Full Text Journal Articles about
Autophagy

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Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response.

Brandon J Berry, Tyrone O Nieves, Andrew P Wojtovich,

Mitochondria are ATP-producing organelles that also signal throughout the cell. Mitochondrial protein homeostasis is regulated through membrane potential-dependent protein import and quality control signaling. The mitochondrial unfolded protein response (UPR<sup>mt</sup>) is a specific program that responds to imbalances in nuclear and mitochondrial gene expression. Mounting evidence suggests that the electrochemical ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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ATG8 is conserved between Saccharomyces cerevisiae and psychrophilic, polar-collected fungi.

Brenna J Ivory, Hannah M Smith, Elizabeth Cabrera, Meaghan R Robinson, Jackson T Sparks, Amanda Solem, Jun-Ichi Ishihara, Hiroki Takahashi, Masaharu Tsuji, Verónica A Segarra,

Autophagy is a conserved catabolic process by which eukaryotic cells respond to stress by targeting damaged or unneeded molecules or organelles for sequestration into specialized vesicles known as autophagosomes. Autophagosomes ultimately facilitate the digestion and recycling of their contents by fusing with the degradative organelle of the cell. Studies of ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Swimming exercise reduces native ⍺-synuclein protein species in a transgenic C. elegans model of Parkinson's disease.

Minna Y Schmidt, Manish Chamoli, Gordon J Lithgow, Julie K Andersen,

Exercise has been historically recommended to prevent many disease conditions. Intense exercise in particular, has been shown to be beneficial for Parkinson's disease (PD) - stopping and even reversing symptoms in some patients. Recent research in mammalian animal models of Parkinson's have shown that exercise affects ⍺-synuclein aggregate species, considered ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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YML018C protein localizes to the vacuolar membrane independently of Atg27p.

Candyce M Sturgeon, Nicholas Zanghi, Hannah M Smith, Emily K Davis, Meaghan R Robinson, Elizabeth Cabrera, Molly C Holbrook, Verónica A Segarra,

The function of the budding yeast YML018C protein remains to be determined. High-throughput studies have reported that the YML018C protein localizes to the vacuolar membrane and physically interacts with the autophagy-related protein Atg27p. While this evidence suggests a potential role for this uncharacterized protein in the process of autophagy, the ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Atg27p co-fractionates with clathrin-coated vesicles in budding yeast.

Verónica A Segarra, Anupam Sharma, Sandra K Lemmon,

Atg27p, a single-pass transmembrane protein that functions in autophagy, localizes to a variety of cellular compartments including the pre-autophagosomal structure, late Golgi, vacuolar membrane, as well as early and late endosomes. Its cytoplasmic C-terminus contains a tyrosine sorting motif that allows for its transport to the vacuolar membrane and an ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Atg27p localization is clathrin- and Ent3p/5p-dependent.

Verónica A Segarra, Anupam Sharma, Sandra K Lemmon,

The autophagy-related protein Atg27p has been previously shown to localize to the autophagy-specific pre-autophagosomal structure (PAS) as well as to several organelles, including the late Golgi, the vacuolar membrane, and the endosome. Given that Atg27p localization to the vacuolar membrane in particular has been shown to be dependent on both ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Genetic interactions in a C. elegans sod-1 ALS model: glutamatergic neuron degeneration.

Jennifer F Osborne, Katherine S Yanagi, Anne C Hart,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos.

Fan-Suo Geng, Elisa de la Calle-Mustienes, José Luis Gómez-Skarmeta, Ryan Lister, Ozren Bogdanovic,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer's disease Causes Activation of the Mitochondrial Unfolded Protein Response in C. elegans touch neurons.

Sanjib Guha, Sarah Fischer, Anson Cheng, Gail V W Johnson, Keith Nehrke,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 1 time

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Vitellogenin-2 acts downstream of PRY-1/Axin to regulate lipids and lifespan in C. elegans.

Avijit Mallick, Bhagwati P Gupta,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans: Integration.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans I.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 2 times

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans II.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 1 time

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans III.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 1 time

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Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.

Jia-Nan Yan, Hai-Ying Zhang, Jun-Rui Li, Ying Chen, Yong-Cheng Jiang, Jia-Bing Shen, Kai-Fu Ke, Xiao-Su Gu,

Autophagy has been shown to play an important role in Parkinson's disease. We hypothesized that skin-derived precursor cells exhibit neuroprotective effects in Parkinson's disease through affecting autophagy. In this study, 6-hydroxydopamine-damaged SH-SY5Y cells were pretreated with a culture medium containing skin-derived precursors differentiated into Schwann cells (SKP-SCs). The results showed ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1357-1363]

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SARS-CoV-2-induced autophagy dysregulation may cause neuronal dysfunction in COVID-19.

Madepalli K Lakshmana,

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1255-1256]

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Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease.

Qing Gao, Rui Chen, Liang Wu, Qing Huang, Xi-Xi Wang, You-Yong Tian, Ying-Dong Zhang,

Abnormal accumulation of α-synuclein contributes to the formation of Lewy bodies in the substantia nigra, which is considered the typical pathological hallmark of Parkinson's disease. Recent research indicates that angiotensin-(1-7) plays a crucial role in several neurodegenerative disorders, including Parkinson's disease, but the underlying mechanisms remain elusive. In this study, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1138-1145]

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Potential neuroprotection by Dendrobium nobile Lindl alkaloid in Alzheimer's disease models.

Dai-Di Li, Chang-Qing Zheng, Feng Zhang, Jing-Shan Shi,

At present, treatments for Alzheimer's disease can temporarily relieve symptoms but cannot prevent the decline of cognitive ability and other neurodegenerative changes. Dendrobium nobile Lindl alkaloid is the main active component of Dendrobium nobile Lindl. Dendrobium nobile Lindl alkaloid has been shown to resist aging, prolong life span, and exhibit ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):972-977]

Cited: 1 time

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Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury.

Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhang,

Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system diseases. However, the mechanism behind the neuroprotective effects remains unclear. In this study, rat models of spinal cord injury were established using a modified Allen's ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1080-1087]

Cited: 1 time

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Iron, the endolysosomal system and neuroinflammation: a matter of balance.

Daniel A Borquez, Pamela J Urrutia, Marco T Núñez,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1003-1004]

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APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes.

Schmukler Eran, Pinkas-Kramarski Ronit,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):777-778]

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Long non-coding RNA MEG3 regulates autophagy after cerebral ischemia/reperfusion injury.

Tian-Hao Li, Hong-Wei Sun, Lai-Jun Song, Bo Yang, Peng Zhang, Dong-Ming Yan, Xian-Zhi Liu, Yu-Ru Luo,

Severe cerebral ischemia/reperfusion injury has been shown to induce high-level autophagy and neuronal death. Therefore, it is extremely important to search for a target that inhibits autophagy activation. Long non-coding RNA MEG3 participates in autophagy. However, it remains unclear whether it can be targeted to regulate cerebral ischemia/reperfusion injury. Our ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):824-831]

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Promise of metformin for preventing age-related cognitive dysfunction.

Leelavathi N Madhu, Maheedhar Kodali, Ashok K Shetty,

The expanded lifespan of people, while a positive advance, has also amplified the prevalence of age-related disorders, which include mild cognitive impairment, dementia, and Alzheimer's disease. Therefore, competent therapies that could improve the healthspan of people have great significance. Some of the dietary and pharmacological approaches that augment the lifespan ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):503-507]

Cited: 1 time

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Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases.

Serra Ozgen, Judith Krigman, Ruohan Zhang, Nuo Sun,

Mitochondria play a multidimensional role in the function and the vitality of the neurological system. From the generation of neural stem cells to the maintenance of neurons and their ultimate demise, mitochondria play a critical role in regulating our neural pathways' homeostasis, a task that is critical to our cognitive ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):741-747]

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The emerging world of subcellular biological medicine: extracellular vesicles as novel biomarkers, targets, and therapeutics.

Leon G Coleman,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1020-1022]

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