Full Text Journal Articles by
Author Ziying Lin

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Prediction of Epilepsy Based on Tensor Decomposition and Functional Brain Network.

Han Li, Qizhong Zhang, Ziying Lin, Farong Gao,

Epilepsy is a chronic neurological disorder which can affect 65 million patients worldwide. Recently, network based analyses have been of great help in the investigation of seizures. Now graph theory is commonly applied to analyze functional brain networks, but functional brain networks are dynamic. Methods based on graph theory find ... Read more >>

Brain Sci (Brain sciences)
[2021, 11(8):]

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A modified alternative fistula risk score (a-FRS) obtained from the computed tomography enhancement pattern of the pancreatic parenchyma predicts pancreatic fistula after pancreatoduodenectomy.

Bingjun Tang, Ziying Lin, Yongsu Ma, Aoran Zhang, Weikang Liu, Jixin Zhang, Xiaoying Wang, Xiaodong Tian, Yinmo Yang,

<h4>Background</h4>Alternative fistula risk score (a-FRS) is useful to predict clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatoduodenectomy (PD).<h4>Methods</h4>Clinical data from 239 patients undergoing PD were collected. The CT value of the pancreatic parenchyma was measured in the nonenhanced (N), arterial (A), portal venous (P), and late (L) phases. The A/N, ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2021, :]

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Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.

Jing Liao, Wenju Lu, Yuqin Chen, Xin Duan, Chenting Zhang, Xiaoyun Luo, Ziying Lin, Jiyuan Chen, Shiyun Liu, Han Yan, Yilin Chen, Huazhuo Feng, Dansha Zhou, Xu Chen, Zizhou Zhang, Qifeng Yang, Xinyi Liu, Haiyang Tang, Jing Li, Ayako Makino, Jason X-J Yuan, Nanshan Zhong, Kai Yang, Jian Wang,

[Figure: see text]. ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2021, 77(6):1974-1989]

Cited: 1 time

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PTEN Loss Correlates with T cell Exclusion across Human Cancers

Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou,

<h4>Background: </h4> Recent evidences had shown that loss in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was associated with immunotherapy resistance, which may be attributed to the non-T-cell-inflamed tumor microenvironment. The impact of PTEN loss on tumor microenvironment, especially regarding T cell infiltration across tumor types is not ... Read more >>

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Preoperative prediction of clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy.

Ziying Lin, Bingjun Tang, Jinxiu Cai, Xiangpeng Wang, Changxin Li, Xiaodong Tian, Yinmo Yang, Xiaoying Wang,

<h4>Objectives</h4>To develop a radiomics model and a combined model for preoperative prediction of clinically relevant postoperative pancreatic fistula (CR-POPF) in patients undergoing pancreaticoduodenectomy and to compare the predictive performance of the two models with the traditional Fistula Risk Score system.<h4>Methods</h4>A total of 250 patients who underwent pancreaticoduodenectomy (PD) with preoperative ... Read more >>

Eur J Radiol (European journal of radiology)
[2021, 139:109693]

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Age-specific risk factors of severe pneumonia among pediatric patients hospitalized with community-acquired pneumonia.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Qiuyu Tang, Yuan Dong, Meng Bai, Yibing Zhu, Guanghua Liu,

<h4>Background</h4>Risk factors that predispose the development of severe community-acquired pneumonia (CAP) among pediatric CAP patients of different age ranges are yet to be identified.<h4>Methods</h4>We retrospectively analyzed pediatric in-patients (< 6 years old) diagnosed with CAP in our hospital. We subdivided patients into four age groups (< 6 months, 6 months-1 year, 1-2 years, and 2-6 years). Their medical ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2021, 47(1):100]

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PTEN loss correlates with T cell exclusion across human cancers.

Ziying Lin, Lixia Huang, Shao Li Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou,

<h4>Background</h4>Recent evidences had shown that loss in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was associated with immunotherapy resistance, which may be attributed to the non-T-cell-inflamed tumor microenvironment. The impact of PTEN loss on tumor microenvironment, especially regarding T cell infiltration across tumor types is not well understood.<h4>Methods</h4>Utilizing ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):429]

Cited: 1 time

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Diuretic-induced hypokalaemia: an updated review.

Ziying Lin, Louisa Y F Wong, Bernard M Y Cheung,

Diuretic-induced hypokalaemia is a common and potentially life-threatening adverse drug reaction in clinical practice. Previous studies revealed a prevalence of 7%-56% of hypokalaemia in patients taking thiazide diuretics. The clinical manifestations of hypokalaemia due to diuretics are non-specific, varying from asymptomatic to fatal arrhythmia. Diagnosis of hypokalaemia is based on ... Read more >>

Postgrad Med J (Postgraduate medical journal)
[2021, :]

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Risk factors associated with wheezing in severe pediatric community-acquired pneumonia: a retrospective study.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Xi Liu, Libo Xu, Guanghua Liu,

<h4>Background</h4>Wheezing is a common clinical manifestation in children with pneumonia. However, the risk factors associated with the development of wheezing pneumonia and its clinical features are not fully characterized, especially in children with severe pneumonia.<h4>Methods</h4>We retrospectively recruited 1434 pediatric patients diagnosed with severe pneumonia between April 2012 and September 2019 ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2021, :]

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Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure.

Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou,

How the genomic landscape of a tumor shapes the formation of tertiary lymphoid structure (TLS) and how might TLS alter the clinical outcome or response to immunotherapy had not been systematically explored. Utilizing the genomic and transcriptome data of solid tumors on TCGA, we quantified TLS based on a previous ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21530]

Cited: 4 times

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8-Oxoguanine DNA glycosylase modulates the cell transformation process in pulmonary fibrosis by inhibiting Smad2/3 and interacting with Smad7.

Yahong Wang, Ting Chen, Zhanchun Pan, Ziying Lin, Lawei Yang, Baoan Zou, Weimin Yao, Dehui Feng, Changmei Huangfu, Chunyu Lin, Guiqing Wu, Huayu Ling, Gang Liu,

The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) is involved in early embryonic development, as well as in multiple conditions, including cardiac fibrosis, diabetes, and neurodegenerative diseases. But, function of OGG1 in pulmonary fibrosis was not entirely clear. In this study, we identified a novel function of OGG1 in the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(10):13461-13473]

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Structural and functional definition of the pulmonary vein system in a chronic hypoxia-induced pulmonary hypertension rat model.

Xiongting Wu, Wenju Lu, Mengzhang He, Haixia Chen, Yuqin Chen, Xin Duan, Qiuyu Zheng, Yi Li, Jiyuan Chen, Shiyun Liu, Jing Liao, Meidan Kuang, Ziying Lin, Kai Yang, Jian Wang,

Unlike the pulmonary artery (PA), the pathophysiological changes of the pulmonary vein (PV) in the development of pulmonary hypertension (PH) remain largely unknown. In this study, we comprehensively investigated the structural and functional changes in the PV isolated from the chronic hypoxia (CH; 10% O2, 21 days)-induced PH rat model ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2020, 318(3):C555-C569]

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Retrospective study on the efficacy of bisphosphonates in tyrosine kinase inhibitor-treated patients with non-small cell lung cancer exhibiting bone metastasis.

Xiaoxian Cui, Shaoli Li, Jincui Gu, Ziying Lin, Bipeng Lai, Lixia Huang, Jinlun Feng, Baomo Liu, Yanbin Zhou,

Bisphosphonates (Bps) inhibit the maturation of osteoclasts and suppress the adhesion of cancer cells to the bone matrix. They are recommended as the standard treatment for tumors exhibiting bone metastasis (BM). However, whether Bps can improve the prognosis of patients with tyrosine kinase inhibitor (TKI)-treated non-small cell lung cancer (NSCLC) ... Read more >>

Oncol Lett (Oncology letters)
[2019, 18(5):5437-5447]

Cited: 1 time

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lncINS-IGF2 Promotes Cell Proliferation and Migration by Promoting G1/S Transition in Lung Cancer.

Shenglan Gao, Ziying Lin, Chunyan Li, Yahong Wang, Lawei Yang, Bao'an Zou, Jie Chen, Jianwen Li, Dehui Feng, Zeqing Song, Gang Liu,

Long noncoding RNAs are capable of regulating gene expression at multiple levels. These RNA molecules are also involved in a variety of physiological and pathological processes. Emerging data demonstrate that a series of differentially expressed long noncoding RNAs are implicated in tumorigenesis. In the present study, we used microarray analysis ... Read more >>

Technol Cancer Res Treat (Technology in cancer research & treatment)
[2019, 18:1533033818823029]

Cited: 4 times

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Deciphering Microenvironment of NSCLC based on CD8+ TIL Density and PD-1/PD-L1 Expression.

Ziying Lin, Jincui Gu, Xiaoxian Cui, Lixia Huang, ShaoLi Li, Jinlun Feng, Baomo Liu, Yanbin Zhou,

<b>Purpose:</b> To determine whether distinct tissue immune microenvironments differentially impact on clinical outcome in non-small cell lung cancer (NSCLC), an extended analysis of PD-1/PD-L1 and Tumor Infiltrating Lymphocytes (TILs) was performed. <b>Materials and Methods:</b> 1016 NSCLC mRNA-sequence samples from The Genome Data Analysis Center (TCGA) and 275 NSCLC mRNA-microarray samples ... Read more >>

J Cancer (Journal of Cancer)
[2019, 10(1):211-222]

Cited: 8 times

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Tetraspanin 1 as a mediator of fibrosis inhibits EMT process and Smad2/3 and beta-catenin pathway in human pulmonary fibrosis.

Gang Liu, Yahong Wang, Lawei Yang, Baoan Zou, Shenglan Gao, Zeqing Song, Ziying Lin,

Tetraspanin 1(TSPAN1) as a clinically relevant gene target in cancer has been studied, but there is no direct in vivo or vitro evidence for pulmonary fibrosis (PF). Using reanalysing Gene Expression Omnibus data, here, we show for the first time that TSPAN1 was markedly down-regulated in lung tissue of patient ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2019, 23(5):3583-3596]

Cited: 9 times

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Tetraspanin 1 inhibits TNFα-induced apoptosis via NF-κB signaling pathway in alveolar epithelial cells.

Lawei Yang, Yahong Wang, Zhanchun Pan, Shenglan Gao, Bao'an Zou, Ziying Lin, Dehui Feng, Changmei HuangFu, Gang Liu,

<h4>Objective</h4>Tetraspanin family plays an important role in the pathogenesis of cancer, but its role in lung fibrosis is unknown. To determine whether tetraspanin 1 (TSPAN1), a member of the family, may be involved in the pathogenesis of pulmonary fibrosis.<h4>Methods</h4>TNFα -stimulated human alveolar epithelial (A549) and alveolar epithelial type II cell ... Read more >>

Inflamm Res (Inflammation research : official journal of the European Histamine Research Society ... [et al.])
[2018, 67(11-12):951-964]

Cited: 3 times

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MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.

Lawei Yang, Ziying Lin, Yahong Wang, Shenglan Gao, Qinglan Li, Chunyan Li, Wenya Xu, Jie Chen, Tie Liu, Zeqing Song, Gang Liu,

Cisplatin-based chemotherapy is the most commonly used treatment regimen for lung cancer. Cancer stem cells (CSCs) are postulated to be important promoters of drug resistance. We previously found that miR-5100 is overexpressed in lung cancer, but it is unknown whether and how miR-5100 regulates cisplatin resistance. Here, we demonstrated that ... Read more >>

Mol Carcinog (Molecular carcinogenesis)
[2018, 57(3):419-428]

Cited: 6 times

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TFPI2AS1, a novel lncRNA that inhibits cell proliferation and migration in lung cancer.

Shenglan Gao, Ziying Lin, Chunyan Li, Yahong Wang, Lawei Yang, Baoan Zou, Jie Chen, Jianwen Li, Zeqing Song, Gang Liu,

Accumulating evidence demonstrates that a series of differentially expressed lncRNAs is important in tumorigenesis. However, the function of many of the lncRNAs in lung cancer remains elusive. In the present study, we used microarray analysis to identify lncRNAs that are dysregulated in non-small-cell lung cancer (NSCLC) as compared with normal ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2017, 16(23):2249-2258]

Cited: 11 times

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β-8-Oxoguanine DNA Glycosylase Overexpression Reduces Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis Through the JNK Signaling Pathway in Human Bronchial Epithelial Cells.

Ziying Lin, Wenya Xu, Chunyan Li, Yahong Wang, Lawei Yang, Bao'an Zou, Shenglan Gao, Weimin Yao, Zeqing Song, Gang Liu,

8-Oxoguanine DNA glycosylase (OGG1) is responsible for repairing 8-oxo-7,8-dihydroguanine (8-oxoG). Our previous study demonstrated that α-OGG1 protects cells from oxidative damage-induced apoptosis and mitochondrial dysfunction in human lung cancer cells. However, the function of β-OGG1 remains to be elucidated. In this study, we demonstrated that overexpressed β-OGG1 has the same ... Read more >>

DNA Cell Biol (DNA and cell biology)
[2017, 36(12):1071-1080]

Cited: 1 time

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The c-Jun N-terminal kinase signaling pathway mediates chrysotile asbestos-induced alveolar epithelial cell apoptosis.

Peng Li, Tie Liu, David W Kamp, Ziying Lin, Yahong Wang, Donghong Li, Lawei Yang, Huijuan He, Gang Liu,

Exposure to chrysotile asbestos exposure is associated with an increased risk of mortality in combination with pulmonary diseases including lung cancer, mesothelioma and asbestosis. Multiple mechanisms by which chrysotile asbestos fibers induce pulmonary disease have been identified, however the role of apoptosis in human lung alveolar epithelial cells (AEC) has ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2015, 11(5):3626-3634]

Cited: 4 times

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miR-363-3p inhibits tumor growth by targeting PCNA in lung adenocarcinoma.

Yahong Wang, Ting Chen, Haili Huang, Yun Jiang, Lawei Yang, Ziying Lin, Huijuan He, Tie Liu, Bin Wu, Jie Chen, David W Kamp, Gang Liu,

Increasing evidence suggests that microRNAs play key roles in lung cancer. Our previous study demonstrated that microRNA 363-3p (miR-363-3p) is downregulated in lung cancer tissues. In this study, we demonstrated that overexpression of miR-363-3p inhibits the proliferation and colony formation of A549 and H441 cells, while silencing of miR-363-3p has ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(12):20133-20144]

Cited: 31 times

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Reduced apurinic/apyrimidinic endonuclease activity enhances the antitumor activity of oxymatrine in lung cancer cells.

Zhiqiang Wang, Wenya Xu, Ziying Lin, Chunyan Li, Yahong Wang, Lawei Yang, Gang Liu,

Lung cancer is the leading cause of cancer-related deaths worldwide and is associated with a very poor outcome. Oxymatrine exerts antitumor effects by inducing apoptosis and inhibiting the proliferation of different cancer cells; however, the anticancer effects and mechanism of action of oxymatrine have not been evaluated sufficiently in human ... Read more >>

Int J Oncol (International journal of oncology)
[2016, 49(6):2331-2340]

Cited: 3 times

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Abnormal miRNA-30e Expression is Associated with Breast Cancer Progression.

Ziying Lin, Jian-wen Li, Yahong Wang, Ting Chen, Nina Ren, Lawei Yang, Wenya Xu, Huijuan He, Yun Jiang, Xiaodong Chen, Tie Liu, Gang Liu,

<h4>Background</h4>microRNAs (miRNAs) are involved in the regulation of various cellular processes, such as differentiation, proliferation, metabolism, and apoptosis, and they have been implicated in several diseases, including cancers.<h4>Methods</h4>To assess the role of miRNA in the progression of breast cancer, we performed TaqMan-based miRNA profiling for plasma from patients with breast ... Read more >>

Clin Lab (Clinical laboratory)
[2016, 62(1-2):121-128]

Cited: 12 times

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miR-5100 promotes tumor growth in lung cancer by targeting Rab6.

Haili Huang, Yun Jiang, Yahong Wang, Ting Chen, Lawei Yang, Huijuan He, Ziying Lin, Tie Liu, Teng Yang, David W Kamp, Bin Wu, Gang Liu,

Our previous study demonstrated that microRNA 5100 (miR-5100) is overexpressed in lung cancer tissues; however, the function of miR-5100 remained elusive. In this study, we demonstrate that miR-5100 is highly expressed in a wide variety of lung cancer tissues and lung cancer cell lines. Exogenous expression of miR-5100 in A549 ... Read more >>

Cancer Lett (Cancer letters)
[2015, 362(1):15-24]

Cited: 28 times

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