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[email protected] nanotubes for photo/chemodynamic and photo-thermal dual-mode synergistic therapy under 808 nm laser irradiation.

Mingdi Sun, Dan Yang, Wu Fanqi, Zhao Wang, Hongjiao Ji, Zhiliang Liu, Shili Gai, Fangmei Zhang, Piaoping Yang,

Photodynamic therapy (PDT) is a light-based modality for tumor treatment that involves the generation of reactive oxygen species (ROS) by the combination of light, a photosensitizer, and molecular oxygen. Nevertheless, the therapeutic effects of PDT are limited by hypoxic conditions that worsen with oxygen consumption during the PDT process. Photo/chemodynamic ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(26):5707-5721]

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Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase.

Zhao Wang, Zhiqi Wang, Yusheng Pang, Huili Tong, Yunqin Yan, Shuang Li, Shufeng Li,

FNDC4 is an anti-inflammatory factor that alters the activation state of macrophages; it is used to treat colitis in mice. However, its role in muscle formation and mechanism of function remains unknown. We found that FNDC4 promotes the bovine MDSCs migration and differentiation. Furthermore, we reported that it interacts with ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2020, 14(1):153-164]

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Intelligent Fe-Mn Layered Double Hydroxides Nanosheets Anchored with Upconversion Nanoparticles for Oxygen-Elevated Synergetic Therapy and Bioimaging.

Tao Jia, Zhao Wang, Qianqian Sun, Shuming Dong, Jiating Xu, Fangmei Zhang, Lili Feng, Fei He, Dan Yang, Piaoping Yang, Jun Lin,

Multimodal synergistic therapy based on photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) has attracted increasing attention in cancer therapy. However, the scant therapeutic efficiency is always a barrier for further application. Herein, a smart tumor microenvironment (TME) responsive nanocatalysts are developed by adopting Fe-Mn layered double hydroxides ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, :e2001343]

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Author Correction: Application and Evaluation of Highly Automated Software for Comprehensive Stent Analysis in Intravascular Optical Coherence Tomography.

Hong Lu, Juhwan Lee, Martin Jakl, Zhao Wang, Pavel Cervinka, Hiram G Bezerra, David L Wilson,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18491]

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Effects of Phase Purity and Pore Reinforcement on Mechanical Behavior of NU-1000 and Silica-Infiltrated NU-1000 Metal-Organic Frameworks.

Zhao Wang, Kevin M Schmalbach, Rebecca L Combs, Youxing Chen, R Lee Penn, Nathan A Mara, Andreas Stein,

Metal-organic framework (MOF) materials have shown promise in many applications, ranging from gas storage to absorption and catalysis. Because of the high porosity and low density of many MOFs, densification methods such as pelletization and extrusion are needed for practical use and for commercialization of MOF materials. Therefore, it is ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, :]

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Effects of chrysophanol on hippocampal damage and mitochondrial autophagy in mice with cerebral ischemia reperfusion.

Wei-Hua Cui, Hai-Hong Zhang, Zi-Mei Qu, Zhao Wang, De-Jin Zhang, Shu Wang,

OBJECTIVE:The cerebral ischemia-reperfusion (I/R) model is crucial for the study of cerebral stroke. Chrysophanol (Chry) can protect nerve damage of mice in cerebral ischemia-reperfusion injury. This study aimed at investigating the neuroprotective effects of chrysophanol through mitochondrial autophagy in mice with ischemia-reperfusion injury. MATERIALS AND METHODS:Adult mice were stochastically divided ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2020, :1-8]

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The effect of Epstein-Barr virus infection in central nervous system on prognosis of patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis

Zhili Jin, Yini Wang, Lin Wu, Zhao Wang,

Abstract Background This study was conducted to investigate the effect of Epstein–Barr virus (EBV) infection in the central nervous system(CNS) on the prognosis of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) patients. Methods Clinical information of 88 EBV-HLH patients diagnosed and treated in our medical center from January 1, 2017 ... Read more >>

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MRGPRX2 is the codeine receptor of human skin mast cells: desensitization via β-arrestin and lack of correlation with the FcεRI pathway.

Magda Babina, Zhao Wang, Saptarshi Roy, Sven Guhl, Kristin Franke, Metin Artuc, Hydar Ali, Torsten Zuberbier,

Codeine stimulates skin mast cells (MCs) and is therefore used in skin tests and as inducer of experimental itch. MRGPRX2 responds to various drugs, including opioids, to elicit pseudo-allergic reactions, but whether it represents the main opiate receptor of skin MCs remains unknown. By combining a number of approaches, including ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2020, :]

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Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages.

Weihua Yu, Xin Wang, Jiuzhou Zhao, Rui Liu, Jiangzheng Liu, Zhao Wang, Jie Peng, Hao Wu, Xiaodi Zhang, Zi Long, Deqin Kong, Wenli Li, Chunxu Hai,

Macrophage recruitment and pro-inflammatory differentiation are hallmarks of various diseases, including infection and sepsis. Although studies suggest that mitochondria may regulate macrophage immune responses, it remains unclear whether mitochondrial mass affects macrophage pro-inflammatory differentiation. Here, we found that lipopolysaccharide (LPS)-activated macrophages possess higher mitochondrial mass than resting cells. Therefore, this ... Read more >>

Redox Biol (Redox biology)
[2020, 37:101761]

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Enhancing the Performance of Rubber with Nano ZnO as Activators.

Xuan Qin, Haoshu Xu, Ganggang Zhang, Jiadong Wang, Zhao Wang, Yuqi Zhao, Zongyu Wang, Tianwei Tan, Michael R Bockstaller, Liqun Zhang, Krzysztof Matyjaszewski,

The vulcanization of rubber is a chemical process to improve the mechanical properties by cross-linking unsaturated polymer chains. Zinc oxide (ZnO) acts as an activator, boosting the rubbers' sulfur vulcanization. Maintaining the level of ZnO content in the rubber compounds as low as possible is desirable, not only for economic ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(42):48007-48015]

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Construction of thiol-capped ultrasmall Au-Bi bimetallic nanoparticles for X-ray CT imaging and enhanced antitumor therapy efficiency.

Fei He, Hongjiao Ji, Lili Feng, Zhao Wang, Qianqian Sun, Chongna Zhong, Dan Yang, Shili Gai, Piaoping Yang, Jun Lin,

Thiol capped gold nanoparticles with small size, high dispersity, and broad light absorption covering ultraviolet (UV) to near infrared (NIR) region have been developed for catalysis, fluorescence imaging and photodynamic therapy (PDT). The constitution of the metal core in such nanoparticles can strongly influence the luminescence, catalysis, and stability properties. ... Read more >>

Biomaterials (Biomaterials)
[2020, 264:120453]

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Study on the simultaneous removal of fluoride, heavy metals and nitrate by calcium precipitating strain Acinetobacter sp. H12.

Zizhen Wu, Junfeng Su, Amjad Ali, Xiaofen Hu, Zhao Wang,

The removal properties and mechanisms of fluoride (F-) and nickel (Ni2+) were studied by biomineralizing bacteria (Acinetobacter sp. H12). The results showed that the removal ratio of F-, Ca2+ and Ni2+ reached 75% (0.031 mg·L-1·h-1), 84.96% (2.123 mg·L-1·h-1), and 56.67% (0.024 mg·L-1·h-1) after 72 h, respectively. The removal ratio of nitrate (NO3-) reached 100% ... Read more >>

J Hazard Mater (Journal of hazardous materials)
[2020, :124255]

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Enhanced Efficiency of flySAM by Optimization of sgRNA Parameters in Drosophila.

Decai Mao, Yu Jia, Ping Peng, Da Shen, Xingjie Ren, Ruibao Zhu, Yuhao Qiu, Yuting Han, Jinchao Yu, Qinyun Che, Yutong Li, Xinyi Lu, Lu-Ping Liu, Zhao Wang, Qingfei Liu, Jin Sun, Jian-Quan Ni,

The flySAM/CRISPRa system has recently emerged as a powerful tool for gain-of-function studies in Drosophila melanogaster This system includes Gal4/UAS-driven dCas9 activators and U6 promoter-controlled sgRNA. Having established dCas9 activators superior to other combinations, to further enhance the efficiency of the targeting activators we systematically optimized the parameters of the ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2020, :]

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New Perspectives on the Aberrant Alveolar Repair of Idiopathic Pulmonary Fibrosis.

Zhao Ni Wang, Xiao Xiao Tang,

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown etiology and high mortality. Current therapeutic strategies have limited efficacy and the prognosis remains poor. Based on the histological observations of IPF lung tissues and experimental studies using lung fibrosis animal models, it is gradually accepted that impaired epithelial ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:580026]

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Prognostic Value of the Modified Systemic Inflammation Score in Patients With Extranodal Natural Killer/T-Cell Lymphoma.

He Huang, Li Min Chen, Xiao Jie Fang, Cheng Cheng Guo, Xiao Ping Lin, Huang Ming Hong, Xi Li, Zhao Wang, Ying Tian, Mei Ting Chen, Yu Yi Yao, Zegeng Chen, Xiao Qian Li, Fei Pan,

Background:Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare and extremely malignant tumor. The systemic inflammation score (SIS), which is based on the pretreatment level of lymphocyte-to-monocyte ratio (LMR) and serum albumin (Alb), has been shown to be of prognostic value in a number of cancers. We integrate several other pretreatment ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:593392]

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The combination of excimer laser ablation and drug eluting balloon for treating superficial femoral arterial occlusion following stent implantation: A case report.

Xueliang Wu, Zhao Wang, Tian Li,

RATIONALE:Recent research shows that in-stent restenosis (ISR) occurs in half of the patients treated with stenting of femoral and popliteal artery for lower extremity arteriosclerotic occlusive disease (LEASO). Combined therapy is mainly used clinically to obtain better medium- and long-term treatment outcomes and reduce the occurrences of reintervention, among which, ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(43):e22935]

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Rapid Decomposition and Catalytic Cascade Nanoplatforms Based on Enzymes and Mn-Etched Dendritic Mesoporous Silicon for MRI-Guided Synergistic Therapy.

Bin Liu, Zhao Wang, Tianyao Li, Qianqian Sun, Shuming Dong, Chongna Zhong, Dan Yang, Fei He, Shili Gai, Piaoping Yang,

The endogenous tumor microenvironment (TME) can signally influence the therapeutic effects of cancer, so it is necessary to explore effective synergistic therapeutic strategies based on changing of the TME. Here, a catalytic cascade nanoplatform based on manganese (Mn)-etched dendritic mesoporous silicon nanoparticles (designated as DMMnSiO3 NPs) loaded with indocyanine green ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(41):45772-45788]

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Monocyte volumetric parameters and lymph index are increased in SARS-CoV-2 infection.

Xiaoqian Zeng, Hui Xing, Yan Wei, Zhaoming Tang, Xiao Lu, Zhao Wang, Yuying Liu, Liang Xu, Lihua Hu, Lin Wang, Dongsheng Xu,

Int J Lab Hematol (International journal of laboratory hematology)
[2020, :]

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Publisher Correction: A mass spectrometry-based proteome map of drug action in lung cancer cell lines.

Benjamin Ruprecht, Julie Di Bernardo, Zhao Wang, Xuan Mo, Oleg Ursu, Matthew Christopher, Rafael B Fernandez, Li Zheng, Brian D Dill, Huijun Wang, Yuting Xu, Andy Liaw, Jonathan D Mortison, Nirodhini Siriwardana, Brian Andresen, Meir Glick, James R Tata, Victoria Kutilek, Ivan Cornella-Taracido, An Chi,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(10):1149]

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A proposal for a prognostic index for non-nasal type natural killer/T cell lymphoma after asparaginase-based treatment.

Zegeng Chen, Xiaojie Fang, He Huang, Zhao Wang, Huangming Hong, Meiting Chen, Quanguang Ren, Yuyi Yao, Limei Zhang, Ying Tian, Suxia Lin, Tongyu Lin,

In the era of asparaginase-based therapy for extranodal natural killer/T cell lymphoma (ENKTL), the clinical outcomes of ENKTL have notably improved. However, as a rare subtype of ENKTL, the therapeutic effect and prognostic factors of non-nasal type ENKTL remain unclear. Thus, we performed this study to analyze the clinical characteristics ... Read more >>

Ann Hematol (Annals of hematology)
[2020, :]

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The strategies to reduce cost and improve productivity in DHA production by Aurantiochytrium sp.: from biochemical to genetic respects.

Xiaodan Xu, Changyi Huang, Zhexian Xu, Huixia Xu, Zhao Wang, Xinjun Yu,

The marine oleaginous protist Aurantiochytrium sp. (Schizochytrium sp.) is a well-known docosahexaenoic acid (DHA) producer and its different DHA products are the ideal substitute for the traditional fish oil resource. However, the cost of the DHA products derived from Aurantiochytrium sp. (Schizochytrium sp.) is still high, limiting their wide applications. ... Read more >>

Appl Microbiol Biotechnol (Applied microbiology and biotechnology)
[2020, 104(22):9433-9447]

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Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems.

Le Qian, Suzhen Qi, Zhao Wang, Jason T Magnuson, David C Volz, Daniel Schlenk, Jiazhen Jiang, Chengju Wang,

Boscalid is a persistent fungicide that is frequently detected in surface waters and may be neurotoxic to aquatic organisms. Herein, we evaluated the effects of environmentally relevant boscalid concentrations to zebrafish to explore its potentially neurotoxic mechanisms of effect. Behavioral responses (swimming, phototaxis, and predation), histopathology, transcriptomics, biochemical parameter analysis ... Read more >>

J Hazard Mater (Journal of hazardous materials)
[2020, 404(Pt A):124083]

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Directed evolution of Aspergillus oryzae lipase for the efficient resolution of (R,S)-ethyl-2-(4-hydroxyphenoxy) propanoate.

Mengjie Zhang, Qi Li, Xing Lan, Xiaojun Li, Yinjun Zhang, Zhao Wang, Jianyong Zheng,

Aspergillus oryzae lipase (AOL) is a potential biocatalyst for industrial application. In this study, a mutant lipase AOL-3F38N/V230R was screened through two rounds of directed evolution, resulting in a fourfold increase in lipase activity, and threefold in catalytic efficiency (kcat/Km), while maintaining its excellent stereoselectivity. AOL-3F38N/V230R enzyme activity was maximum ... Read more >>

Bioprocess Biosyst Eng (Bioprocess and biosystems engineering)
[2020, 43(12):2131-2141]

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Activatable Two-Photon Near-Infrared Fluorescent Probe Tailored toward Peroxynitrite In Vivo Imaging in Tumors.

Weiwei Wang, Jianhua Xiong, Xinjian Song, Zhao Wang, Fan Zhang, Zhiqiang Mao,

A malignant tumor remains one of the leading causes of deaths across the world. Thus, diagnosis of tumor development with noninvasive visualizing methods is significant for tumor therapy. Herein, an activatable two-photon NIR fluorescent probe DHQ-Rd-PN for in vivo imaging of peroxynitrite in a tumor was elaborately designed. The probe ... Read more >>

Anal Chem (Analytical chemistry)
[2020, 92(19):13305-13312]

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Investigations of drug-induced liver injury by a peroxynitrite activatable two-photon fluorescence probe.

Zhao Wang, Fan Zhang, Jianhua Xiong, Zhiqiang Mao, Zhihong Liu,

Drug-induced liver injury (DILI) is a prevalent liver disease and the leading cause for acute liver failure (ALF) worldwide. Screening of DILI in patients is central to ensure drug safety and improve therapy efficiency. Mounting evidences revealed that peroxynitrite (ONOO-) is involved in the DILI process and can be a ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2020, 246:118960]

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