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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen,

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):761-770]

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Ureteral anastomosis with a polyimide stent in rat kidney transplantation.

Tong Wang, Zhou Yu, Chen Chen, Yajuan Song, Xianhui Zeng, Yingjun Su, Chenggang Yi,

Background: Complications associated with ureteral anastomosis in kidney transplantation are highly prevalent, despite the development of various types of stents. The current stent materials and placement methods have several limitations. This study attempts to provide an alternative by investigating ureteral anastomosis with a polyimide stent and a modified placement method ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):193-199]

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Network-based Transcriptome-wide Expression Study for Postmenopausal Osteoporosis.

Lan Zhang, Tian-Liu Peng, Le Wang, Xiang-He Meng, Wei Zhu, Yong Zeng, Jia-Qiang Zhu, Yu Zhou, Hong-Mei Xiao, Hong-Wen Deng,

PURPOSE:Menopause is a crucial physiological transition during a woman's life, and it occurs with growing risks of health issues like osteoporosis. To identify postmenopausal osteoporosis-related genes, we performed transcriptome-wide expression analyses for human peripheral blood monocytes (PBMs) using Affymetrix 1.0 ST arrays in 40 Caucasian postmenopausal women with discordant bone ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(8):]

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The diagnostic performance of TB-IGRA on HIV infected patients with active tuberculosis is associated with CD4+ T-cell counts

Mengyan Wang, Yu Zhou, Tongtong Chen, Xiaotian Dong, Jun Yan, Zhongdong Zhang, Jinchuan Shi, Shourong Liu,

Abstract Background To investigate the factors associated with the diagnostic performance of interferon-gamma release assay (IGRA) on HIV infected patients with active tuberculosis (TB). Methods We retrospectively collected and analyzed the data of HIV infected patients with active tuberculosis hospitalized in Xixi Hospital of Hangzhou and Ruian ... Read more >>

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Efferent Synaptic Transmission at the Vestibular Type II Hair Cell Synapse.

Zhou Yu, J Michael McIntosh, Soroush G Sadeghi, Elisabeth Glowatzki,

In the vestibular peripheral organs, type I and type II hair cells (HCs) transmit incoming signals via glutamatergic quantal transmission onto afferent nerve fibers. Additionally, type I HCs transmit via 'non-quantal' transmission to calyx afferent fibers, by accumulation of glutamate and potassium in the synaptic cleft. Vestibular efferent inputs originating ... Read more >>

J. Neurophysiol. (Journal of neurophysiology)
[2020, :]

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Microstructural evolution and mechanical properties of in situ nano Ta4HfC5 reinforced SiBCN composite ceramics

Bingzhu Wang, Li Daxin, Zhihua Yang, Dechang Jia, Jingyi Guan, Hao Peng, Delong Cai, Peigang He, Xiaoming Duan, Yu Zhou,

Abstract In this paper, the in situ nano Ta 4 HfC 5 reinforced SiBCN-Ta 4 HfC 5 composite ceramics were prepared by a combination of two-step mechanical alloying and reactive hot-pressing sintering. The microstructural evolution and mechanical properties of the resulting SiBCN-Ta 4 HfC 5 were studied. After the first-step ... Read more >>

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Association of Polymorphism rs67920064 in ADAMTS9 Gene with Mandibular Retrognathism in a Chinese Population.

Chi Wang, Zhenyu Ni, Ying Cai, Yu Zhou, Weiting Chen,

BACKGROUND Mandibular retrognathism is a common oral and maxillofacial deformity that may cause a series of physical and psychological diseases. Many studies indicated that genetic factors play an important role in the occurrence of mandibular retrognathism. In this study, we assess the association between polymorphism rs67920064 in ADAMTS9 gene and ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e925965]

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Management of Burning Mouth Syndrome: a position paper of the Chinese Society of Oral Medicine.

Qianming Chen, Yujie Shi, Lu Jiang, Yu Zhou, Hongxia Dan, Xin Jin, Silu Sun, Xin Zeng,

BACKGROUND:Burning mouth syndrome is a syndrome with tongue as the main affected site and burning pain as the main complaint. Although a variety of therapies have been reported to treat BMS, there is a lack of widely recognized therapies and it is still a dilemma for clinicians to treat BMS. ... Read more >>

J. Oral Pathol. Med. (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2020, :]

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Symmetric Sodium-Ion Battery Based on Dual-Electron Reactions of NASICON-Structured Na3MnTi(PO4)3 Material.

Yu Zhou, Xiji Shao, Kwok-Ho Lam, You Zheng, Lingzhi Zhao, Kedong Wang, Jinzhu Zhao, Fuming Chen, Xianhua Hou,

Symmetric sodium-ion batteries possess promising features such as low cost, easy manufacturing process, and facile recycling post-process, which are suitable for the application of large-scale stationary energy storage. Herein, we proposed a symmetric sodium-ion battery based on dual-electron reactions of a NASICON-structured Na3MnTi(PO4)3 material. The Na3MnTi(PO4)3 electrode can deliver a ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Correction to "Tailoring Passivation Molecular Structures for Extremely Small Open-Circuit Voltage Loss in Perovskite Solar Cells".

Shuang Yang, Jun Dai, Zhenhua Yu, Yuchuan Shao, Yu Zhou, Xun Xiao, Xiao Cheng Zeng, Jinsong Huang,

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, :]

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Coherent Lattice Wobbling and Out-of-Phase Intensity Oscillations of Friedel Pairs Observed by Ultrafast Electron Diffraction.

Qingkai Qian, Xiaozhe Shen, Duan Luo, Lanxin Jia, Michael Kozina, Renkai Li, Ming-Fu Lin, Alexander H Reid, Stephen Weathersby, Suji Park, Jie Yang, Yu Zhou, Kunyan Zhang, Xijie Wang, Shengxi Huang,

The inspection of Friedel's law in ultrafast electron diffraction (UED) is important to gain a comprehensive understanding of material atomic structure and its dynamic response. Here, monoclinic gallium telluride (GaTe), as a low-symmetry, layered crystal in contrast to many other 2D materials, is investigated by mega-electronvolt UED. Strong out-of-phase oscillations ... Read more >>

ACS Nano (ACS nano)
[2020, :]

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Radial artery diameterand and age related functional maturation of the radio-cephalic arteriovenous fistula.

Zi-Ming Wan, Bo Hu, Qi-Quan Lai, Xue-Jing Gao, Bo Tu, Yu Zhou, Wen-Bo Zhao,

BACKGROUND:Previous studies have not described the relationship between reducing radial artery diameter as well as increasing age and functional maturation of the radio-cephalic arteriovenous fistula (RCAVF) and no data identify these as linear relationship. The objective of this study was to perform trend analysis to assess these aspects. METHODS:Our retrospective ... Read more >>

BMC Nephrol (BMC Nephrology)
[2020, 21(1):234]

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Extensive serum biomarker analysis before and after treatment in healing of diabetic foot ulcers using a cytokine antibody array.

Jun Wang, Yu Zhou, Yunping Li, Yang Xu, Guotao Liu, Zengzhen Lu,

Diabetic foot ulcers (DFU) remain a serious public health problem. However, the current evaluation and confirmation of the efficacy of DFU is unclear. The present study aimed to measure the alterations of circulating proteins in patients after DFU healing for the exploration of the prognostic biomarkers. The serum cytokine profiles ... Read more >>

Cytokine (Cytokine)
[2020, 133:155173]

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Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS.

Ruangang Pan, Qinran Zhang, Scott M Anthony, Yu Zhou, Xiufen Zou, Martin Cassell, Stanley Perlman,

Neurotropic strains of mouse hepatitis virus (MHV), a coronavirus, cause acute and chronic demyelinating encephalomyelitis with similarities to the human disease multiple sclerosis. Here, using a lineage-tracking system, we show that some cells, primarily oligodendrocytes (OLs) and oligodendrocyte precursor cells (OPCs), survive the acute MHV infection, are associated with regions ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, :]

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Association between NT5C2 rs11191580 and autism spectrum disorder in the Chinese Han population.

Xinyan Xie, Fangfang Liu, Qi Xue, Yu Zhou, Qi Liu, Shuting Tang, Kaiheng Zhu, Zihao Wan, Jiajia Zhang, Pengxiang Zuo, Ranran Song,

Asian J Psychiatr (Asian Journal of Psychiatry)
[2020, 53:102231]

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Decoupled pH- and Thermo-Responsive Injectable Chitosan/PNIPAM Hydrogel via Thiol-Ene Click Chemistry for Potential Applications in Tissue Engineering.

Haichang Ding, Baoqiang Li, Zonglin Liu, Gang Liu, Shouzhi Pu, Yujie Feng, Dechang Jia, Yu Zhou,

Stimuli-responsive chitosan (CS) hydrogels exhibit great potential for drug delivery and tissue engineering; however, the structure of these stimuli-responsive CS hydrogels, such as dual pH- and thermo-responsive hydrogels, is difficult to control or needs additional crosslinking agents. Here, a new dual pH- and thermo-responsive hydrogel system is developed by combining ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2020, :e2000454]

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Clinical Efficacy of Intramedullary Fixation vs. Plate Fixation for Femoral Intertrochanteric Fractures

Yu Zhou, Chongjun Xia, Xiaowei Ma, Xiaobing Yu,

Abstract Background To compare the clinical efficacy of proximal femoral intramedullary fixation and anatomical locking compression plate in the treatment of femoral intertrochanteric fractures among the elderly. Methods In this retrospective study, 210 surgically treated patients with intertrochanteric fractures of the femur were analyzed and divided into groups ... Read more >>

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Origin of Unusual Acidity and Li+ Diffusivity in a Series of Water-in-Salt Electrolytes.

Kee Sung Han, Zhou Yu, Hui Wang, Paul C Redfern, Lin Ma, Lei Cheng, Ying Chen, Jian Zhi Hu, Larry A Curtiss, Kang Xu, Vijayakumar Murugesan, Karl T Mueller,

Superconcentrated aqueous electrolytes ("water-in-salt" electrolytes, or WiSEs) enable various aqueous battery chemistries beyond the voltage limits imposed by the Pourbaix diagram of water. However, their detailed structural and transport properties remain unexplored and could be better understood through added studies. Here, we report on our observations of strong acidity (pH ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2020, 124(25):5284-5291]

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Cloning and Characterization of a New β-Galactosidase from Alteromonas sp. QD01 and Its Potential in Synthesis of Galacto-Oligosaccharides.

Dandan Li, Shangyong Li, Yanhong Wu, Mengfei Jin, Yu Zhou, Yanan Wang, Xuehong Chen, Yantao Han,

As prebiotics, galacto-oligosaccharides (GOSs) can improve the intestinal flora and have important applications in medicine. β-galactosidases could promote the synthesis of GOSs in lactose and catalyze the hydrolysis of lactose. In this study, a new β-galactosidase gene (gal2A), which belongs to the glycoside hydrolase family 2, was cloned from marine ... Read more >>

Mar Drugs (Marine drugs)
[2020, 18(6):]

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The Study on the Molecular Mechanism of Erchen Tang on Asthma Based on Network Pharmacology

Yuzhe Ren, Haijing Zhang, Zhou Yu, Jun Wan, Xuejin Peng, Yilin Huang, Chengke Li, Xiangzheng Yang,

Abstract Objective: To explore the active ingredients of ECT and their targets of asthma and investigate the potential mechanism of ECT on asthma. Methods: Firstly, the active ingredients and target of ECT were screened for BATMAN and TCMSP, functional analysis was finished via DAVID. Then, animal model was induced by ... Read more >>

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Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes.

Liqing Kang, Xiaowen Tang, Jian Zhang, Minghao Li, Nan Xu, Wei Qi, Jingwen Tan, Xiaoyan Lou, Zhou Yu, Juanjuan Sun, Zhenkun Wang, Haiping Dai, Jia Chen, Guoqing Lin, Depei Wu, Lei Yu,

Background:T cells expressing a chimeric antigen receptor (CAR) engineered to target CD19 can treat leukemia effectively but also increase the risk of complications such as cytokine release syndrome (CRS) and CAR T cell related encephalopathy (CRES) driven by interleukin-6 (IL-6). Here, we investigated whether IL-6 knockdown in CART-19 cells can ... Read more >>

Exp Hematol Oncol (Experimental Hematology & Oncology)
[2020, 9:11]

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Alterations in DNA methylation profiles in cancellous bone of postmenopausal women with osteoporosis.

Yu Zhou, Ling Yang, Hong Wang, Xi Chen, Wei Jiang, Zhicong Wang, Shuping Liu, Yuehong Liu,

Osteoporosis is characterized by systemic microarchitecture impairment and bone loss, which ultimately lead to fragility fractures. This disease is most common in older people, especially in postmenopausal women. Cancellous bone is affected by osteoporosis earlier than cortical bone, and DNA methylation microarray analysis of the hip cancellous bone of patients ... Read more >>

FEBS Open Bio (FEBS open bio)
[2020, :]

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Expression of gallus epidermal growth factor (gEGF) with food-grade Lactococcus lactis expression system and its biological effects on broiler chickens

Yu Zhou, Pinpin Chen, Shuai Shi, Xiaowen Li, Deshi Shi, Zutao Zhou, Zili Li, Yuncai Xiao,

Abstract Background Epidermal growth factor (EGF) is a multifunctional polypeptide, which could be utilized to solve problems in the industry such as increasing growth performance of commercial broilers or enhancing resistance to diseases under adverse conditions. Thus far, very few studies have focused on the gallus epidermal growth factor (gEGF) ... Read more >>

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[Professor WU Zhong-chao's clinical experiences of "syndrome differentiation and Chinese herbal plaster application" based on meridian and zangfu theories].

Yu Zhou, Zhong-Jie Chen, Tian-Yi Liu, Bing Wang, Ning Zhang, Tong Wang,

Focusing on the limits of the plaster application of Chinese herbal medicine in clinical practice, i.e. limit in the region exerted, inadequate meridian effect, more attention to the exterior rather than the interior and limit in the application of zangfu differentiation, professor WU Zhong-chao proposes his clinical experiences in the ... Read more >>

Zhongguo Zhen Jiu (Zhongguo zhen jiu = Chinese acupuncture & moxibustion)
[2020, 40(6):645-647]

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Cholecystokinin type 2 receptor in colorectal cancer: diagnostic and therapeutic target.

Jiang Chang, Zeng-Shan Liu, De-Feng Song, Meng Li, Song Zhang, Ke Zhao, Yu-Ting Guan, Hong-Lin Ren, Yan-Song Li, Yu Zhou, Xi-Lin Liu, Shi-Ying Lu, Pan Hu,

INTRODUCTION:Cholecystokinin type 2 receptor (CCK2R), which mediates the action of gastrin and cholecystokinin (CCK), has been demonstrated to promote the proliferation of colorectal cancer (CRC). A number of studies showed that CCK2R overexpressed in gastric cancer and pancreatic cancer but few in CRC. The correlation between CCK2R expression and clinicopathological ... Read more >>

J. Cancer Res. Clin. Oncol. (Journal of cancer research and clinical oncology)
[2020, :]

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