Full Text Journal Articles by
Author Ziying Wang

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CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

Zeyu Su, Yujia Li, Hang Lv, Xiaoyang Cui, Min Liu, Ziying Wang, Yan Zhang, Junhui Zhen, Wei Tang, Xiaojie Wang, Fan Yi,

Podocyte injury is a major determinant of focal segmental glomerular sclerosis (FSGS) and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance for the treatment of FSGS. CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21711]

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Structural insights into two distinct nanobodies recognizing the same epitope of green fluorescent protein.

Peiyu Zhong, Ziying Wang, Shihao Cheng, Yiran Zhang, He Jiang, Rui Liu, Yu Ding,

Green fluorescent protein (GFP) and its derivatives are widely used in biomedical research, and the manipulation of GFP-tagged proteins by GFP-specific binders is highly desired. However, structural information on how these binders bind with GFP is still lacking. In this study, we determined the crystal structure of the nanobody Nb2 ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 565:57-63]

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Structural Insights into the Binding of Nanobodies Lam2 and Lam4 to the Red Fluorescent Protein mCherry

Ziying Wang, Long Li, Rongting Hu, Peiyu Zhong, Yiran Zhang, Shihao Cheng, Rui Liu, Yu Ding,

<h4>Background: </h4> Red fluorescent proteins (RFPs) are widely used in molecular biology research, especially in deep tissues and animal models, because of their superior autofluorescence, light scattering, and phototoxicity to GFP. Although RFP can be easily monitored in vivo , improved manipulation of RFP is still desired. Using suitable nanobodies ... Read more >>

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Recent Advances in Natural Functional Biopolymers and Their Applications of Electronic Skins and Flexible Strain Sensors.

Ziying Wang, Zongtao Ma, Jingyao Sun, Yuhua Yan, Miaomiao Bu, Yanming Huo, Yun-Fei Li, Ning Hu,

In order to replace nonrenewable resources and decrease electronic waste disposal, there is a rapidly rising demand for the utilization of reproducible and degradable biopolymers in flexible electronics. Natural biopolymers have many remarkable characteristics, including light weight, excellent mechanical properties, biocompatibility, non-toxicity, low cost, etc. Thanks to these superior merits, ... Read more >>

Polymers (Basel) (Polymers)
[2021, 13(5):]

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Metabolomics and molecular docking to compare of the efficacies of wild-simulated and transplanted Astragali Radix based on its compatibility with Angelicae Sinensis Radix against blood deficiency.

YueTao Liu, ZiYing Wang, XueMei Qin,

Astragali Radix (AR) has been widely used as bulk medicines in China. Currently, there are mainly two types in the market, wild-simulated AR (WAR) and transplanted AR (TAR). The present work was designed to compare their effects in treatment of blood deficiency with its compatibility with Angelicae Sinensis Radix, a ... Read more >>

J Chromatogr B Analyt Technol Biomed Life Sci (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences)
[2021, 1173:122682]

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Recent advances in analytical techniques for the detection of adulteration and authenticity of bee products - A review.

Ziying Wang, Pingping Ren, Yongning Wu, Qinghua He,

Bee products have been considered as functional foods for a long time in China because of their wide range of biological activity. China has the largest number of bee colonies and the highest production of bee products in the world. Major bee products include honey, royal jelly, propolis and bee ... Read more >>

Food Addit Contam Part A Chem Anal Control Expo Risk Assess (Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment)
[2021, 38(4):533-549]

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Small Molecule-Based Prodrug Targeting Prostate Specific Membrane Antigen for the Treatment of Prostate Cancer.

Xinning Wang, Aditi Shirke, Ethan Walker, Rongcan Sun, Gopolakrishnan Ramamurthy, Jing Wang, Lingpeng Shan, Joey Mangadlao, Zhipeng Dong, Jing Li, Ziying Wang, Mark Schluchter, Dong Luo, Yu Wang, Shaun Stauffer, Susann Brady-Kalnay, Christopher Hoimes, Zhenghong Lee, James P Basilion,

Metastatic castration-resistant prostate cancer poses a serious clinical problem with poor outcomes and remains a deadly disease. New targeted treatment options are urgently needed. PSMA is highly expressed in prostate cancer and has been an attractive biomarker for the treatment of prostate cancer. In this study, we explored the feasibility ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(3):]

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Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.

Yi Fu, Yu Sun, Mei Wang, Yunfeng Hou, Wei Huang, Di Zhou, Ziying Wang, Shuting Yang, Wei Tang, Junhui Zhen, Yujia Li, Xiaojie Wang, Min Liu, Yan Zhang, Baobao Wang, Guangyi Liu, Xiao Yu, Jinpeng Sun, Chun Zhang, Fan Yi,

Lipid accumulation in podocytes is a major determinant of diabetic kidney disease (DKD) and identification of potential therapeutic targets by mediating podocyte lipid metabolism has clinical importance. This study was to elucidate the role of JAML (junctional adhesion molecule-like protein) in the pathogenesis of DKD. We first confirmed the expression ... Read more >>

Cell Metab (Cell metabolism)
[2020, 32(6):1052-1062.e8]

Cited: 3 times

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Personalized Body Constitution Inquiry Based on Machine Learning.

Baochao Fan, Yanghui Li, Guihua Wen, Yan Ren, Yantong Lu, Ziying Wang, Yuan Zhang, Changjun Wang,

<h4>Background</h4>Body constitution (BC) is the abstract concept indicating the state of a person's health in Traditional Chinese Medicine (TCM). The doctor identifies the body constitution of the patient through inspection and inquiry. Previous research simulates doctors to identify BC types according to a patient's objective physical indicators. However, the lack ... Read more >>

J Healthc Eng (Journal of healthcare engineering)
[2020, 2020:8834465]

Cited: 1 time

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Mining the potential of VRS1-5 gene to raise barley grain yield

Liping Shen, Yangyang Liu, Zhiwen Sun, Ziying Wang, Lili Zhang, Yu Cai, Yuannian Jiao, He Wu, Kuocheng Shen, Ping Yang, Zifeng Guo,

VRS1-5 genes determine spike row types during the early stages of spike development in barley ( Hordeum vulgare ), yet their functions for the determination of grain yield during the late stages of spike development are largely unknown. To assess the role of VRS1-5 genes in determining grain yield components, ... Read more >>

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Safety stressors, safety-specific trust, and safety citizenship behavior: A contingency perspective.

Dan Wang, Xueqing Wang, Mark A Griffin, Ziying Wang,

Employee safety citizenship behavior (SCB) is critical for workplace safety in a high-risk work environment, but few studies have addressed how safety stressors affect SCB. This study investigates the different relationships between safety stressors (safety role ambiguity, safety role conflict, and interpersonal safety conflict) and two forms of SCB (proactive ... Read more >>

Accid Anal Prev (Accident; analysis and prevention)
[2020, 142:105572]

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Ppd-1 Remodels Spike Architecture by Regulating Floral Development in wheat

Yangyang Liu, Lili Zhang, Michael Melzer, Liping Shen, Zhiwen Sun, Ziying Wang, Thorsten Schnurbusch, Zifeng Guo,

The determination of spike architecture is critical to grain yield in wheat ( Triticum aestivum ), yet the underlying mechanisms remain largely unknown. Here, we measured 51 traits associated with spike architecture and floral development in 197 wheat accessions with photoperiod sensitive and insensitive alleles. We included five distinct allele ... Read more >>

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A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro.

Ziying Wang, Chuanbin Yang, Jia Liu, Benjamin Chun-Kit Tong, Zhou Zhu, Sandeep Malampati, Sravan Gopalkrishnashetty Sreenivasmurthy, King-Ho Cheung, Ashok Iyaswamy, Chengfu Su, Jiahong Lu, Juxian Song, Min Li,

<b>A</b>bstract<b>:</b> TFEB (transcription factor EB), which is a master regulator of autophagy and lysosome biogenesis, is considered to be a new therapeutic target for Parkinson's disease (PD). However, only several small-molecule TFEB activators have been discovered and their neuroprotective effects in PD are unclear. In this study, a curcumin derivative, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

Cited: 3 times

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Jianpi Huayu Decoction Attenuates the Immunosuppressive Status of H22 Hepatocellular Carcinoma-Bearing Mice: By Targeting Myeloid-Derived Suppressor Cells.

Yingjie Xie, Yuan Zhang, Xiaohan Wei, Cheng Zhou, Yajing Huang, Xingwang Zhu, Yongxu Chen, Huihong Wen, Xuhui Huang, Juze Lin, Ziying Wang, Yan Ren, Baochao Fan, Xue Deng, Wei Tan, Changjun Wang,

Tumor-induced immunosuppressive microenvironment in which myeloid-derived suppressor cells (MDSCs) plays an important role, remains an obstacle for effective oncotherapy currently. Inducing MDSCs into maturation was confirmed as an effective method to reduce the tumor-bearing host's immunosuppression. Traditional Chinese medicines (TCM) possess characteristics of alleviating immunosuppression of cancer patients and low ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:16]

Cited: 1 time

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Targeting Aggrephagy for the Treatment of Alzheimer's Disease.

Sandeep Malampati, Ju-Xian Song, Benjamin Chun-Kit Tong, Anusha Nalluri, Chuan-Bin Yang, Ziying Wang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Jia Liu, Chengfu Su, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, King-Ho Cheung, Jia-Hong Lu, And Min Li,

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading ... Read more >>

Cells (Cells)
[2020, 9(2):]

Cited: 1 time

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Photodynamic Therapy Is an Effective Adjuvant Therapy for Image-Guided Surgery in Prostate Cancer.

Xinning Wang, Gopolakrishnan Ramamurthy, Aditi A Shirke, Ethan Walker, Joey Mangadlao, Ziying Wang, Yu Wang, Lingpeng Shan, Mark D Schluchter, Zhipeng Dong, Susann M Brady-Kalnay, Natalie K Walker, Madhusudhana Gargesha, Gregory MacLennan, Dong Luo, Rongcan Sun, Bryan Scott, Debashish Roy, Jing Li, James P Basilion,

Local and metastatic relapses of prostate cancer often occur following attempted curative resection of the primary tumor, and up to 66% of local recurrences are associated with positive margins. Therefore, technologies that can improve the visualization of tumor margins and adjuvant therapies to ablate remaining tumor tissues are needed during ... Read more >>

Cancer Res (Cancer research)
[2020, 80(2):156-162]

Cited: 4 times

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Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds.

Zhaoyang Li, Cen Wang, Ziying Wang, Chenggang Zhu, Jie Li, Tian Sha, Lixiang Ma, Chao Gao, Yi Yang, Yimin Sun, Jian Wang, Xiaoli Sun, Chenqi Lu, Marian Difiglia, Yanai Mei, Chen Ding, Shouqing Luo, Yongjun Dang, Yu Ding, Yiyan Fei, Boxun Lu,

Accumulation of mutant proteins is a major cause of many diseases (collectively called proteopathies), and lowering the level of these proteins can be useful for treatment of these diseases. We hypothesized that compounds that interact with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)<sup>1</sup> and the disease-causing ... Read more >>

Nature (Nature)
[2019, 575(7781):203-209]

Cited: 22 times

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Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions.

Di Zhou, Meng Zhou, Ziying Wang, Yi Fu, Meng Jia, Xiaojie Wang, Min Liu, Yan Zhang, Yu Sun, Yabin Zhou, Yi Lu, Wei Tang, Fan Yi,

Podocyte injury is considered a major contributor to the development of diabetic nephropathy (DN). Therefore, identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Recent studies have indicated that autophagy is a key homeostatic mechanism to maintaining podocyte integrity and function. This study was to elucidate the ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2019, 97(11):1507-1520]

Cited: 3 times

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PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy.

Di Zhou, Meng Zhou, Ziying Wang, Yi Fu, Meng Jia, Xiaojie Wang, Min Liu, Yan Zhang, Yu Sun, Yi Lu, Wei Tang, Fan Yi,

Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold considerable promise for the treatment of DN. In this study, we investigated the role of progranulin (PGRN), a secreted glycoprotein, in mediating mitochondrial homeostasis and its therapeutic potential in ... Read more >>

Cell Death Dis (Cell death & disease)
[2019, 10(7):524]

Cited: 18 times

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Construction of ZnO/SnO2 Heterostructure on Reduced Graphene Oxide for Enhanced Nitrogen Dioxide Sensitive Performances at Room Temperature.

Ziying Wang, Shang Gao, Teng Fei, Sen Liu, Tong Zhang,

The employment of n-n homotypic heterogeneous junctions is an efficient method to improve sensitive performance of metal oxide-based gas sensors owing to the generation of charge accumulation regions. Herein, in order to further enhance nitrogen dioxide (NO2) sensing properties of the sensors based on reduced graphene oxide (RGO) at room ... Read more >>

ACS Sens (ACS sensors)
[2019, 4(8):2048-2057]

Cited: 3 times

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Simultaneous detection of aflatoxin B1, ochratoxin A, zearalenone and deoxynivalenol in corn and wheat using surface plasmon resonance.

Tao Wei, Pingping Ren, Linli Huang, Zicheng Ouyang, Ziying Wang, Xiangfeng Kong, Tiejun Li, Yulong Yin, Yongning Wu, Qinghua He,

Mycotoxins are toxic metabolites produced by fungi or molds, which may cause serious harm to human health through polluted cereal foods. In order to measure the typical mycotoxin contaminations in wheat and corn, a surface plasmon resonance (SPR) method was established using SPR sensor chip that was fabricated based on ... Read more >>

Food Chem (Food chemistry)
[2019, 300:125176]

Cited: 9 times

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Structural insights into the mechanism of single domain VHH antibody binding to cortisol.

Lulu Ding, Ziying Wang, Peiyu Zhong, He Jiang, Zhixuan Zhao, Yiran Zhang, Zhen Ren, Yu Ding,

To date, few structural models of VHH antibody binding to low molecular weight haptens have been reported. Here, we report the crystal structure of cortisol binding to its VHH antibody NbCor at pH 3.5 and 10.5. Cortisol binds to NbCor mainly by burying itself under the tunnel formed by the ... Read more >>

FEBS Lett (FEBS letters)
[2019, 593(11):1248-1256]

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Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling.

Jian Guo, Ziying Wang, Jichao Wu, Min Liu, Mengmeng Li, Yu Sun, Wei Huang, Yujia Li, Yan Zhang, Wei Tang, Xiaoyan Li, Chun Zhang, Fanzhen Hong, Ningjun Li, Jing Nie, Fan Yi,

RATIONALE:Endothelial dysfunction is an important determinant risk factor for the development of hypertension and its complications. Thus, identification of potential therapeutic targets for preventing endothelial dysfunction has major clinical importance. Emerging evidence indicates that epigenetic modifications are closely associated with the regulation of endothelial function. Among them, HDAC (histone deacetylase)-mediated ... Read more >>

Circ Res (Circulation research)
[2019, 124(10):1448-1461]

Cited: 14 times

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Modulating Charge Density Wave Order in a 1T-TaS2/Black Phosphorus Heterostructure.

Ziying Wang, Leiqiang Chu, Linjun Li, Ming Yang, Junyong Wang, Goki Eda, Kian Ping Loh,

Controllability of collective electron states has been a long-sought scientific and technological goal and promises development of new devices. Herein, we investigate the tuning of charge density wave (CDW) in 1T-TaS2 via a two-dimensional (2D) van der Waals heterostructure of 1T-TaS2/BP. Unusual gate-dependent conductance oscillations were observed in 1T-TaS2 nanoflake ... Read more >>

Nano Lett (Nano letters)
[2019, 19(5):2840-2849]

Cited: 2 times

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Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease.

Zhou Zhu, Chuanbin Yang, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Jia Liu, Ziying Wang, Benjamin Chun-Kit Tong, Juxian Song, Jiahong Lu, King-Ho Cheung, Min Li,

The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the activity of the unc51-like kinase ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(3):]

Cited: 18 times

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