Full Text Journal Articles by
Author Zhifeng You


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Asporin inhibits collagen matrix-mediated intercellular mechanocommunications between fibroblasts during keloid progression.

Longwei Liu, Hongsheng Yu, Yi Long, Zhifeng You, Rei Ogawa, Yanan Du, Chenyu Huang,

Keloids are fibrotic lesions that grow unceasingly and invasively and are driven by local mechanical stimuli. Unlike other fibrotic diseases and normal wound healing, keloids exhibit little transformation of dermal fibroblasts into α-SMA<sup>+</sup> myofibroblasts. This study showed that asporin is the most strongly expressed gene in keloids and its gene-ontology ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21705]

Cited: 0 times

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Comparison of Chondrocytes in Knee Osteoarthritis and Regulation by Scaffold Pore Size and Stiffness.

Yu Zhao, Zhifeng You, Dan Xing, Jiao Jiao Li, Qingxi Zhang, Hesuyuan Huang, Zhikun Li, Shumeng Jiang, Zhaozhao Wu, Yuying Zhang, Wenjing Li, Lin Zhang, Yanan Du, Jianhao Lin,

In knee osteoarthritis (OA), there is more pronounced cartilage damage in the medial compartment ("lesion zone") than the lateral compartment ("remote zone"). This study fills a gap in the literature by conducting a systematic comparison of cartilage and chondrocyte characteristics from these two zones. It also investigates whether chondrocytes from ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2021, 27(3-4):223-236]

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TGase-Enhanced Microtissue Assembly in 3D-Printed-Template-Scaffold (3D-MAPS) for Large Tissue Defect Reparation.

Hongsheng Yu, Zhifeng You, Xiaojun Yan, Wei Liu, Zhirui Nan, Dan Xing, Chenyu Huang, Yanan Du,

Engineering large and functional tissue constructs with complex structures (e.g., external ear or nose) for reparation and reconstruction of tissue defects remains one of the major challenges in regenerative medicine, which demands abundant cell sources, advanced biofabrication schemes, and satisfactory integration with the host for long-term efficacy post implantation. Here ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2020, 9(18):e2000531]

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Engineering 3D functional tissue constructs using self-assembling cell-laden microniches.

Dan Xing, Wei Liu, Jiao Jiao Li, Longwei Liu, Anqi Guo, Bin Wang, Hongsheng Yu, Yu Zhao, Yuling Chen, Zhifeng You, Cheng Lyu, Wenjing Li, Aifeng Liu, Yanan Du, Jianhao Lin,

Tissue engineering using traditional size fixed scaffolds and injectable biomaterials are faced with many limitations due to the difficulties of producing macroscopic functional tissues. In this study, 3D functional tissue constructs were developed by inducing self-assembly of microniches, which were cell-laden gelatin microcryogels. During self-assembly, the accumulation of extracellular matrix ... Read more >>

Acta Biomater (Acta biomaterialia)
[2020, 114:170-182]

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Managing keloid scars: From radiation therapy to actual and potential drug deliveries.

Chenyu Huang, Longwei Liu, Zhifeng You, Yanan Du, Rei Ogawa,

The aetiology of keloids is becoming clearer, but many questions remain, including about the most optimal treatment. Current therapies include surgical excision, radiotherapy, and various pharmaceutical drugs. However, none of these drugs are keloid-specific. Moreover, all current interventions are associated with high recurrence rates. Here, we review the pharmaceutical interventions ... Read more >>

Int Wound J (International wound journal)
[2019, 16(3):852-859]

Cited: 6 times

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3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening.

Yaqian Li, Xiaojun Yan, Wei Liu, Lyu Zhou, Zhifeng You, Yanan Du,

To upgrade traditional 2D cell culture to 3D cell culture, we have integrated microfabrication with cryogelation technology to produce macroporous microscale cryogels (microcryogels), which can be loaded with a variety of cell types to form 3D microtissues. Herein, we present the protocol to fabricate versatile 3D microtissues and their applications ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2017, (128):]

Cited: 1 time

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Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis.

Longwei Liu, Zhifeng You, Hongsheng Yu, Lyu Zhou, Hui Zhao, Xiaojun Yan, Dulei Li, Bingjie Wang, Lu Zhu, Yuzhou Xu, Tie Xia, Yan Shi, Chenyu Huang, Wei Hou, Yanan Du,

The role of pathological angiogenesis on liver fibrogenesis is still unknown. Here, we developed fibrotic microniches (FμNs) that recapitulate the interaction of liver sinusoid endothelial cells (LSECs) and hepatic stellate cells (HSCs). We investigated how the mechanical properties of their substrates affect the formation of capillary-like structures and how they ... Read more >>

Nat Mater (Nature materials)
[2017, 16(12):1252-1261]

Cited: 25 times

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Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGase.

Chunxiao Qi, Yaqian Li, Patrick Badger, Hongsheng Yu, Zhifeng You, Xiaojun Yan, Wei Liu, Yan Shi, Tie Xia, Jiahong Dong, Chenyu Huang, Yanan Du,

Targeted cell delivery to lesion sites via minimally invasive approach remains an unmet need in regenerative medicine to endow satisfactory therapeutic efficacy and minimized side-effects. Here, we rationally designed a pathology-targeted cell delivery strategy leveraging injectable micro-scaffolds as cell-loading capsule and endogenous tissue transglutaminase (TGase) at lesion site as adhesive. ... Read more >>

Biomaterials (Biomaterials)
[2017, 126:1-9]

Cited: 3 times

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Keloid progression: a stiffness gap hypothesis.

Chenyu Huang, Longwei Liu, Zhifeng You, Bingjie Wang, Yanan Du, Rei Ogawa,

Keloids are fibroproliferative skin disorders characterised clinically by continuous horizontal progression and post-surgical recurrence and histologically by the accumulation of collagen and fibroblast ingredients. Till now, their aetiology remains clear, which may cover genetic, environmental and metabolic factors. Evidence in the involvement of local mechanics (e.g. predilection site and typical ... Read more >>

Int Wound J (International wound journal)
[2017, 14(5):764-771]

Cited: 8 times

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