20-fold when an endotracheal tube is placed in a patient. VAP is one of the most common hospital-acquired infections and comprises 86% of the nosocomial pneumonia cases. This work introduces the idea of nitric oxide-releasing endotracheal tubes (NORel-ETTs) fabricated by the ... Read more >>

Biotechnol. Bioeng. (Biotechnology and bioengineering)
[2020, :]

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Corynebacterium species as one of the major causative pathogens of bacterial pneumonia.

Kazuhiro Yatera, Hiroshi Mukae,

Recent advances using molecular methods, matrix-assisted laser desorption ionization time of flightmass spectrometry, and next-generation sequencers enable rapid and precise detection of bacterial species in the clinical samples, revealing bacterial diversities in the human body. Corynebacterium species are Gram-positive bacilli, which can cause pneumonia and have been reported as causative ... Read more >>

Respir Investig (Respiratory investigation)
[2020, :]

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Rapid ultrasensitive diagnosis of pneumonia caused by Acinetobacter baumannii using a combination of enrichment and phage-based qPCR assay

Hongping Wei, Junping Yu, Jun Luo, Mengwei Jiang, Jin Xiong, Junhua Li,

<title>Abstract</title> <p> Background Accurate and rapid identification of ventilator associated or nosocomial pneumonia caused by Acinetobacter baumannii ( A. baumannii ) could improve the treatment.Methods In current study, we developed a phage-based real-time quantitative PCR (qPCR) combined with enrichment culture for rapid and specific detection of viable A. ... Read more >>

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Septic shock: ECMO beyond ARDS? Introducing the Simon two-stage protocol when randomisation is considered unethical.

Alexander Buia, Hans-Bernd Hopf, Eva Herrmann, Thomas Schmandra, Ernst Hanisch,

Scand J Trauma Resusc Emerg Med (Scandinavian journal of trauma, resuscitation and emergency medicine)
[2020, 28(1):22]

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Reconstituted High-density Lipoprotein Therapy Improves Survival in Mouse Models of Sepsis.

Sébastien Tanaka, Claire Genève, Nathalie Zappella, Jennyfer Yong-Sang, Cynthia Planesse, Liliane Louedec, Wildriss Viranaïcken, Matthieu Bringart, Philippe Montravers, Erick Denamur, Jacques Duranteau, David Couret, Olivier Meilhac,

BACKGROUND:High-density lipoproteins exert pleiotropic effects including antiinflammatory, antiapoptotic, and lipopolysaccharide-neutralizing properties. The authors assessed the effects of reconstituted high-density lipoproteins (CSL-111) intravenous injection in different models of sepsis. METHODS:Ten-week-old C57BL/6 mice were subjected to sepsis by cecal ligation and puncture or intraperitoneal injection of Escherichia coli or Pseudomonas aeruginosa pneumonia. ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):825-838]

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Assessing Animal Models of Bacterial Pneumonia Used in Investigational New Drug Applications for the Treatment of Bacterial Pneumonia.

Ursula Waack, Edward A Weinstein, John J Farley,

Animal models of bacterial infection have been widely used to explore the in vivo activity of antibacterial drugs. These data are often submitted to the US Food and Drug Administration to support human use in an investigational new drug application (IND). To better understand the range and scientific use of ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2020, :]

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Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation?

Claire Lhommet, Denis Garot, Leslie Grammatico-Guillon, Cassandra Jourdannaud, Pierre Asfar, Christophe Faisy, Grégoire Muller, Kimberly A Barker, Emmanuelle Mercier, Sylvie Robert, Philippe Lanotte, Alain Goudeau, Helene Blasco, Antoine Guillon,

BACKGROUND:Community-acquired pneumonia (CAP) requires urgent and specific antimicrobial therapy. However, the causal pathogen is typically unknown at the point when anti-infective therapeutics must be initiated. Physicians synthesize information from diverse data streams to make appropriate decisions. Artificial intelligence (AI) excels at finding complex relationships in large volumes of data. We ... Read more >>

BMC Pulm Med (BMC Pulmonary Medicine)
[2020, 20(1):62]

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15-Epi-LXA4 and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation.

Meriem Sekheri, Driss El Kebir, Natalie Edner, János G Filep,

Timely resolution of bacterial infections critically depends on phagocytosis of invading pathogens by polymorphonuclear neutrophil granulocytes (PMNs), followed by PMN apoptosis and efferocytosis. Here we report that bacterial DNA (CpG DNA) and mitochondrial DNA impair phagocytosis and attenuate phagocytosis-induced apoptosis in human PMNs through Toll-like receptor 9 (TLR9)-mediated release of ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, :]

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Umbilical cord-derived CD362+ mesenchymal stromal cells for E. coli pneumonia: impact of dose regimen, passage, cryopreservation, and antibiotic therapy.

Shahd Horie, Claire Masterson, Jack Brady, Paul Loftus, Emma Horan, Lisa O'Flynn, Steve Elliman, Frank Barry, Timothy O'Brien, John G Laffey, Daniel O'Toole,

BACKGROUND:Mesenchymal stromal cells (MSCs) demonstrate considerable promise for acute respiratory distress syndrome (ARDS) and sepsis. However, standard approaches to MSC isolation generate highly heterogeneous cell populations, while bone marrow (BM) constitutes a limited and difficult to access MSC source. Furthermore, a range of cell manufacturing considerations and clinical setting practicalities remain ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2020, 11(1):116]

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Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill patients with pneumonia.

Luzelena Caro, David P Nicolau, Jan J De Waele, Joseph L Kuti, Kajal B Larson, Elaine Gadzicki, Brian Yu, Zhen Zeng, Adedayo Adedoyin, Elizabeth G Rhee,

OBJECTIVES:Ceftolozane/tazobactam is approved for hospital-acquired/ventilator-associated bacterial pneumonia at double the dose (i.e. 2 g/1 g) recommended for other indications. We evaluated the bronchopulmonary pharmacokinetic/pharmacodynamic profile of this 3 g ceftolozane/tazobactam regimen in ventilated pneumonia patients. METHODS:This was an open-label, multicentre, Phase 1 trial (clinicaltrials.gov: NCT02387372). Mechanically ventilated patients with proven/suspected pneumonia received ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2020, :]

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Pathological Study of the 2019 Novel Coronavirus Disease (COVID-19) through Post-Mortem Core Biopsies

Sufang Tian, Yong Xiong, Huan Liu, Li Niu, Jianchun Guo, Meiyan Liao, Shu-Yuan Xiao,

Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed post-mortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia. The patients&rsquo; ages ranged ... Read more >>

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Active or latent tuberculosis increases susceptibility to COVID-19 and disease severity

Yongyu Liu, Lijun Bi, Yu Chen, Yaguo Wang, Joy Fleming, Yanhong Yu, Ye Gu, Chang Liu, Lichao Fan, Xiaodan Wang, Moxin Cheng,

Importance: Risk factors associated with COVID-19, the viral pneumonia originating in Wuhan, China, in Dec 2019, require clarification so that medical resources can be prioritized for those at highest risk of severe COVID-19 complications. Infection with M. tuberculosis (MTB), the pathogen that causes TB and latently infects ~25% of the ... Read more >>

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