Full Text Journal Articles about
Autonomic Neuropathy

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Acquired long QT syndrome in chronic kidney disease patients.

Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li,

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):54-65]

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Correction to: Ambulatory blood pressure profiles in familial dysautonomia.

Lior Goldberg, Bat-El Bar-Aluma, Alex Krauthammer, Ori Efrati, Yehonatan Sharabi,

Unfortunately, the original version of this article contained. ... Read more >>

Clin. Auton. Res. (Clinical autonomic research : official journal of the Clinical Autonomic Research Society)
[2020, :]

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Molecular genetic analysis in 21 Chinese families with congenital insensitivity to pain with or without anhidrosis.

F Zhao, B Mao, X Geng, X Ren, Y Wang, Y Guan, S Li, L Li, S Zhang, Y You, Y Cao, T Yang, X Zhao,

BACKGROUND AND PURPOSE:Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous neurological disorders characterized by sensory dysfunctions. Here we report 21 affected Chinese families, including nineteen with congenital insensitivity to pain with anhidrosis (CIPA; namely HSAN IV) and two with congenital insensitivity to pain (CIP; ... Read more >>

Eur. J. Neurol. (European journal of neurology)
[2020, :]

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Not Always as It Seems: A Case of Ascending Paralysis.

Joseph P Staszel, MaryAnn Miknevich,

Although generally presenting as a chronic, progressive peripheral neuropathy, we present a case of acute alcoholic neuropathy initially mistaken for acute Guillain-Barré syndrome. Electrodiagnostic evaluation of alcoholic neuropathy reveals an axonal neuropathy and may be complicated by demyelination if comorbid nutritional deficiencies are present. This is in contrast to the ... Read more >>

Am J Phys Med Rehabil (American journal of physical medicine & rehabilitation)
[2020, 99(3):e32-e34]

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Clinical Tools for Peripheral Neuropathy to Exclude Cardiovascular Autonomic Neuropathy in Type 2 Diabetes Mellitus.

Kalliopi Pafili, Grigorios Trypsianis, Dimitrios Papazoglou, Efstratios Maltezos, Nikolaos Papanas,

INTRODUCTION:Assessment for cardiovascular autonomic neuropathy (CAN) remains difficult in everyday clinical practice. We sought to examine the diagnostic utility of various simple tools for diabetic peripheral neuropathy (DPN) in the detection of CAN in type 2 diabetes mellitus. METHODS:We examined 153 type 2 diabetes mellitus subjects by various DPN tools ... Read more >>

Diabetes Ther (Diabetes therapy : research, treatment and education of diabetes and related disorders)
[2020, 11(4):979-986]

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Treatment induced neuropathy of diabetes.

Christopher H Gibbons,

BACKGROUND:Treatment induced neuropathy of diabetes (TIND) is an iatrogenic painful sensory and autonomic neuropathy. Although the prevalence is not known, it is seen in up to 10% of tertiary cases referred for evaluation of diabetic neuropathy. EVIDENCE:TIND is associated with a decrease in the glycosylated hemoglobin A1C in individuals with ... Read more >>

Auton Neurosci (Autonomic neuroscience : basic & clinical)
[2020, 226:102668]

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Novel NTRK1 mutation in Chinese patient with congenital insensitivity to pain with anhidrosis: A Case Report

Yong Xu, Jing Sha, Zaochun Xu, Jingfang Zhai, Bei Zhang, Yanling Zhang,

<title>Abstract</title> <p> Objective : Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessively inherited disorder characterized by insensitivity to noxious stimuli and inability to sweat. Methods : In this case report, an 18-year-old Chinese boy diagnosed with CIPA with the clinical features of loss of ... Read more >>

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Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study.

Michael L Rosenberg, Vahid Tohidi, Karna Sherwood, Sujoy Gayen, Rosina Medel, Gad M Gilad,

Peripheral neuropathies associated with painful small fiber neuropathy (SFN) are complex conditions, resistant to treatment with conventional medications. Previous clinical studies strongly support the use of dietary agmatine as a safe and effective treatment for neuropathic pain. Based on this evidence, we conducted an open-label consecutive case series study to ... Read more >>

Nutrients (Nutrients)
[2020, 12(2):]

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Impact of Non-Cardiac Clinicopathologic Characteristics on Survival in Transthyretin Amyloid Polyneuropathy.

Alejandra González-Duarte, Isabel Conceição, Leslie Amass, Marc F Botteman, John A Carter, Michelle Stewart,

INTRODUCTION:Hereditary (variant) transthyretin amyloidosis (ATTRv) with polyneuropathy (ATTR-PN) is a rare genetic disorder that causes progressive autonomic and sensorimotor neuropathy, severe disability, and death within 10 years of onset. Previous studies have primarily focused on how baseline cardiac characteristics affect mortality, but the impact of non-cardiac baseline characteristics is less defined. ... Read more >>

Neurol Ther (Neurology and therapy)
[2020, :]

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Specific gene expression in type 1 diabetic patients with and without cardiac autonomic neuropathy.

Joanna Gastol, Anna Polus, Maria Biela, Urszula Razny, Lukasz Pawlinski, Bogdan Solnica, Beata Kiec-Wilk,

We hypothesized that some molecular pathways might interact to initiate the process of nervous tissue destruction, promoting cardiac autonomic neuropathy (CAN) in the course of diabetes type 1 (T1D). The study group consisted of 60 T1D patients (58.33% women/41.67% men), on standard therapy. The control group consisted of twenty healthy ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5554]

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Baroreflex Sensitivity with Different Lags for the Evaluation of Cardiovascular Autonomic Neuropathy in Subjects with Diabetes

Daiana Petry, Claudia Mirian de Godoy Marques, Jefferson Luiz Brum Marques,

<title>Abstract</title> <p> <bold>Background</bold>: Impaired Baroreflex sensitivity (BRS) may indicate cardiovascular autonomic neuropathy (CAN), which often remains undiagnosed during the initial course of diabetes mellitus. The baroreflex mechanism can be considered negative feedback because of baroreflex delay, the time delay between a change in blood pressure, and the counteracting ... Read more >>

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Cardiovascular Disorders Mediated by Autonomic Nervous System Dysfunction.

Pravin Khemani, Ali A Mehdirad,

Cardiovascular disorders, such as orthostatic hypotension and supine hypertension, are common in patients with neurodegenerative synucleinopathies such as Parkinson disease (PD), and may also occur in other conditions, such as peripheral neuropathies, that result in autonomic nervous system (ANS) dysfunction. Dysfunction and degeneration of the ANS are implicated in the ... Read more >>

Cardiol Rev (Cardiology in review)
[2020, 28(2):65-72]

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Acute diabetic neuropathy following improved glycaemic control: a case series and review.

N Siddique, R Durcan, S Smyth, T Kyaw Tun, S Sreenan, J H McDermott,

Summary:We present three cases of acute diabetic neuropathy and highlight a potentially underappreciated link between tightening of glycaemic control and acute neuropathies in patients with diabetes. Case 1: A 56-year-old male with poorly controlled type 2 diabetes (T2DM) was commenced on basal-bolus insulin. He presented 6 weeks later with a ... Read more >>

Endocrinol Diabetes Metab Case Rep (Endocrinology, diabetes & metabolism case reports)
[2020, 2020:]

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Autonomic Peripheral Neuropathy.

Roy Freeman,

PURPOSE OF REVIEW:This article provides a summary of the autonomic neuropathies, including neuropathies associated with diabetes mellitus, neuropathies due to amyloid deposition, immune-mediated autonomic neuropathies (including those associated with a paraneoplastic syndrome), inherited autonomic neuropathies, and toxic autonomic neuropathies. The presenting features, diagnostic investigations, and natural history of these neuropathies ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2020, 26(1):58-71]

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Editorial: Integrity of the Autonomic Nervous System in Psychiatric and Neurological Disorders.

Timo Siepmann, Ben Min-Woo Illigens, Kristian Barlinn,

Front Neurol (Frontiers in Neurology)
[2020, 11:138]

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Diagnosis and Treatment of Hereditary Transthyretin Amyloidosis (hATTR) Polyneuropathy: Current Perspectives on Improving Patient Care.

Marco Luigetti, Angela Romano, Andrea Di Paolantonio, Giulia Bisogni, Mario Sabatelli,

Hereditary transthyretin amyloidosis (hATTR) with polyneuropathy (formerly known as Familial Amyloid Polyneuropathy) is a rare disease due to mutations in the gene encoding transthyretin (TTR) and characterized by multisystem extracellular deposition of amyloid, leading to dysfunction of different organs and tissues. hATTR amyloidosis represents a diagnostic challenge for neurologists considering ... Read more >>

Ther Clin Risk Manag (Therapeutics and clinical risk management)
[2020, 16:109-123]

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Ganglionic Acetylcholine Receptor Antibodies and Autonomic Dysfunction in Autoimmune Rheumatic Diseases.

Michie Imamura, Akihiro Mukaino, Koutaro Takamatsu, Hiroto Tsuboi, Osamu Higuchi, Hideki Nakamura, Saori Abe, Yukio Ando, Hidenori Matsuo, Tadashi Nakamura, Takayuki Sumida, Atsushi Kawakami, Shunya Nakane,

Autonomic neuropathy has been reported in autoimmune rheumatic diseases (ARD) including Sjögren's syndrome, systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. However, the pathophysiological mechanism underlying autonomic dysfunction remains unknown to researchers. On the other hand, autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder, which causes dysautonomia that is ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Diabetes-associated cardiac autonomic neuropathy.

Angela K Wooton, Lynne Melchior,

Cardiac autonomic neuropathy (CAN) is an underdiagnosed cardiovascular complication associated with diabetes. NPs are in a pivotal position to screen patients for CAN. As the incidence of diabetes increases in an aging population, NPs can help prevent complications associated with diabetes and CAN. ... Read more >>

Nurse Pract (The Nurse practitioner)
[2020, 45(2):24-31]

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Autonomic History, Examination, and Laboratory Evaluation.

William P Cheshire,

PURPOSE OF REVIEW:Autonomic disorders offer a fascinating view of the complexity of the nervous system. Their impact on human health ranges from benign to severe. Deciphering autonomic symptoms and signs draws on the cognitive skills and personal interest in the plight of patients that first attracted many physicians to the ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2020, 26(1):25-43]

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Diphtheria outbreak among the Rohingya refugees in Bangladesh: What strategies should be utilized for prevention and control?

Kamrul Hsan, Jannatul Mawa Misti, David Gozal, Mark D Griffiths, Mohammed A Mamun,

Travel Med Infect Dis (Travel medicine and infectious disease)
[2020, :101591]

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Assessment of cutaneous axon-reflex responses to evaluate functional integrity of autonomic small nerve fibers.

Mido M Hijazi, Sylvia J Buchmann, Annahita Sedghi, Ben M Illigens, Heinz Reichmann, Gabriele Schackert, Timo Siepmann,

Cutaneous autonomic small nerve fibers encompass unmyelinated C-fibers and thinly myelinated Aδ-fibers, which innervate dermal vessels (vasomotor fibers), sweat glands (sudomotor fibers), and hair follicles (pilomotor fibers). Analysis of their integrity can capture early pathology in autonomic neuropathies such as diabetic autonomic neuropathy or peripheral nerve inflammation due to infectious ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Instruments of Choice for Assessment and Monitoring Diabetic Foot: A Systematic Review.

Raúl Fernández-Torres, María Ruiz-Muñoz, Alberto J Pérez-Panero, Jerónimo García-Romero, Manuel Gónzalez-Sánchez,

Diabetic foot is the most frequent disorder among the chronic complications of diabetes, happening in 25% of patients. Objective clinical outcome measures are tests or clinical instruments that provide objective values for result measurement. The aim of this study was to carry out a systematic review of specific objective clinical ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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Influence of cardiac autonomic neuropathy on cardiac repolarisation during incremental adrenaline infusion in type 1 diabetes.

Alan Bernjak, Elaine Chow, Emma J Robinson, Jenny Freeman, Jefferson L B Marques, Ian A Macdonald, Paul J Sheridan, Simon R Heller,

AIMS/HYPOTHESIS:We examined the effect of a standardised sympathetic stimulus, incremental adrenaline (epinephrine) infusion on cardiac repolarisation in individuals with type 1 diabetes with normal autonomic function, subclinical autonomic neuropathy and established autonomic neuropathy. METHODS:Ten individuals with normal autonomic function and baroreceptor sensitivity tests (NAF), seven with subclinical autonomic neuropathy (SAN; ... Read more >>

Diabetologia (Diabetologia)
[2020, :]

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Prediabetes, diabetes, metabolic syndrome, and small fiber neuropathy.

Pariwat Thaisetthawatkul, Elizabeth Lyden, J Americo Fernandes, David N Herrmann,

INTRODUCTION:This study was conducted to evaluate the association between prediabetes (PD), elements of the metabolic syndrome (MetS), and small fiber neuropathy (SFN). METHODS:A total of 268 patients with SFN symptoms and normal electrophysiology underwent tests to assess small fibers. SFN was diagnosed based on abnormality of at least two among ... Read more >>

Muscle Nerve (Muscle & nerve)
[2020, 61(4):475-479]

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Beating the ER: novel insights into FAM134B function and regulation.

Chiara De Leonibus, Laura Cinque, Carmine Settembre,

To maintain cellular homeostasis, the endoplasmic reticulum (ER) necessitates a continuous removal of ER fragments via a selective, receptor-mediated, form of autophagy known as ER-phagy. In this issue of The EMBO Journal, Jiang et al (2020) shed light on how the best characterized autophagy receptor FAM134B mediates ER membrane fragmentation, the ... Read more >>

EMBO J. (The EMBO journal)
[2020, 39(5):e104546]

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