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Author Zheng Cui

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Assessment of liver metastases radiomic feature reproducibility with deep-learning-based semi-automatic segmentation software.

Lan Wang, Jingwen Tan, Yingqian Ge, Xinwei Tao, Zheng Cui, Zhenyu Fei, Jing Lu, Huan Zhang, Zilai Pan,

BACKGROUND:Good feature reproducibility enhances model reliability. The manual segmentation of gastric cancer with liver metastasis (GCLM) can be time-consuming and unstable. PURPOSE:To assess the value of a semi-automatic segmentation tool in improving the reproducibility of the radiomic features of GCLM. MATERIAL AND METHODS:Patients who underwent dual-source computed tomography were retrospectively ... Read more >>

Acta Radiol (Acta radiologica (Stockholm, Sweden : 1987))
[2020, :284185120922822]

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Pyridoxal-5'-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis.

Zheng Cui, Jonathan Overbay, Xiachang Wang, Xiaodong Liu, Yinan Zhang, Minakshi Bhardwaj, Anke Lemke, Daniel Wiegmann, Giuliana Niro, Jon S Thorson, Christian Ducho, Steven G Van Lanen,

Several nucleoside antibiotics are structurally characterized by a 5″-amino-5″-deoxyribose (ADR) appended via a glycosidic bond to a high-carbon sugar nucleoside (5'S,6'S)-5'-C-glycyluridine (GlyU). GlyU is further modified with an N-alkylamine linker, the biosynthetic origin of which has yet to be established. By using a combination of feeding experiments with isotopically labeled ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Facile and Efficient Patterning Method for Silver Nanowires and Its Application to Stretchable Electroluminescent Displays.

Yong Lin, Wei Yuan, Chen Ding, Shulin Chen, Wenming Su, Hailong Hu, Zheng Cui, Fushan Li,

The patterning of silver nanowires (AgNWs) is subject to critical challenges, which have seriously limited their practical applications. This work describes a simple and efficient method combining screen printing with vacuum filtration for patterning AgNW networks. The screen-printed poly(dimethylsiloxane) (PDMS) mask layer was shown to be strongly adhered to the ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(21):24074-24085]

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Roles of Co-solvents in hydrothermal liquefaction of low-lipid, high-protein algae.

Zheng Cui, Feng Cheng, Jacqueline M Jarvis, Catherine E Brewer, Umakanta Jena,

Valorization of algal biomass is often limited by its low lipid content. Here, different alcohols: ethanol, isopropanol, and glycerol, were studied as co-solvents to improve the conversion efficiency of a lipid-poor microalgae, Galdieria sulphuraria, by hydrothermal liquefaction. Bio-crude oil yield increases, from 13 to 73 wt% (on dry algae basis), were ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 310:123454]

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Sugar-Pirating as an Enabling Platform for the Synthesis of 4,6-Dideoxyhexoses.

Yinan Zhang, Jianjun Zhang, Larissa V Ponomareva, Zheng Cui, Steven G Van Lanen, Jon S Thorson,

An efficient divergent synthetic strategy that leverages the natural product spectinomycin to access uniquely functionalized monosaccharides is described. Stereoselective 2'- and 3'-reduction of key spectinomycin-derived intermediates enabled facile access to all eight possible 2,3-stereoisomers of 4,6-dideoxyhexoses as well as representative 3,4,6-trideoxysugars and 3,4,6-trideoxy-3-aminohexoses. In addition, the method was applied to ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, 142(20):9389-9395]

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A multifunctional magnetic nanosystem based on "two strikes" effect for synergistic anticancer therapy in triple-negative breast cancer.

Yu Zhang, Huiping Hu, Wenqi Tang, Qian Zhang, Min Li, Honglin Jin, Zi Huang, Zheng Cui, Jingya Xu, Kaiping Wang, Chen Shi,

Multifunctional magnetic nanoparticles (MNPs) were widely used for ablation of cancer cells because of their potential on physical treatment. Herein, we developed the "cell targeting destructive" multifunctional polymeric nanoparticles (named as HA-Olb-PPMNPs) based on PEI-PLGA co-loaded with the anticancer drug Olaparib (Olb) and superparamagnetic iron oxide nanoparticles (Fe3O4 NPs), and ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2020, 322:401-415]

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Tetranuclear cobalt(ii)-isonicotinic acid frameworks: selective CO2 capture, magnetic properties, and derived "Co3O4" exhibiting high performance in lithium ion batteries.

Lei Zhou, Honghong Fan, Baolei Zhou, Zheng Cui, Bowen Qin, Xiaoying Zhang, Wenliang Li, Jingping Zhang,

Two new 3D cobalt metal-organic frameworks (MOFs), [Co4(CH3COO)(in)5(μ3-OH)2]·2H2O (1) and [Co4(SO4)2(in)4(DMF)2]·3DMF (2) (Hin = isonicotinic acid), have been prepared through the anion template method. Compound 1 consists of rare odd-number connected (9-connected) cubane-like SBUs, while compound 2 consists of 8-connected high-symmetry square-planar clusters. Magnetic studies indicate that compound 1 exhibits ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2018, 48(1):296-303]

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Realizing 22.3% EQE and 7-Fold Lifetime Enhancement in QLEDs via Blending Polymer TFB and Cross-Linkable Small Molecules for a Solvent-Resistant Hole Transport Layer.

Pengyu Tang, Liming Xie, Xueying Xiong, Changting Wei, Wenchao Zhao, Ming Chen, Jinyong Zhuang, Wenming Su, Zheng Cui,

Poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt(4,4'-(N-(4-butylphenyl)))] (TFB) has been widely used as a hole transport layer (HTL) material in cadmium-based quantum dot light-emitting diodes (QLEDs) because of its high hole mobility. However, as the highest occupied molecular orbital (HOMO) energy level of TFB is -5.4 eV, the hole injection from TFB to the quantum dot ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(11):13087-13095]

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Optimization Method for Grooved Surface Structures Regarding the Evaporation Heat Transfer of Ultrathin Liquid Films at the Nanoscale.

Qun Cao, Zheng Cui, Wei Shao,

Rough nanostructured surfaces can enhance evaporation heat transfer. Most studies artificially optimized the geometry and size during the design of nanostructured surfaces. Instead of the empirical design of nanostructured surfaces, this paper proposes a mathematical optimization method of the grooved nanostructured surface design. This method is inspired by the molecular ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2020, 36(11):2802-2815]

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A new ergostane derivative from the leaves of Heynea trijuga Roxburgh.

Shou-Bai Liu, Zheng Cui, Hui-Qin Chen, Hao Wang, Wen-Hua Dong, Cai-Hong Cai, Wen-Li Mei, Hao-Fu Dai,

During the course of searching for structurally interesting and bioactive compounds, a further chemical investigation of the leaves of Heynea trijuga Roxburgh was performed, which led to the isolation of a new ergostane derivative, named 3β, 4β, 20S-trihydroxyergosta-5, 24(28)-dien-16-one (1), together with five known sterides (3β, 23S)-ergosta-5, 24(28)-diene-3, 23-diol (2), ... Read more >>

Nat. Prod. Res. (Natural product research)
[2020, :1-6]

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Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection.

Kaiping Wang, Jingya Xu, Yan Liu, Zheng Cui, Zihao He, Ziming Zheng, Xiao Huang, Yu Zhang,

The present work aimed to study the feasibility of Angelica sinensis polysaccharide (ASP) as an instinctive liver-targeting drug delivery carrier with applications in acute alcoholic liver damage (ALD). Amphipathic cholesteryl hemisuccinate-ASP (ASP-CHEMS) conjugate was synthesized by an esterification reaction and characterized by conventional methods. ASP-CHEMS self-assembled nanoparticles (ACNPs) and Curcumin-loaded ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 577:118996]

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Semiconductor-Ferromagnetic Insulator-Superconductor Nanowires: Stray Field and Exchange Field.

Yu Liu, Saulius Vaitiekėnas, Sara Martí-Sánchez, Christian Koch, Sean Hart, Zheng Cui, Thomas Kanne, Sabbir A Khan, Rawa Tanta, Shivendra Upadhyay, Martin Espiñeira Cachaza, Charles M Marcus, Jordi Arbiol, Kathryn A Moler, Peter Krogstrup,

Nanowires can serve as flexible substrates for hybrid epitaxial growth on selected facets, allowing for the design of heterostructures with complex material combinations and geometries. In this work we report on hybrid epitaxy of freestanding vapor-liquid-solid grown and in-plane selective area grown semiconductor-ferromagnetic insulator-superconductor (InAs/EuS/Al) nanowire heterostructures. We study the ... Read more >>

Nano Lett. (Nano letters)
[2020, 20(1):456-462]

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A general framework in single and multi-modality registration for lung imaging analysis using statistical prior shapes.

Zheng Cui, Sasan Mahmoodi, Matthew Guy, Emma Lewis, Tom Havelock, Michael Bennett, Joy Conway,

BACKGROUND AND OBJECTIVE:A fusion of multi-slice computed tomography (MSCT) and single photon emission computed tomography (SPECT) represents a powerful tool for chronic obstructive pulmonary disease (COPD) analysis. In this paper, a novel and high-performance MSCT/SPECT non-rigid registration algorithm is proposed to accurately map the lung lobe information onto the functional ... Read more >>

Comput Methods Programs Biomed (Computer methods and programs in biomedicine)
[2020, 187:105232]

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Overcoming Electrochemical Instabilities of Printed Silver Electrodes in All-Printed Ion Gel Gated Carbon Nanotube Thin-Film Transistors.

Malo Robin, Luis Portilla, Miaomiao Wei, Tianqi Gao, Jianwen Zhao, Shuangshuang Shao, Vincenzo Pecunia, Zheng Cui,

Silver ink is the most widely used conductive material for printing electrodes in the fabrication of all-printed ion gel gated transistors because of their high conductivity and low cost. However, electrochemical instability of printed silver electrodes is generally one of the biggest issues, whether it is in air where silver ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2019, 11(44):41531-41543]

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A nano-immunotraining strategy to enhance the tumor targeting of neutrophils via in vivo pathogen-mimicking stimulation.

Haiqing Dong, Yan Li, Yiqiong Liu, Ya Wen, Zui Zou, Tianshu Yang, Zheng Cui, Donglu Shi, Yongyong Li,

Due to unsatisfactory tumor-targeting efficiency, hitch-hiking nanomedicines with tumor "smelling" immune cells have rapidly evolved to achieve a more precision delivery. However, the current research tends to default to the smelling capacity of neutrophils and largely overlooks the capacity of those immune cells that are heavily dependent on the pathogen ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(12):5238-5246]

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Special clinical characteristics and outcomes in Chinese pediatric patients with early-onset Crohn's disease.

Wen Juan Tang, Peng Shi, Cui Fang Zheng, Jie Ru Shi, Xiao Xia Qiu, Sheng Nan Wang, Ying Huang,

OBJECTIVE:To study the clinical and nutritional characteristics of early-onset Crohn's disease (EO-CD) in China. METHODS:Patients were defined as having EO-CD (age at diagnosis <10 y) or late-onset Crohn's disease (LO-CD; age at diagnosis of 10-17 y). Their characteristics, clinical, and nutritional data were collected at baseline and at each follow-up visit. ... Read more >>

J Dig Dis (Journal of digestive diseases)
[2019, 20(10):539-546]

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mRNA and miRNA Expression Analysis Reveal the Regulation for Flower Spot Patterning in Phalaenopsis 'Panda'.

Anjin Zhao, Zheng Cui, Tingge Li, Huiqin Pei, Yuhui Sheng, Xueqing Li, Ying Zhao, Yang Zhou, Wenjun Huang, Xiqiang Song, Ting Peng, Jian Wang,

Phalaenopsis cultivar 'Panda' is a beautiful and valuable ornamental for its big flower and unique big spots on the petals and sepals. Although anthocyanins are known as the main pigments responsible for flower colors in Phalaenopsis, and the anthocyanins biosynthetic pathway in Phalaenopsis is generally well known, the detailed knowledge ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(17):]

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Printable Stretchable Silver Ink and Application to Printed RFID Tags for Wearable Electronics.

Tao Zhong, Ning Jin, Wei Yuan, Chunshan Zhou, Weibing Gu, Zheng Cui,

A printable elastic silver ink has been developed, which was made of silver flakes, dispersant, and a fluorine rubber and could be sintered at a low temperature. The printed elastic conductors showed low resistivity at 21 μΩ·cm, which is about 13.2 times of bulk silver (1.59 μΩ·cm). Their mechanical properties ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2019, 12(18):]

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Visualizing in vitro-in vivo correlation of miktoarm copolymer nanomicelles in cancer cellular uptake and trafficking

Zheng Cui, Xiaofei Zhang, Xiaojin Zhang, Suna He, Wei Gao, Bing He, Xueqing Wang, Hua Zhang, Zhenlin Zhong, Qiang Zhang,

Abstract In this study, a clear correlation between the in vitro and in vivo cellular uptake and trafficking was discovered by delivering miktoarm copolymer nanomicelles (MCNs) to cancer cells and tumor tissues. To monitor this process, two different FRET pairs, DiO and DiI, DiD and DiR, were loaded into MCNs ... Read more >>

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Suppression of the innate cancer-killing activity in human granulocytes by stress reaction as a possible mechanism for affecting cancer development.

Xin Huang, Wenjun Le, Qian Chen, Jingyao Chen, Yuqian Zhu, Donglu Shi, Bingdi Chen, Zheng Cui,

Psychological stress may be linked to cancer incidence; however, more direct evidence is required to support this viewpoint. In this study, we investigated the effects of stress on immunosurveillance against cancer cells using a previously established examination stress model. We showed that the cancer killing activity (CKA) of granulocytes (also ... Read more >>

Stress (Stress (Amsterdam, Netherlands))
[2020, 23(1):87-96]

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Total synthesis of griseusins and elucidation of the griseusin mechanism of action.

Yinan Zhang, Qing Ye, Larissa V Ponomareva, Yanan Cao, Yang Liu, Zheng Cui, Steven G Van Lanen, S Randal Voss, Qing-Bai She, Jon S Thorson,

A divergent modular strategy for the enantioselective total synthesis of 12 naturally-occurring griseusin type pyranonaphthoquinones and 8 structurally-similar analogues is described. Key synthetic highlights include Cu-catalyzed enantioselective boration-hydroxylation and hydroxyl-directed C-H olefination to afford the central pharmacophore followed by epoxidation-cyclization and maturation via diastereoselective reduction and regioselective acetylation. Structural revision ... Read more >>

Chem Sci (Chemical science)
[2019, 10(32):7641-7648]

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S-Petasin isolated from Petasites japonicus exerts anti-adipogenic activity in the 3T3-L1 cell line by inhibiting PPAR-γ pathway signaling.

Lu Guo, Ke Li, Zheng Wei Cui, Jum Soon Kang, Beung Gu Son, Young Whan Choi,

Petasites japonicus is an edible and medicinal plant with a good flavor, and it is a rich source of bioactive compounds. S-Petasin has been isolated from Petasites hybridus (L.), Petasites officinalis (L.) and Petasites formosanus, but not from Petasites japonicus. In this study, we found that hexane extracts of Petasites ... Read more >>

Food Funct (Food & function)
[2019, 10(7):4396-4406]

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Cryogen-free variable temperature scanning SQUID microscope.

Logan Bishop-Van Horn, Zheng Cui, John R Kirtley, Kathryn A Moler,

Scanning Superconducting QUantum Interference Device (SQUID) microscopy is a powerful tool for imaging local magnetic properties of materials and devices, but it requires a low-vibration cryogenic environment, traditionally achieved by thermal contact with a bath of liquid helium or the mixing chamber of a "wet" dilution refrigerator. We mount a ... Read more >>

Rev Sci Instrum (The Review of scientific instruments)
[2019, 90(6):063705]

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Tailoring the Temperature Coefficient of Resistance of Silver Nanowire Nanocomposites and their Application as Stretchable Temperature Sensors.

Zheng Cui, Felipe Robles Poblete, Yong Zhu,

Body temperature is an important indicator of the health condition. It is of critical importance to develop a smart temperature sensor for wearable applications. Silver nanowire (AgNW) is a promising conductive material for developing flexible and stretchable electrodes. Here, a stretchable and breathable thermoresistive temperature sensor based on AgNW composites is ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2019, 11(19):17836-17842]

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Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces.

Xiachang Wang, Muhammad Abbas, Yinan Zhang, Sherif I Elshahawi, Larissa V Ponomareva, Zheng Cui, Steven G Van Lanen, Imran Sajid, S Randal Voss, Khaled A Shaaban, Jon S Thorson,

The structures and bioactivities of three unprecedented fused 5-hydroxyquinoxaline/alpha-keto acid amino acid metabolites (baraphenazines A-C, 1-3), two unique diastaphenazine-type metabolites (baraphenazines D and E, 4 and 5) and two new phenazinolin-type (baraphenazines F and G, 6 and 7) metabolites from the Himalayan isolate Streptomyces sp. PU-10A are reported. This study ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2019, 82(6):1686-1693]

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