Full Text Journal Articles by
Author Zyad J Carr

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Endocrine emergencies in anesthesia.

Claudia Fernandez-Robles, Zyad J Carr, Adriana D Oprea,

<h4>Purpose of review</h4>An increasing number of patients with endocrine disorders will present to the operating rooms. In this review, we outline the common endocrine disorders that the anesthesiologist may face in the perioperative time span, review the controversies in optimal management, as well as summarize the recent literature for the ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):326-334]

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Perioperative risk factors in patients with idiopathic pulmonary fibrosis: a historical cohort study.

Brittany J McDowell, Kunal Karamchandani, Erik B Lehman, Matthew J Conboy, Zyad J Carr,

<h4>Purpose</h4>Perioperative complications of patients with idiopathic pulmonary fibrosis (IPF) are not well described. The aim of this study was to identify risk factors associated with adverse postoperative outcomes in IPF patients.<h4>Methods</h4>We performed a single-centre historical cohort study of adult patients with IPF who underwent surgery between 2008 and 2018. We ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, 68(1):81-91]

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An Update on Systemic Sclerosis and its Perioperative Management.

Zyad J Carr, John Klick, Brittany J McDowell, Jean G Charchaflieh, Kunal Karamchandani,

<h4>Purpose of review</h4>Systemic sclerosis or scleroderma (SSc) is a systemic, immune-mediated disease characterized by abnormal cutaneous and organ-based fibrosis that results in progressive end-organ dysfunction and decreased survival. SSc results in significant challenges for the practicing anesthesiologist due to its rarity, multi-system involvement, and limited evidence-based guidance for optimal perioperative ... Read more >>

Curr Anesthesiol Rep (Current anesthesiology reports)
[2020, :1-10]

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Stroke prophylaxis in critically-ill patients with new-onset atrial fibrillation.

Robert S Schoaps, Ashley Quintili, Anthony Bonavia, Zyad J Carr, Erik B Lehman, Thomas Abendroth, Kunal Karamchandani,

Despite a high incidence of new onset atrial fibrillation (NOAF) in critically ill patients and its association with short and long-term incidence of stroke, there is limited data assessing anticoagulation on hospital discharge in these patients. We retrospectively reviewed electronic medical records of all adult patients admitted to non-cardiac ICUs ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2019, 48(3):394-399]

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Post-operative intensive care unit admission after elective non-cardiac surgery: A single-center analysis of the NSQIP database.

Melanio Bruceta, Luisa De Souza, Zyad J Carr, Anthony Bonavia, Allen R Kunselman, Kunal Karamchandani,

BACKGROUND:Admission to the intensive care unit (ICU) after surgery can be associated with significant morbidity and mortality. This observational cohort study aims to identify perioperative factors associated with post-operative ICU admission in patients undergoing elective non-cardiac surgery. METHODS:Data from the ACS NSQIP® database at a tertiary care academic medical center ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2020, 64(3):319-328]

Cited: 1 time

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CHA2DS2-VASc Score and In-Hospital Mortality in Critically Ill Patients With New-Onset Atrial Fibrillation.

Kunal Karamchandani, Robert S Schoaps, Thomas Abendroth, Zyad J Carr, Tonya S King, Anthony Bonavia,

<h4>Objective</h4>To examine the role of the CHA<sub>2</sub>DS<sub>2</sub>-VASc (Congestive heart failure; Hypertension; Age ≥75 years [doubled]; Diabetes; previous Stroke, transient ischemic attack, or thromboembolism [doubled]; Vascular disease; Age 65-75 years; and Sex category) score as a prognostic marker of in-hospital mortality in critically ill patients who develop new-onset atrial fibrillation (NOAF).<h4>Design</h4>Retrospective ... Read more >>

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2020, 34(5):1165-1171]

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Cardiovascular Collapse in a Patient With Parotid Abscess: Dangerous Cross Talk Between the Brain and Heart: A Case Report.

Kofi Owusu, Edward S Stredny, Gregory Williamson, Zyad J Carr, Kunal Karamchandani,

Postsurgical trigeminal neuralgia (TN), although rare, can lead to significant hemodynamic perturbations by triggering the trigeminocardiac reflex (TCR). The combination can lead to diagnostic as well as management challenges for clinicians. We present the case of a patient with a parotid abscess, which developed as a complication of his otolaryngologic ... Read more >>

A A Pract (A&A practice)
[2019, 13(7):281-283]

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In a Model of Neuroinflammation Designed to Mimic Delirium, Quetiapine Reduces Cortisol Secretion and Preserves Reversal Learning in the Attentional Set Shifting Task.

Zyad J Carr, Lauren Miller, Victor Ruiz-Velasco, Allen R Kunselman, Kunal Karamchandani,

Quetiapine, an atypical antipsychotic medication has lacked pre-clinical validation for its purported benefits in the treatment of delirium. This laboratory investigation examined the effects of quetiapine on the attentional set shifting task (ASST), a measure of cognitive flexibility and executive functioning, in a rodent model of lipopolysaccharide (LPS) mediated neuroinflammation. ... Read more >>

J Neuroimmune Pharmacol (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology)
[2019, 14(3):383-390]

Cited: 1 time

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Pain management in trauma patients affected by the opioid epidemic: A narrative review.

Kunal Karamchandani, John C Klick, Melissa Linskey Dougherty, Anthony Bonavia, Steven R Allen, Zyad J Carr,

Acute and chronic pain in trauma patients remains a challenging entity, particularly in the setting of the escalating opioid epidemic. It has been reported that chronic opioid use increases the likelihood of hospital admissions as a result of traumatic injuries. Furthermore, patients admitted with traumatic injuries have a greater than ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2019, 87(2):430-439]

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Continuation of atypical antipsychotic medications in critically ill patients discharged from the hospital: a single-center retrospective analysis.

Kunal Karamchandani, Robert S Schoaps, Anthony Bonavia, Amit Prasad, Ashley Quintili, Erik B Lehman, Zyad J Carr,

<h4>Background</h4>Atypical antipsychotics (AAP) have been associated with reduced duration of delirium in the intensive care setting. However, long-term use of these drugs is associated with significant adverse events, including increased all-cause mortality in the elderly. Inappropriate continuation of AAPs after discharge from the intensive care unit (ICU) is worrisome and ... Read more >>

Ther Adv Drug Saf (Therapeutic advances in drug safety)
[2019, 10:2042098618809933]

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Gender differences in the use of atypical antipsychotic medications for ICU delirium.

Kunal Karamchandani, Robert S Schoaps, Jillian Printz, Jeffrey M Kowaleski, Zyad J Carr,

Crit Care (Critical care (London, England))
[2018, 22(1):220]

Cited: 0 times

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A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea.

Zyad J Carr, Brian Vells, Brendan R Wood, Joshua D Lowery, Ann M Rogers, Allen A Kunselman, Kunal Karamchandani, Sonia J Vaida,

<h4>Background</h4>We theorized that modafinil, an atypical psychomotor stimulant, utilized to improve daytime somnolence in patients with obstructive sleep apnea, would improve functional recovery after general anesthesia by improving time to extubation, post-anesthesia care unit (PACU) length of stay and subjective recovery after general anesthesia.<h4>Methods</h4>A double blind, randomized, placebo-controlled pilot study ... Read more >>

Medicine (Madr) (Medicine)
[2018, 97(39):e12585]

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Critical Care Pain Management in Patients Affected by the Opioid Epidemic: A Review.

Kunal Karamchandani, Zyad J Carr, Anthony Bonavia, Avery Tung,

The rapid rise in the opioid epidemic has had a deleterious impact across the United States. This increase has drawn the attention of the critical care community not only because of the surge in acute opioid overdose-related admissions, but also due to the increase in the number of opioid-dependent and ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2018, 15(9):1016-1023]

Cited: 0 times

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Does Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature.

Zyad J Carr, Theodore J Cios, Kenneth F Potter, John T Swick,

<h4>Purpose of review</h4>Postoperative cognitive dysfunction (POCD) occurs in 20-50% of postsurgical patients with a higher prevalence in elderly patients and patients with vascular disease and heart failure. In addition, POCD has been associated with many negative outcomes, such as increased hospital length of stay, increased rates of institutionalization, and higher ... Read more >>

Curr Neurol Neurosci Rep (Current neurology and neuroscience reports)
[2018, 18(10):64]

Cited: 8 times

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Organ Dysfunction After Surgery in Patients Treated With Individualized or Standard Blood Pressure Management.

Kunal Karamchandani, Zyad J Carr, Anthony Bonavia,

JAMA (JAMA)
[2018, 319(7):719]

Cited: 0 times

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Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis.

Zyad J Carr, Andry Van De Louw, Graham Fehr, Jialiu D Li, Allen Kunselman, Victor Ruiz-Velasco,

Sepsis is a condition associated with a dysregulated inflammatory response to infection with significant morbidity. Recent advances have elucidated the vital role that the short chain fatty acid glycoprotein receptor 43 (FFA2/GPR43) plays in inflammatory and immunomodulatory pathways. We hypothesized that elevated whole blood GPR43 RNA expression would be associated ... Read more >>

BMC Res Notes (BMC research notes)
[2018, 11(1):41]

Cited: 2 times

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Does every code need a "reader?" improvement of rare event management with a cognitive aid "reader" during a simulated emergency: a pilot study.

Amanda R Burden, Zyad J Carr, Gregory W Staman, Jeffrey J Littman, Marc C Torjman,

<h4>Introduction</h4>Prompt treatment is necessary to assure patient survival during crisis. Obstetric cardiac arrest (OCA) and malignant hyperthermia (MH) are rarely occurring crises. Cognitive aids (CAs) consolidate management and assist treatment decisions. We investigated a novel method to encourage resident physician CA use during simulated crises.<h4>Methods</h4>Resident physicians were examined during 31 ... Read more >>

Simul Healthc (Simulation in healthcare : journal of the Society for Simulation in Healthcare)
[2012, 7(1):1-9]

Cited: 46 times

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Spatial memory using active allothetic place avoidance in adult rats after isoflurane anesthesia: a potential model for postoperative cognitive dysfunction.

Zyad J Carr, Marc C Torjman, Kwasi Manu, George Dy, Michael E Goldberg,

<h4>Background</h4>We described a paradigm of active allothetic place avoidance (AAPA) as a measure of spatial memory in adult rats. We hypothesized that, pending successful AAPA training, treatment with isoflurane would trigger spatial memory deficits.<h4>Methods</h4>Fifteen of 20 adult rats were successfully trained and randomly allocated to control and isoflurane treatment groups. ... Read more >>

J Neurosurg Anesthesiol (Journal of neurosurgical anesthesiology)
[2011, 23(2):138-145]

Cited: 15 times

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Ball valve effect precipitating an anesthesia circuit obstruction by an intravenous set cap within the elbow connector.

Zyad J Carr, Edward R Deal, Michael E Goldberg,

J Clin Anesth (Journal of clinical anesthesia)
[2010, 22(6):486-487]

Cited: 1 time

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