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Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation.

Qin Jiang, Keli Huang, Fang Lu, Shaoping Deng, Zhenglin Yang, Shengshou Hu,

Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient ... Read more >>

Gen Thorac Cardiovasc Surg (General thoracic and cardiovascular surgery)
[2021, :]

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Identification and Pyramid of QTLs Based on Rice Short-wide Grain CSSL-Z414, SSSL, DSSL and Candidate Gene Analysis of qGL11 and qGW5

Juan Li, Hongxia Yang, Guangyi Xu, Keli Deng, Jinjin Yu, Siqian Xiang, Kai Zhou, Qiuli Zhang, Ruxiang Li, Miaomiao Li, Yinghua Ling, Zhenglin Yang, Guanghua He, Fangming Zhao,

<h4>Background: </h4> Most of rice agronomic traits as grain length etc. are complex traits controlled by multiple genes. Chromosome segment substitution lines (CSSLs) are ideal materials for dissecting and studying of these complex traits. ResultsA rice short-wide grain CSSL Z414 was identified among progeny of the recipient parent Xihui 18 ... Read more >>

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A quick protocol for the preparation of mouse retinal cryosections for immunohistochemistry.

Jialiang Yang, Tongdan Zou, Fang Yang, Zilong Zhang, Chen Sun, Zhenglin Yang, Houbin Zhang,

Immunohistochemistry (IHC) using mouse retinal cryosections is widely used to study the expression and intracellular localization of proteins in mouse retinas. Conventionally, the preparation of retinal cryosections from mice involves tissue fixation, cryoprotection, the removal of the cornea and lens, embedding and sectioning. The procedure takes 1-2 days to complete. ... Read more >>

Open Biol (Open biology)
[2021, 11(7):210076]

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The association of OPG polymorphisms with diabetic retinopathy in Chinese population.

Huijuan Xu, Huan Li, Qian Luo, Yihui Li, Guo Huang, Chuntao Lei, Fang Hao, Jialing Xiao, Chen Yang, Man Yu, Ziyang Wang, Yi Shi, Ling Zhong, Lixin Duan, Huafu Chen, Yao Dezhong, Bo Gong, Zhenglin Yang,

<h4>Purpose</h4>Genetic factors have been studied to be associated with diabetic retinopathy (DR). This study aimed to investigate the association between the polymorphisms in the <i>osteoproterin</i> (<i>OPG</i>) gene and DR in a Han Chinese population.<h4>Methods</h4>There were 475 patients with diabetic retinopathy (DR), 478 type 2 diabetes mellitus without retinopathy (DNR) and ... Read more >>

Ophthalmic Genet (Ophthalmic genetics)
[2021, :1-5]

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Probing the Functional and Structural Connectivity Underlying EEG Traveling Waves.

Yun Qin, Nan Zhang, Yan Chen, Yue Tan, Zhenglin Yang, Yi Shi, Cheng Luo, Tiejun Liu, Dezhong Yao,

Neural oscillations play an important role in the maintenance of brain function by regulating multi-scale neural activity. Characterizing the traveling properties of EEG is helpful for understanding the spatiotemporal dynamics of neural oscillations. However, traveling EEG based on non-invasive approach has little been investigated, and the relationship with brain intrinsic ... Read more >>

Brain Topogr (Brain topography)
[2021, :]

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PNA-Assisted DNAzymes to Cleave Double-Stranded DNA for Genetic Engineering with High Sequence Fidelity.

Mingkuan Lyu, Linggen Kong, Zhenglin Yang, Yuting Wu, Claire E McGhee, Yi Lu,

DNAzymes have been widely used in many sensing and imaging applications but have rarely been used for genetic engineering since their discovery in 1994, because their substrate scope is mostly limited to single-stranded DNA or RNA, whereas genetic information is stored mostly in double-stranded DNA (dsDNA). To overcome this major ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(26):9724-9728]

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Brain variability in dynamic resting-state networks identified by fuzzy entropy: a scalp EEG study.

Fali Li, Lin Jiang, Yuanyuan Liao, Yajing Si, Chanli Yi, Yangsong Zhang, Xianjun Zhu, Zhenglin Yang, Dezhong Yao, Zehong Cao, Peng Xu,

<i>Objective.</i>Exploring the temporal variability in spatial topology during the resting state attracts growing interest and becomes increasingly useful to tackle the cognitive process of brain networks. In particular, the temporal brain dynamics during the resting state may be delineated and quantified aligning with cognitive performance, but few studies investigated the ... Read more >>

J Neural Eng (Journal of neural engineering)
[2021, 18(4):]

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Whole-Exome Sequencing Reveals Novel TSPAN12 Variants in Autosomal Dominant Familial Exudative Vitreoretinopathy.

Chen Chen, Mu Yang, Lulin Huang, Rulian Zhao, Periasamy Sundaresan, Xianjun Zhu, Shujin Li, Zhenglin Yang,

<b><i>Background:</i></b> Familial exudative vitreoretinopathy (FEVR), a group of rare inherited retinal vascular disorders, is the major cause of vision loss in juveniles. At present, the diagnosis of FEVR remains difficult due to its clinical and genetic heterogeneities. <b><i>Aims:</i></b> To identify the causative genetic variants in two unrelated FEVR-affected families: one ... Read more >>

Genet Test Mol Biomarkers (Genetic testing and molecular biomarkers)
[2021, 25(6):399-404]

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The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis.

Mu Yang, Shujin Li, Wenjing Liu, Xiao Li, Yunqi He, Yeming Yang, Kuanxiang Sun, Lin Zhang, Wanli Tian, Lixin Duan, Huafu Chen, Dezhong Yao, Zhenglin Yang, Xianjun Zhu,

The endoplasmic reticulum (ER) membrane protein complex (EMC) regulates the synthesis and quality control of membrane proteins with multiple transmembrane domains. One of the membrane spanning subunits, EMC3, is a core member of the EMC complex that provides essential hydrophilic vestibule for substrate insertion. Here, we show that the EMC ... Read more >>

Sci China Life Sci (Science China. Life sciences)
[2021, :]

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Whole-Exome Sequencing Identified DLG1 as a Candidate Gene for Familial Exudative Vitreoretinopathy.

Shanshan Zhang, Xiao Li, Wenjing Liu, Xiang Zhang, Lulin Huang, Shujin Li, Mu Yang, Peiquan Zhao, Jiyun Yang, Ping Fei, Xianjun Zhu, Zhenglin Yang,

<b><i>Purpose:</i></b> Familial exudative vitreoretinopathy (FEVR) is a blinding retinal vascular disease. Clinically, FEVR is characterized by incomplete vascularization of the peripheral retina and pathological neovascularization. Only about 50% of FEVR cases can be explained by known FEVR disease gene variations. This study aimed to identify novel genes associated with the ... Read more >>

Genet Test Mol Biomarkers (Genetic testing and molecular biomarkers)
[2021, 25(5):309-316]

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Identification and Pyramiding of QTLs for Rice Grain Size Based on Short-Wide Grain CSSL-Z563 and Fine-Mapping of qGL3-2.

Peixuan Liang, Hui Wang, Qiuli Zhang, Kai Zhou, Miaomiao Li, Ruxiang Li, Siqian Xiang, Ting Zhang, Yinghua Ling, Zhenglin Yang, Guanghua He, Fangming Zhao,

<h4>Background</h4>Chromosome segment substitution lines (CSSLs) can be used to dissect complex traits, from which single-segment substitution lines (SSSLs) containing a target quantitative trait loci (QTL) can be developed, and they are thus important for functional analysis and molecular breeding.<h4>Results</h4>A rice line with short wide grains, CSSL-Z563, was isolated from advanced-generation ... Read more >>

Rice (N Y) (Rice (New York, N.Y.))
[2021, 14(1):35]

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Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia.

Xiangjia Zhu, Yu Du, Dan Li, Jie Xu, Qingfeng Wu, Wenwen He, Keke Zhang, Jie Zhu, Linying Guo, Ming Qi, Ailin Liu, Jiao Qi, Guangyu Wang, Jiaqi Meng, Zhenglin Yang, Kang Zhang, Yi Lu,

High myopia is a leading cause of blindness worldwide. Myopia progression may lead to pathological changes of lens and affect the outcome of lens surgery, but the underlying mechanism remains unclear. Here, we find an increased lens size in highly myopic eyes associated with up-regulation of β/γ-crystallin expressions. Similar findings ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2102]

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Cell Surface Engineering Using DNAzymes: Metal Ion Mediated Control of Cell-Cell Interactions.

Ruo-Can Qian, Ze-Rui Zhou, Weijie Guo, Yuting Wu, Zhenglin Yang, Yi Lu,

Regulating cell-cell interactions and cell behaviors via cell surface engineering is of significance for biological research such as cell fate control and cell therapy. While extensive efforts have been made to induce cell-cell assembly via various cell surface modifications triggered by macromolecules or organic metabolites, controllable cell-cell interactions that include ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(15):5737-5744]

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Dynamic blood single-cell immune responses in patients with COVID-19.

Lulin Huang, Yi Shi, Bo Gong, Li Jiang, Zhixin Zhang, Xiaoqi Liu, Jialiang Yang, Yongquan He, Zhilin Jiang, Ling Zhong, Juan Tang, Chunfang You, Qi Jiang, Bo Long, Tao Zeng, Mei Luo, Fanwei Zeng, Fanxin Zeng, Shuqiang Wang, Xingxiang Yang, Zhenglin Yang,

The 2019 coronavirus disease (COVID-19) outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency. However, the virus' pathogenesis remains unclear, and there is no cure for the disease. We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5' ... Read more >>

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2021, 6(1):110]

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Integrative analyses identify potential key genes and pathways in Keshan disease using whole-exome sequencing

Jichang Huang, Chenqing Zheng, Rong Luo, Mingjiang Liu, Qingquan Gu, Jinshu Li, Xiushan Wu, Zhenglin Yang, Xia Shen, Xiaoping Li,

Keshan disease (KD), an endemic heart disease with multifocal necrosis and replacement fibrosis of the myocardium,is still a nightmare situation for human health. However, molecular mechanism in the pathogenesis of KD remains unclear. Herein, blood samples were collected from 68 KD patients and 100 controls, and we systematically analyzed mutation ... Read more >>

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The Clinical Prognosis of Presence and Location of Late Gadolinium Enhancement by Cardiac Magnetic Resonance Imaging in Patients with Hypertrophic Cardiomyopathy: a Single-Center Cohort Study.

Xiaoping Li, Li Lai, Rong Luo, Hao Yang, Huihui Ma, Zhenglin Yang, Shihua Zhao, Wilber Su, Wei Hua,

Increasing data have indicated that late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) images is associated with the clinical prognosis of hypertrophic cardiomyopathy (HCM). Recently, pioneer studies indicated that the location of LGE in CMR images also had potential predictive value for HCM prognosis. The aim of the present ... Read more >>

J Cardiovasc Transl Res (Journal of cardiovascular translational research)
[2021, :]

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Identification and pyramiding of QTLs for rice grain size based on short-wide grain CSSL-Z563 and fine-mapping of qGL3-2

Peixuan Liang, Hui Wang, Qiuli Zhang, Kai Zhou, Miaomiao Li, Ruxiang Li, Siqian Xiang, Ting Zhang, Yinghua Ling, Zhenglin Yang, Guanghua He, Fangming Zhao,

<h4>Background: </h4> Chromosome segment substitution lines (CSSLs) can be used to dissect complex traits, from which single-segment substitution lines (SSSLs) containing a target quantitative trait loci (QTL) can be developed, and they are thus important for functional analysis and molecular breeding. <h4>Results: </h4>: A rice line with short wide grains, ... Read more >>

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Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling.

Xianjun Zhu, Mu Yang, Peiquan Zhao, Shujin Li, Lin Zhang, Lulin Huang, Yi Huang, Ping Fei, Yeming Yang, Shanshan Zhang, Huijuan Xu, Ye Yuan, Xiang Zhang, Xiong Zhu, Shi Ma, Fang Hao, Periasamy Sundaresan, Weiquan Zhu, Zhenglin Yang,

Familial exudative vitreoretinopathy (FEVR) is a severe retinal vascular disease that causes blindness. FEVR has been linked to mutations in several genes associated with inactivation of the Norrin/β-catenin signaling pathway, but these account for only approximately 50% of cases. We report that mutations in α-catenin (CTNNA1) cause FEVR by overactivating ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(6):]

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Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.

Jingyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi, Linlin Bao, Fei Mo, Xue Li, Yong Huang, Weiqi Hong, Yun Yang, Yuan Zhao, Fei Ye, Sheng Lin, Wei Deng, Hua Chen, Hong Lei, Ziqi Zhang, Min Luo, Hong Gao, Yue Zheng, Yanqiu Gong, Xiaohua Jiang, Yanfeng Xu, Qi Lv, Dan Li, Manni Wang, Fengdi Li, Shunyi Wang, Guanpeng Wang, Pin Yu, Yajin Qu, Li Yang, Hongxin Deng, Aiping Tong, Jiong Li, Zhenling Wang, Jinliang Yang, Guobo Shen, Zhiwei Zhao, Yuhua Li, Jingwen Luo, Hongqi Liu, Wenhai Yu, Mengli Yang, Jingwen Xu, Junbin Wang, Haiyan Li, Haixuan Wang, Dexuan Kuang, Panpan Lin, Zhengtao Hu, Wei Guo, Wei Cheng, Yanlin He, Xiangrong Song, Chong Chen, Zhihong Xue, Shaohua Yao, Lu Chen, Xuelei Ma, Siyuan Chen, Maling Gou, Weijin Huang, Youchun Wang, Changfa Fan, Zhixin Tian, Ming Shi, Fu-Sheng Wang, Lunzhi Dai, Min Wu, Gen Li, Guangyu Wang, Yong Peng, Zhiyong Qian, Canhua Huang, Johnson Yiu-Nam Lau, Zhenglin Yang, Yuquan Wei, Xiaobo Cen, Xiaozhong Peng, Chuan Qin, Kang Zhang, Guangwen Lu, Xiawei Wei,

Nature (Nature)
[2021, 590(7844):E23]

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The CC-NB-LRR OsRLR1 mediates rice disease resistance through interaction with OsWRKY19.

Dan Du, Changwei Zhang, Yadi Xing, Xin Lu, Linjun Cai, Han Yun, Qiuli Zhang, Yingying Zhang, Xinlong Chen, Mingming Liu, Xianchun Sang, Yinghua Ling, Zhenglin Yang, Yunfeng Li, Benoit Lefebvre, Guanghua He,

Nucleotide-binding site-leucine-rich repeat (NB-LRR) resistance proteins are critical for plant resistance to pathogens; however, their mechanism of activation and signal transduction is still not well understood. We identified a mutation in an as yet uncharacterized rice coiled-coil (CC)-NB-LRR, Oryza sativa RPM1-like resistance gene 1 (OsRLR1), which leads to hypersensitive response ... Read more >>

Plant Biotechnol J (Plant biotechnology journal)
[2021, 19(5):1052-1064]

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Improving Detection Efficiency of SARS-CoV-2 Nucleic Acid Testing.

Jie Zhang, Kecheng Li, Ling Zheng, Jianbo Zhang, Zhilin Ren, Tiange Song, Hua Yu, Zhenglin Yang, Li Wang, Li Jiang,

<h4>Background</h4>SARS-CoV-2 nucleic acid testing (NAT) has been routinely used for COVID-19 diagnosis during this pandemic; however, there have been concerns about its high false negative rate. We dissected its detection efficiency with a large COVID-19 cohort study.<h4>Methods</h4>We analyzed SARS-CoV-2 NAT positive rates of 4,275 specimens from 532 COVID-19 patients in ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:558472]

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Dysfunction of VIPR2 leads to myopia in humans and mice.

Fuxin Zhao, Qihang Li, Wei Chen, He Zhu, Dengke Zhou, Peter Sol Reinach, Zhenglin Yang, Mingguang He, Anquan Xue, Deng Wu, Tianzi Liu, Qian Fu, Changqing Zeng, Jia Qu, Xiangtian Zhou,

<h4>Background</h4>Myopia is the leading cause of refractive errors. As its pathogenesis is poorly understood, we determined if the retinal VIP-VIPR2 signalling pathway axis has a role in controlling signalling output that affects myopia development in mice.<h4>Methods</h4>Association analysis meta-study, single-cell transcriptome, bulk RNA sequencing, pharmacological manipulation and VIPR2 gene knockout studies ... Read more >>

J Med Genet (Journal of medical genetics)
[2020, :]

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G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity.

Guanying Feng, Jingshu Cai, Yunchuanxiang Huang, Xianjun Zhu, Bo Gong, Zhenglin Yang, Chunhong Yan, Zhuowei Hu, Lu Yang, Ziyan Wang,

Due to its intricate heterogeneity and limited treatment, hepatocellular carcinoma (HCC) has been considered a major cause of cancer-related mortality worldwide. Increasing evidence indicates that G-protein-coupled estrogen receptor 1 (GPER1) can promote estrogen-dependent hepatocellular proliferation by activating AKT signaling. The mTOR complex 2 (mTORC2), whose integrity and activity are modulated ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2020, 18(12):1863-1875]

Cited: 1 time

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Author Correction: Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China.

Xin Xu, Jian Sun, Sheng Nie, Huiyuan Li, Yaozhong Kong, Min Liang, Jinlin Hou, Xianzhong Huang, Dongfeng Li, Tean Ma, Jiaqing Peng, Shikui Gao, Yong Shao, Hong Zhu, Johnson Yiu-Nam Lau, Guangyu Wang, Chunbao Xie, Li Jiang, Ailong Huang, Zhenglin Yang, Kang Zhang, Fan Fan Hou,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Med (Nature medicine)
[2020, 26(9):1494]

Cited: 9 times

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A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.

Jingyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi, Linlin Bao, Fei Mo, Xue Li, Yong Huang, Weiqi Hong, Yun Yang, Yuan Zhao, Fei Ye, Sheng Lin, Wei Deng, Hua Chen, Hong Lei, Ziqi Zhang, Min Luo, Hong Gao, Yue Zheng, Yanqiu Gong, Xiaohua Jiang, Yanfeng Xu, Qi Lv, Dan Li, Manni Wang, Fengdi Li, Shunyi Wang, Guanpeng Wang, Pin Yu, Yajin Qu, Li Yang, Hongxin Deng, Aiping Tong, Jiong Li, Zhenling Wang, Jinliang Yang, Guobo Shen, Zhiwei Zhao, Yuhua Li, Jingwen Luo, Hongqi Liu, Wenhai Yu, Mengli Yang, Jingwen Xu, Junbin Wang, Haiyan Li, Haixuan Wang, Dexuan Kuang, Panpan Lin, Zhengtao Hu, Wei Guo, Wei Cheng, Yanlin He, Xiangrong Song, Chong Chen, Zhihong Xue, Shaohua Yao, Lu Chen, Xuelei Ma, Siyuan Chen, Maling Gou, Weijin Huang, Youchun Wang, Changfa Fan, Zhixin Tian, Ming Shi, Fu-Sheng Wang, Lunzhi Dai, Min Wu, Gen Li, Guangyu Wang, Yong Peng, Zhiyong Qian, Canhua Huang, Johnson Yiu-Nam Lau, Zhenglin Yang, Yuquan Wei, Xiaobo Cen, Xiaozhong Peng, Chuan Qin, Kang Zhang, Guangwen Lu, Xiawei Wei,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a pandemic. An effective preventive vaccine against this virus is urgently needed. As an essential step during infection, SARS-CoV-2 uses the receptor-binding domain (RBD) of the spike ... Read more >>

Nature (Nature)
[2020, 586(7830):572-577]

Cited: 128 times

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