Full Text Journal Articles by
Author Zekai Halici

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Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats.

Halil Keskin, Taha Tavaci, Hamza Halici, Tugba Nurcan Yuksel, Mustafa Ozkaraca, Arzu Bilen, Duygu Kose, Ali Sefa Mendil, Zekai Halici,

<h4>Background</h4>A sepsis model was created, induced by cecal ligation and puncture (CLP) in junevile rat groups. Milrinone, which is known to have a modulatory effect on proinflammatory cytokines, was administered to the designated groups in the early period before severe sepsis developed. It was aimed to investigate the possible protective ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2021, :]

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Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties.

Duygu Kose, Harun Un, Rustem Anil Ugan, Zekai Halici, Elif Cadirci, Tugba Bal Tastan, Aysenur Kahramanlar,

<h4>Objectives</h4>We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically.<h4>Methods</h4>A total of 40 rats were divided into 5 groups with 8 animals in each group. Group 1 (SHAM), control group; Group 2 ... Read more >>

J Pharm Pharmacol (The Journal of pharmacy and pharmacology)
[2021, :]

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Fluid Rate Is Important As Much As Fluid Tonicity: An Experimental Study.

Halil Keskin, Filiz Keskin, Zuhal Keskin Yildirim, Muhammet Akif Guler, Nurinnisa Ozturk, Berna Ozturk Karagoz, Zekai Halici,

<h4>Objective</h4>There is no study evaluating the effect on plasma osmolality of both fluid tonicity and high fluid rate at the same time. The aim of this experimental study was to determine the change in the plasma osmolality by different fluid tonicity and rate, and to suggest the safest and the ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2021, 53(2):118-122]

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The Effects of Agomelatine Treatment on Lipopolysaccharide-Induced Septic Lung Injuries in Rats.

Duygu Köse, Tuğba Nurcan Yüksel, Zekai Halıcı, Elif Çadırcı, Muhammed Ali Gürbüz,

<h4>Objective</h4>We designed an experimental model of sepsis in rats to investigate the effects of agomelatine (AGO) on lung tissues using molecular and histopathological methods.<h4>Materials and methods</h4>In our experimental model, the 32 rats were divided into 4 groups: group 1: control group (HEALTHY); group 2: lipopolysaccharide group (LPS); group 3: LPS ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2021, 53(2):127-131]

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Neuroprotective effect of roflumilast under cerebral ischaemia/reperfusion injury in juvenile rats through NLRP-mediated inflammatory response inhibition.

Halil Keskin, Filiz Keskin, Taha Tavaci, Hamza Halici, Tugba Nurcan Yuksel, Mustafa Ozkaraca, Arzu Bilen, Zekai Halici,

This study aims to investigate the protective effect of roflumilast, a phosphodiesterase (PDE)-4 enzyme inhibitor, and demonstrate its possible role in the development prevention of cerebral ischemia/reperfusion injury (CI/RI) after stroke induced by carotid artery ligation in juvenile rats. The rats were randomly divided into five groups: healthy group without ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2021, 48(8):1103-1110]

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A New Approach to Sepsis Treatment by Rasagiline: A Molecular, Biochemical and Histopathological Study

harun un, Rustem Anil Ugan, duygu Köse, muhammed yayla, Tugba Bal Tastan, Yasin Bayir, Zekai Halici,

<h4>Aim: </h4> We aimed to investigate the effects of rasagiline, which has a strong antioxidant, anti-apoptotic and anti-inflammatory effect, on acute lung injury that develops in the sepsis model induced with the CLP in rats. Main Methods: The rats were separated into the following six groups, Group 1: Sham, Group ... Read more >>

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A Sensitive UPLC-MS/MS Method for the Determination of Flurbiprofen in Rat Plasma: Application to Real Sample.

Mehmet Emrah Yaman, Alptug Atila, Tugrul Cagri Akman, Mevlut Albayrak, Yucel Kadioglu, Zekai Halici,

For the quantification of flurbiprofen in rat plasma, a simple UPLC-MS/MS method with high sensitivity and short retention time for flurbiprofen was developed and validated using specific parameters. Etodolac was used as internal standard. The transitions (precursor to the product) of flurbiprofen and internal standard were obtained using the electrospray ... Read more >>

J Chromatogr Sci (Journal of chromatographic science)
[2021, 59(6):502-509]

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Roflumilast as a Potential Therapeutic Agent for Cecal Ligation and Puncture-Induced Septic Lung Injury.

Zafer Bayraktutan, Busra Dincer, Halil Keskin, Duygu Kose, Arzu Bilen, Erdem Toktay, Busra Sirin, Zekai Halici,

<h4>Purpose/aims</h4>This study focused on delineating the possible effects of roflumilast (ROF), a selective phosphodiesterase 4 (PDE4) inhibitor, in rats with cecal ligation and puncture (CLP)-induced polymicrobial sepsis, and investigated whether ROF can act as a protective agent in sepsis-induced lung damage.<h4>Material and methods</h4>Four experimental groups were organized, each comprising eight ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2021, :1-9]

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5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues.

Irfan Cinar, Busra Sirin, Zekai Halici, Saziye Sezin Palabiyik-Yucelik, Erol Akpinar, Elif Cadirci,

Prostate cancer (PCa) is one of the most common types of cancer seen among men worldwide. Previous studies have demonstrated that serotonin regulates cell proliferation, migration, and invasion in vitro; the presence of 5-HT receptors in cancer cells; and the role of serotonin in tumor development. The most recently discovered ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2021, 394(6):1205-1213]

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Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation.

Harun Un, Rustem Anil Ugan, Muhammet Ali Gurbuz, Yasin Bayir, Aysenur Kahramanlar, Gokce Kaya, Elif Cadirci, Zekai Halici,

<h4>Aim</h4>Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity.<h4>Main methods</h4>Totally, 48 Balb/C female mice were separated into eight groups (n = 6). ... Read more >>

Life Sci (Life sciences)
[2021, 266:118869]

Cited: 2 times

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Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity.

Erdem Toktay, Jale Selli, Muhammed Ali Gurbuz, Tugba Bal Tastan, Rustem Anıl Ugan, Harun Un, Zekai Halici,

<h4>Objectives</h4>This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.<h4>Materials and methods</h4>In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg ... Read more >>

Iran J Basic Med Sci (Iranian journal of basic medical sciences)
[2020, 23(12):1603-1609]

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Protective effect of luteolin on acute lung injury in a rat model of sepsis.

Demet Celebi, Pelin Aydin, Irfan Cinar, Zerrin Kutlu, Ilknur Calik, Zekai Halici, Dilek Bilici, Zafer Bayraktutan,

We investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). LUT was administered 1 h after CLP surgery. Administration of LUT reduced ... Read more >>

Biotech Histochem (Biotechnic & histochemistry : official publication of the Biological Stain Commission)
[2020, :1-7]

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Investigation of the Role of Stimulation and Blockade of 5-HT7 Receptors in Ketamine Anesthesia.

Busra Dincer, Zekai Halici, Elif Cadirci,

Although several pieces of evidence have indicated the ability of the serotonin-7 receptor (5-HTR<sub>7</sub>) to modulate N-methyl-<sub>D</sub>-aspartate receptor (NMDAR) activation, the possible impact on ketamine anesthesia has not been examined directly. The purpose of the present study is thus to investigate the possible role of the 5-HTR<sub>7</sub> in ketamine anesthesia ... Read more >>

J Mol Neurosci (Journal of molecular neuroscience : MN)
[2021, 71(5):1095-1111]

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Investigation of serum and brain superoxide dismutase levels depending on atomoxetine used in attention-deficit/hyperactivity disorder treatment: A combination of in vivo and molecular docking studies.

Fatma Gür, Bahri Gür, Beyzagül Erkayman, Zekai Halıcı, Akar Karakoç,

This study aims to determine whether atomoxetine (ATX), used as an alternative to methylphenidate, affects superoxide dismutase (SOD) activity besides glutathione (GSH) and malondialdehyde (MDA) levels, apart from determining possible effects of ATX on SOD activity through molecular docking studies. 24 male Wistar rats were divided into 4 groups, each ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 105:104435]

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Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture.

Duygu Köse, Ahmet Köse, Zekai Halıcı, Muhammed Ali Gürbüz, Ali Aydın, Rüstem Anıl Ugan, Adem Karaman, Erdem Toktay,

Melatonin improves fracture healing, but the long-term use of melatonin seems impracticable in the treatment of fracture due to side effects caused by hormonal stress on chronological rhythm. Ramelteon (RAMEL) and agomelatine (AGO) are non-selective peripheral melatonin receptor (MT) agonists. This study investigated the effects on bone fracture healing of ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2020, 887:173577]

Cited: 2 times

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Biochemical Research of the Effects of Essential Oil Obtained from the Fruit of Myrtus communis L. on Cell Damage Associated with Lipopolysaccharide-Induced Endotoxemia in a Human Umbilical Cord Vein Endothelial Cells.

Zerrin Kutlu, Mine Gulaboglu, Zekai Halıcı, İrfan Cınar, Busra Dıyarbakır,

The aim of this study to investigate the potential effects of essential oils and compounds obtained from MC fruit on sepsis induced endothelial cell damage in human umbilical cord vein endothelial cells (HUVECs) at molecular and cellular levels on in vitro sepsis model. A sepsis model was induced by the ... Read more >>

Biochem Genet (Biochemical genetics)
[2021, 59(1):315-334]

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Possible contribution of the neprilysin/ACE pathway to sepsis in mice.

Rustem Anil Ugan, Harun Un, Muhammed Ali Gurbuz, Gokce Kaya, Aysenur Kahramanlar, Zeynep Berna Aksakalli-Magden, Zekai Halici, Elif Cadirci,

<h4>Aim</h4>Omapatrilat is an antagonist of angiotensin-converting (ACE) and neprilysin-neuropeptidase (NEP) enzymes. The aim of our study is to show that omapatrilat may have beneficial effects as a treatment for polymicrobial sepsis.<h4>Main methods</h4>A cecal ligation and puncture (CLP) sepsis model was used to evaluate 10 and 20 mg/kg doses of omapatrilat in ... Read more >>

Life Sci (Life sciences)
[2020, 258:118177]

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Can aprepitant used for nausea and vomiting be good gastrointestinal complaints?

Rustem Anil Ugan, Harun Un, Duygu Kose, Elif Cadirci, Tugba Bal Tastan, Muhammed Yayla, Zekai Halici,

Aprepitant is a selective SP/NK-1 receptor antagonist and used in postoperative and chemotherapeutics induced emesis and vomiting. The aim of our study is to show aprepitant may have beneficial effects on gastrointestinal complaints in cancer patients undergoing chemotherapeutics by indomethacin-induced gastric ulcer model. A total of 48 rats were fasted ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2020, 393(12):2463-2472]

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LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats.

Ilknur Calik, Muhammed Yayla, Irfan Cinar, Elif Cadirci, Abdulmecit Albayrak, Busra Sirin, Muhammet Calik, Zekai Halici,

<h4>Aim</h4>This study aimed to demonstrate the role of serotonin 7 receptor (5-HT<sub>7</sub>) and the effects of 5-HT<sub>7</sub> agonists and antagonists in an indomethacin-induced gastric ulcer.<h4>Material and method</h4>Male albino Wistar rats (n = 60) were used in the experiments. LP44 (5-HT<sub>7</sub> agonist) and SB269970 (5-HT<sub>7</sub> antagonist) were administered at 10 mg/kg as a pre-treatment. One ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2020, 28(4):893-902]

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Is Ebselen A Therapeutic Target in Fracture Healing?

Ahmet Kose, Duygu Kose, Zekai Halici, Ali Aydin, Naci Ezirmik, Orhan Karsan, Erdem Toktay,

Objective:We investigated the effect of ebselen on fracture healing in an experimental fracture model. Materials and Methods:We divided rats into two groups, 6 rats in each: the experimental femur fracture control group and the ebselen treatment group with an experimental femur fracture. In the experimental femur fracture control group, we ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2020, 52(2):171-175]

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5-HT7 receptorsare over-expressed in patients with nasal polyps.

Muhammed Yayla, Zekai Halici, Duygu Kose, Arzu Tatar, Mustafa SitkiGozeler,

Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT7 ... Read more >>

Ear Nose Throat J (Ear, nose, & throat journal)
[2020, :145561320919603]

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A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity.

Harun Un, Rustem Anil Ugan, Duygu Kose, Yasin Bayir, Elif Cadirci, Jale Selli, Zekai Halici,

Cisplatin is widely used chemotherapeutic drug and have some serious side effects as tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug for cisplatin treated patient to prevent nausea and vomiting. We aimed to investigate the protective effects of Aprepitant on cisplatin-induced nephrotoxicity and ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2020, 880:173168]

Cited: 4 times

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Regenerative Effect of Resorbable Scaffold Embedded Boron-Nitride/Hydroxyapatite Nanoparticles in Rat Parietal Bone.

Muhammed Yayla, Elif Cadirci, Zekai Halici, Feray Bakan, Nuran Ay, Selami Demirci, Adem Karaman, Fikrettin Sahin,

BN has important roles in several physiological events, including bone growth and immune system. New infection-free cranioplasty and has an osteogenic activities material that are compatible with tissue are being developed. We aimed in our study to examine whether different combinations of Boron-nitride/Hydroxyapatite are embedded into the scaffold in the ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2020, 20(2):680-691]

Cited: 1 time

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Protective Effect of Lycopene against Reperfusion Injury in Rats with Ovarian Torsion: A Biochemical and Histopathological Evaluation.

Emsal Pinar Topdagi Yilmaz, Harun Un, Betul Gundogdu, Elif Polat, Seda Askin, Yunus Emre Topdagi, Zekai Halici,

Objective  The aim of our study was to evaluate the effect of two different doses of lycopene, an antioxidant, on experimentally induced ovarian ischemia/reperfusion (IR) injury in rat model. Materials and Methods  Twenty-four female rats were randomly divided into four groups: sham operation (group 1), 3-hour ischemia, 3-hour reperfusion (IR) ... Read more >>

J Lab Physicians (Journal of laboratory physicians)
[2020, 12(1):32-37]

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Olfactory bulbectomy and raphe nucleus relationship: a new vision for well-known depression model.

Halil Ozcan, Nazan Aydın, Mehmet Dumlu Aydın, Elif Oral, Cemal Gündoğdu, Sare Şipal, Zekai Halıcı,

Background/aim: The olfactory bulbectomy (OBX) technic is a well-known animal model for depression. According to serotonin hypothesis of depression, one of the possible explanations to this mechanism is the destroying effect of OBX on raphe nuclei which especially include serotonergic neurons. In this study, we aimed to explore histopathological findings ... Read more >>

Nord J Psychiatry (Nordic journal of psychiatry)
[2020, 74(3):194-200]

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