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Pembrolizumab alone or with chemotherapy for squamous cell carcinoma of the head and neck: A cost-effectiveness analysis from Chinese perspective.

Kexun Zhou, Yunzhu Li, Weiting Liao, Mengxi Zhang, Liangliang Bai, Qiu Li,

OBJECTIVES:The KEYNOTE-048 trial indicated pembrolizumab plus chemotherapy is an appropriate first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), while pembrolizumab monotherapy is optimal for PD-L1 positive patient. This study was powered to determine the most cost-effective strategy for patient with different combined positive score (CPS). ... Read more >>

Oral Oncol. (Oral oncology)
[2020, 107:104754]

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Generative adversarial network based regularized image reconstruction for PET.

Zhaoheng Xie, Reheman Baikejiang, Tiantian Li, Xuezhu Zhang, Kuang Gong, Mengxi Zhang, Wenyuan Qi, Evren Asma, Jinyi Qi,

Positron emission tomography (PET) is an ill-posed inverse problem and suffers high noise due to limited number of detected events. Prior information can be used to improve the quality of reconstructed PET images. Deep neural networks have also been applied to regularized image reconstruction. One method is to use a ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2020, :]

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A study on the relationship between air pollution and pulmonary tuberculosis based on the general additive model in Wulumuqi, China.

Jiandong Yang, Mengxi Zhang, Yanggui Chen, Li Ma, Rayibai Yadikaer, Yaoqin Lu, Pengwei Lou, Yujiao Pu, Ran Xiang, Baolin Rui,

OBJECTIVE:This study aimed to explore the impact of atmospheric pollutants on the incidence of tuberculosis (TB), and provide new ideas for the prevention and control of TB in the future. METHODS:It explored the relationship between air pollutants and meteorological factors, as well as between air pollutants and heating through Spearman ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 96:42-47]

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Motion correction of respiratory-gated PET images using deep learning based image registration framework.

Tiantian Li, Mengxi Zhang, Wenyuan Qi, Evren Asma, Jinyi Qi,

Artifacts caused by patient breathing and movement during PET data acquisition affect image quality. Respiratory gating is commonly used to gate the list-mode PET data into multiple bins over a respiratory cycle. Non-rigid registration of respiratory-gated PET images can reduce motion artifacts and preserve count statistics, but it is time ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2020, :]

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Efficient removal of formaldehyde by polyethyleneimine modified activated carbon in a fixed bed.

Dongdong Zhang, Mengxi Zhang, Feng Ding, Wei Liu, Long Zhang, Longzhe Cui,

Polyethyleneimine modified activated carbon (PEI-AC) was prepared through a treatment of immersion, and used for the adsorption of formaldehyde. The adsorption capacity of formaldehyde by unmodified AC is 190.1 mg g-1, and the adsorption capacity of formaldehyde can reach to 317.6 mg g-1 after 10 g L-1 of PEI modified, being about 1.67 times than unmodified ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(15):18109-18116]

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Cost-Effectiveness Analysis of Bevacizumab plus Paclitaxel versus Bevacizumab plus Capecitabine for HER2-Negative Locally Recurrent or Metastatic Breast Cancer.

Qiuji Wu, Xinyuan Wang, Mengxi Zhang, Weiting Liao, Feng Wang, Qiu Li,

BACKGROUND:The aim of the current study was to estimate two protocols for HER2-negative locally recurrent or metastatic breast cancer patients, bevacizumab combined with paclitaxel versus bevacizumab combined with capecitabine, from the economic view. METHODS:The process of HER2-negative locally recurrent or metastatic breast cancer treated with bevacizumab combined with paclitaxel or ... Read more >>

Oncol Res Treat (Oncology research and treatment)
[2020, 43(4):153-159]

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Automatic left ventricle segmentation from cardiac magnetic resonance images using a capsule network.

Yangsu He, Wenjian Qin, Yin Wu, Mengxi Zhang, Yongfeng Yang, Xin Liu, Hairong Zheng, Dong Liang, Zhanli Hu,

PURPOSE:Segmentation of magnetic resonance images (MRI) of the left ventricle (LV) plays a key role in quantifying the volumetric functions of the heart, such as the area, volume, and ejection fraction. Traditionally, LV segmentation is performed manually by experienced experts, which is both time-consuming and prone to subjective bias. This ... Read more >>

J Xray Sci Technol (Journal of X-ray science and technology)
[2020, :]

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A unified approach for divergent synthesis of contiguous stereodiads employing a small boronyl group.

Miao Zhan, Zhengwei Ding, Shaozhi Du, Haohua Chen, Chao Feng, Ming Xu, Zhi Liu, Mengxi Zhang, Chao Wu, Yu Lan, Pengfei Li,

Acyclic contiguous stereocenters are frequently seen in biologically active natural and synthetic molecules. Although various synthetic methods have been reported, predictable and unified approaches to all possible stereoisomers are rare, particularly for those containing non-reactive hydrocarbon substituents. Herein, a β-boronyl group is employed as a readily accessible handle for predictable ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):792]

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Culturally-Appropriate Orientation Increases the Effectiveness of Mental Health First Aid Training for Bhutanese Refugees: Results from a Multi-state Program Evaluation.

Ashok Gurung, Parangkush Subedi, Mengxi Zhang, Changwei Li, Timothy Kelly, Curi Kim, Katherine Yun,

Poor mental health remains a significant source of morbidity and mortality in the Bhutanese refugee community. Mental Health First Aid (MHFA) is a promising intervention that has been used in other immigrant communities to prepare individuals to recognize and respond to mental health warning signs. This was a non-randomized program ... Read more >>

J Immigr Minor Health (Journal of immigrant and minority health)
[2020, :]

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Asymmetric Total Syntheses of Di- and Sesquiterpenoids by Catalytic C-C Activation of Cyclopentanones.

Si-Hua Hou, Adriana Y Prichina, Mengxi Zhang, Guangbin Dong,

To show the synthetic utility of the catalytic C-C activation of less strained substrates, described here are the collective and concise syntheses of the natural products (-)-microthecaline A, (-)-leubehanol, (+)-pseudopteroxazole, (+)-seco-pseudopteroxazole, pseudopterosin A-F and G-J aglycones, and (+)-heritonin. The key step in these syntheses involve a Rh-catalyzed C-C/C-H activation cascade of 3-arylcyclopentanones, ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, 59(20):7848-7856]

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Molecular-Sieving Membrane by Partitioning the Channels in Ultrafiltration Membrane by In Situ Polymerization.

Pengpeng Shao, Ruxin Yao, Ge Li, Mengxi Zhang, Shuai Yuan, Xiaoqi Wang, Yuhao Zhu, Xianming Zhang, Lin Zhang, Xiao Feng, Bo Wang,

Commercial ultrafiltration membranes have proliferated globally for water treatment. However, their pore sizes are too large to sieve gases. Conjugated microporous polymers (CMPs) feature well-developed microporosity yet are difficult to be fabricated into membranes. Herein, we report a strategy to prepare molecular-sieving membranes by partitioning the mesoscopic channels in water ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, 59(11):4401-4405]

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Adjuvant Chemoradiotherapy for Gastric Cancer: Efficacy and Cost-Effectiveness Analysis.

Mengxi Zhang, Feng Wen, Xiaofeng He, Weihan Zhang, Jiankun Hu, Qiu Li,

Purpose: The benefit of adjuvant chemotherapy (CT) for localized gastric cancer (GC) after D2-gastrectomy has been clearly demonstrated. However, adjuvant chemoradiotherapy (CRT) remains controversial. This study aimed to assess the efficacy and cost-effectiveness of treatment for GC after D2-gastrectomy. Materials and methods: Stage IB-IIICGC patients who had received adjuvant CRT ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:1357]

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Remarkable Response of Metastatic Gallbladder Carcinoma to Apatinib After Failed Multiline Chemotherapies: A Case Report and Literature Review.

Mengxi Zhang, Pengfei Zhang, Kexun Zhou, Qiu Li,

Gallbladder carcinoma (GBC) is a relatively rare and aggressive malignant tumor with a poor prognosis. A systematic review of current clinical studies illustrates an extreme paucity of second-line therapeutic options following the failure of standard-of-care cisplatin-gemcitabine chemotherapy. The efficacy of apatinib, an highly potent and selective oral inhibitor of VEGFR-2 ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:1180]

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Prototype Small-Animal PET-CT Imaging System for Image-guided Radiation Therapy.

Ekaterina Mikhaylova, Jamison Brooks, Darren Zuro, Farouk Nouizi, Maciej Kujawski, Srideshikan Sargur Madabushi, Jinyi Qi, Mengxi Zhang, Junie Chea, Erasmus K Poku, Nicole Bowles, Jeffrey Y C Wong, John E Shively, Paul J Yazaki, Gultekin Gulsen, Simon R Cherry, Susanta Hui,

Molecular imaging is becoming essential for precision targeted radiation therapy, yet progress is hindered from a lack of integrated imaging and treatment systems. We report the development of a prototype positron emission tomography (PET) scanner integrated into a commercial cone beam computed tomography (CBCT) based small animal irradiation system for ... Read more >>

IEEE Access (IEEE access : practical innovations, open solutions)
[2019, 7:143207-143216]

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p53-cyclophilin D mediates renal tubular cell apoptosis in ischemia-reperfusion-induced acute kidney injury.

Huan Yang, Ruizhao Li, Li Zhang, Shu Zhang, Wei Dong, Yuanhan Chen, Weidong Wang, Chunling Li, Zhiming Ye, Xingchen Zhao, Zhilian Li, Yanhua Wu, Mengxi Zhang, Shuangxin Liu, Zheng Dong, Xinling Liang,

Ischemia-reperfusion (I/R)-induced acute kidney injury (I/R-AKI) favors mitochondrial permeability transition pore (mPTP) opening and subsequent cell death. Cyclophilin D (CypD) is an essential component of the mPTP, and recent findings have implicated the p53-CypD complex in cell death. To evaluate the role of p53-CypD after I/R-AKI, we tested the hypothesis ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2019, 317(5):F1311-F1317]

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Nutrition Transition & Double Burden of Malnutrition in Africa: A Case Study of Four Selected Countries with Different Income Levels (P10-074-19).

Kilee Kimmel, Teresia Mbogori, Mengxi Zhang, Jayanthi Kandiah, Youfa Wang,

AbstractObjectivesDisease and lifestyle patterns have been changing rapidly worldwide including Africa due to recent changes in economic growth and urbanization. However, research related to the effects of these changes on nutrition status in Africa is limited. This study investigated the shifts in nutritional status (undernutrition, overweight, obesity) in children and ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2019, 3(Suppl 1):]

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RIPK3 mediates renal tubular epithelial cell apoptosis in endotoxin‑induced acute kidney injury.

Shu Zhang, Ruizhao Li, Wei Dong, Huan Yang, Li Zhang, Yuanhan Chen, Weidong Wang, Chunling Li, Yanhua Wu, Zhiming Ye, Xingchen Zhao, Zhilian Li, Mengxi Zhang, Shuangxin Liu, Xinling Liang,

Renal tubular epithelial cell apoptosis is an important pathological mechanism of septic acute kidney injury (AKI). Endotoxin, also known as lipopolysaccharide (LPS), has a key role in septic AKI and can directly induce tubular epithelial cell apoptosis. The upregulation of receptor‑interacting protein kinase 3 (RIPK3) in tubular epithelial cells has ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2019, 20(2):1613-1620]

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Electropolymerization of Molecular-Sieving Polythiophene Membranes for H2 Separation.

Mengxi Zhang, Xuechun Jing, Shuang Zhao, Pengpeng Shao, Yuanyuan Zhang, Shuai Yuan, Yanshuo Li, Cheng Gu, Xiaoqi Wang, Yanchun Ye, Xiao Feng, Bo Wang,

Membrane technologies that do not rely on heat for industrial gas separation would lower global energy cost. While polymeric, inorganic, and mixed-matrix separation membranes have been rapidly developed, the bottleneck is balancing the processability, selectivity, and permeability. Reported here is a softness adjustment of rigid networks (SARs) strategy to produce ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2019, 58(26):8768-8772]

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Flexible Films of Covalent Organic Frameworks with Ultralow Dielectric Constants under High Humidity.

Pengpeng Shao, Jie Li, Fan Chen, Li Ma, Qingbin Li, Mengxi Zhang, Junwen Zhou, Anxiang Yin, Xiao Feng, Bo Wang,

Covalent organic framework (COF) films combine the processability of polymers with the porosity and atomic precision of crystalline porous materials, properties that are long-sought-after in electronics yet hard to realize. Herein, we prepared four flexible COF films with different alkoxy side chains via interfacial polymerization. The COF films exhibit an ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2018, 57(50):16501-16505]

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Positron emission tomography image reconstruction using feature extraction.

Juan Gao, Qiyang Zhang, Qiegen Liu, Xuezhu Zhang, Mengxi Zhang, Yongfeng Yang, Dong Liang, Xin Liu, Hairong Zheng, Zhanli Hu,

PURPOSE:To reduce the cost of positron emission tomography (PET) scanning systems, image reconstruction algorithms for low-sampled data have been extensively studied. However, the current method based on total variation (TV) minimization regularization nested in the maximum likelihood-expectation maximization (MLEM) algorithm cannot distinguish true structures from noise resulting losing some fine ... Read more >>

J Xray Sci Technol (Journal of X-ray science and technology)
[2019, 27(5):949-963]

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Few-view CT image reconstruction using improved total variation regularization.

Kuai Li, Ziru Sang, Xuezhu Zhang, Mengxi Zhang, Changhui Jiang, Qiyang Zhang, Yongshuai Ge, Dong Liang, Yongfeng Yang, Xin Liu, Hairong Zheng, Zhanli Hu,

X-ray radiation is harmful to human health. Thus, obtaining a better reconstructed image with few projection view constraints is a major challenge in the computed tomography (CT) field to reduce radiation dose. In this study, we proposed and tested a new algorithm that combines penalized weighted least-squares using total generalized ... Read more >>

J Xray Sci Technol (Journal of X-ray science and technology)
[2019, 27(4):739-753]

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A Meta-analysis of the Association Between Needle Exchange Programs and HIV Seroconversion Among Injection Drug Users.

Mohammed U Mir, Faisal Akhtar, Mengxi Zhang, Nicholas J Thomas, Hui Shao,

We assessed the association between different levels of needle exchange program (NEP) use and human immunodeficiency virus (HIV) seroconversion in the injecting drug user (IDU) population using meta-analysis to aggregate risk estimates from any reported cohort studies or randomized controlled trials (RCTs) in the literature. We searched the literature for ... Read more >>

Cureus (Cureus)
[2018, 10(9):e3328]

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Cost-effectiveness analysis of adjuvant treatment for resected pancreatic cancer in China based on the ESPAC-4 trial.

Jiaxing Huang, Weiting Liao, Jing Zhou, Pengfei Zhang, Feng Wen, Xinyuan Wang, Mengxi Zhang, Kexun Zhou, Qiuji Wu, Qiu Li,

Background:The effectiveness of gemcitabine plus capecitabine compared with gemcitabine monotherapy for resected pancreatic cancer has been evaluated in the ESPAC-4 trial. We aimed to assess the cost-effectiveness of these adjuvant regimens on resected pancreatic cancer. Methods:A Markov model was established to simulate the disease process of resected pancreatic cancer (relapse-free ... Read more >>

Cancer Manag Res (Cancer management and research)
[2018, 10:4065-4072]

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Early-life exposure to severe famine and subsequent risk of depressive symptoms in late adulthood: the China Health and Retirement Longitudinal Study.

Changwei Li, Toni Miles, Luqi Shen, Ye Shen, Tingting Liu, Mengxi Zhang, Shengxu Li, Cheng Huang,

BACKGROUND:The Chinese Great Famine caused widespread starvation in 1959-1961. Its long-term association with depressive symptoms has not been studied.AimsTo estimate the burden of depressive symptoms and the association of famine exposure with depressive symptoms. METHOD:The China Health and Retirement Longitudinal Study is a nationwide representative survey of 17 708 Chinese ... Read more >>

Br J Psychiatry (The British journal of psychiatry : the journal of mental science)
[2018, 213(4):579-586]

Cited: 3 times

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Stable Aluminum Metal-Organic Frameworks (Al-MOFs) for Balanced CO2 and Water Selectivity.

Haiwei Li, Xiao Feng, Dou Ma, Mengxi Zhang, Yuanyuan Zhang, Yi Liu, Jinwei Zhang, Bo Wang,

Three new Al-MOFs in the formation of [Al4(OH)2(OCH3)4(OH-BDC)3]·xH2O (BIT-72), [Al4(OH)2(OCH3)4(CH3-BDC)3]·xH2O (BIT-73) and {Al4(OH)2(OCH3)4[(CH3)2-BDC]3}·xH2O (BIT-74) have been synthesized by assembling Al3+ ion with terephthalic acid ions decorated with monohydroxyl, monomethyl or dimethyl groups, respectively. All of these three MOFs exhibit high stability in boiling water and acidic conditions. Among them, BIT-72 ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2018, 10(4):3160-3163]

Cited: 3 times

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