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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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3' untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein.

Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li,

<h4>Aims</h4>3' untranslated region (3' UTR) of mRNA is more conserved than other non-coding sequences in vertebrate genomes, and its sequence space has substantially expanded during the evolution of higher organisms, which substantiates their significance in biological regulation. However, the independent role of 3' UTR in cardiovascular disease was largely unknown.<h4>Methods ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(36):3786-3799]

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

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Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation.

Yinlong Zhao, Shukuan Ling, Guohui Zhong, Yuheng Li, Jianwei Li, Ruikai Du, Xiaoyan Jin, Dingsheng Zhao, Zizhong Liu, Guanghan Kan, Yan-Zhong Chang, Yingxian Li,

Different kinds of mechanical stimuli acting on the heart lead to different myocardial phenotypes. Physiological stress, such as exercise, leads to adaptive cardiac hypertrophy, which is characterized by a normal cardiac structure and improved cardiac function. Pathological stress, such as sustained cardiac pressure overload, causes maladaptive cardiac remodeling and, eventually, ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:678863]

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A case of micro-melanoma and its dermoscopic features.

Yuanbo Huang, Jun Yang, Mingye Bi, Zizhong Liu,

Indian J Dermatol Venereol Leprol (Indian journal of dermatology, venereology and leprology)
[2021, 87(1):71-75]

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The coupling of reduced type H vessels with unloading-induced bone loss and the protection role of Panax quinquefolium saponin in the male mice.

Shuai Liang, Shukuan Ling, Ruikai Du, Yuheng Li, Caizhi Liu, Junhe Shi, Jie Gao, Weijia Sun, Jianwei Li, Guohui Zhong, Zizhong Liu, Dingsheng Zhao, Huiyuan Sun, Yang Li, Xinxin Yuan, Hua Qu, Xiaoyan Jin, Dong Li, Dazhuo Shi, Yingxian Li,

Unloading-induced bone loss is a critical complication characterized by the imbalance of bone formation and resorption induced by long-term confinement in bed or spaceflight. CD31<sup>hi</sup>Emcn<sup>hi</sup> (type H) vessel is a specific subtype of capillary, which was coupled with osteogenesis. However, the change of type H vessel and its contributions to ... Read more >>

Bone (Bone)
[2021, 143:115712]

Cited: 1 time

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Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Jianwei Li, Yang Li, Hua Qu, Ruikai Du, Ying Zhang, Feng Xu, Yuheng Li, Caizhi Liu, Guohui Zhong, Shuai Liang, Zizhong Liu, Xingcheng Gao, Xiaoyan Jin, Yingxian Li, Dazhuo Shi,

Previous studies have shown an attenuating effect of ginsenoside Re on myocardial injury induced by hypoxia/reoxygenation (H/R). However, the underlying mechanism remains unclear. This study was designed to determine the underlying mechanism by which ginsenoside Re protects from myocardial injury induced by H/R. HL-1 cells derived from AT-1 mouse atrial ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:532041]

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Altered Yersinia pestis virulence is associated with the small regulatory RNA HmsA encoded on the plasmid pPCP1.

Xiaofang Gao, Min Wang, Zizhong Liu, Yujing Bi, Yajun Song, Ruifu Yang, Yanping Han,

<b>Aim:</b> The aim of this study was to access the effect of HmsA, a 65-nt small regulatory RNA encoded by the pPCP1 plasmid, on <i>Yersinia pestis</i> virulence. <b>Materials & methods:</b> Survival and the competition index were determined in mice infected with wild-type <i>Y. pestis</i> and an <i>hmsA</i> deletion mutant. RNA-seq was used to ... Read more >>

Future Microbiol (Future microbiology)
[2020, 15:1207-1215]

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How to Stabilize a Heptagon-Containing C80 Cage by Endohedral Derivation.

Ruisheng Zhao, Zizhong Liu, Xiang Zhao,

Nonclassical fullerene is a new member of the fullerene family. In the present work, a systematic investigation on [email protected] (x = 0-3) covering both classical and nonclassical C80 cages was performed utilizing density functional theory combined with statistical mechanics. At absolute zero, [email protected](6)-Cs(2)-C80 with a heptagon-containing nonclassical carbon is the ... Read more >>

Inorg Chem (Inorganic chemistry)
[2020, 59(12):8099-8107]

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miR-214 stimulated by IL-17A regulates bone loss in patients with ankylosing spondylitis.

Zizhong Liu, Feng Huang, Gui Luo, Yiwen Wang, Ruikai Du, Weijia Sun, Jianwei Li, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Shukuan Ling, Deqing Wang, Yingxian Li,

<h4>Objective</h4>Bone loss is common in AS, and miR-214 plays an important role in regulating bone formation. The aim of this study was to investigate the effect of miR-214, the production of which is stimulated by IL-17A, on bone loss in AS.<h4>Methods</h4>Peripheral blood was obtained from 32 patients with AS and ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(5):1159-1169]

Cited: 3 times

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Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity.

Caizhi Liu, Guohui Zhong, Yuezhang Zhou, Yuchen Yang, Yingjun Tan, Yuheng Li, Xingcheng Gao, Weijia Sun, Jianwei Li, Xiaoyan Jin, Dengchao Cao, Xinxin Yuan, Zizhong Liu, Shuai Liang, Youyou Li, Ruikai Du, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Jinping Song, Shukuan Ling, Yingxian Li,

<h4>Objectives</h4>Cardiac Ca<sup>2+</sup> signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca<sup>2+</sup> signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and ... Read more >>

Cell Prolif (Cell proliferation)
[2020, 53(3):e12783]

Cited: 3 times

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Effects of spaceflight on the composition and function of the human gut microbiota.

Zizhong Liu, Gui Luo, Ruikai Du, Weijia Sun, Jianwei Li, Haiyun Lan, Pu Chen, Xinxin Yuan, Dengchao Cao, Yuheng Li, Caizhi Liu, Shuai Liang, Xiaoyan Jin, Ruifu Yang, Yujing Bi, Yanping Han, Ping Cao, Wei Zhao, Shukuan Ling, Yingxian Li,

Interaction between humans and the gut microbiota is important for human physiology. Here, the gut microbiota was analyzed via metagenomic sequencing, and the fluctuations in the gut microbiota under the conditions of spaceflight were characterized. The composition and function of the gut microbiota were substantially affected by spaceflight; however, individual ... Read more >>

Gut Microbes (Gut microbes)
[2020, 11(4):807-819]

Cited: 5 times

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A multi-responsive crown ether-based colorimetric/fluorescent chemosensor for highly selective detection of Al3+, Cu2+ and Mg2.

Qiang Zhang, Ruifang Ma, Zhuying Li, Zizhong Liu,

A novel multi-response chemosensor L based on coumarin-chalcone-crown ether was designed and synthesized, which exhibited a high selectivity for the colorimetric detecting Al3+ and Cu2+ and fluorescent recognizing Al3+ and Mg2+ in ethanol. L can monitor Al3+ and Cu2+ via distinct color changes from a slight yellow to pink and ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2020, 228:117857]

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Hfq Globally Binds and Destabilizes sRNAs and mRNAs in Yersinia pestis.

Yanping Han, Dong Chen, Yanfeng Yan, Xiaofang Gao, Zizhong Liu, Yaqiang Xue, Yi Zhang, Ruifu Yang,

Hfq is a ubiquitous Sm-like RNA-binding protein in bacteria involved in physiological fitness and pathogenesis, while its <i>in vivo</i> binding nature remains elusive. Here we reported genome-wide Hfq-bound RNAs in <i>Yersinia pestis</i>, a causative agent of plague, by using cross-linking immunoprecipitation coupled with deep sequencing (CLIP-seq) approach. We show that ... Read more >>

mSystems (mSystems)
[2019, 4(4):]

Cited: 2 times

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The mechanosensitive Piezo1 channel is required for bone formation.

Weijia Sun, Shaopeng Chi, Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao, Yingxian Li,

Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is critical for various biological processes, plays ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 36 times

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TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.

Jianwei Li, Caizhi Liu, Yuheng Li, Qiaoxia Zheng, Youjia Xu, Beibei Liu, Weijia Sun, Yuan Li, Shuhui Ji, Mingwei Liu, Jing Zhang, Dingsheng Zhao, Ruikai Du, Zizhong Liu, Guohui Zhong, Cuiwei Sun, Yanqing Wang, Jinping Song, Shu Zhang, Jun Qin, Shukuan Ling, Xianhua Wang, Yingxian Li,

Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca<sup>2+</sup> leak channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with dysmorphism, mental retardation, glaucoma and the occurrence of cancer. Here we show an essential role of TMCO1 in osteogenesis mediated by local Ca<sup>2+</sup>/CaMKII signaling in osteoblasts. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1589]

Cited: 7 times

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Hfq Globally Binds and Destabilizes the bound sRNAs and mRNAs in Yersinia pestis

Yanping Han, Dong Chen, Yanfeng Yan, Hongduo Wang, Zizhong Liu, Yaqiang Xue, Ruifu Yang, Yi Zhang,

<h4>ABSTRACT</h4> Hfq is a ubiquitous Sm-like RNA binding protein in bacteria involved in physiological fitness and pathogenesis, while its in vivo binding natures still remain elusive. Here we reported the first study of the Hfq-bound RNAs map in Yersinia pestis , the causative agent of a kind of plague, by ... Read more >>

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A novel crown ether-acylhydrazone turn-on fluorescent chemosensor for Al3+ ion.

Qing Zhang, Qiyue Jiao, Qiang Zhang, Zizhong Liu,

A novel fluorescent chemosensor based on crown ether-acylhydrazone (L) was synthesized and characterized. The sensor L exhibited high selectivity and sensitive recognition towards Al<sup>3+</sup> through a significant "turn-on" fluorescence response at 444 nm in methanol solution. While, other competitive ions had no such significant effects on the fluorescence emission. The associated ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2019, 211:1-8]

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Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Yang Li, Guohui Zhong, Ming Guo, Yuheng Li, Lin Yang, Jianpeng Du, Yuezhang Zhou, Jianwei Li, Shuai Liang, Yanqing Wang, Xingcheng Gao, Yating Zhang, Dengchao Cao, Caizhi Liu, Xiaoyan Jin, Zizhong Liu, Weijia Sun, Xiaorui Wu, Jinping Song, Yingxian Li, Dazhuo Shi,

<h4>Background</h4>Cardiac atrophy and reduced cardiac distensibility have been reported following space flight. Cardiac function is correspondingly regulated in response to changes in loading conditions. Panax quinquefolium saponin (PQS) improves ventricular remodeling after acute myocardial infarction by alleviating endoplasmic reticulum stress and Ca<sup>2+</sup>overload. However, whether PQS can ameliorate cardiac atrophy following ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2019, 56:83-93]

Cited: 2 times

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Myocardial CKIP-1 Overexpression Protects from Simulated Microgravity-Induced Cardiac Remodeling.

Shukuan Ling, Yuheng Li, Guohui Zhong, Yongjun Zheng, Qing Xu, Dingsheng Zhao, Weijia Sun, Xiaoyan Jin, Hongxing Li, Jianwei Li, Huiyuan Sun, Dengchao Cao, Jinping Song, Caizhi Liu, Xinxin Yuan, Xiaorui Wu, Yinlong Zhao, Zizhong Liu, Qi Li, Yingxian Li,

Human cardiovascular system has adapted to Earth's gravity of 1G. The microgravity during space flight can induce cardiac remodeling and decline of cardiac function. At present, the mechanism of cardiac remodeling induced by microgravity remains to be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an important inhibitor of pressure-overload induced ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:40]

Cited: 5 times

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Photodynamic inactivation of fibroblasts and inhibition of Staphylococcus epidermidis adhesion and biofilm formation by toluidine blue O.

Xin Li, Zizhong Liu, Houfang Liu, Xi Chen, Yue Liu, Honglue Tan,

Treating skin and soft tissue infections of severe limb traumas can be challenging. Crucial concerns focus on inhibiting biofilm formation by antibiotic‑resistant bacteria, and preventing scar formation by fibroblastic hyperproliferation. The local use of toluidine blue O (TBO)‑mediated photodynamic therapy (PDT) may be a promising strategy for treating such lesions. ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2017, 15(4):1816-1822]

Cited: 5 times

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Plasmid pPCP1-derived sRNA HmsA promotes biofilm formation of Yersinia pestis.

Zizhong Liu, Xiaofang Gao, Hongduo Wang, Haihong Fang, Yanfeng Yan, Lei Liu, Rong Chen, Dongsheng Zhou, Ruifu Yang, Yanping Han,

<h4>Background</h4>The ability of Yersinia pestis to form a biofilm is an important characteristic in flea transmission of this pathogen. Y. pestis laterally acquired two plasmids (pPCP1and pMT1) and the ability to form biofilms when it evolved from Yersinia pseudotuberculosis. Small regulatory RNAs (sRNAs) are thought to play a crucial role ... Read more >>

BMC Microbiol (BMC microbiology)
[2016, 16(1):176]

Cited: 5 times

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Increased biofilm formation ability in Klebsiella pneumoniae after short-term exposure to a simulated microgravity environment.

Haili Wang, Yanfeng Yan, Dan Rong, Jing Wang, Hongduo Wang, Zizhong Liu, Jiaping Wang, Ruifu Yang, Yanping Han,

Biofilm formation is closely related to the pathogenetic processes of Klebsiella pneumoniae, which frequently causes infections in immunocompromised individuals. The immune system of astronauts is compromised in spaceflight. Accordingly, K. pneumoniae, which used to be isolated from orbiting spacecraft and astronauts, poses potential threats to the health of astronauts and mission ... Read more >>

Microbiologyopen (MicrobiologyOpen)
[2016, 5(5):793-801]

Cited: 16 times

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Recombinant murine toxin from Yersinia pestis shows high toxicity and β-adrenergic blocking activity in mice.

Yanxiao Fan, Yazhou Zhou, Na Feng, Qiong Wang, Guang Tian, Xiaohong Wu, Zizhong Liu, Yujing Bi, Ruifu Yang, Xiaoyi Wang,

Yersinia pestis murine toxin (Ymt) encoded on pMT1 is a 61-kDa protein, a member of the phospholipase D superfamily, which is found in all the domains of life. It is considered to be an intracellular protein required for the survival of Y. pestis in the midgut of the flea, but ... Read more >>

Microbes Infect (Microbes and infection)
[2016, 18(5):329-335]

Cited: 1 time

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Intrinsic plasmids influence MicF-mediated translational repression of ompF in Yersinia pestis.

Zizhong Liu, Haili Wang, Hongduo Wang, Jing Wang, Yujing Bi, Xiaoyi Wang, Ruifu Yang, Yanping Han,

Yersinia pestis, which is the causative agent of plague, has acquired exceptional pathogenicity potential during its evolution from Y. pseudotuberculosis. Two laterally acquired plasmids, namely, pMT1 and pPCP1, are specific to Y. pestis and are critical for pathogenesis and flea transmission. Small regulatory RNAs (sRNAs) commonly function as regulators of ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2015, 6:862]

Cited: 5 times

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