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Effect of Treatment With Sacubitril/Valsartan in Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.

Douglas L Mann, Michael M Givertz, Justin M Vader, Randall C Starling, Palak Shah, Steven E McNulty, Kevin J Anstrom, Kenneth B Margulies, Michael S Kiernan, Claudius Mahr, Divya Gupta, Margaret M Redfield, Anuradha Lala, Gregory D Lewis, Adam D DeVore, Patrice Desvigne-Nickens, Adrian F Hernandez, Eugene Braunwald, ,

<h4>Importance</h4>The use of sacubitril/valsartan is not endorsed by practice guidelines for use in patients with New York Heart Association class IV heart failure with a reduced ejection fraction because of limited clinical experience in this population.<h4>Objective</h4>To compare treatment with sacubitril/valsartan treatment with valsartan in patients with advanced heart failure and ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2022, 7(1):17-25]

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Parenchymal Mass Loss During Partial Nephrectomy: Role of Devascularized Parenchymal Mass and Excised Parenchymal Mass and Impact on Functional Preservation.

Qi Liu, Ming Gao, Tian X Lin, Bei Liao, Ya H Wang, Shao X Wu, Shi Z Xu, Jie X Pan, Zi X Xu, Jian Huang, Wen Dong,

This study included 93 patients with renal masses who underwent standard partial nephrectomy or tumor enucleation. After surgery, parenchymal mass loss caused by devascularization resulted in more damage to renal function than excised parenchymal mass loss. Surgeons should seek better techniques to decrease devascularization during reconstruction.<h4>Introduction</h4>To evaluate the importance of ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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[email protected] nanocomplex for ratiometric fluorescent detection of alkaline phosphatase activity.

Yu Ling, Lin Zhao He, Chu Chu Wan, Lei Han, Xiao Hu Wang, Zi Yi Xu, Xiao Lin Li, Nian Bing Li, Hong Qun Luo,

Luminescent metal-organic frameworks (LMOFs) and their functional materials with unique characteristics can provide the basis for the construction of new analytical techniques, which can meet the continuous demand for various fields. In this work, guanosine monophosphate (GMP), terbium ion (Tb<sup>3+</sup>) and zeolitic imidazolate framework-8 (ZIF-8) are self-assembled to form a ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2022, 264:120230]

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Predicting factors of central lymph node metastasis and BRAFV600E mutation in Chinese population with papillary thyroid carcinoma.

Sheng Li Zhou, Yan Ping Guo, Lei Zhang, Tao Deng, Zi Guang Xu, Chao Ding, Wen Cong Sun, Yue Wu Zhao, Ling Fei Kong,

<h4>Objective</h4>The aim of this study was to evaluate the predictive factors of central lymph node metastasis (CLNM) and BRAF<sup>V600E</sup> mutation in Chinese patients with papillary thyroid carcinoma (PTC).<h4>Methods</h4>A total of 943 PTC patients who underwent thyroidectomy from 2014 to 2016 at our hospital were enrolled. Those patients were divided into ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2021, 19(1):211]

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Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights From the VICTORIA Trial.

Carolyn S P Lam, Anna Giczewska, Karen Sliwa, Frank Edelmann, Jens Refsgaard, Edimar Bocchi, Justin A Ezekowitz, Adrian F Hernandez, Christopher M O'Connor, Lothar Roessig, Mahesh J Patel, Burkert Pieske, Kevin J Anstrom, Paul W Armstrong, ,

<h4>Importance</h4>The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH.<h4>Objective</h4>To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time from index HFH in the Vericiguat Global Study in Subjects With Heart Failure With ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2021, 6(6):706-712]

Cited: 8 times

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Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance.

Michael S Dahabieh, Fan Huang, Christophe Goncalves, Raúl Ernesto Flores González, Sathyen Prabhu, Alicia Bolt, Erminia Di Pietro, Elie Khoury, John Heath, Zi Yi Xu, Joelle Rémy-Sarrazin, Koren K Mann, Alexandre Orthwein, François-Michel Boisvert, Nancy Braverman, Wilson H Miller, Sonia V Del Rincón,

Promoting the macroautophagy/autophagy-mediated degradation of specific proteins and organelles can potentially be utilized to induce apoptosis in cancer cells or sensitize tumor cells to therapy. To examine this concept, we enriched for autophagosomes from histone deacetylase inhibitor (HDACi)-sensitive U937 lymphoma cells and isogenic HDACi-resistant cells. Mass spectrometry on autophagosome-enriched fractions ... Read more >>

Autophagy (Autophagy)
[2021, :1-19]

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Ultrasensitive fluorescent probe for visual biosensing of esterase activity in living cells and its imaging application.

Yu Zhu Yang, Zi Yi Xu, Nian Bing Li, Hong Qun Luo,

Esterase activity is often used as an index to evaluate the health status of cells and plays an important role in cell metabolism and apoptosis. Herein, we develop two fluorescent probes for visual biosensing of esterase activity and imaging in living cells. In vitro, after the introduction of esterase, enzymolysis ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2021, 262:120094]

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Clinical Features and Death Risk Factors in COVID-19 Patients with Cancer: A Retrospective Study

Yi Zhou, Qiao Yang, Jun Ye, Xiaocheng Wu, Xianhua Hou, Yimei Feng, Bangyu Luo, Jixi Li, Guangrong Yang, Lingchen Li, Xiu Yang, Bin Wang, Songtao Zhao, Li Li, Qi Li, Zi Xu, Hao Wu, Jianguo Sun,

<h4>Purpose: </h4> Coronavirus disease 2019 (COVID-19) has spread around the world. This retrospective study aims to analyze the clinical features of COVID-19 patients with cancer and identify death outcome related risk factors. <h4>Methods: </h4>: From February 10th to April 15th, 2020, 103 COVID-19 patients with cancer were enrolled. Difference analyses ... Read more >>

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The Association of the BRAF V600E  Mutation with Clinicopathologic Characteristics in Chinese Population with Conventional Papillary Thyroid Carcinoma

Sheng Li Zhou, Yan Ping Guo, Lei Zhang, Tao Deng, Zi Guang Xu, Chao Ding, Wen Cong Sun, Yue Wu Zhao, Ling Fei Kong,

<h4>Objective: </h4> The aim of the study is to evaluate the association of the BRAFV600E mutation with the clinicopathologic characteristics in Chinese population with papillary thyroid carcinoma (PTC).MethodsA total of 943 PTC patients who underwent thyroidectomy from 2014 to 2016 at Henan Provincial People’s Hospital were included in the present ... Read more >>

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Time series analysis of microbiome and metabolome at multiple body sites in steady long-term isolation confinement.

Qiang Feng, Xiang Lan, Xiaoli Ji, Meihui Li, Shili Liu, Jianghui Xiong, Yanbo Yu, Zhipeng Liu, Zi Xu, Li He, Ying Chen, Haisheng Dong, Pu Chen, Bin Chen, Kunlun He, Yinghui Li,

Gut (Gut)
[2021, 70(7):1409-1412]

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Discovery and biosynthesis of bosamycins from Streptomyces sp. 120454.

Zi Fei Xu, Sheng Tao Bo, Mei Jing Wang, Jing Shi, Rui Hua Jiao, Yang Sun, Qiang Xu, Ren Xiang Tan, Hui Ming Ge,

Nonribosomal peptides (NRPs) that are synthesized by modular megaenzymes known as nonribosomal peptide synthetases (NRPSs) are a rich source for drug discovery. By targeting an unusual NRPS architecture, we discovered an unusual biosynthetic gene cluster (<i>bsm</i>) from <i>Streptomyces</i> sp. 120454 and identified that it was responsible for the biosynthesis of ... Read more >>

Chem Sci (Chemical science)
[2020, 11(34):9237-9245]

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Radiomics features of ascending and descending nasopharyngeal carcinoma.

Jiajia Yao, Pei Yang, Lina Zhao, Hekun Jin, Xiaoxue Xie, Jingru Yang, Fan Lou, Rong Zhang, Zi Xu, Chaowei Chen,

<h4>Objectives</h4>To evaluate the application value of CT-based radiomics features for the ascending and descending types of nasopharyngeal carcinoma (NPC).<h4>Methods</h4>A total of 217 NPC patients (48 ascending type and 169 descending type), who obtained CT images before radiotherapy in Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University from ... Read more >>

Zhong Nan Da Xue Xue Bao Yi Xue Ban (Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences)
[2020, 45(7):819-826]

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The inhibitory effect of mixotrophic Ochromonas gloeopara on the survival and reproduction of Daphnia similoides sinensis.

Hengxing Tang, ShuangShuang Zhu, Na Wang, Zi Xu, Jing Huang, Lei Gu, Yunfei Sun, Lu Zhang, Zhou Yang, Yuan Huang,

Mixotrophs account for a high proportion (occasionally up to 80%) of the phytoplankton biomass. Chrysophyte is one major component of mixotrophs. Because of their possible toxicity and linkage between microbial community and higher trophic levels, the effect of mixotrophic golden algae on potential grazers received much attention. The present study ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(23):29068-29074]

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Discovery, Biosynthesis, and Heterologous Production of Loonamycin, a Potent Anticancer Indolocarbazole Alkaloid.

Cheng Long Yang, Bo Zhang, Wen Wen Xue, Wu Li, Zi Fei Xu, Jing Shi, Yan Shen, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge,

Genome mining of an indolocarbazole-type gene cluster from a marine-derived <i>Nocardiopsis flavescens</i> NA01583 strain led to the discovery of three new indolocarbazole alkaloids (<b>1</b>-<b>3</b>). Heterologous expression of the intact <i>loo</i> gene cluster in a surrogate host <i>Streptomyces lividans</i> K4-114 led to the successful production of <b>3</b>. Notably, compound <b>1</b> showed ... Read more >>

Org Lett (Organic letters)
[2020, 22(12):4665-4669]

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Mutation of the KIT Gene, excluding Exon 11, in Gastrointestinal Stromal Tumors.

Qiu Yu Liu, Ling Fei Kong, Zi Gung Xu, Zhen Li, Huan Zhou Xue,

Biomed Environ Sci (Biomedical and environmental sciences : BES)
[2020, 33(5):369-373]

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Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction.

Paul W Armstrong, Burkert Pieske, Kevin J Anstrom, Justin Ezekowitz, Adrian F Hernandez, Javed Butler, Carolyn S P Lam, Piotr Ponikowski, Adriaan A Voors, Gang Jia, Steven E McNulty, Mahesh J Patel, Lothar Roessig, Joerg Koglin, Christopher M O'Connor, ,

<h4>Background</h4>The effect of vericiguat, a novel oral soluble guanylate cyclase stimulator, in patients with heart failure and reduced ejection fraction who had recently been hospitalized or had received intravenous diuretic therapy is unclear.<h4>Methods</h4>In this phase 3, randomized, double-blind, placebo-controlled trial, we assigned 5050 patients with chronic heart failure (New York ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 382(20):1883-1893]

Cited: 100 times

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Physiological Acclimatization of the Liver to 180-Day Isolation and the Mars Solar Day.

Hailong Chen, Ke Lv, Guohua Ji, Yanhong Yuan, Liang Lu, Fengji Liang, Kai Li, Zi Xu, Jianghui Xiong, Lina Qu, Yinghui Li,

Physiological changes in humans are evident under environmental conditions similar to those on a Mars mission involving both a space factor (long-term isolation) and a time factor (the Mars solar day). However, very few studies have investigated the response of the liver to those conditions. Serum protein levels, bilirubin levels, ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:2796510]

Cited: 1 time

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Diaper dermatitis prevalence and severity: Global perspective on the impact of caregiver behavior.

Andrew N Carr, Thomas DeWitt, Michael J Cork, Lawrence F Eichenfield, Regina Fölster-Holst, Daniel Hohl, Alfred T Lane, Amy Paller, Larry Pickering, Alain Taieb, Tao Y Cui, Zi G Xu, Xeumin Wang, Susanna Brink, Yeuqing Niu, Julie Ogle, Mauricio Odio, Roger D Gibb,

<h4>Objectives</h4>To compare prevalence and severity of diaper dermatitis (DD) in infants and toddlers (babies) across three countries (China, USA, and Germany), including diapered skin measures and caregiver practices.<h4>Methods</h4>A cross-sectional study of 1791 babies (~600 from each country) was recruited at each clinical site. Based on regional toilet-training habits, exclusively diaper-wearing ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, 37(1):130-136]

Cited: 4 times

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Rearing pattern alters porcine myofiber type, fat deposition, associated microbial communities and functional capacity

Keke Qi, Xiaoming Men, Jie Wu, Zi wei Xu,

<h4>Background: </h4> The Chinese believe that the meat of pigs reared in the past with free range tastes better than that of the pigs reared indoor on a large scale today. Gastrointestinal microflora is closely associated with the main factor of meat flavour, including fibre characteristics and lipid metabolism. Our ... Read more >>

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Integrated Analysis of DNA Methylation and Biochemical/Metabolic Parameter During the Long-Term Isolation Environment.

Yuan Quan, Fengji Liang, Yuexing Zhu, Ying Chen, Zi Xu, Fang Du, Ke Lv, Hailong Chen, Lina Qu, Ruifeng Xu, Hong-Yu Zhang, Jianghui Xiong, Yinghui Li,

Numerous studies have shown that changes in the epigenome are an important cause of human biochemical or metabolic parameter changes. Biochemical/metabolic parameter disorders of the human body are usually closely related to the occurrence of disease. Therefore, constructing credible DNA methylation site-biochemical/metabolic parameter associations are key in interpreting the pathogenesis ... Read more >>

Front Physiol (Frontiers in physiology)
[2019, 10:917]

Cited: 1 time

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Long non-coding RNA myocardial infarction associated transcript promotes epithelial-mesenchymal transition and is an independent risk factor for poor prognosis of tongue squamous cell carcinoma.

Waisheng Zhong, Zi Xu, Senli Wen, Tao Xie, Fang Wang, Qiwei Wang, Jie Chen,

<h4>Background</h4>Long non-coding RNA myocardial infarction associated transcript (MIAT) has been suspected to be associated with poor prognosis in several malignancies. This study aims to investigate the association between MIAT expression levels and prognosis of tongue squamous cell carcinoma (TSCC).<h4>Materials and methods</h4>Expressions of MIAT in TSCC specimens, corresponding adjacent non-neoplastic tongue ... Read more >>

J Oral Pathol Med (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2019, 48(8):720-727]

Cited: 1 time

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Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment.

Ming Yuan, Marc-Antoine Custaud, Zi Xu, Jingyu Wang, Min Yuan, Carole Tafforin, Loïc Treffel, Philippe Arbeille, Michel Nicolas, Claude Gharib, Guillemette Gauquelin-Koch, Laurent Arnaud, Jean-Christophe Lloret, Yinghui Li, Nastassia Navasiolava,

Confinement experiments are essential to prepare long-term space exploration. The 180-day Chinese CELSS (Controlled Ecological Life Support System) study is unique in its design, including a closed-loop system and mid-mission simulation of Mars-like day-night cycle of 24 h 40 min for 36 days (days 72-108). Our aim was to study ... Read more >>

Front Physiol (Frontiers in physiology)
[2019, 10:575]

Cited: 5 times

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A case of pityriasis lichenoides et varioliformis acuta pemphigoides successfully treated with methotrexate and corticosteroids.

Lei Jiao, Ying Liu, Xin Xiang, Jiaosheng Xu, Lin Ma, Zi Gang Xu,

Pityriasis lichenoides et varioliformis acuta (PLEVA) pemphigoides is an uncommon skin disease, which is characterized by the appearance of blistering skin lesions in patients with PLEVA. We present a 3-year-old boy, who was diagnosed with PLEVA pemphigoides. Combined treatment of oral methotrexate and corticosteroids was more effective than corticosteroids alone ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2019, 32(4):e12833]

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Pediatric dermatology-Critical approach to the new treatments.

Yuan Liang, Yun Liu Chen, Mu Tong Zhao, Zhao Yang Wang, Li Li, Bin Zhang, Chun Ping Shen, Shan Wang, Zi Gang Xu, Lin Ma,

The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. The use of biologics and small molecules in children with ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2019, 32(4):e12801]

Cited: 1 time

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A Grading Scale for Pial Collaterals in Middle Cerebral Artery Total Occlusion Based on Time-of-flight MR Angiography Source Images.

Huai Wu Yuan, Ren Jie Ji, An Li Wang, Ya Jie Lin, Han Feng Chen, Zi Qi Xu, Guo Ping Peng, Ben Yan Luo,

<h4>Purpose</h4>To verify whether a new grading based on time-of-flight magnetic resonance angiography source images (TOF-MRAsi) can reflect the abundance of pial collaterals, in patients with total occlusion of M1 segment of middle cerebral artery in the chronic stage.<h4>Methods</h4>In this single-center retrospective study, consecutive patients with total occlusion of M1 segment ... Read more >>

Magn Reson Med Sci (Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine)
[2019, 18(1):62-69]

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