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Effects of S-adenosylmethionine on production of secondary metabolites in Streptomycesdiastatochromogenes 1628.

Yefeng Hu, Juan Wang, Jie Xu, Zheng Ma, Andreas Bechthold, Xiaoping Yu,

Streptomyces are famous for their ability to synthesize a large number of bioactive compounds as secondary metabolites containing antibiotics, enzyme inhibitors, and other small molecules with potential physiological activity (Niu et al., 2016; Song et al., 2019; Yin et al., 2019). Secondary metabolites are produced by a multi-step reaction of ... Read more >>

J Zhejiang Univ Sci B (Journal of Zhejiang University. Science. B)
[2021, 22(9):767-773]

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Qingluoyin granules protect against adjuvant-induced arthritis in rats via downregulating the CXCL12/CXCR4-NF-κB signalling pathway.

Min Si, Zheng Ma, Jie Zhang, Xinwei Li, Rui Li, Chao Wang, Huiyu Jia, Shengyong Luo,

<h4>Context</h4>Qingluoyin (QLY) is a traditional Chinese medicine (TCM) formula which has been used in treating human rheumatoid arthritis (RA) for years in China.<h4>Objective</h4>This study investigates the effect of QLY granules on adjuvant arthritis (AA) and the possible mechanism.<h4>Materials and methods</h4>Sprague-Dawley (SD) rats were injected with Complete Freund's adjuvant (CFA) to ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1441-1451]

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Specific detection of IMP-1 β-lactamase activity using a trans cephalosporin-based fluorogenic probe.

Liqiang Hu, Runqiu Liu, Zheng Ma, Tao Yu, Ziyao Li, Yingqiu Zou, Chang Yuan, Fangfang Chen, Hexin Xie,

A fluorogenic probe for the specific detection of IMP-1 β-lactamase activity has been developed. This imaging reagent features a unique <i>trans</i>-acetylamino cephalosporin as an enzymatic recognition moiety, exhibiting excellent selectivity to IMP-1 β-lactamase over other β-lactamases, including serine- and metallo-β-lactamases. The selective activation of the probe by IMP-1 β-lactamase leads ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, :]

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Scutellarin ameliorates neonatal hypoxic-ischemic encephalopathy associated with GAP43-dependent signaling pathway.

Rui-Ze Niu, Liu-Lin Xiong, Hao-Li Zhou, Lu-Lu Xue, Qing-Jie Xia, Zheng Ma, Yuan Jin, Li Chen, Ya Jiang, Ting-Hua Wang, Jia Liu,

<h4>Background</h4>Neonatal hypoxic-ischemic encephalopathy (HIE) refers to the perinatal asphyxia caused by the cerebral hypoxic-ischemic injury. The current study was aimed at investigating the therapeutic efficacy of Scutellarin (Scu) administration on neurological impairments induced by hypoxic-ischemic injury and exploring the underlying mechanisms.<h4>Methods</h4>Primary cortical neurons were cultured and subjected to oxygen-glucose deprivation ... Read more >>

Chin Med (Chinese medicine)
[2021, 16(1):105]

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Structure and activity of an anti-epidermal growth factor receptor antibody without galactose-α-1,3-galactose residues.

Keyun Ren, Hao Gong, Zheng Ma, Lvming Tian, Wei Ye, Xingkai Lv, Chutse Wu,

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, which has been considered as one of the key targets for cancer therapy. However, currently approved therapeutic anti-EGFR antibody may cause the hypersensitivity reaction induced by galactose-α-1,3-galactose (α-Gal) structure, which is inevitable in insect cell expression system. In this study, the ... Read more >>

Drug Dev Res (Drug development research)
[2021, :]

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Insights Into mRNA and Long Non-coding RNA Profiling RNA Sequencing in Uterus of Chickens With Pink and Blue Eggshell Colors.

Siyu Chen, Kecheng Chen, Jiaming Xu, Fangwei Li, Jinlong Ding, Zheng Ma, Gen Li, Hua Li,

The blue egg is both of biological interest and economic importance for consumers, egg retailers, and scientists. To date, the genetic mechanisms underlying pigment have mainly focused on protein-coding genes. However, the underpinning mechanism of non-coding RNAs on the pigment deposition among different eggshell colors remains unknown. In this study, ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2021, 8:736387]

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The Elabela-APJ axis: a promising therapeutic target for heart failure.

Zheng Ma, Juan-Juan Song, Sara Martin, Xin-Chun Yang, Jiu-Chang Zhong,

Heart failure (HF) is a growing epidemic with high morbidity and mortality at an international scale. The apelin-APJ receptor pathway has been implicated in HF, making it a promising therapeutic target. APJ has been shown to be activated by a novel endogenous peptide ligand known as Elabela (ELA, also called ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, 26(5):1249-1258]

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Achievement of Excellent Thermoelectric Properties in Cu-Se-S Compounds via In Situ Phase Separation.

Yi-Xin Zhang, Yun-Qiao Tang, Zheng Ma, Ming-Yu Hu, Jing Feng, Zhen-Hua Ge,

In this study, Cu<sub>2</sub>Se<sub>1-<i>x</i></sub>S<sub><i>x</i></sub> (<i>x</i> = 0.1, 0.3, and 0.5) alloy powders were prepared by the hydrothermal synthesis method. In the subsequent sintering process, the spontaneous in situ phase separation process of the sample forms a two-phase hybrid structure. The generated Cu<sub>2</sub>S precipitates in the Cu<sub>2</sub>Se matrix noticeably enhance phonon ... Read more >>

Inorg Chem (Inorganic chemistry)
[2021, 60(17):13269-13277]

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Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial.

Yuan Lu, Luyan Wang, Hongyi Wang, Jianlei Gu, Zheng J Ma, Zheng Lian, Zhiying Zhang, Harlan Krumholz, Ningling Sun,

<h4>Objective</h4>To test the effectiveness of an impedance cardiography (ICG) guided treatment strategy on improving blood pressure (BP) control in real-world clinical practice.<h4>Design</h4>A single-centre, pragmatic randomised trial.<h4>Setting</h4>A hypertension clinic of the Peking University People's Hospital in Beijing, China.<h4>Participants</h4>Adults who sought outpatient care for hypertension in the hypertension clinic at the Peking ... Read more >>

Open Heart (Open heart)
[2021, 8(2):]

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Declined ELABELA plasma levels in hypertension patients with atrial fibrillation: a case control study.

Zheng Ma, Lei Zhao, Ye-Ping Zhang, Jiu-Chang Zhong, Xin-Chun Yang,

<h4>Background</h4>Atrial fibrillation (AF) is a common arrhythmia in patients with hypertension. ELABELA, which has cardioprotective effects, is decreased in the plasma of patients with hypertension and might be associated with AF in the hypertensive population. This study aims to measure the ELABELA plasma levels in hypertension patients with and without ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2021, 21(1):390]

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Cubic AgMnSbTe3 Semiconductor with a High Thermoelectric Performance.

Yubo Luo, Tian Xu, Zheng Ma, Dan Zhang, Zhongnan Guo, Qinghui Jiang, Junyou Yang, Qingyu Yan, Mercouri G Kanatzidis,

The reaction of MnTe with AgSbTe<sub>2</sub> in an equimolar ratio (ATMS) provides a new semiconductor, AgMnSbTe<sub>3</sub>. AgMnSbTe<sub>3</sub> crystallizes in an average rock-salt NaCl structure with Ag, Mn, and Sb cations statistically occupying the Na sites. AgMnSbTe<sub>3</sub> is a p-type semiconductor with a narrow optical band gap of ∼0.36 eV. A ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(34):13990-13998]

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Reference Intervals of the Ratio of Urine Iodine to Creatinine in Pregnant Women in an Iodine-Replete Area of China : Reference Intervals of the Ratio of Urine Iodine to Creatinine in Pregnant Women in an Iodine-Replete Area of China.

Shuchang Liu, Zheng Feei Ma,

Biol Trace Elem Res (Biological trace element research)
[2021, :]

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[Effectiveness of limited middle and posterior column osteotomy via transvertebral space approach for old thoracolumbar compression fracture].

Zheng Ma, Wenyuan Ding, Jianbao Jiao, Taoping Chen, Ligang Qian, Kang Chen,

<h4>Objective</h4>To investigate the effectiveness of limited middle and posterior column osteotomy via transvertebral space approach in treatment of old thoracolumbar compression fracture.<h4>Methods</h4>A clinical data of 47 patients with old thoracolumbar compression fractures, who met the selection criteria between January 2010 and March 2018, was retrospectively analyzed. Twenty-five patients (group A) ... Read more >>

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery)
[2021, 35(7):868-872]

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The Impact of Mental Health and Stress Concerns on Relationship and Sexuality Amidst the COVID-19 Lockdown.

Yingfei Zhang, Conghua Wen, Yutong Zhang, Xiaoqin Luo, Zheng Feei Ma,

<h4>Background</h4>Since January 23, 2020, the Chinese government has imposed restrictive measures including self-isolation, travel restrictions and lockdown of Wuhan city in order to prevent the incoming waves of COVID-19 outbreak in the country. However, the impact of mental health and stress concerns on relationship and sexuality amidst the COVID-19 lockdown ... Read more >>

J Sex Med (The journal of sexual medicine)
[2021, 18(11):1843-1850]

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The Potential Use of Dynamics Changes of ctDNA and cfDNA in the Perioperative Period to Predict the Recurrence Risk in Early NSCLC.

Xiaolong Zhao, Fuqiang Dai, Longyong Mei, Depei Huang, Xudong Shen, Hushan Zhang, Xueke She, Zheng Ma,

<h4>Background</h4>Postoperative circulation tumor DNA (ctDNA) is a promising method to predict the risk of recurrence. However, the amount of ctDNA in patients with early NSCLC is too small. Cell damages caused during the intraoperative period leads to a significant increase in cell free DNA (cfDNA). Whether cfDNA content is restored ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:671963]

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Ferromagnetic Liquid Droplet on a Superhydrophobic Surface for the Transduction of Mechanical Energy to Electricity Based on Electromagnetic Induction.

Zheng Ma, Qi Wang, Jingwei Ai, Bin Su,

Ferromagnetic liquids undergo reversible magnetization changes upon varying external magnetic field levels. The movement of ferromagnetic liquid droplets across a coil under an external magnetic field holds promise as an energy transducer from mechanical force to electricity; however, it suffers from an adhesive issue between the ferromagnetic liquid and the ... Read more >>

ACS Nano (ACS nano)
[2021, :]

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Core-shell nanostructures introduce multiple potential barriers to enhance energy filtering for the improvement of the thermoelectric properties of SnTe.

Zheng Ma, Chao Wang, Jingdan Lei, De Zhang, Yanqun Chen, Yuanxu Wang, Jianli Wang, Zhenxiang Cheng,

Using dispersed nanostructures to induce an energy filtering effect is an easy and effective mechanism to optimize the performance of bulk thermoelectric materials. Compared with other nanostructures, core-shell nanostructures possess more interfaces and multiple potential barriers, which would lead to a significant impact on the thermal and electrical properties of ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(3):1904-1911]

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Development and experiments on reel with improved tine trajectory for harvesting oilseed rape

Yiren Qing, Yaoming Li, Yi Yang, Lizhang Xu, Zheng Ma,

Crops with branching characteristics, such as rapeseed, are difficult to harvest owing to their specific plant geometry. To solve this problem, an harvesting reel with improved tine trajectory, considering the reel working process and a function suitable for oilseed rape, is proposed in this study. The improved tine, of which ... Read more >>

Biosyst Eng (Biosystems engineering.)
[2021, 206:19-31]

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BDNF promotes neuronal survival after neonatal hypoxic-ischemic encephalopathy by up-regulating Stx1b and suppressing VDAC1.

Lu-Lu Xue, Ruo-Lan Du, Yue Hu, Liu-Lin Xiong, Zhang-Yu Su, Zheng Ma, Ya-Xin Tan, Jia Liu, Qiao Hu, Zhao-Qiong Zhu, Xue-Zheng Liu, Ting-Hua Wang,

Neonatal hypoxic-ischemic encephalopathy (HIE), is a major cause of neurologic disorders in terms of neonates, with the unclear underlying mechanisms. In the study, triphenyl tetrazolium chloride (TTC) staining and Zea-longa score were performed to examine the neurologic damage in hypoxia and ischemia (HI) rats. The results showed that HI induced ... Read more >>

Brain Res Bull (Brain research bulletin)
[2021, 174:131-140]

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Genome and Evolutionary Analysis of Nosema ceranae: A Microsporidian Parasite of Honey Bees.

Qiang Huang, Zhi Hao Wu, Wen Feng Li, Rui Guo, Jin Shan Xu, Xiao Qun Dang, Zheng Gang Ma, Yan Ping Chen, Jay D Evans,

Microsporidia comprise a phylum of single cell, intracellular parasites and represent the earliest diverging branch in the fungal kingdom. The microsporidian parasite <i>Nosema ceranae</i> primarily infects honey bee gut epithelial cells, leading to impaired memory, suppressed host immune responses and colony collapse under certain circumstances. As the genome of <i>N. ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:645353]

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Mutation of Klotho rs3752472 protect the kidney from the renal epithelial cell injury caused by CaOx crystals through the Wnt/β-catenin signaling pathway.

Chen Xu, Wei Zhang, Pei Lu, Jian-Chun Chen, Yong-Qiang Zhou, Gang Shen, Zhen-Fan Wang, Zheng Ma, Min-Jun Jiang, Ri-Jin Song,

Calcium oxalate (CaOx) is a major contributor to urolithiasis, one of the most common urological diseases. Our previous study has shown that Klotho rs3752472 polymorphism correlates with an increased risk of CaOx-related urolithiasis in human cohorts. This study aims to identify the effect of Klotho rs3752472 polymorphism on the renal ... Read more >>

Urolithiasis (Urolithiasis)
[2021, 49(6):543-550]

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A Simple and Standardized Method for the Determination of Total Solanesol in Potato Leaves and Its Extracts Based on HPLC-MS.

Tao Lan, Congcong Yu, Ren Li, Zheng Ma, Xingjun Xi, Qiao Chu,

<h4>Background</h4>Solanesol is an important pharmaceutical intermediate raw material, mainly used to synthesize coenzyme Q10, vitamin K2. It can be found prominent in potato stems and leaves. But now potato stems and leaves are always abandoned or discarded as they are not suitable for use as feed in aquaculture or other ... Read more >>

J AOAC Int (Journal of AOAC International)
[2021, 104(2):479-484]

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Community dynamics in rhizosphere microorganisms at different development stages of wheat growing in confined isolation environments.

Zheng Ma, Zhihao Yi, Kaanuru Bayar, Yuming Fu, Hong Liu,

Wheat is the core food crop in bioregenerative life support systems (BLSSs). In confined isolation environments, wheat growth suffers from a lack of stable microbial communities and is susceptible to pathogenic infections due to the culture substrate's limitations. To overcome this limitation, the time series changes of wheat rhizosphere microorganisms ... Read more >>

Appl Microbiol Biotechnol (Applied microbiology and biotechnology)
[2021, 105(9):3843-3857]

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Does taking an angiotensin inhibitor increase the risk for COVID-19? - a systematic review and meta-analysis.

Zheng Ma, Mei-Ping Wang, Lian Liu, Shuang Yu, Tian-Ran Wu, Lei Zhao, Ye-Ping Zhang, Hai-Feng Liang, Xin-Chun Yang,

Because SARS-COV2 entry into cells is dependent on angiotensin converting enzyme 2 (ACE2) and angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) increase ACE2 activity, the safety of ACEI/ARB usage during the coronavirus disease 2019 (COVID-19) pandemic is a controversial topic. To address that issue, we performed a ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(8):10853-10865]

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Effect of Pre-Stretch on the Precipitation Behavior and the Mechanical Properties of 2219 Al Alloy.

Guo-Ai Li, Zheng Ma, Jian-Tang Jiang, Wen-Zhu Shao, Wei Liu, Liang Zhen,

The influence of pre-stretch on the mechanical properties of 2219 Al alloys sheets were systematically investigated, with the aim of examining the age-strengthening in parts draw-formed from as-quenched sheets. The precipitation was characterized based on differential scanning calorimetry (DSC) analysis and transmission electron microscope (TEM) observation of specimens of as-quenched ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2021, 14(9):]

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