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Author Zoi Dorothea Pana

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul T Heath, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

BACKGROUND:The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, recruited in single centres or countries, evaluated antibiotics not in clinical use anymore ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229380]

Cited: 0 times

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Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study.

Adilia Warris, Zoi-Dorothea Pana, Andrea Oletto, Rebecca Lundin, Elio Castagnola, Thomas Lehrnbecher, Andreas H Groll, Emmanuel Roilides, Cecilie T Andersen, Maiken C Arendrup, Valentina Arsic Arsenijevic, Sonia Bianchini, Ulrich von Both, Martin Chmelnik, Tiziana Controzzi, Marieke Emonts, Susanna Esposito, Laura Ferreras-Antolin, Stefanie Henriet, Elias Iosifidis, Adam Irwin, John Kopsidas, Katrien Lagrou, Hermione Lyall, Angela Manzanares Casteleiro, Alessio Mesini, Peter Olbrich, Stephane Paulus, Karen Rokkedal Lausch, Pere Soler-Palacin, Nikos Spyridis, Volker Strenger, Martha Theodoraki, Tom Wolfs, , ,

BACKGROUND:Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia. MATERIAL AND METHODS:All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered. Patients' demographic and ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(2):114-120]

Cited: 0 times

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Efficacy and Safety of Echinocandins for the Treatment of Invasive Candidiasis in Children: A Meta-analysis.

Magdalini Tsekoura, Maria Ioannidou, Zoi-Dorothea Pana, Anna-Bettina Haidich, Charalampos Antachopoulos, Elias Iosifidis, George Kolios, Emmanuel Roilides,

BACKGROUND:Echinocandins are recommended for the treatment of suspected or confirmed invasive candidiasis (IC) in adults. Less is known about the use of echinocandins for the management of IC in children. The aim of this study was to investigate the overall efficacy and safety of echinocandin class in neonatal and pediatric ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(1):42-49]

Cited: 1 time

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Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): a randomised controlled trial

Irja Lutsar, Corine Chazallon, Ursula Trafojer, Vincent Meiffredy de Cabre, Cinzia Auriti, Chiara Bertaina, Francesca Ippolita Calo Carducci, Fuat Emre Canpolat, Susanna Esposito, Isabelle Fournier, Maarja Hallik, Paul Heath Frcpch, Mari-Liis Ilmoja, Elias Iosifidis, Jelena Kuznetsova, Laurence Meyer, Tuuli Metsvaht, George Mitsiakos, Zoi Dorothea Pana, Fabio Mosca, Lorenza Pugni, Emmanuel Roilides, Paolo Rossi, Kosmas Sarafidis, Laura Sanchez, Michael Sharland, Vytautas Usonis, Adilia Warris, Jean-Pierre Aboulker, Carlo Giaquinto, ,

Abstract Background The early use of broad-spectrum antibiotics remains the cornerstone for the treatment of neonatal late onset sepsis (LOS). However, which antibiotics should be used is still debatable, as relevant studies were conducted more than 20 years ago, were single centre or country, insufficiently powered, evaluated antibiotics not in ... Read more >>

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Invasive Candidiasis in Pediatric Intensive Care Unit: More Challenges.

Zoi Dorothea Pana, Dimitrios Kotzadamis, Emmanuel Roilides,

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2018, 37(12):1309-1311]

Cited: 1 time

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Treatment of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLs) infections: what have we learned until now?

Zoi Dorothea Pana, Theoklis Zaoutis,

The spread of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-PE) has dramatically increased worldwide, and this "evolving crisis" is currently regarded as one of the most important public health threats. The growing problem of ESBL-PE antimicrobial resistance seems to have a dual face between "Scylla and Charybdis": on one hand the potential ... Read more >>

F1000Res (F1000Research)
[2018, 7:]

Cited: 1 time

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Toxoplasmosis in Transplant Recipients, Europe, 2010-2014.

Florence Robert-Gangneux, Valeria Meroni, Damien Dupont, Françoise Botterel, José M Aguado Garcia, Marie-Pierre Brenier-Pinchart, Isabelle Accoceberry, Hamdi Akan, Isabella Abbate, Katia Boggian, Fabrizio Bruschi, Jordi Carratalà, Miruna David, Lubos Drgona, Olgica Djurković-Djaković, Maria Carmen Farinas, Francesca Genco, Effrossyni Gkrania-Klotsas, Andreas H Groll, Edward Guy, Cédric Hirzel, Nina Khanna, Özgür Kurt, Lia Monica Junie, Tiziana Lazzarotto, Oscar Len, Nicolas J Mueller, Patricia Munoz, Zoi Dorothea Pana, Emmanuel Roilides, Tijana Stajner, Christian van Delden, Isabelle Villena, Hervé Pelloux, Oriol Manuel,

Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2018, 24(8):1497-1504]

Cited: 5 times

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Treatment of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLs) infections: what have we learned until now?

Zoi Dorothea Pana, Theoklis Zaoutis,

The spread of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-PE) has dramatically increased worldwide, and this “evolving crisis” is currently regarded as one of the most important public health threats. The growing problem of ESBL-PE antimicrobial resistance seems to have a dual face between “Scylla and Charybdis”: on one hand the potential ... Read more >>

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Voriconazole Antifungal Prophylaxis in Children With Malignancies: A Nationwide Study.

Zoi Dorothea Pana, Maria Kourti, Katerina Vikelouda, Antonia Vlahou, Nikolaos Katzilakis, Maria Papageorgiou, Dimitrios Doganis, Loizos Petrikkos, Anna Paisiou, Dimitrios Koliouskas, Antonios Kattamis, Eftichia Stiakaki, Maria Chatzistilianou, Helen Vasilatou-Kosmidis, Sophia Polychronopoulou, Stelios Grafakos, Emmanuel Roilides,

BACKGROUND:Antifungal prophylaxis (AFP) is recommended in at-risk hematology-oncology patients. We evaluated the safety of AFP with voriconazole (VRC) in pediatric hematology/oncology patients. MATERIALS AND METHODS:A retrospective study of VRC AFP in children with malignancies hospitalized in all 7 Greek pediatric hematology/oncology centers during 2008 to 2012 was conducted. Patients' demographics, ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2018, 40(1):22-26]

Cited: 3 times

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Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children.

Jill King, Zoi-Dorothea Pana, Thomas Lehrnbecher, William J Steinbach, Adilia Warris,

Invasive fungal diseases (IFDs) are devastating opportunistic infections that result in significant morbidity and death in a broad range of pediatric patients, particularly those with a compromised immune system. Recognizing them can be difficult, because nonspecific clinical signs and symptoms or isolated fever are frequently the only presenting features. Therefore, ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2017, 6(suppl_1):S12-S21]

Cited: 1 time

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Performance of QuantiFERON®-TB Gold In-Tube assay in children receiving disease modifying anti-rheumatic drugs.

Francesca Gabriele, Maria Trachana, Maria Simitsopoulou, Polixeni Pratsidou-Gertsi, Elias Iosifidis, Zoi Dorothea Pana, Emmanuel Roilides,

To evaluate the performance of the Quantiferon®-TB Gold In-Tube (QFT-IT) interferon (IFN)-γ assay for the detection of latent tuberculosis infection (LTBI) in children receiving anti-rheumatic treatment in a tertiary referral hospital of Northern Greece.A total of 79 consecutive children receiving anti-rheumatic treatment [of which 18 screened prior to antitumor necrosis ... Read more >>

World J Pediatr (World journal of pediatrics : WJP)
[2017, 13(5):472-478]

Cited: 1 time

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Epidemiology of Invasive Fungal Disease in Children.

Zoi Dorothea Pana, Emmanuel Roilides, Adilia Warris, Andreas H Groll, Theoklis Zaoutis,

Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the growing number of ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2017, 6(suppl_1):S3-S11]

Cited: 11 times

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Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries.

Zoi Dorothea Pana, Danila Seidel, Anna Skiada, Andreas H Groll, Georgios Petrikkos, Oliver A Cornely, Emmanuel Roilides, ,

Mucormycosis has emerged as a rare but frequently fatal invasive fungal disease. Current knowledge on paediatric mucormycosis is based on case reports and small series reported over several decades. Contemporary data on a large cohort of patients is lacking.Two large international registries (Zygomyco.net and FungiScope™) were searched for mucormycosis cases ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2016, 16(1):667]

Cited: 28 times

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A 13-Year-Old Child with Lupus-Like Nephritis and 22q11 Microduplication Syndrome.

Zoi Dorothea Pana, Maria Stamou, Ioannis Kalevrosoglou, Ioannis Kyriakidis, Maria Hatzistilianou,

J. Clin. Immunol. (Journal of clinical immunology)
[2017, 37(1):25-26]

Cited: 0 times

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Diagnosis of invasive fungal diseases in pediatric patients.

Zoi-Dorothea Pana, Katerina Vikelouda, Emmanuel Roilides,

The optimal management of invasive fungal infections (IFIs) in children requires prompt and precise diagnosis that enables timely implementation of appropriate antifungal therapy and decreased use of unnecessary toxic antifungals. Areas covered: Traditional approaches such as culture, microscopy and histopathology remain the gold standard but are often not sufficiently sensitive ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2016, 14(12):1203-1213]

Cited: 3 times

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Therapeutic strategies for invasive fungal infections in neonatal and pediatric patients: an update.

Zoi-Dorothea Pana, Victoria Kougia, Emmanuel Roilides,

INTRODUCTION: Invasive fungal infections (IFIs) in neonatal and pediatric patients are still associated with high morbidity and mortality, increased length of hospital stay and high healthcare cost. Two key components are prerequisite to combat pediatric IFIs; first, definition of the 'at-risk' populations that could benefit the most from prophylactic treatment ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2015, 16(5):693-710]

Cited: 6 times

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Exserohilum infections: review of 48 cases before the 2012 United States outbreak.

Aspasia Katragkou, Zoi-Dorothea Pana, David S Perlin, Dimitrios P Kontoyiannis, Thomas J Walsh, Emmanuel Roilides,

Exserohilum species are soilborne fungi that have been uncommon causes of human disease. The ongoing outbreak in the United States warrants improved understanding of this pathogen. We systematically reviewed all cases of Exserohilum spp. infections published before the outbreak in 2012 in order to provide a better understanding of the ... Read more >>

Med. Mycol. (Medical mycology)
[2014, 52(4):376-386]

Cited: 14 times

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Application of diagnostic markers to invasive aspergillosis in children.

Emmanuel Roilides, Zoi-Dorothea Pana,

Early mycological detection of Aspergillus species is the cornerstone for a prompt diagnosis, appropriate treatment strategies, and improved survival of patients with invasive aspergillosis (IA), irrespective of age. However, the currently available laboratory tests for the diagnosis of IA include culture with direct microscopy, histology, and antigenic markers, such as ... Read more >>

Ann. N. Y. Acad. Sci. (Annals of the New York Academy of Sciences)
[2012, 1272:1-8]

Cited: 7 times

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