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Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells.

Jian-An Pan, Hui Zhang, Hao Lin, Lin Gao, Hui-Li Zhang, Jun-Feng Zhang, Chang-Qian Wang, Jun Gu,

The dose-dependent toxicity to cardiomyocytes has been well recognized as a central characteristic of doxorubicin (DOX)-induced cardiotoxicity (DIC), however, the pathogenesis of DIC in the cardiac microenvironment remains elusive. Irisin is a new hormone-like myokine released into the circulation in response to exercise with distinct functions in regulating apoptosis, inflammation, ... Read more >>

Redox Biol (Redox biology)
[2021, 46:102120]

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MiR-21-3p Inhibits Adipose Browning by Targeting FGFR1 and Aggravates Atrial Fibrosis in Diabetes.

Jian-An Pan, Hao Lin, Jian-Ying Yu, Hui-Li Zhang, Jun-Feng Zhang, Chang-Qian Wang, Jun Gu,

A relationship between excess epicardial adipose tissue (EAT) and the risk of atrial fibrillation (AF) has been reported. Browning of EAT may be a novel approach for the prevention or treatment of AF by attenuating atrial fibrosis. Previous studies have identified microRNA-21 (miR-21) as a regulatory factor in atrial fibrosis. ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:9987219]

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Sacubitril-valsartan in Heart Failure With Preserved Ejection Fraction Following Acute Coronary Syndrome

Zhi-hua Han, Chang-qian Wang, Jun-feng Zhang, Jun Gu,

<h4>Background: </h4> It was indicated that sacubitril-valsartan could improve the clinical prognosis in specific phenotype of heart failure with preserved ejection fraction (HFpEF) patients compared with valsartan. However, there is lack of evidence of the comparative effectiveness in HFpEF patients following acute coronary syndrome (ACS). The aim of this study ... Read more >>

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Predictive and prognostic value of v-set and transmembrane domain-containing 1 expression in monocytes for coronary artery disease.

Xiao-Fei Wang, Meng-Cheng Xu, Cheng-Yu Mao, En-Zhou, Qing He, Xing-Qian Qu, Yu-Qi Fan, Chang-Qian Wang, Jun-Feng Zhang,

The aim of this study was to investigate the correlation between v-set and transmembrane domain-containing 1 (VSTM1) expression and incidence of major adverse cardiac events (MACE) in patients with coronary heart disease (CHD). A total of 310 patients were divided into a non-acute coronary syndrome (non-ACS) group (containing the stable ... Read more >>

Rev Cardiovasc Med (Reviews in cardiovascular medicine)
[2021, 22(3):1009-1017]

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DMFMDA: Prediction of Microbe-Disease Associations Based on Deep Matrix Factorization Using Bayesian Personalized Ranking.

Yue Liu, Shu-Lin Wang, Jun-Feng Zhang, Wei Zhang, Su Zhou, Wen Li,

Identifying the microbe-disease associations is conducive to understanding the pathogenesis of disease from the perspective of microbe. In this paper, we propose a deep matrix factorization prediction model (DMFMDA) based on deep neural network. First, the disease one-hot encoding is fed into neural network, which is transformed into a low-dimensional ... Read more >>

IEEE/ACM Trans Comput Biol Bioinform (IEEE/ACM transactions on computational biology and bioinformatics)
[2021, 18(5):1763-1772]

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Conjugative Plasmid-Mediated Extended Spectrum Cephalosporin Resistance in Genetically Diverse Escherichia coli from a Chicken Slaughterhouse.

Bai Wei, Ke Shang, Se-Yeoun Cha, Jun-Feng Zhang, Hyung-Kwan Jang, Min Kang,

ESC-resistant <i>E. coli</i> isolates were collected from broiler chickens, a slaughterhouse, and retail meat to assess their dispersion and their involvement in cross-contamination. ESBL-/AmpC-producing <i>E. coli</i> were isolated during the slaughter process of all six investigated chicken flocks from scalding, feather removal, first conveyor, evisceration, second washing, third conveyor, and ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(9):]

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Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes.

Yu-Qiang Zhao, Jiahong Duan, Le Yu, Ilwha Kim, Yumin Wang, Yi-Cheng Ma, Cheng-Gang Zou, Ying Zhou, Jun Feng Zhang, Jong Seung Kim,

A cocktail [1 + 2] dual-fluorescent probe system was developed to realize the real-time visualization of dynamic iron state changes between Fe2+ and Fe3+ at the cellular level and in multicellular organisms, providing insights into the effect of DMT1 and ferroportin on iron regulation. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(64):7902-7905]

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Balloon Deflation Strategy during Primary Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Clinical Trial and Numerical Simulation-Based Analysis.

Jun Gu, Yang Zhuo, Tian-Jiao Liu, Jie Li, Zhao-Fang Yin, Zuo-Jun Xu, Li Fan, Qing He, Kan Chen, Hua-Su Zeng, Xiao-Fei Wang, Yu-Qi Fan, Jun-Feng Zhang, Fu-You Liang, Chang-Qian Wang,

<h4>Background</h4>Primary percutaneous coronary intervention (PCI) is the best available reperfusion strategy in patients with acute ST-segment elevation myocardial infarction (STEMI). However, PCI is associated with a serious problem known as no-reflow phenomenon, resulting in poor clinical and functional outcomes. This study aimed to compare the influences of different balloon deflation ... Read more >>

Cardiol Res Pract (Cardiology research and practice)
[2020, 2020:4826073]

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The use of embryonic chicken eggs as an alternative model to evaluate the virulence of Salmonella enterica serovar Gallinarum.

Jun-Feng Zhang, Bai Wei, Se-Yeoun Cha, Ke Shang, Hyung-Kwan Jang, Min Kang,

Salmonella enterica serovar Gallinarum (S. Gallinarum) can cause fowl typhoid, a severe systemic disease responsible for considerable economic losses. Chicken pathogenicity test is the traditional method for assessing the virulence of S. Gallinarum. However, this method is limited by several factors, including ethical considerations, costs, and the need for specialized ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238630]

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Characterization of Extended-Spectrum Cephalosporin (ESC) Resistance in Salmonella Isolated from Chicken and Identification of High Frequency Transfer of blaCMY-2 Gene Harboring Plasmid In Vitro and In Vivo.

Bo-Ram Kwon, Bai Wei, Se-Yeoun Cha, Ke Shang, Jun-Feng Zhang, Hyung-Kwan Jang, Min Kang,

A total of 136 <i>Salmonella</i> isolates from chicken feces and meat samples of the top 12 integrated chicken production companies throughout Korea were collected. Among the 17 ESC-resistant <i>Salmonella</i>; <i>bla</i><sub>CTX-M-15</sub> was the most prevalent gene and two strains carried <i>bla</i><sub>TEM-1</sub>/<i>bla</i><sub>CTX-M-15</sub> and <i>bla</i><sub>CMY-2</sub>, respectively. The transferable <i>bla</i><sub>CTX-M-15</sub> gene was carried by ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(6):]

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SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A-c-Myc axis.

Jian-Yu Yang, Yan-Miao Huo, Min-Wei Yang, Yang Shen, De-Jun Liu, Xue-Liang Fu, Ling-Ye Tao, Rui-Zhe He, Jun-Feng Zhang, Rong Hua, Shu-Heng Jiang, Yong-Wei Sun, Wei Liu,

Hot spot gene mutations in splicing factor 3b subunit 1 (SF3B1) are observed in many types of cancer and create abundant aberrant mRNA splicing, which is profoundly implicated in tumorigenesis. Here, we identified that the SF3B1 K700E (SF3B1<sup>K700E</sup> ) mutation is strongly associated with tumor growth in pancreatic ductal adenocarcinoma ... Read more >>

Mol Oncol (Molecular oncology)
[2021, :]

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Left ventricular geometry transition in hypertensive patients with heart failure with preserved ejection fraction.

Ping Guan, Jun Gu, Zhi-Ping Song, Chang-Qian Wang, Wei Hu, Jun-Feng Zhang,

<h4>Aims</h4>Heart failure with preserved ejection fraction (HFpEF) develops in response to hypertensive left ventricular (LV) hypertrophy and is associated with increased cardiovascular events. Although the progression to systolic heart failure is a known consequence of LV hypertrophy and HFpEF, few data are available on the LV geometry change and frequency ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(4):2784-2790]

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CD74 promotes perineural invasion of cancer cells and mediates neuroplasticity via the AKT/EGR-1/GDNF axis in pancreatic ductal adenocarcinoma.

Jun-Feng Zhang, Ling-Ye Tao, Min-Wei Yang, Da-Peng Xu, Shu-Heng Jiang, Xue-Liang Fu, De-Jun Liu, Yan-Miao Huo, Wei Liu, Jian-Yu Yang, Rong Hua, Ping Lu, Yong-Wei Sun,

Perineural invasion (PNI) is a common feature of pancreatic ductal adenocarcinoma (PDAC) and is one of the important causes of local recurrence in resected pancreatic cancer, but the molecular mechanism remains largely unexplored. Here, we used immunohistochemistry staining to determine the expression of CD74. Then the in vivo PNI model, ... Read more >>

Cancer Lett (Cancer letters)
[2021, 508:47-58]

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Association of Circulating Irisin Levels and the Characteristics and Prognosis of Coronary Artery Disease.

Jian-An Pan, Hui Zhang, Quan Yu, Jun-Feng Zhang, Chang-Qian Wang, Jun Gu, Kan Chen,

<h4>Background</h4>Irisin is a new muscle factor discovered in recent years that shows a strong association with metabolic diseases. However, its role in coronary artery disease (CAD) is still controversial. We performed this study to determine the relationship of serum irisin with the characteristics and prognosis of CAD.<h4>Materials and methods</h4>Patients with ... Read more >>

Am J Med Sci (The American journal of the medical sciences)
[2021, 362(1):63-71]

Cited: 2 times

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Helicobacter pylori infection is associated with the co-occurrence of bacteria in the oral cavity and the gastric mucosa.

Zhen-Feng Wu, Kun Zou, Chun-Jie Xiang, Zhao-Jia Jin, Hai-Hua Ding, Shuo Xu, Guan-Nan Wu, Yao-Hui Wang, Xiao-Yu Wu, Che Chen, Xue-Quan Yao, Jun-Feng Zhang, Fu-Kun Liu,

<h4>Background</h4>Pathogens capable of impacting gastrointestinal tract tumor development are located in the oral cavity, but whether these oral bacteria are able to colonize the gastric mucosa in gastric cancer (GC) patients and whether Helicobacter pylori infection can influence this process remains to be established.<h4>Methods</h4>Microbial 16S rDNA deep sequencing was conducted ... Read more >>

Helicobacter (Helicobacter)
[2021, 26(2):e12786]

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Clonal dissemination of Salmonella enterica serovar albany with concurrent resistance to ampicillin, chloramphenicol, streptomycin, sulfisoxazole, tetracycline, and nalidixic acid in broiler chicken in Korea.

Bai Wei, Ke Shang, Se-Yeoun Cha, Jun-Feng Zhang, Hyung-Kwan Jang, Min Kang,

The aim of this study was to determine the prevalence, serovar distribution, antimicrobial resistance, and genotypic analyses of the dominating serovars of Salmonella in chickens from a national study in Korea. Between 2017 and 2018, a total of 550 chicken samples were collected from the top 12 integrated broiler chicken ... Read more >>

Poult Sci (Poultry science)
[2021, 100(7):101141]

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Incident Heart Failure in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention

Jun Gu, Zhao-fang Yin, Zuo-jun Xu, Yu-qi Fan, Chang-qian Wang, Jun-feng Zhang,

Background: The contemporary incidence of heart failure (HF) in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) remains unclear. This prospective cohort study was designed to study the incidence and predictors of new-onset HF in CAD patients after PCI (ChiCTR1900023033). Methods: From January 2014 to December 2018, ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:]

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The Occurrence of Antimicrobial-Resistant Salmonella enterica in Hatcheries and Dissemination in an Integrated Broiler Chicken Operation in Korea.

Ke Shang, Bai Wei, Se-Yeoun Cha, Jun-Feng Zhang, Jong-Yeol Park, Yea-Jin Lee, Hyung-Kwan Jang, Min Kang,

Positive identification rates of <i>Salmonella enterica</i> in hatcheries and upstream breeder farms were 16.4% (36/220) and 3.0% (6/200), respectively. Among the <i>Salmonella</i> serovars identified in the hatcheries, <i>S</i>. <i>enterica</i> ser. Albany (17/36, 47.2%) was the most prevalent, followed by the serovars <i>S</i>. <i>enterica</i> ser. Montevideo (11/36, 30.6%) and <i>S</i>. <i>enterica</i> ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(1):]

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Genetic diversity of extended-spectrum cephalosporin resistance in Salmonella enterica and E. coli isolates in a single broiler chicken.

Bai Wei, Se-Yeoun Cha, Ke Shang, Jun-Feng Zhang, Hyung-Kwan Jang, Min Kang,

Extended-spectrum cephalosporin (ESC) resistance investigated in Salmonella and E. coli from the same chicken was to improve the understanding of the inter-species transmission of ESC resistance determinants in Salmonella and E. coli from a single chicken individual. Fifteen (13.6%) farms and 44 (8.0%) chicken individuals were positive for ESC-resistant E. ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2021, 254:109010]

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Longitudinal Study of the Distribution of Antimicrobial-Resistant Campylobacter Isolates from an Integrated Broiler Chicken Operation.

Bo-Ram Kwon, Bai Wei, Se-Yeoun Cha, Ke Shang, Jun-Feng Zhang, Min Kang, Hyung-Kwan Jang,

The aim of this study was to analyze the prevalence, antimicrobial resistance, and genetic diversity of <i>Campylobacter</i> isolates that were obtained from whole chicken production stages in Korea. A total of 1348 samples were collected from 10 production lines. The prevalence of <i>Campylobacter</i> in breeder farm, broiler farm, slaughterhouse, and ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(2):]

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Antimicrobial Susceptibility and Association with Toxin Determinants in Clostridium perfringens Isolates from Chickens.

Bai Wei, Se-Yeoun Cha, Jun-Feng Zhang, Ke Shang, Hae-Chul Park, JeongWoo Kang, Kwang-Jick Lee, Min Kang, Hyung-Kwan Jang,

The aim of the present study was to investigate variation in antimicrobial resistance in <i>Clostridium perfringens</i> (<i>C. perfringens</i>) isolated from chickens after withdrawal of antimicrobial growth promoters (AGPs); and to investigate the correlation between the presence of toxin genes (<i>cpb2</i>, <i>netB</i>, and <i>tpeL</i>) and antimicrobial resistance. Altogether, 162 isolates of ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(11):]

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Prevalence and potential risk of Salmonella enterica in migratory birds from South Korea.

Bai Wei, Ke Shang, Se-Yeoun Cha, Jun-Feng Zhang, Min Kang, Hyung-Kwan Jang,

Salmonella is a type of zoonotic bacteria that represents an economic and public health concern worldwide. Difficulties in sample collection from migratory birds mean little is known about their importance as a reservoir of Salmonella. The present study evaluated the prevalence and potential risk of Salmonella enterica in migratory birds. ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2020, 249:108829]

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Characteristics, prognosis and treatment response in distinct phenogroups of heart failure with preserved ejection fraction.

Jun Gu, Jian-An Pan, Hao Lin, Jun-Feng Zhang, Chang-Qian Wang,

<h4>Background</h4>Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. We aimed to derive HFpEF phenotype-based groups based on clinical features using machine learning, and to compare clinical characteristics, outcomes and treatment response across the phenogroups.<h4>Methods</h4>We applied model-based clustering to 11 clinical and laboratory variables collected in 970 HFpEF ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 323:148-154]

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Optimal management of blood glucose, blood pressure and atrial fibrillation to reduce the risk of heart failure with preserved ejection fraction.

Li Fan, Jian-An Pan, Hao Lin, Chang-Qian Wang, Jun-Feng Zhang, Jun Gu,

<h4>Background</h4>Type 2 diabetes mellitus (T2DM), hypertension, and atrial fibrillation (AF) are risk factors for heart failure with preserved ejection fraction (HFpEF). This study examined the effects of the simultaneous control of all 3 conditions on the new-onset HFpEF in this population.<h4>Methods</h4>This prospective cohort study enrolled 552 patients with T2DM, hypertension ... Read more >>

Intern Med J (Internal medicine journal)
[2020, :]

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Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization.

Le Yu, Jun Feng Zhang, Mingle Li, Dewei Jiang, Ying Zhou, Peter Verwilst, Jong Seung Kim,

We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(49):6684-6687]

Cited: 1 time

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