Full Text Journal Articles by
Author Zichen Xu

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Habenula lesions improve glucose metabolism in rats with type 2 diabetes by increasing insulin sensitivity and inhibiting gluconeogenesis.

Peng Qu, Yachun Wang, Lei Liu, Mengmeng Qi, Yimeng Sun, Siyang Zheng, Zichen Xu, Changhong Liu, Xiaoyan Bai, Qinggao Zhang, Limin Yang,

INTRODUCTION:The habenular nucleus (Hb), a famous relay station in the midbrain, is vital for controlling many physiological functions of vertebrates. The role of Hb in the pathogenesis of depression has been thoroughly studied, but whether it functions in the pathogenesis of diabetes remains unknown. In this study, we found that ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

Cited: 0 times

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Platinum(IV) prodrugs multiply targeting genomic DNA, histone deacetylases and PARP-1.

Zichen Xu, Weiwei Hu, Zhimei Wang, Shaohua Gou,

Several Pt(IV) prodrugs containing SAA, a histone deacetylases inhibitor, were designed and prepared for multiply targeting genomic DNA, histone deacetylases and PARP-1. The resulting Pt(IV) prodrug had significantly strong antiproliferative activity against the tested cancer cell lines, especially SAA1, derived from the conjugation of cisplatin and SAA, had potent ability ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2017, 141:211-220]

Cited: 1 time

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Exploring the Hydrolytic Behavior of the Platinum(IV) Complexes with Axial Acetato Ligands.

Jian Zhao, Zichen Xu, Jing Lin, Shaohua Gou,

Platinum(IV) complexes are generally thought to be kinetically inert, and are expected to be stable enough to resist premature aquation before entering the cancer cells. Nevertheless, in this work, complex 2 with axial acetato ligands can hydrolyze relatively quickly under biologically relevant conditions with a half-life of 91.7 min, resulting ... Read more >>

Inorg Chem (Inorganic chemistry)
[2017, 56(16):9851-9859]

Cited: 2 times

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Novel hypoxia-targeting Pt(iv) prodrugs.

Zichen Xu, Jian Zhao, Shaohua Gou, Gang Xu,

Novel Pt(iv) prodrugs targeting hypoxia inducible factor HIF-1α were prepared for evaluating their antitumor activity on hypoxic cancer cells for the first time. The resulting Pt(iv) prodrug exhibited effective inhibition on tumor growth in the HCT-116 xenograft mouse model with low toxicity in vivo. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2017, 53(26):3749-3752]

Cited: 4 times

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Regulation of BMP2-induced intracellular calcium increases in osteoblasts.

Wenfeng Xu, Bo Liu, Xue Liu, Martin Y M Chiang, Bo Li, Zichen Xu, Xiaoling Liao,

Although bone morphogenetic protein-2 (BMP2) is a well-characterized regulator that stimulates osteoblast differentiation, little is known about how it regulates intracellular Ca2+ signaling. In this study, intracellular Ca2+ concentration ([Ca2+ ]i ) upon BMP2 application, focal adhesion kinase (FAK) and Src activities were measured in the MC3T3-E1 osteoblast cell line ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2016, 34(10):1725-1733]

Cited: 4 times

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