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Predictive serum biomarkers of patients with cerebral infarction.

Yan Kong, Yu-Qing Feng, Ya-Ting Lu, Shi-Sui Feng, Zheng Huang, Qian-Yi Wang, Hui-Min Huang, Xue Ling, Zhi-Heng Su, Yue Guo,

<h4>Objectives</h4>Stroke is the third most common cause of death and also causes seizures and disability. Biomarkers are abnormal signal indicators at the biological level that are present before the organism is seriously affected and are more sensitive to early diagnosis than are traditional imaging methods. Early diagnosis of stroke can ... Read more >>

Neurol Res (Neurological research)
[2021, :1-11]

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Urinary metabonomics study of anti-depressive mechanisms of Millettia speciosa Champ on rats with chronic unpredictable mild stress-induced depression.

Chi Zhang, Yi-Yi Mo, Shi-Sui Feng, Ming-Wei Meng, Si-Ying Chen, Hui-Min Huang, Xue Ling, Hui Song, Yong-Hong Liang, Song-Feng Ou, Hong-Wei Guo, Zhi-Heng Su,

As a traditional Chinese medicine (TCM), Millettia speciosa Champ (MSC), exerts a wide range of pharmacological activities. Our research group previously found that MSC has antidepressant effects, but the specific antidepressant mechanisms remain unclear. Therefore, in this study, urine metabolomics based on ultra-performance liquid chromatography/quadrupole time of flight mass spectrometry ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 205:114338]

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Simultaneous Measurement of Tadehaginoside and its Principal Metabolite in Rats by HPLC–MS/MS and its Application in Pharmacokinetics and Tissue Distribution Study

Cai-Yun Zhang, Ya-Ting Lu, Yin-Feng Tan, Lin Dong, Zhi-Heng Su, Xiao-Po Zhang,

<h4>Background: </h4> Tadehaginoside, an active ingredient isolated from Tadehagi triquetrum L., exhibited various biological activities. However, the pharmacokinetics and tissue-distribution which affects tadehaginoside’s therapeutic actions and application remain elusive.MethodsTo clarify the metabolism of tadehaginoside in vivo , a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established to detect the ... Read more >>

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The study of neuroprotective effect of ferulic acid based on cell metabolomics.

Chun-Li Yin, Ri-Gang Lu, Jin-Fang Zhu, Hui-Min Huang, Xi Liu, Qiao-Feng Li, Yi-Yi Mo, Hong-Jia Zhu, Bonnie Chin, Jin-Xia Wu, Xu-Wen Liu, Bang Cheng, Jun-Xiang Ruan, Yong-Hong Liang, Hui Song, Hong-Wei Guo, Zhi-Heng Su, Hua Zheng,

Ferulic acid (FA), a naturally derived phenolic compound, has antioxidant and antidepressant-like effects. It is still a challenge to study its mechanism due to the complexity of the pathophysiology of depression. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to perform metabolomics ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2019, 864:172694]

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Comparative analysis of the compatibility effects of Danggui-Sini Decoction on a blood stasis syndrome rat model using untargeted metabolomics.

Jin-Xia Wu, Hua Zheng, Xia Yao, Xu-Wen Liu, Hong-Jia Zhu, Chun-Li Yin, Xi Liu, Yi-Yi Mo, Hui-Min Huang, Bang Cheng, Fang Wu, Zhao-Ni Chen, Fang-Ming Song, Jun-Xiang Ruan, Hong-Ye Zhang, Ping Liu, Yong-Hong Liang, Hui Song, Hong-Wei Guo, Zhi-Heng Su,

Danggui-Sini Decoction (DSD) is one of the most widely used traditional Chinese medicine formulae (TCMF) for treating various diseases caused by cold coagulation and blood stasis due to its effect of nourishing blood to warm meridians in clinical use. However, studies of the mechanism of how it dispels blood stasis ... Read more >>

J Chromatogr B Analyt Technol Biomed Life Sci (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences)
[2019, 1105:164-175]

Cited: 3 times

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Investigation of the hepatoprotective effect of Corydalis saxicola Bunting on carbon tetrachloride-induced liver fibrosis in rats by 1H-NMR-based metabonomics and network pharmacology approaches.

Xu-Wen Liu, Chao-Ling Tang, Hua Zheng, Jin-Xia Wu, Fang Wu, Yi-Yi Mo, Xi Liu, Hong-Jia Zhu, Chun-Li Yin, Bang Cheng, Jun-Xiang Ruan, Fang-Ming Song, Zhao-Ni Chen, Hui Song, Hong-Wei Guo, Yong-Hong Liang, Zhi-Heng Su,

Liver fibrosis is a common consequence of chronic liver diseases resulting from multiple etiologies. Furthermore, prolonged unresolved liver fibrosis may gradually progress to cirrhosis, and eventually evolve into hepatocellular carcinoma (HCC). Corydalis saxicola Bunting (CS), a type of traditional Chinese folk medicine, has been reported to have hepatoprotective effects on ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2018, 159:252-261]

Cited: 5 times

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Urinary metabonomics study of the hepatoprotective effects of total alkaloids from Corydalis saxicola Bunting on carbon tetrachloride-induced chronic hepatotoxicity in rats using 1H NMR analysis.

Fang Wu, Hua Zheng, Zheng-Teng Yang, Bang Cheng, Jin-Xia Wu, Xu-Wen Liu, Chao-Ling Tang, Shi-Yin Lu, Zhao-Ni Chen, Fang-Ming Song, Jun-Xiang Ruan, Hong-Ye Zhang, Yong-Hong Liang, Hui Song, Zhi-Heng Su,

Chronic liver injury has been shown to cause liver fibrosis due to the sustained pathophysiological wound healing response of the liver, and eventually progresses to cirrhosis. The total alkaloids of Corydalis saxicola Bunting (TACS), a collection of important bioactive ingredients derived from the traditional Chinese folk medicine Corydalis saxicola Bunting ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2017, 140:199-209]

Cited: 8 times

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Serum metabonomics study of the hepatoprotective effect of Corydalis saxicola Bunting on carbon tetrachloride-induced acute hepatotoxicity in rats by (1)H NMR analysis.

Yong-Hong Liang, Chao-Ling Tang, Shi-Yin Lu, Bang Cheng, Fang Wu, Zhao-Ni Chen, Fangming Song, Jun-Xiang Ruan, Hong-Ye Zhang, Hui Song, Hua Zheng, Zhi-Heng Su,

Corydalis saxicola Bunting (CS), a traditional Chinese folk medicine, has been effectively used for treating liver disease in Zhuang nationality in South China. However, the exact hepatoprotective mechanism of CS was still looking forward to further elucidation by far. In present work, metabonomic study of biochemical changes in the serum ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2016, 129:70-79]

Cited: 9 times

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[Discrimination of Chemical Constituents Changes of Citrus reticulata Pericarp Before and After Processing with Vinegar Based on Partial Least Squares-Discriminate Analysis].

Jun-xiang Ruan, Zhi-heng Su, Yong-hong Liang, Xiu-cai Wu, Hui Song, Hua Zheng,

<h4>Objective</h4>To investigate the chemical constituents changes of Citrus reticulata pericarp before and after processing with vinegar,and to provide scientific basis for the study of active components in Citrus reticulata pericarp.<h4>Methods</h4>Citrus reticulata pericarp was processed with vinegar according to the Zhongyao Paozhixue Cidian. The extracts of unprocessed and processed Citrus reticulata ... Read more >>

Zhong Yao Cai (Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials)
[2016, 39(1):70-73]

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[¹H-NMR based metabonomic approach to evaluate anti-coagulant effect of Danggui Sini decoction].

Hua Zheng, Xia Qin, Hui Song, Chao-lin Tang, Jun-xiang Ruan, Hong-ye Zhang, Shi-yin Lu, Yong-hong Liang, Zhi-heng Su,

To study the anti-coagulant effect and influence of danggui Sini decoction (DSD) on rat's plasma endogenous metabolites by animal experiment and ¹H-NMR based metabolomics method. After intragastric administration of Danggui Sini Decoction for 7 days, Plasma thrombin time (TT) was measured. Rat plasma metabolic fingerprint in two groups was analyzed ... Read more >>

Zhongguo Zhong Yao Za Zhi (Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica)
[2015, 40(20):4088-4093]

Cited: 3 times

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Characterization and determination of antioxidant components in the leaves of Camellia chrysantha (Hu) Tuyama based on composition-activity relationship approach.

Jin-Bin Wei, Xiong Li, Hui Song, Yong-Hong Liang, Yu-Zheng Pan, Jun-Xiang Ruan, Xia Qin, Yong-Xin Chen, Cai-Li Nong, Zhi-Heng Su,

Camellia chrysantha (Hu) Tuyama (CCT), an ornamental plant possessing antioxidant activity, has been infused as tea and drank for its health benefits. The antioxidant components in CCT, however, had not been clearly characterized. To quickly identify the antioxidant constituents of CCT, a composition-activity relationship strategy based on ultra high-pressure liquid ... Read more >>

J Food Drug Anal (Journal of food and drug analysis)
[2015, 23(1):40-48]

Cited: 1 time

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Hippocampus and serum metabolomic studies to explore the regulation of Chaihu-Shu-Gan-San on metabolic network disturbances of rats exposed to chronic variable stress.

Zhi-heng Su, Hong-mei Jia, Hong-wu Zhang, Yu-Fei Feng, Lei An, Zhong-mei Zou,

Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine formula, has been effectively used for the treatment of depression. However, studies of its anti-depressive mechanism are challenging, due to the complex pathophysiology of depression, and complexity of CSGS with multiple constituents acting on different receptors. In the present work, metabolomic studies of biochemical ... Read more >>

Mol Biosyst (Molecular bioSystems)
[2014, 10(3):549-561]

Cited: 14 times

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Urinary metabonomics study of anti-depressive effect of Chaihu-Shu-Gan-San on an experimental model of depression induced by chronic variable stress in rats.

Zhi-Heng Su, Shu-Qi Li, Guo-An Zou, Chang-Yuan Yu, Yan-Guo Sun, Hong-Wu Zhang, Ying Gu, Zhong-Mei Zou,

Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula, has been effectively used for the treatment of depression in clinic. However, studies of its anti-depressive mechanism are challenging, accounted for the complex pathophysiology of depression, and complexity of CSGS with multiple constituents acting on different metabolic pathways. The variations of endogenous ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2011, 55(3):533-539]

Cited: 48 times

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Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook.

Guo-An Zou, Zhi-Heng Su, Hong-Wu Zhang, Yuan Wang, Jun-Shan Yang, Zhong-Mei Zou,

A new flavone, named crotoncaudatin (1), was isolated from the stems of Croton caudatus Geisel. var. tomentosus Hook., together with nine known analogues: 3,5,6,7,8,3',4'-heptamethoxyflavone (2), tangeretin (3), nobiletin (4), 5,6,7,4'-tetramethoxy-flavone (5), sinensetin (6), kaempferol (7), tiliroside (8), kaempferol-3-O-rutinoside (9) and rutin (10). The structures of the above compounds were established ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2010, 15(3):1097-1102]

Cited: 12 times

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Online identification of the antioxidant constituents of traditional Chinese medicine formula Chaihu-Shu-Gan-San by LC-LTQ-Orbitrap mass spectrometry and microplate spectrophotometer.

Zhi-Heng Su, Guo-An Zou, Alfred Preiss, Hong-Wu Zhang, Zhong-Mei Zou,

Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in treatment of gastritis, peptic ulcer, irritable bowel syndrome and depression clinically. However, the chemical constituents in CSGS had not been studied so far. To quickly identify the chemical constituents of CSGS and to understand ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2010, 53(3):454-461]

Cited: 25 times

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Lactonecembranoids from Croton laevigatus.

Guo-An Zou, Gang Ding, Zhi-Heng Su, Jun-Shan Yang, Hone-Wu Zhang, Chao-Zhong Peng, Haiji Akber Aisa, Zhong-Mei Zou,

Six new cembranoids, laevigatlactones A-F (1-6), and the known compound neocrotocembraneic acid (7) were isolated from leaves of Croton laevigatus. Their structures were elucidated on the basis of spectroscopic analysis, and that of 1 was confirmed by X-ray crystallography. Compound 2 exhibited modest cytotoxicity against HeLa cells, with an IC(50) ... Read more >>

J Nat Prod (Journal of natural products)
[2010, 73(4):792-795]

Cited: 14 times

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