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Author Zhibin Chen

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Role of tight junction-associated MARVEL protein marvelD3 in migration and epithelial-mesenchymal transition of hepatocellular carcinoma.

Yanmeng Li, Teng Li, Donghu Zhou, Jia Wei, Zhenkun Li, Xiaojin Li, Siyu Jia, Qin Ouyang, Saiping Qi, Zhibin Chen, Bei Zhang, Jing Yu, Jidong Jia, Anjian Xu, Jian Huang,

MarvelD3, a recently identified tight junction membrane protein, could be associated with hepatocellular carcinoma (HCC). We aimed to investigate the role of marvelD3 in Epithelial-Mesenchymal Transition (EMT) and migration of HCC and explore the underlying molecular mechanisms. First, we assessed marvlD3 expression in HCC and normal liver tissues and found loss ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2021, 15(1):249-260]

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Apoptosis-induced translocation of centromere protein F in its corresponding autoantibody production in hepatocellular carcinoma

Xiaojin Li, Yanmeng Li, Anjian Xu, Donghu Zhou, Bei Zhang, Saiping Qi, Zhibin Chen, Xiaoming Wang, Xiaojuan Ou, Bangwei Cao, Chunfeng Qu, Jian Huang,

ABSTRACT Serum autoantibodies against tumor-associated antigen have important value in the early diagnosis of hepatocellular carcinoma (HCC), but the mechanism of autoantibody production is poorly understood. We previously showed that autoantibodies against the centromere protein F (CENPF) may be useful as an early diagnostic marker for HCC. Here we explored ... Read more >>

(Oncoimmunology)
[2021, 10(1):]

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Low prevalence of amyloid and tau pathology in drug-resistant temporal lobe epilepsy.

Juliana C Silva, Lucy Vivash, Charles B Malpas, Yong Hao, Catriona McLean, Zhibin Chen, Terence J O'Brien, Nigel C Jones, Patrick Kwan,

<h4>Objective</h4>Cognitive impairment is common in patients with chronic drug-resistant temporal lobe epilepsy (TLE). Hyperphosphorylated tau (pTau) and amyloid-β (Aβ) plaques, pathological hallmarks of Alzheimer disease, have been hypothesized to play a mechanistic role. We investigated Aβ plaques and pTau prevalence in TLE patients who underwent resective surgery and correlated their ... Read more >>

Epilepsia (Epilepsia)
[2021, :]

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Machine learning models for decision support in epilepsy management: A critical review.

Eliot D Smolyansky, Haris Hakeem, Zongyuan Ge, Zhibin Chen, Patrick Kwan,

<h4>Purpose</h4>There remain major challenges for the clinician in managing patients with epilepsy effectively. Choosing anti-seizure medications (ASMs) is subject to trial and error. About one-third of patients have drug-resistant epilepsy (DRE). Surgery may be considered for selected patients, but time from diagnosis to surgery averages 20 years. We reviewed the potential ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2021, 123:108273]

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Lymph Node Stromal Cell-Intrinsic MHC Class II Expression Promotes MHC Class I-Restricted CD8 T Cell Lineage Conversion to Regulatory CD4 T Cells.

Amanda M Honan, Emily N Vazquez, Zhibin Chen,

MHC class I (MHC-I)-restricted CD4<sup>+</sup> T cells have long been discovered in the natural repertoire of healthy humans as well as patients with autoimmune diseases or cancer, but the exact origin of these cells remains to be fully characterized. In mouse models, mature peripheral CD8<sup>+</sup> T cells have the potential ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2021, 207(6):1530-1544]

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Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells.

Yajie Lu, Min Zhang, Qinjun Wei, Zhibin Chen, Guangqian Xing, Jun Yao, Xin Cao,

GPRASP2 is implicated in nervous system diseases, tumors and immune inflammation. In our previous study, G protein-coupled receptor associated sorting protein 2 (GPRASP2) was identified as a novel causal gene for X-linked recessive syndromic hearing loss (SHL). However, the role of GPRASP2 in auditory function has not been elucidated. The ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 574:1-7]

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Surface Enhanced Raman Scattering on Silver sinusoidal nano-grating: Impact of Interactions of grating-coupled Surface Plasmon polaritons

Zhaoyi Chen, Ke Feng, Zhibin Chen, Jinxing Shen, Huanliang Li,

In this study, we reported a silver sinusoidal nanograting used in microchannels, forming H 2 O/Ag/NOA heterostructure, and studied the impact of interactions of grating-coupled surface Plasmon polaritons (SPPs) on Surface-enhanced Raman Scattering (SERS). FDTD simulations showed that when the refractive index of NOA is close to that of H ... Read more >>

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Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion.

David K Wright, Georgia F Symons, William T O'Brien, Stuart J McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D Brady, Mujun Sun, Meng Law, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz,

Sports-related concussion (SRC) is a serious health concern. However, the temporal profile of neuropathophysiological changes after SRC and how these relate to biological sex are still poorly understood. This preliminary study investigated whether diffusion-weighted magnetic resonance imaging (dMRI) was sensitive to neuropathophysiological changes following SRC; whether these changes were sex-specific; ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, 31(10):4411-4419]

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Angioplasty alone versus acute stenting for acute tandem occlusions due to internal carotid artery atherosclerotic.

Wei Li, Chenhao Zhao, Min Zhang, Shu Yang, Zhenqiang Zhao, Tan Wang, Liu Yang, Zhibin Chen,

<h4>Objective</h4>The aim of the study is to compare the efficacy and safety of angioplasty alone with acute stenting for acute tandem occlusions (TO) due to internal carotid artery atherosclerotic.<h4>Methods</h4>We identified 112 patients who underwent an endovascular treatment (EVT) for acute tandem internal carotid artery occlusions from the prospectively maintained registries ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2021, 208:106818]

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One step closer towards personalized epilepsy management.

Zhibin Chen, Alison Anderson, Zongyuan Ge, Patrick Kwan,

Brain (Brain : a journal of neurology)
[2021, 144(6):1624-1626]

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The cardiac STAT3 intercalated disc specific expression in tail suspension rat

He Dongyu, Hu Aihua, Tong Jun, Zheng Chang, Liu Yiming, Chen Zhibin, Gao Lingfeng, Wang Yang,

<h4>Background</h4> The cardiovascular system is significantly agitated by loss of gravity. In microgravity, the body fluids shift toward the thoracic cavity, induced the heart becomes more spherical. This further increased the cardiac preload with an increasing of transmural central venous pressure, affects the right heart ventricles to tolerating the enhanced ... Read more >>

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Autoimmunity as an Etiological Factor of Cancer: The Transformative Potential of Chronic Type 2 Inflammation.

Chris M Li, Zhibin Chen,

Recent epidemiological studies have found an alarming trend of increased cancer incidence in adults younger than 50 years of age and projected a substantial rise in cancer incidence over the next 10 years in this age group. This trend was exemplified in the incidence of non-cardia gastric cancer and its ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:664305]

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Effects of DSPP Gene Mutations on Periodontal Tissues.

Zhaojun Jing, Zhibin Chen, Yong Jiang,

Dentin sialophosphoprotein ( <i>DSPP</i> ) gene mutations cause autosomal dominantly inherited diseases. <i>DSPP</i> gene mutations lead to abnormal expression of DSPP, resulting in a series of histological, morphological, and clinical abnormalities. A large number of previous studies demonstrated that DSPP is a dentinal-specific protein, and <i>DSPP</i> gene mutations lead to ... Read more >>

Glob Med Genet (Global medical genetics)
[2021, 8(3):90-94]

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Study protocol for a phase II randomised, double-blind, placebo-controlled trial of perampanel as an antiepileptogenic treatment following acute stroke.

John-Paul Nicolo, Zhibin Chen, Bradford Moffat, David K Wright, Benjamin Sinclair, Rebecca Glarin, Andrew Neal, Vincent Thijs, Udaya Seneviratne, Bernard Yan, Geoffrey Cloud, Terence J O'Brien, Patrick Kwan,

<h4>Introduction</h4>Stroke is a common cause of epilepsy that may be mediated via glutamate dysregulation. There is currently no evidence to support the use of antiseizure medications as primary prevention against poststroke epilepsy. Perampanel has a unique antiglutamatergic mechanism of action and may have antiepileptogenic properties. This study aims to evaluate ... Read more >>

BMJ Open (BMJ open)
[2021, 11(5):e043488]

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Multiple drivers, interaction effects, and trade-offs of efficient and cleaner combustion of torrefied water hyacinth.

Hongyi Huang, Jingyong Liu, Laiguo Chen, Fatih Evrendilek, Hui Liu, Zhibin Chen,

Developing cleaner and affordable alternatives to the sole reliance on fossil fuels has intensified efforts to improve the thermochemical conversion property of the second-generation lignocellulosic biomass. This study aimed to explore the effects of the two torrefaction temperatures (200 and 300 °C), the two reaction atmospheres (N<sub>2</sub>/O<sub>2</sub> and CO<sub>2</sub>/O<sub>2</sub>), and ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 786:147278]

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Biodegradation of polylactic acid by yellow mealworms (larvae of Tenebrio molitor) via resource recovery: A sustainable approach for waste management.

Bo-Yu Peng, Zhibin Chen, Jiabin Chen, Xuefei Zhou, Wei-Min Wu, Yalei Zhang,

Polylactic acid (PLA) is biodegraded rapidly under composting or thermophilic temperature but slowly under natural conditions with substantial microplastics generated. In this study, we examined the feasibility of PLA biodegradation and developed a novel approach for PLA waste management using yellow mealworms (Tenebrio molitor larvae) to achieve biodegradation and resource ... Read more >>

J Hazard Mater (Journal of hazardous materials)
[2021, 416:125803]

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Short- and long-term outcomes of immediate and delayed treatment in epilepsy diagnosed after one or multiple seizures.

Sameer Sharma, Zhibin Chen, Maria Rychkova, John Dunne, Judy Lee, Nicholas Lawn, Patrick Kwan,

<h4>Objectives</h4>To compare the outcomes between immediate and deferred treatments in patients diagnosed after one or multiple (two or more) seizures.<h4>Methods</h4>Our observational study investigated seizure recurrence and 12-month seizure remission in patients with newly diagnosed epilepsy, comparing immediate to deferred treatment in patients diagnosed after one seizure or after two or ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2021, 117:107880]

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Development and validation of a clinical score to predict late seizures after intracerebral hemorrhage in Chinese.

Yan Wang, Zhen Li, Xiaosai Zhang, Zhibin Chen, Dongmei Li, Wenxian Chen, Jiamei Gu, Dongyun Sun, Ting Rong, Patrick Kwan,

<h4>Background</h4>Seizures are a frequent complication after intracerebral hemorrhage (ICH). The CAVE score was developed in Europeans to predict late seizures after ICH. Given the higher incidence of ICH in Asians, we aimed to develop and validate a clinical scoring tool for predicting post-ICH late seizures in Chinese.<h4>Methods</h4>We retrospectively included patients ... Read more >>

Epilepsy Res (Epilepsy research)
[2021, 172:106600]

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Role of tight junction-associated MARVEL protein marvelD3 in migration and Epithelial–Mesenchymal Transition of hepatocellular carcinoma

Yanmeng Li, Teng Li, Donghu Zhou, Jia Wei, Zhenkun Li, Xiaojin Li, Siyu Jia, Qin Ouyang, Saiping Qi, Zhibin Chen, Bei Zhang, Jing Yu, Jidong Jia, Anjian Xu, Jian Huang,

<h4>Background: </h4> Tight junction (TJ) imbalance is associated with hepatocellular carcinoma (HCC). MarvelD3, which contains a conserved MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain similarly to occludin and tricellulin, is a recently identified integral membrane protein that forms TJs. However, little is known about the ... Read more >>

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Predictors of New-Onset Epilepsy in People With Younger-Onset Neurocognitive Disorders.

Xinshi Wang, Samantha M Loi, Emma Foster, Zhibin Chen, Dennis Velakoulis, Patrick Kwan,

<b>Objective:</b> People with neurocognitive disorders (NCDs) have an increased risk of epilepsy. However, most studies investigating the risk of seizures in people with NCDs are limited to those with Alzheimer's disease (AD) and vascular dementia (VD), and those who developed dementia after age 65 years. A knowledge gap exists regarding ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2021, 13:637260]

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Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans.

Ye Xu, Lin Zhang, Yan Liu, Irini Topalidou, Cera Hassinan, Michael Ailion, Zhenqiang Zhao, Tan Wang, Zhibin Chen, Jihong Bai,

Animals require robust yet flexible programs to support locomotion. Here we report a pathway that connects the D1-like dopamine receptor DOP-1 with a sleep mechanism to modulate swimming in <i>C. elegans</i>. We show that DOP-1 plays a negative role in sustaining swimming behavior. By contrast, a pathway through the D2-like dopamine ... Read more >>

iScience (iScience)
[2021, 24(4):102247]

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Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans

Ye Xu, Lin Zhang, Yan Liu, Irini Topalidou, Cera Hassinan, Michael Ailion, Zhenqiang Zhao, Tan Wang, Zhibin Chen, Jihong Bai,

<h4>Summary</h4> Animals require robust yet flexible programs to support locomotion. While it is clear that a variety of processes must be engaged to ensure rhythmic actions, the exact mechanisms remain largely unknown. Here we report a novel pathway that connects the D1-like dopamine receptor DOP-1 with a sleep mechanism to ... Read more >>

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Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis.

Israa Alfares, Muhammad Shahid Javaid, Zhibin Chen, Alison Anderson, Ana Antonic-Baker, Patrick Kwan,

<h4>Background</h4>Cutaneous adverse drug reactions (cADRs) are one of the most common, severe, and life-threatening types of adverse reactions following treatment with antiseizure medications (ASMs). Some studies have reported a higher incidence of ASM-induced cADRs in females than in males.<h4>Objective</h4>This study sought to perform a systematic review, meta-analysis, and meta-regression to ... Read more >>

CNS Drugs (CNS drugs)
[2021, 35(2):161-176]

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Treatment of periodontal intrabony defects using bovine porous bone mineral and guided tissue regeneration with/without platelet-rich fibrin: a randomized controlled clinical trial.

Kaining Liu, Zhen Huang, Zhibin Chen, Bing Han, Xiangying Ouyang,

<h4>Background</h4>To investigate the regenerative effect of adjunctive use of guided tissue regeneration (GTR), bovine porous bone mineral (BPBM), and platelet-rich fibrin (PRF) in intrabony defects.<h4>Methods</h4>Fourteen participants were enrolled, and for each patient their left and right two sides were randomized to the test group or control group. Only the worst ... Read more >>

J Periodontol (Journal of periodontology)
[2021, :]

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Phloem Delivery of Fludioxonil by Plant Amino Acid Transporter-Mediated Polysuccinimide Nanocarriers for Controlling Fusarium Wilt in Banana.

Hanxiang Wu, Pengtong Hu, Ye Xu, Chunxia Xiao, Zhibin Chen, Xiaojing Liu, Jinliang Jia, Hanhong Xu,

Fusarium wilt disease poses a serious threat to the global production of bananas. The targeted delivery of fungicides to banana phloem tissues may offer new hope for controlling this hard-to-treat vascular disease. In this study, fludioxonil (FLU)-loaded glycine methyl ester-conjugated polysuccinimide nanoparticles (PGA) were prepared with a loading efficiency (LE) ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2021, 69(9):2668-2678]

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