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Author Zheng Ge

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LncRNA CASC15 promotes tumour progression through SOX4/Wnt/β-catenin signalling pathway in hepatocellular carcinoma.

Chaoyang Wang, Hao Zi, Yang Wang, Binghui Li, Zheng Ge, Xuequn Ren,

Objective: The present study aimed to investigate the function of lncRNA CASC15 (cancer susceptibility candidate 15) in hepatocellular carcinoma (HCC), as well as its regulatory roles in SOX4 expression and Wnt/β-catenin pathway.Methods: Quantitative real-time polymerase chain reaction (QRT-PCR) method was used to detect the relative expression of CASC15 mRNA in ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):763-769]

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Methylprednisolone alleviates multiple sclerosis by expanding myeloid-derived suppressor cells via glucocorticoid receptor β and S100A8/9 up-regulation.

Zhongkun Wang, Ge Zheng, Guangjian Li, Mengkun Wang, Zhanchuan Ma, Huimin Li, Xiang-Yang Wang, Huanfa Yi,

Methylprednisolone is an effective drug in the treatment of autoimmune disease, such as multiple sclerosis (MS), due to long-acting anti-inflammatory, antiallergic and immunosuppressant. Previous studies have noted the importance of myeloid-derived suppressor cells (MDSC) in MS progression. However, it is still not known whether methylprednisolone could influence the ratio and ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, :]

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Cryptic t(15;17) acute promyelocytic leukemia with a karyotype of add(11)(p15) and t(13,20)- A case report with a literature review.

Siyu Gu, Jie Zi, Jinlong Ma, Zheng Ge,

Most acute promyelocytic leukemia (APL) are characterized by reciprocal translocations t(15;17)(q22;21), which results in the fusion of PML gene at 15q22 with RARα gene at 17q21. However, several complex variant translocations also have been reported. Here we report a 62-year-old man with typical morphology and clinical features of APL with ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia.

Chunhua Song, Zheng Ge, Yali Ding, Bi-Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P Robertson, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L Payne, Mark E Reeves, Zafer Gurel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathalia M Cury, José Andrés Yunes, Mary McGrath, Joe Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Muschen, Kimberly J Payne, Chandrika Gowda, Sinisa Dovat,

High-risk B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive disease, often characterized by resistance to chemotherapy. A frequent feature of high-risk B-ALL is loss of function of the IKAROS (encoded by the IKZF1 gene) tumor suppressor. Here, we report that IKAROS regulates expression of the BCL2L1 gene (encodes the BCL-XL ... Read more >>

Blood (Blood)
[2020, 136(13):1520-1534]

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Bibliometric analysis of randomized controlled trials of colorectal cancer over the last decade.

Chen-Yu Wang, Shi-Can Zhou, Xing-Wang Li, Bing-Hui Li, Jun-Jie Zhang, Zheng Ge, Quan Zhang, Jun-Hong Hu,

BACKGROUND:Colorectal cancer is one of the most common cancers globally. In China, its prevalence ranks fourth and fifth among females and males, respectively. Presently, treatment of rectal cancer follows a multidisciplinary comprehensive treatment approach involving surgery, radiotherapy, chemotherapy, and targeted therapy. With deepening theoretical and molecular research on colorectal cancer, ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(14):3021-3030]

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Commentary: Recurrent chordee in 59 adolescents and young adults following childhood hypospadias repair.

Li-Qu Huang, Zheng Ge, Geng Ma,

J Pediatr Urol (Journal of pediatric urology)
[2020, 16(4):521-522]

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Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia.

Siyu Gu, Jie Zi, Qi Han, Chunhua Song, Zheng Ge,

Background:We used bioinformatic tools to dichotomize 157 non-M3 AML patients from the TCGA dataset based on the presence or absence of TP53 mutations, and screened out a key gene related to TP53 mutation for future analysis. Methods:DEGs were analyzed by R package "DESeq2" and then run GSEA, GO enrichment, KEGG ... Read more >>

Cancer Cell Int (Cancer cell international)
[2020, 20:146]

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CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia.

Qi Zhang, Qi Han, Jie Zi, Chunhua Song, Zheng Ge,

BACKGROUND:CD37, a member of the transmembrane 4 superfamilies (TM4SF), has been proved to be abnormally expressed in a range of malignancies. Herein, we investigate the effects of CD37 expression and analyze its clinical outcome in acute myeloid leukemia (AML) patients. METHODS:The RNA-seq and clinical data of AML patients were obtained ... Read more >>

Biosci Rep (Bioscience reports)
[2020, 40(5):]

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Moisture retention extended enhanced bioelectrochemical remediation of unsaturated soil.

Huan Wang, Yixiao Cui, Lu Lu, Song Jin, Yi Zuo, Zheng Ge, Zhiyong Jason Ren,

Bioelectrochemical systems (BESs) have demonstrated great promise in augmented biodegradation of petroleum hydrocarbons in water-saturated soils. However, bioremediation of unsaturated soil in vadose zone has been a challenge due to poor mass transfer and low conductivity. This study proposed a moisture retention layer (2 cm thickness) around the BES anodes to ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 724:138169]

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Use of double-J ureteric stents post-laparoscopic pyeloplasty to treat ureteropelvic junction obstruction in hydronephrosis for pediatric patients: a single-center experience.

Haobo Zhu, Jun Wang, Yongji Deng, Liqu Huang, Xiaojiang Zhu, Jun Dong, Jintong Sha, Nannan Gu, Zheng Ge, Geng Ma, Yunfei Guo, Aihua Zhang,

OBJECTIVES:We aimed to investigate the safety concerns associated with placing double-J ureteric stents post-laparoscopic pyeloplasty surgery for congenital ureteropelvic junction obstruction (UPJO) and hydronephrosis. METHODS:A total of 1349 patients with postoperative double-J stent placement at our center were included. Clinical variables for enrolled patients were collected by two independent authors. ... Read more >>

J. Int. Med. Res. (The Journal of international medical research)
[2020, 48(4):300060520918781]

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Registration of Rectal Cancer-Related Clinical Trials on Chinese Clinical Trial Registry over past decades

Jun-hong Hu, Shi-Can Zhou, Quan Zhang, Xing- Wang Li, Chen-Yu Wang, Jun-Jie Zhang, Zheng Ge,

Abstract Background This study investigated and analyzed rectal cancer-related clinical trials registered on Chinese Clinical Trial Registry (Chi-CTR) by the end of 2018. We aimed to discuss the characteristics and developmental trends. Methods The Chi-CTR database was searched and all clinical trials related to rectal cancer extracted. The time limit ... Read more >>

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FBXW4 Is Highly Expressed and Associated With Poor Survival in Acute Myeloid Leukemia.

Qi Han, Qi Zhang, Huihui Song, Yevgeniya Bamme, Chunhua Song, Zheng Ge,

The F-box and WD repeat domain-containing (FBXW) proteins play an important role in ubiquitin proteasome by inducing protein degradation. Ten FBXW proteins have been identified in humans. The functions of FBXW proteins, like FBXW7, have been well-established in many human cancers. However, little is known about their transcriptional expression profiles ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:149]

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Bibliometric analysis on randomized controlled trials of colorectal cancer over the last decade

Jun-hong Hu, Chen-Yu Wang, Shi-Can Zhou, Xing-Wang Li, Bing-Hui Li, Jun-jie Zhang, Zheng Ge, Quan Zhang,

Abstract Background The aim of this bibliometric analysis was to evaluate the clinical trials of randomized controlled trials (RCTs) of colorectal cancer all the world over the past decade. Methods The PubMed and Web of Science database were searched to obtain a randomized controlled trial of colorectal cancer from January ... Read more >>

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Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy.

Chao-Yang Wang, Jin Yang, Hao Zi, Zhong-Li Zheng, Bing-Hui Li, Yang Wang, Zheng Ge, Guang-Xu Jian, Jun Lyu, Xiao-Dong Li, Xue-Qun Ren,

BACKGROUND:Surgery is the only way to cure gastric adenocarcinoma (GAC), and chemotherapy is the basic adjuvant management for GAC. A significant prognostic nomogram for predicting the respective disease-specific survival (DSS) rates of GAC patients who receive surgery and chemotherapy has not been established. OBJECTIVE:We were planning to establish a survival ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):10]

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BCR-ABL1 transcript decline ratio combined BCR-ABL1IS as a precise predictor for imatinib response and outcome in the patients with chronic myeloid leukemia.

Zhimei Cai, Xiting Jia, Jie Zi, Huihui Song, Shujun Wang, Mary McGrath, Lidong Zhao, Chunhua Song, Zheng Ge,

Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospectively analyzed the ... Read more >>

J Cancer (Journal of Cancer)
[2020, 11(8):2234-2240]

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Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single-center experience.

Jun Wang, Haobo Zhu, Liqu Huang, Xiaojiang Zhu, Jun Dong, Jintong Sha, Nannan Gu, Zheng Ge, Yongji Deng, Geng Ma, Yunfei Guo,

BACKGROUND:Urinary tract infection (UTI) is common in children. The purpose of this retrospective study was to determine the various risk factors that usually affect the prognosis of UTI in children diagnosed with the disease. METHODS:In the present retrospective study, we enrolled all pediatric patients diagnosed with UTI and hospitalized between ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(2):189-192]

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Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy

Chao-Yang Wang, Jin Yang, Hao Zi, Zhong-Li Zheng, Bing-Hui Li, Yang Wang, Zheng Ge, Guang-Xu Jian, Jun Lyu, Xiao-Dong Li, Xue-Qun Ren,

Abstract Background: Surgery is the only way to cure gastric adenocarcinoma (GAC), and chemotherapy is the basic adjuvant management for GAC. A significant prognostic nomogram for predicting the respective disease-specific survival (DSS) rates of GAC patients who receive surgery and chemotherapy has not been established.Objective: We were planning to establish ... Read more >>

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Peripheral blood BDNF-TrkB signaling in first-episode, drug-free patients with major depressive disorder and schizophrenia.

Lei Chen, Xue-Song Li, Guang-En Zheng, Guo-Jun Xie, Yong Cheng,

Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of psychiatric disorders, and studies have shown BDNF aberrations in major psychiatric diseases including schizophrenia (SCZ) and major depressive disorder (MDD). However, data from clinical studies were inconsistent. In this study, we recruited 34 patients with MDD, 77 patients with ... Read more >>

Neurosci Lett (Neuroscience letters)
[2020, 714:134618]

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A New Conditioning Regimen Can Significantly Promote Post-Transplant Immune Reconstitution and Improve the Outcome of Umbilical Cord Blood Transplantation for Patients.

Zheng-Ping Yu, Jia-Hua Ding, Ai-Ning Sun, Bao-An Chen, Zheng Ge, De-Pei Wu,

This study included data from 81 consecutively enrolled patients with hematological diseases who had been treated with unrelated umbilical cord blood transplantation (UCBT) between September 2014 and April 2019. All patients received intense conditioning regimens with combined fludarabine and high-dose cyclophosphamide (FC) before undergoing UCBT. Sixty-seven patients received a single ... Read more >>

Stem Cells Dev. (Stem cells and development)
[2019, 28(20):1376-1383]

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Short-term efficacy of transvaginal specimen extraction for right colon cancer based on propensity score matching: A retrospective cohort study.

Xing-Wang Li, Chen-Yu Wang, Jun-Jie Zhang, Zheng Ge, Xu-Hong Lin, Jun-Hong Hu,

BACKGROUND:Recently, the incidence of colorectal cancer has increased each year. Natural orifice specimen extraction surgery (NOSES) removes the specimen from a natural cavity of the human body (anal or vaginal) and completes reconstruction of the digestive tract. There are only a few trocar scars in the abdomen after surgery. Transvaginal ... Read more >>

Int J Surg (International journal of surgery (London, England))
[2019, 72:102-108]

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Dysregulation of Fibroblast Growth Factor 10 in the Peripheral Blood of Patients with Schizophrenia.

Yun Yu, Guo-Jun Xie, Yang Hu, Xue-Song Li, Guang-Yang Chen, Guang-En Zheng, Xi Chen, Yong Cheng,

The fibroblast growth factor (FGF) system has been suggested to be involved in the development of schizophrenia (SCZ). However, the potential roles of all FGFs have not been well studied in the literature. Here, we investigated the concentration of peripheral blood fibroblast 10 (FGF10) in patients with SCZ to determine ... Read more >>

J. Mol. Neurosci. (Journal of molecular neuroscience : MN)
[2019, 69(1):69-74]

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Fate of dissolved organic nitrogen during the Anammox process using ultra-high resolution mass spectrometry.

Li Zhang, Yongzhen Peng, Zheng Ge, Kechen Xu,

Anaerobic ammonium oxidation (Anammox) is a cost-effective process for treating highly nitrogenous wastewater. However, the fate of organic nitrogen during Anammox treatment is still unclear, which limits its practical application. In this work, the changes in the quality of dissolved organic nitrogen (DON) in coal liquefaction wastewater (CLW) during Anammox ... Read more >>

Environ Int (Environment international)
[2019, 131:105042]

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Tempol Protects Against Acetaminophen Induced Acute Hepatotoxicity by Inhibiting Oxidative Stress and Apoptosis.

Zheng Ge, Chenyu Wang, Junjie Zhang, Xiwang Li, Junhong Hu,

Acetaminophen (APAP)-induced acute hepatotoxicity is the leading cause of drug-induced acute liver failure. The aim of this study was to evaluate the effects of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol) on the protection of APAP-induced hepatotoxicity in mice. Mice were pretreated with a single dose of tempol (20 mg/kg per day) orally for 7 days. On ... Read more >>

(Frontiers in physiology)
[2019, 10:660]

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A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia.

Zhimei Cai, Shuo Liu, Jie Zi, Jinlong Ma, Zheng Ge,

Chronic myeloid leukemia (CML) and Non-Hodgkin Lymphoma (NHL) are two different origins of hematological malignancies, which rarely occur at the same time. Moreover, NHL secondary to CML is common in T cell lymphoma, while NHL of B cell origin is rare. Since 1999, only 22 cases with B cell lymphoma ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2019, 12:5917-5923]

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Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis.

Anqi Zhou, Qi Han, Huihui Song, Jie Zi, Jinlong Ma, Zheng Ge,

Purpose: To investigate the overall efficacy and toxicity of cladribine and cladribine-based chemotherapy in the treatment of patients with refractory acute myeloid leukemia (AML) based on meta-analysis. Methods: PubMed, EMBASE database, and the Cochrane Library were searched for relevant studies. Eligible studies were clinical trials of refractory AML assigned to ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2019, 13:1867-1878]

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