Full Text Journal Articles by
Author Zhendong A Zhong

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LDL receptor-related protein LRP6 senses nutrient levels and regulates Hippo signaling.

Wonyoung Jeong, Soyoung Kim, Ukjin Lee, Zhendong A Zhong, Mikhail Savitsky, Hyeryun Kwon, Jiyoung Kim, Taebok Lee, Jin Won Cho, Bart O Williams, Vladimir L Katanaev, Eek-Hoon Jho,

Controlled cell growth and proliferation are essential for tissue homeostasis and development. Wnt and Hippo signaling are well known as positive and negative regulators of cell proliferation, respectively. The regulation of Hippo signaling by the Wnt pathway has been shown, but how and which components of Wnt signaling are involved ... Read more >>

EMBO Rep (EMBO reports)
[2020, 21(9):e50103]

Cited: 0 times

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Loss of Myeloid-Specific TGF-β Signaling Decreases CTHRC1 to Downregulate bFGF and the Development of H1993-Induced Osteolytic Bone Lesions.

Sourik S Ganguly, Paul G Daft, Jingchen Cao, Xiangqi Meng, Zhendong A Zhong, Alexandra Vander Ark, Austin Meadows, Zach Madaj, Bart Williams, Xiaohong Li,

The role of myeloid cell-specific TGF-β signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a genetically engineered mouse model, Tgfbr2LysMCre knockout (KO), which has a loss of TGF-β signaling specifically in myeloid lineage cells, and we found that the area of H1993 cell-induced osteolytic ... Read more >>

Cancers (Basel) (Cancers)
[2018, 10(12):]

Cited: 2 times

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Enhanced cortical bone expansion in Lgals3-deficient mice during aging.

Kevin A Maupin, Kevin Weaver, Alexis Bergsma, Cheryl Christie, Zhendong A Zhong, Tao Yang, Bart O Williams,

Imbalances between bone formation and bone resorption, which can occur due to aging or sex hormone deprivation, result in decreased bone mass and an increased risk of fracture. Previous studies have suggested that the β-galactoside binding lectin, galectin-3, is involved in bone remodeling. We compared bone parameters of mice having ... Read more >>

Bone Res (Bone research)
[2018, 6:7]

Cited: 0 times

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Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells.

Alexander Kot, Zhendong A Zhong, Hongliang Zhang, Yu-An Evan Lay, Nancy E Lane, Wei Yao,

Increasing peak bone mass is a promising strategy to prevent osteoporosis. A mouse model of global progesterone receptor (PR) ablation showed increased bone mass through a sex-dependent mechanism. Cre-Lox recombination was used to generate a mouse model of osteoprogenitor-specific PR inactivation, which recapitulated the high bone mass phenotype seen in ... Read more >>

J Mol Endocrinol (Journal of molecular endocrinology)
[2017, 59(4):351-363]

Cited: 2 times

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Sex-Dependent, Osteoblast Stage-Specific Effects of Progesterone Receptor on Bone Acquisition.

Zhendong A Zhong, Alexander Kot, Yu-An E Lay, Hongliang Zhang, Junjing Jia, Nancy E Lane, Wei Yao,

The role of the progesterone receptor (PR) in the regulation of sexual dimorphism in bone has yet to be determined. Here we utilized genetic fate mapping and Western blotting to demonstrate age-dependent PR expression in the mouse femoral metaphysis and diaphysis. To define sex-dependent and osteoblast stage-specific effects of PR ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2017, 32(9):1841-1852]

Cited: 4 times

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Use of Primary Calvarial Osteoblasts to Evaluate the Function of Wnt Signaling in Osteogenesis.

Zhendong A Zhong, Nicole J Ethen, Bart O Williams,

In vitro culture and genetic manipulation of primary calvarial cell cultures is a convenient and robust system to investigate gene function in osteoblast differentiation. We have used this system to study the functions of many genes in the Wnt signaling pathway within osteoblasts. Here, we describe a detailed protocol outlining ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2016, 1481:119-125]

Cited: 2 times

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Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms.

Zhendong A Zhong, Juraj Zahatnansky, John Snider, Emily Van Wieren, Cassandra R Diegel, Bart O Williams,

Canonical and noncanonical Wnt signaling pathways both play pivotal roles in bone development. Wntless/GPR177 is a chaperone protein that is required for secretion of all Wnt ligands. We previously showed that deletion of Wntless within mature osteoblasts severely impaired postnatal bone homeostasis.In this study, we systemically evaluated how deletion of ... Read more >>

Dev Dyn (Developmental dynamics : an official publication of the American Association of Anatomists)
[2015, 244(10):1347-1355]

Cited: 10 times

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Inactivation of the Progesterone Receptor in Mx1+ Cells Potentiates Osteogenesis in Calvaria but Not in Long Bone.

Zhendong A Zhong, Weihua Sun, Haiyan Chen, Hongliang Zhang, Nancy E Lane, Wei Yao,

The effect of progesterone on bone remains elusive. We previously reported that global progesterone receptor (PR) knockout mice displayed high bone mass phenotype, suggesting that PR influences bone growth and modeling. Recently, Mx1+ cells were characterized to be mesenchymal stem cell-like pluripotent Cells. The aim of this study was to ... Read more >>

PLoS One (PloS one)
[2015, 10(10):e0139490]

Cited: 5 times

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β-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes.

Weiwei Dai, HongLiang Zhang, Zhendong A Zhong, Li Jiang, Haiyan Chen, Yu-An Evan Lay, Alexander Kot, Robert O Ritchie, Nancy E Lane, Wei Yao,

One of the strongest predictors for osteoporosis is peak bone mass. Interventions to augment peak bone mass have yet to be developed. β-Ecdysone (βEcd), a natural steroid-like compound produced by arthropods to initiate metamorphosis, is believed to have androgenic effects and so may be used to augment bone mass.The purpose ... Read more >>

Clin Orthop Relat Res (Clinical orthopaedics and related research)
[2015, 473(8):2495-2504]

Cited: 1 time

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Optimizing tamoxifen-inducible Cre/loxp system to reduce tamoxifen effect on bone turnover in long bones of young mice.

Zhendong A Zhong, Weihua Sun, Haiyan Chen, Hongliang Zhang, Yu-An E Lay, Nancy E Lane, Wei Yao,

For tamoxifen-dependent Cre recombinase, also known as CreER recombinase, tamoxifen (TAM) is used to activate the Cre to generate time- and tissue-specific mouse mutants. TAM is a potent CreER system inducer; however, TAM is also an active selective estrogen receptor modulator (SERM) that can influence bone homeostasis. The purpose of ... Read more >>

Bone (Bone)
[2015, 81:614-619]

Cited: 16 times

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(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice.

Zhendong A Zhong, Anderson Peck, Shihong Li, Jeff VanOss, John Snider, Casey J Droscha, Tingtung A Chang, Bart O Williams,

(99m)Tc-Methylene diphosphonate ((99m)Tc-MDP) is widely used in clinical settings to detect bone abnormalities. However, the mechanism of (99m)Tc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography (gamma scintigraphy or SPECT), ex vivo micro-computed tomography, and histology to ... Read more >>

Bone Res (Bone research)
[2015, 3:15013]

Cited: 4 times

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