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Mechanism Based Quality Control (MBQC) of Herbal Products: A Case Study YIV-906 (PHY906).

Wing Lam, Yongshen Ren, Fulan Guan, Zaoli Jiang, William Cheng, Chang-Hua Xu, Shwu-Huey Liu, Yung-Chi Cheng,

YIV-906 (PHY906), a four-herb Chinese medicine formulation, is inspired by an 1800 year-old Chinese formulation called Huang Qin Tang which is traditionally used to treat gastrointestinal (GI) symptoms. In animal studies, it could enhance anti-tumor activity of different classes of anticancer agents and promote faster recovery of the damaged intestines ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1324]

Cited: 1 time

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Multikinase inhibitor sorafenib induces skin toxicities in tumor-bearing mice.

Aiping Tian, Haizhen Lu, Jingxuan Zhang, Shilan Fu, Zaoli Jiang, Wing Lam, Fulan Guan, Linlin Chen, Li Feng, Yungchi Cheng,

OBJECTIVES:To investigate the pathologic changes and pathogenesis of multikinase inhibitor (MKI)-induced skin lesions in an animal model. METHODS:Tumor-bearing nude mice and BDF1 mice were treated with different doses (30-240 mg/kg, Bid) of sorafenib. The pathology and severity of the skin lesions was assessed and evaluated. The concentration of sorafenib in the ... Read more >>

Cancer Chemother. Pharmacol. (Cancer chemotherapy and pharmacology)
[2018, 81(6):1025-1033]

Cited: 1 time

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Study of Malformin C, a Fungal Source Cyclic Pentapeptide, as an Anti-Cancer Drug.

Jing Wang, Zaoli Jiang, Wing Lam, Elizabeth A Gullen, Zhe Yu, Ying Wei, Lihui Wang, Caroline Zeiss, Amanda Beck, Ee-Chun Cheng, Chunfu Wu, Yung-Chi Cheng, Yixuan Zhang,

Malformin C, a fungal cyclic pentapeptide, has been claimed to have anti-cancer potential, but no in vivo study was available to substantiate this property. Therefore, we conducted in vitro and in vivo experiments to investigate its anti-cancer effects and toxicity. Our studies showed Malformin C inhibited Colon 38 and HCT ... Read more >>

PLoS ONE (PloS one)
[2015, 10(11):e0140069]

Cited: 7 times

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PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment.

Wing Lam, Zaoli Jiang, Fulan Guan, Xiu Huang, Rong Hu, Jing Wang, Scott Bussom, Shwu-Huey Liu, Hongyu Zhao, Yun Yen, Yung-Chi Cheng,

PHY906 (KD018) is a four-herb Chinese Medicine Formula. It has been shown to potentially enhance the therapeutic indices of different class anticancer agents in vivo. Here, PHY906 is reported to enhance the anti-tumor activity of Sorafenib in nude mice bearing HepG2 xenografts. Among the four herbal ingredients of PHY906, Scutellaria ... Read more >>

Sci Rep (Scientific Reports)
[2015, 5:9384]

Cited: 34 times

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The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018).

Wing Lam, Zaoli Jiang, Fulan Guan, Rong Hu, Shwu-Huey Liu, Edward Chu, Yung-Chi Cheng,

The four-herb Chinese medicine PHY906(KD018) has been shown to both enhance the in vivo antitumor activity of irinotecan (CPT-11) against colon cancer tumor allografts and alleviate intestinal toxicity caused by CPT-11.Since intestinal bacteria can metabolize CPT-11 and PHY906, we investigated whether intestinal bacteria play a critical role in the in ... Read more >>

BMC Complement Altern Med (BMC complementary and alternative medicine)
[2014, 14:490]

Cited: 12 times

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First-in-human phase II trial of the botanical formulation PHY906 with capecitabine as second-line therapy in patients with advanced pancreatic cancer.

Muhammad Wasif Saif, Jia Li, Lynne Lamb, Kristin Kaley, Kyle Elligers, Zaoli Jiang, Scott Bussom, Shwu-Huey Liu, Yung-Chi Cheng,

Preclinical studies showed a Chinese botanical formula, PHY906, has synergistic anti-tumor activity with capecitabine. Our phase I study determined maximal tolerated dose of capecitabine 1,500 mg/m(2) BID day 1-7 and PHY906 800 mg BID day 1-4 every 2 weeks. We conducted this phase II study to explore the efficacy of capecitabine and PHY906 ... Read more >>

Cancer Chemother. Pharmacol. (Cancer chemotherapy and pharmacology)
[2014, 73(2):373-380]

Cited: 27 times

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A phase I study of the chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer.

Shivaani Kummar, M Sitki Copur, Michal Rose, Scott Wadler, Joe Stephenson, Mark O'Rourke, Wayne Brenckman, Robert Tilton, Shwu-Huey Liu, Zaoli Jiang, Tahmun Su, Yung-Chi Cheng, Edward Chu,

PHY906 is a novel Chinese herbal preparation that has been used in the Orient for over 1800 years to treat a wide range of gastrointestinal side effects including diarrhea, abdominal cramps, vomiting, fever, and headache. Preclinical and clinical studies were conducted to further investigate the biologic and clinical activities of ... Read more >>

Clin Colorectal Cancer (Clinical colorectal cancer)
[2011, 10(2):85-96]

Cited: 47 times

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Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment.

Ena Wang, Scott Bussom, Jinguo Chen, Courtney Quinn, Davide Bedognetti, Wing Lam, Fulan Guan, Zaoli Jiang, Yichao Mark, Yingdong Zhao, David F Stroncek, Jeffrey White, Francesco M Marincola, Yung-Chi Cheng,

Traditional Chinese Medicine (TCM) has been used for thousands of years to treat or prevent diseases, including cancer. Good manufacturing practices (GMP) and sophisticated product analysis (PhytomicsQC) to ensure consistency are now available allowing the assessment of its utility. Polychemical Medicines, like TCM, include chemicals with distinct tissue-dependent pharmacodynamic properties ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2011, 4:38]

Cited: 35 times

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The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity.

Wing Lam, Scott Bussom, Fulan Guan, Zaoli Jiang, Wei Zhang, Elizabeth A Gullen, Shwu-Huey Liu, Yung-Chi Cheng,

PHY906, a four-herb Chinese medicine formula first described 1800 years ago, decreases gastrointestinal toxicity induced by the chemotherapeutic drug CPT-11 (irinotecan), as shown in a phase I/II clinical study. Similarly, in a murine colon 38 allograft model, PHY906 increased the antitumor activity of CPT-11 while decreasing animal weight loss caused ... Read more >>

Sci Transl Med (Science translational medicine)
[2010, 2(45):45ra59]

Cited: 122 times

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A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906.

Robert Tilton, Anthony A Paiva, Jing-Qu Guan, Rajendra Marathe, Zaoli Jiang, Winfried van Eyndhoven, Jeffrey Bjoraker, Zachary Prusoff, Hailong Wang, Shwu-Huey Liu, Yung-Chi Cheng,

BACKGROUND: Establishing botanical extracts as globally-accepted polychemical medicines and a new paradigm for disease treatment, requires the development of high-level quality control metrics. Based on comprehensive chemical and biological fingerprints correlated with pharmacology, we propose a general approach called PhytomicsQC to botanical quality control. METHODS: Incorporating the state-of-the-art analytical methodologies, ... Read more >>

Chin Med (Chinese medicine)
[2010, 5:30]

Cited: 37 times

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Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS).

Wei Zhang, Muhammad W Saif, Ginger E Dutschman, Xin Li, Wing Lam, Scott Bussom, Zaoli Jiang, Min Ye, Edward Chu, Yung-Chi Cheng,

Traditional Chinese Medicine (TCM) is increasingly being used in combination with Western medicine. In general, TCM is comprised of multiple components in sharp contrast to Western medicine, where a single active chemical is used. Presently, there are no well-established standards for most of the chemical compounds of TCM and their ... Read more >>

J Chromatogr A (Journal of chromatography. A)
[2010, 1217(37):5785-5793]

Cited: 31 times

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Phase I/II study of PHY906/capecitabine in advanced hepatocellular carcinoma.

Yun Yen, Samuel So, Michal Rose, M Wasif Saif, Edward Chu, Shwu-Huey Liu, Angeline Foo, Zaoli Jiang, Tahmun Su, Yung-Chi Cheng,

PHY906 is a Chinese medicine formula with claims for the treatment of severe gastrointestinal distress. PHY906 enhanced the therapeutic index of various chemotherapeutic agents in human hepatocellular carcinoma xenografts. Accordingly, here a phase I/II clinical study was conducted with the combination of capecitabine in patients with advanced, unresectable hepatocellular carcinoma. ... Read more >>

Anticancer Res. (Anticancer research)
[2009, 29(10):4083-4092]

Cited: 29 times

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Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy.

Min Ye, Shwu-Huey Liu, Zaoli Jiang, Yashang Lee, Robert Tilton, Yung-Chi Cheng,

PHY906 is a Chinese medicine formulation prepared from four medicinal herbs for adjuvant cancer chemotherapy. In this paper, liquid chromatography/electrospray ionization time-of-flight mass spectrometry (LC/ESI-TOFMS) was used to clarify the chemical composition of PHY906. The aqueous extract of PHY906 was separated on a Waters Atlantis C(18) column, and was eluted ... Read more >>

Rapid Commun. Mass Spectrom. (Rapid communications in mass spectrometry : RCM)
[2007, 21(22):3593-3607]

Cited: 47 times

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Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.

Yashang Lee, Hosup Yeo, Shwu-Huey Liu, Zaoli Jiang, Ruben M Savizky, David J Austin, Yung-chi Cheng,

The aqueous extract of Scutellariae baicalensis Georgi has inhibitory activity against P-gp 170, a multiple drug resistant gene product. Baicalein, one of the major flavones, was found to be responsible for this activity. The hydroxyl groups of the A ring of baicalein were systematically alkylated in order to assess the ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2004, 47(22):5555-5566]

Cited: 17 times

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Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.

Jieh-Yuan Liou, Ginger E Dutschman, Wing Lam, Zaoli Jiang, Yung-Chi Cheng,

Pyrimidine nucleoside monophosphate kinase [UMP/CMP kinase (UMP/CMPK);EC 2.7.4.14] plays a crucial role in the formation of UDP, CDP, and dCDP, which are required for cellular nucleic acid synthesis. Several cytidine and deoxycytidine analogues are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to their triphosphate forms to exert ... Read more >>

Cancer Res. (Cancer research)
[2002, 62(6):1624-1631]

Cited: 51 times

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