Full Text Journal Articles by
Author Zhihe Qing

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Al centre-powered graphitic nanozyme with high catalytic efficiency for pH-independent chemodynamic therapy of cancer.

Jun Li, Ke Yi, Yanli Lei, Zhihe Qing, Zhen Zou, Yuedong Zhang, Haiyan Sun, Ronghua Yang,

An Al centre-powered graphitic nanozyme derived from a metal organic framework was first developed for a chemodynamic tumor treatment. By virtue of the rapid and efficient generation of ˙OH in the slightly acidic tumor microenvironment, this nanozyme afforded high anti-tumor efficacy both in living cells and in vivo. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(46):6285-6288]

Cited: 0 times

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Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma.

Le Yang, Jing Zheng, Zhen Zou, Haiyan Cai, Peng Qi, Zhihe Qing, Qi Yan, Liping Qiu, Weihong Tan, Ronghua Yang,

As the most abundant protein in blood, human serum albumin (HSA) is usually regarded as an interferent in clinical molecular diagnosis. Herein, we report that HSA is an endogenous signal amplifier for the detection of the prostate-specific antigen (PSA) in human plasma. This is the first study to utilize intrinsic ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(12):1843-1846]

Cited: 1 time

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Adsorption-improved MoSe2 nanosheet by heteroatom doping and its application for simultaneous detection and removal of mercury (II).

Caicheng Long, Xiao Li, Zixin Jiang, Peng Zhang, Zhihe Qing, Taiping Qing, Bo Feng,

Water pollution arising from heavy metal ions continues to be a major environmental problem, which represents a serious threat to human beings and animals worldwide. New materials that can simultaneously detect and remove these toxic ions are urgently required. Herein, nitrogen and sulfur co-doped molybdenum selenide nanosheets (N, S-MoSe<sub>2</sub>) were ... Read more >>

J Hazard Mater (Journal of hazardous materials)
[2021, 413:125470]

Cited: 2 times

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Synchronous screening of multiplexed biomarkers of Alzheimer's disease by a length-encoded aerolysin nanopore-integrated triple-helix molecular switch.

Zhen Zou, Hua Yang, Qi Yan, Peng Qi, Zhihe Qing, Jing Zheng, Xuan Xu, Lihua Zhang, Feng Feng, Ronghua Yang,

Herein, we developed a versatile strategy for the synchronous screening of biomarkers of Alzheimer's disease (AD) by incorporating the high-resolution discrimination of an aerolysin nanopore to length-encoded oligonucleotides and the signal transduction of a triple-helix molecular switch (TMS). This assay is adapted to quantitatively compare multiplexed targets of very different ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2019, 55(45):6433-6436]

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Thiol-suppressed I2-etching of AuNRs: acetylcholinesterase-mediated colorimetric detection of organophosphorus pesticides.

Zhihe Qing, Yacheng Li, Younan Li, Guoyan Luo, Jinlei Hu, Zhen Zou, Yanli Lei, Juewen Liu, Ronghua Yang,

For the first time it is demonstrated that sulfhydryl compounds can suppress longitudinal etching of gold nanorods via consuming oxidizers, which provides a new signaling mechanism for colorimetric sensing. As a proof of concept, a colorimetric assay is developed for detecting organophosphorus pesticides, which are most widely used in modern agriculture ... Read more >>

Mikrochim Acta (Mikrochimica acta)
[2020, 187(9):497]

Cited: 0 times

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Pt-S Bond-Mediated Nanoflares for High-Fidelity Intracellular Applications by Avoiding Thiol Cleavage.

Zhihe Qing, Guoyan Luo, Shuohui Xing, Zhen Zou, Yanli Lei, Juewen Liu, Ronghua Yang,

The Au-S bond is the classic way to functionalize gold nanoparticles (AuNPs). However, cleavage of the bond by biothiols and other chemicals is a long-standing problem hindering practical applications, especially in cells. Instead of replacing the thiol by a carbene or selenol for stronger adsorption, it is now shown that ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2020, 59(33):14044-14048]

Cited: 0 times

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Human Serum Albumin-Occupying-Based Fluorescence Turn-On Analysis of Antiepileptic Drug Tiagabine Hydrochloride.

Zhen Zou, Xiaodou Liao, Le Yang, Ziyun Huang, Hua Yang, Qi Yan, Yufei Zhang, Zhihe Qing, Lihua Zhang, Feng Feng, Ronghua Yang,

Tiagabine hydrochloride (TGB) is a clinically frequently used drug for anticonvulsion and reducing epileptic frequency. Over administration of TGB could bring about adverse effects, such as speech disorder, depression, and even suicidal tendencies. Therefore, accessible and sensitive assay for analysis of TGB becomes an urgent need toward guiding clinical medication. ... Read more >>

Anal Chem (Analytical chemistry)
[2020, 92(5):3555-3562]

Cited: 0 times

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DNA-Templated Fluorescent Nanoclusters for Metal Ions Detection.

Chunxia Song, Jingyuan Xu, Ying Chen, Liangliang Zhang, Ying Lu, Zhihe Qing,

DNA-templated fluorescent nanoclusters (NCs) have attracted increasing research interest on account of their prominent features, such as DNA sequence-dependent fluorescence, easy functionalization, wide availability, water solubility, and excellent biocompatibility. Coupling DNA templates with complementary DNA, aptamers, G-quadruplex, and so on has generated a large number of sensors. Additionally, the preparation ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2019, 24(22):]

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Cytoplasmic Protein-Powered In Situ Fluorescence Amplification for Intracellular Assay of Low-Abundance Analyte.

Yibo Zhou, Sheng Yang, Yue Xiao, Zhen Zou, Zhihe Qing, Juewen Liu, Ronghua Yang,

Fluorescence amplification is critical for in situ and real-time detection of intracellular low abundance biological species. However, current intracellular amplification techniques mainly rely on synthetic nucleic acid-based nanodevices, manipulating them in living cells remains challenging. To solve this problem, herein, a new signal amplification concept named cytoplasmic protein-powered in situ ... Read more >>

Anal Chem (Analytical chemistry)
[2019, 91(23):15179-15186]

Cited: 0 times

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Recent progress in copper nanocluster-based fluorescent probing: a review.

Taiping Qing, Kaiwu Zhang, Zhihe Qing, Xuan Wang, Caicheng Long, Peng Zhang, Haizhi Hu, Bo Feng,

Copper nanoclusters (CuNCs) are an attractive alternative to other metal nanoclusters. The synthesis of CuNCs is highly efficient and fast, with low-cost and without any complicated manipulation. Because of their tunable fluorescence and low toxicity, CuNCs have been highly exploited for biochemical sensing. This review (with 172 refs.) summarizes the ... Read more >>

Mikrochim Acta (Mikrochimica acta)
[2019, 186(10):670]

Cited: 8 times

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Real-Time Visualizing Mitophagy-Specific Viscosity Dynamic by Mitochondria-Anchored Molecular Rotor.

Zhen Zou, Qi Yan, Sixin Ai, Peng Qi, Hua Yang, Yufei Zhang, Zhihe Qing, Lihua Zhang, Feng Feng, Ronghua Yang,

Mitophagy, as an evolutionarily conserved cellular process, plays a crucial role in preserving cellular metabolism and physiology. Various microenvironment alterations assigned to mitophagy including pH, polarity, and deregulated biomarkers are increasingly understood. However, mitophagy-specific viscosity dynamic in live cells remains a mystery and needs to be explored. Here, a water-soluble ... Read more >>

Anal Chem (Analytical chemistry)
[2019, 91(13):8574-8581]

Cited: 4 times

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Cell-Surface-Anchored Ratiometric DNA Nanoswitch for Extracellular ATP Imaging.

Jing Yuan, Zhiwei Deng, Hui Liu, Xiufang Li, Jianbing Li, Yao He, Zhihe Qing, Yanjing Yang, Shian Zhong,

The precise detection of extracellular ATP, although a challenging task, is of great significance for understanding the related cell processes. Herein, we developed a ratiometric DNA nanoswitch by employing a DNA tweezer and split aptamer. The nanoswitch is composed of three specially designed ssDNA strands, namely, the central strands O1, ... Read more >>

ACS Sens (ACS sensors)
[2019, :]

Cited: 1 time

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Colorimetric aminotriazole assay based on catalase deactivation-dependent longitudinal etching of gold nanorods.

Younan Li, Guoyan Luo, Zhihe Qing, Xiaoxuan Li, Zhen Zou, Ronghua Yang,

A colorimetric and visual assay is described for the herbicide aminotriazole (ATZ). It is based on the etching of gold nanorods (AuNRs) by iodine which is formed on oxidation of iodide via H<sub>2</sub>O<sub>2</sub>. Longitudinal etching of the AuNRs occurs quickly and is accompanied by a color change from dark blue ... Read more >>

Mikrochim Acta (Mikrochimica acta)
[2019, 186(8):565]

Cited: 1 time

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In Situ Amplification-Based Imaging of RNA in Living Cells.

Zhihe Qing, Jingyuan Xu, Jinlei Hu, Jing Zheng, Lei He, Zhen Zou, Sheng Yang, Weihong Tan, Ronghua Yang,

Owing to its important physiological functions, especially as molecular biomarkers of diseases, RNA is an important focus of biomedicine and biochemical sensing. Signal amplification detection has been put forward because of the need for accurate identification of RNA at low expression levels, which is significant for the early diagnosis and ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2019, 58(34):11574-11585]

Cited: 7 times

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Progress in biosensor based on DNA-templated copper nanoparticles.

Zhihe Qing, Ailing Bai, Shuohui Xing, Zhen Zou, Xiaoxiao He, Kemin Wang, Ronghua Yang,

During the last decades, by virtue of their unique physicochemical properties and potential application in microelectronics, biosensing and biomedicine, metal nanomaterials (MNs) have attracted great research interest and been highly developed. Deoxyribonucleic acid (DNA) is a particularly interesting ligand for templating bottom-up nanopreparation, by virtue of its excellent properties including ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2019, 137:96-109]

Cited: 8 times

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MIL/Aptamer as a Nanosensor Capable of Resisting Nonspecific Displacement for ATP Imaging in Living Cells.

Jun Li, Yuedong Zhang, Zhen Zou, Zhihe Qing, Sheng Yang, Jianxiao Yang, Lihua Zhang, Feng Feng, Ronghua Yang,

Fluorescent probes physisorbed on nanomaterials have emerged as a kind of useful and facile sensing platform for biological important molecules. However, nonspecific displacement in the physisorption systems is a non-negligible problem for the intracellular analysis. MIL (Materials of Institut Lavoisier), a subclass of metal-organic frameworks (MOFs), has high porosity, large ... Read more >>

ACS Omega (ACS omega)
[2019, 4(5):9074-9080]

Cited: 1 time

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A Ratiometric Two-Photon Fluorescent Cysteine Probe with Well-Resolved Dual Emissions Based on Intramolecular Charge Transfer-Mediated Two-Photon-FRET Integration Mechanism.

Sheng Yang, Chongchong Guo, Yuan Li, Jingru Guo, Jie Xiao, Zhihe Qing, Jiangsheng Li, Ronghua Yang,

The development of an efficient ratiometric two-photon fluorescence imaging probe is crucial for in situ monitoring of biothiol cysteine (Cys) in biosystems, but the current reported intramolecular charge transfer (ICT)-based one suffers from serious overlap between the shifted emission bands. To address this issue, we herein for the first time ... Read more >>

ACS Sens (ACS sensors)
[2018, 3(11):2415-2422]

Cited: 4 times

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Molecular Engineering of α-Substituted Acrylate Ester Template for Efficient Fluorescence Probe of Hydrogen Polysulfides.

Jingru Guo, Sheng Yang, Chongchong Guo, Qinghai Zeng, Zhihe Qing, Zhong Cao, Jishan Li, Ronghua Yang,

In this article, hydrogen polysulfide (H2Sn)-mediated Michael addition/cyclization cascade reactions toward acrylate ester analogues were exploited and utilized to construct novel and robust H2Sn-specific fluorescence probe for the first time. Through rational molecular engineering of the α-substituted acrylate ester template, the optimal candidate probe FP-CF3 containing trifluoromethyl-substituted acrylate ester group ... Read more >>

Anal Chem (Analytical chemistry)
[2018, 90(1):881-887]

Cited: 6 times

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A Target-Lighted dsDNA-Indicator for High-Performance Monitoring of Mercury Pollution and Its Antagonists Screening.

Zhihe Qing, Lixuan Zhu, Xiaoxuan Li, Sheng Yang, Zhen Zou, Jingru Guo, Zhong Cao, Ronghua Yang,

As well-known, the excessive discharge of heavy-metal mercury not only destroys the ecological environment, bust also leads to severe damage of human health after ingestion via drinking and bioaccumulation of food chains, and mercury ion (Hg<sup>2+</sup>) is designated as one of most prevalent toxic metal ions in drinking water. Thus, ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2017, 51(20):11884-11890]

Cited: 1 time

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Direct Detection of Nucleic Acid with Minimizing Background and Improving Sensitivity Based on a Conformation-Discriminating Indicator.

Lixuan Zhu, Zhihe Qing, Lina Hou, Sheng Yang, Zhen Zou, Zhong Cao, Ronghua Yang,

As is well-known, the nucleic acid indicator-based strategy is one of the major approaches to monitor the nucleic acid hybridization-mediated recognition events in biochemical analysis, displaying obvious advantages including simplicity, low cost, convenience, and generality. However, conventional indicators either hold strong self-fluorescence or can be lighted by both ssDNA and ... Read more >>

ACS Sens (ACS sensors)
[2017, 2(8):1198-1204]

Cited: 3 times

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Ratiometric Visualization of NO/H2S Cross-Talk in Living Cells and Tissues Using a Nitroxyl-Responsive Two-Photon Fluorescence Probe.

Yibo Zhou, Xiufang Zhang, Sheng Yang, Yuan Li, Zhihe Qing, Jing Zheng, Jishan Li, Ronghua Yang,

It is of scientific significance to explore the intricate relationship between two crucial gasotransmitters nitric oxide (NO) and hydrogen sulfide (H<sub>2</sub>S) because they exert similar and interdependent biological actions within the living organisms. Nevertheless, visualization of the NO/H<sub>2</sub>S crosstalk using effective molecular imaging tools remains challenging. To address this issue, ... Read more >>

Anal Chem (Analytical chemistry)
[2017, 89(8):4587-4594]

Cited: 13 times

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Quantitative Monitoring of Hypoxia-Induced Intracellular Acidification in Lung Tumor Cells and Tissues Using Activatable Surface-Enhanced Raman Scattering Nanoprobes.

Dandan Ma, Jing Zheng, Pinting Tang, Weijian Xu, Zhihe Qing, Sheng Yang, Jishan Li, Ronghua Yang,

Hypoxia is considered to contribute to pathophysiology in various cells and tissues, and a clear understanding about the relationship between hypoxia and intracellular acidification will help to elucidate the complex mechanism of glycolysis under hypoxia. However, current studies are mainly focused on overexpression of intracellular reductases accelerated by hypoxia, and ... Read more >>

Anal Chem (Analytical chemistry)
[2016, 88(23):11852-11859]

Cited: 5 times

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Visual Biopsy by Hydrogen Peroxide-Induced Signal Amplification.

Wenjie Zhao, Sheng Yang, Jinfeng Yang, Jishan Li, Jing Zheng, Zhihe Qing, Ronghua Yang,

Visual biopsy has attracted special interest by surgeons due to its simplicity and practicality; however, the limited sensitivity of the technology makes it difficult to achieve an early diagnosis. To circumvent this problem, herein, we report a visual signal amplification strategy for establishing a marker-recognizable biopsy that enables early cancer ... Read more >>

Anal Chem (Analytical chemistry)
[2016, 88(21):10728-10735]

Cited: 1 time

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A Reversible Nanolamp for Instantaneous Monitoring of Cyanide Based on an Elsner-Like Reaction.

Zhihe Qing, Lina Hou, Le Yang, Lixuan Zhu, Sheng Yang, Jing Zheng, Ronghua Yang,

It is well-known that cyanide ion (CN<sup>-</sup>) is a hypertoxic anion, which can cause adverse effects in both the environment and living beings; thus, it is highly desirable to develop strategies for detecting CN<sup>-</sup>, especially in water and food. However, due to the short half-life of free cyanide, long analysis ... Read more >>

Anal Chem (Analytical chemistry)
[2016, 88(19):9759-9765]

Cited: 4 times

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Oligonucleotide-templated rapid formation of fluorescent gold nanoclusters and its application for Hg2+ ions sensing.

Taiping Qing, Xiaoxiao He, Dinggeng He, Zhihe Qing, Kemin Wang, Yanli Lei, Ting Liu, Peng Tang, Yue Li,

In this work, we developed a simple, rapid and mild strategy for synthesis of DNA-templated fluorescent gold nanoclusters (AuNCs) through association of gold ions to DNA templates and reduction with 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES). After systematical investigation on the formation of fluorescent AuNCs by using different DNA templates, C5 DNA was ... Read more >>

Talanta (Talanta)
[2016, 161:170-176]

Cited: 0 times

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