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Author Zainul Amiruddin Zakaria

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Synthesis of Functionalized Thiophene Based Pyrazole Amides via Various Catalytic Approaches: Structural Features through Computational Applications and Nonlinear Optical Properties.

Iram Kanwal, Nasir Rasool, Syeda Huda Mehdi Zaidi, Zainul Amiruddin Zakaria, Muhammad Bilal, Muhammad Ali Hashmi, Adeel Mubarik, Gulraiz Ahmad, Syed Adnan Ali Shah,

In the present study, pyrazole-thiophene-based amide derivatives were synthesized by different methodologies. Here, 5-Bromothiophene carboxylic acid (<b>2</b>) was reacted with substituted, unsubstituted, and protected pyrazole to synthesize the amide. It was observed that unsubstituted amide (5-bromo-<i>N</i>-(5-methyl-1<i>H</i>-pyrazol-3-yl)thiophene-2-carboxamide (<b>7</b>) was obtained at a good yield of about 68 percent. The unsubstituted amide ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2022, 27(2):]

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Synthesis of Functionalized Thiophene Based Pyrazole Amides via Various Catalytic Approaches: Structural Features through Computational Applications and Nonlinear Optical Properties

Iram Kanwal, Nasir Rasool, Syeda Huda Mehdi Zaidi, Zainul Amiruddin Zakaria, Muhammad Bilal, Muhammad Ali Hashmi, Adeel Mubarik, Gulraiz Ahmad, Syed Adnan Ali Shah,

In the present study, pyrazole-thiophene-based amide derivatives were synthesized by different methodologies. Here, 5-Bromothiophene carboxylic acid (2) was reacted with substituted, unsubstituted, and protected pyrazole to synthesize the amide. It was observed that unsubstituted amide (5-bromo-N-(5-methyl-1H-pyrazol-3-yl)thiophene-2-carboxamide (7) was obtained at a good yield of about 68 percent. The unsubstituted amide ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2022, 27(2):]

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Pseudocedrela kotschyi: a review of ethnomedicinal uses, pharmacology and phytochemistry.

Alhassan M Alhassan, Qamar Uddin Ahmed, Ibrahim Malami, Zainul Amiruddin Zakaria,

<h4>Context</h4><i>Pseudocedrela kotschyi</i> (Schweinf) Harms (Meliaceae) is an important medicinal plant found in tropical and subtropical countries of Africa. Traditionally, <i>P. kotschyi</i> is used in the treatment of various diseases including diabetes, malaria, abdominal pain and diarrhoea.<h4>Objective</h4>To provide an overview of traditional medicinal claims, pharmacological properties, and phytochemical principles of <i>P. ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):955-963]

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Natural Compounds from Hatikana Extract Potentiate Antidiabetic Actions as Displayed by In Vivo Assays and Verified by Network Pharmacological Tools.

Md Atiar Rahman, Md Nazim Uddin, Nouf Abubakr Babteen, Afnan M Alnajeebi, Zainul Amiruddin Zakaria, Salama Mostafa Aboelenin,

<h4>Background</h4>Hatikana is a traditional medicinal plant used to treat inflammation, urolithiasis, goiter, cancer, wounds and sores, gastrointestinal, tumor, tetanus, arthritis, hepatic damage, neurodegeneration, and other ailments. The goal of this study is to investigate the antidiabetic properties of Hatikana extract (HKEx) and to construct the effects of its natural constituents ... Read more >>

Biomed Res Int (BioMed research international)
[2021, 2021:6978450]

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An In Vitro Anticancer Activity Evaluation of Neolamarckia cadamba (Roxb.) Bosser Leaves' Extract and its Metabolite Profile.

Shakirah Razali, Al'aina Yuhainis Firus Khan, Alfi Khatib, Qamar Uddin Ahmed, Ridhwan Abdul Wahab, Zainul Amiruddin Zakaria,

The leaves of <i>Neolamarckia cadamba</i> (NC) (Roxb.) Bosser (family: Rubiaceae) are traditionally used to treat breast cancer in Malaysia; however, this traditional claim is yet to be scientifically verified. Hence, this study was aimed to evaluate the anticancer effect of NC leaves' ethanol extract against breast cancer cell line (MCF-7 ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:741683]

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Potential Effects of Sweet Potato (Ipomoea batatas) in Hyperglycemia and Dyslipidemia-A Systematic Review in Diabetic Retinopathy Context.

Ruth Naomi, Hasnah Bahari, Muhammad Dain Yazid, Fezah Othman, Zainul Amiruddin Zakaria, Mohd Khairi Hussain,

Hyperglycemia is a condition with high glucose levels that may result in dyslipidemia. In severe cases, this alteration may lead to diabetic retinopathy. Numerous drugs have been approved by officials to treat these conditions, but usage of any synthetic drugs in the long term will result in unavoidable side effects ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(19):]

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The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes.

Rickta Rani Das, Md Atiar Rahman, Salahuddin Qader Al-Araby, Md Shahidul Islam, Md Mamunur Rashid, Nouf Abubakr Babteen, Afnan M Alnajeebi, Hend Faisal H Alharbi, Philippe Jeandet, Md Khalid Juhani Rafi, Tanvir Ahmed Siddique, Md Nazim Uddin, Zainul Amiruddin Zakaria,

The purpose of this study was to look into the effects of green coconut mesocarp juice extract (CMJE) on diabetes-related problems in streptozotocin- (STZ-) induced type 2 diabetes, as well as the antioxidative functions of its natural compounds in regulating the associated genes and biochemical markers. CMJE's antioxidative properties were ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:9711176]

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Discovery of polymethoxyflavones as potential cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and phosphodiesterase 4B (PDE4B) inhibitors.

Muhd Hanis Md Idris, Siti Norhidayah Mohd Amin, Siti Norhidayu Mohd Amin, Agustono Wibowo, Zainul Amiruddin Zakaria, Zurina Shaameri, Ahmad Sazali Hamzah, Manikandan Selvaraj, Lay Kek Teh, Mohd Zaki Salleh,

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed to treat inflammatory-related diseases, pain and fever. However, the prolong use of traditional NSAIDs leads to undesirable side effects such as gastric, ulceration, and renal toxicity due to lack of selectivity toward respective targets for COX-2, 5-LOX, and PDE4B. Thus, targeting multiple sites ... Read more >>

J Recept Signal Transduct Res (Journal of receptor and signal transduction research)
[2021, :1-13]

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Analytical GC-FID Method for the Determination of Organic Solvents in Radiopharmaceuticals.

Hishar Hassan, Muhammad Faiz Othman, Zainul Amiruddin Zakaria, Fathinul Fikri Ahmad Saad, Hairil Rashmizal Abdul Razak,

<h4>Background</h4>Organic solvents play an indispensable role in most of the radiopharmaceutical production stages. It is almost impossible to remove them entirely in the final formulation of the product.<h4>Objective</h4>In this presented work, an analytical method by gas chromatography coupled with flame ionization detection (GC-FID) has been developed to determine organic solvents ... Read more >>

Curr Radiopharm (Current radiopharmaceuticals)
[2021, 14(2):131-144]

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Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats.

Zainul Amiruddin Zakaria, Farah Hidayah Kamisan, Teh Lay Kek, Mohd Zaki Salleh,

<b>Context:</b> <i>Dicranopteris linearis</i> L. (Gleicheniaceae) leaves have been reported to exert hepatoprotective activity.<b>Objective:</b> The hepatoprotective and antioxidant effects of ethyl acetate partition of <i>D. linearis</i> (EADL) are investigated.<b>Materials and methods:</b> EADL was subjected to antioxidant and anti-inflammatory studies, and phytochemical analyses. <i>In vivo</i> study involved six groups (<i>n</i> = 6) of overnight ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):478-489]

Cited: 1 time

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Comparative Efficacy of Selected Phytobiotics with Halquinol and Tetracycline on Gut Morphology, Ileal Digestibility, Cecal Microbiota Composition and Growth Performance in Broiler Chickens.

Muhammad Abdul Basit, Arifah Abdul Kadir, Teck Chwen Loh, Saleha Abdul Aziz, Annas Salleh, Zainul Amiruddin Zakaria, Sherifat Banke Idris,

The current experiment was designed to estimate the comparative efficacy of selected phytobiotics <i>Persicaria odorata</i> leaf meal (POLM) and <i>Piper betle</i> leaf meal (PBLM) with halquinol, and tetracycline in broiler chickens. The 150-day-old broiler chickens were randomly assigned to five dietary groups. The dietary supplementation groups were the basal diet ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2020, 10(11):]

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Analysis of expression of vitamin E-binding proteins in H2O2 induced SK-N-SH neuronal cells supplemented with α-tocopherol and tocotrienol-rich fraction.

Aishatu Ali Chiroma, Huzwah Khaza'ai, Roslida Abd Hamid, Sui Kiat Chang, Zainul Amiruddin Zakaria, Zaida Zainal,

Natural α-tocopherol (α-TCP), but not tocotrienol, is preferentially retained in the human body. α-Tocopherol transfer protein (α-TTP) is responsible for binding α-TCP for cellular uptake and has high affinity and specificity for α-TCP but not α-tocotrienol. The purpose of this study was to examine the modification of α-TTP together with ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0241112]

Cited: 2 times

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Synthesis of Benzimidazole-Based Analogs as Anti Alzheimer's Disease Compounds and Their Molecular Docking Studies.

Bushra Adalat, Fazal Rahim, Muhammad Taha, Foziah J Alshamrani, El Hassane Anouar, Nizam Uddin, Syed Adnan Ali Shah, Zarshad Ali, Zainul Amiruddin Zakaria,

We synthesized <b>10</b> analogs of benzimidazole-based thiosemicarbazide <b>1</b> (<b>a</b>-<b>j</b>) and <b>13</b> benzimidazole-based Schiff bases <b>2</b> (<b>a</b>-<b>m</b>), and characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase (AchE) and butyrylcholinesterase (BchE) inhibition activities. All the synthesized analogs showed varying degrees of acetylcholinesterase and butyrylcholinesterase inhibitory potentials in comparison to ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(20):]

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Safety evaluation of orally-administered methanol extract of Muntingia calabura Linn. leaves: A sub-chronic toxicity study in Sprague Dawley rats.

Nur Liana Md Nasir, Noorsyaza Eddrina Kamsani, Norhafizah Mohtarrudin, Siti Farah Md Tohid, Zainul Amiruddin Zakaria,

Muntingia calabura (M. calabura), locally known as "kerukup siam" or "buah ceri" belongs to the family Muntingiaceae and has been scientifically demonstrated to exert various pharmacological activities. The objectives of the current study are to evaluate the antioxidant activities and to determine the subchronic toxicity of 90 days orally-administered methanol ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(5):2009-2016]

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Selective Arylation of 2-Bromo-4-chlorophenyl-2-bromobutanoate via a Pd-Catalyzed Suzuki Cross-Coupling Reaction and Its Electronic and Non-Linear Optical (NLO) Properties via DFT Studies.

Usman Nazeer, Nasir Rasool, Aqsa Mujahid, Asim Mansha, Muhammad Zubair, Naveen Kosar, Tariq Mahmood, Ali Raza Shah, Syed Adnan Ali Shah, Zainul Amiruddin Zakaria, Muhammad Nadeem Akhtar,

In the present study, 2-bromo-4-chlorophenyl-2-bromobutanoate (<b>3</b>) was synthesized via the reaction of 2-bromo-4-chlorophenol with 2-bromobutanoyl bromide in the presence of pyridine. A variety of 2-bromo-4-chlorophenyl-2-bromobutanoate derivatives (<b>5a</b>-<b>f</b>) were synthesized with moderate to good yields via a Pd-catalyzed Suzuki cross-coupling reaction. To find out the reactivity and electronic properties of the ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(15):]

Cited: 1 time

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Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews.

Muhammad Daniel Hakim Mohd Jamil, Muhammad Taher, Deny Susanti, Md Atiar Rahman, Zainul Amiruddin Zakaria,

<i>Picrasma quassioides</i> is a member of the Simaroubaceae family commonly grown in the regions of Asia, the Himalayas, and India and has been used as a traditional herbal medicine to treat various illnesses such as fever, gastric discomfort, and pediculosis. This study aims to critically review the presence of phytochemicals ... Read more >>

Nutrients (Nutrients)
[2020, 12(9):]

Cited: 3 times

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RAGE modulatory effects on cytokines network and histopathological conditions in malarial mice.

Voon Kin Chin, Yaw Kuang Chuah, Tze Yan Lee, Norshariza Nordin, Zaid Osamah Ibraheem, Zainul Amiruddin Zakaria, Haniza Hassan, Rusliza Basir,

This study was aimed at investigating the involvement of Receptor for Advanced Glycation End Products (RAGE) during malaria infection and the effects of modulating RAGE on the inflammatory cytokines release and histopathological conditions of affected organs in malarial animal model. Plasmodium berghei (P. berghei) ANKA-infected ICR mice were treated with ... Read more >>

Exp Parasitol (Experimental parasitology)
[2020, 216:107946]

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Genus Ophiorrhiza: A Review of Its Distribution, Traditional Uses, Phytochemistry, Biological Activities and Propagation.

Muhammad Taher, Siti Syazwani Shaari, Deny Susanti, Dayar Arbain, Zainul Amiruddin Zakaria,

Almost 50 species of <i>Ophiorrhiza</i> plants were reviewed in this work and the main objective is to critically analyse their distribution, phytochemical content, biological activity, and propagation. Moreover, the information would be useful in promoting the relevant uses of the plant, especially in the medicinal fields based on in vitro ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(11):]

Cited: 4 times

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Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues.

Muhammad Taha, Fazal Rahim, Hayat Ullah, Abdul Wadood, Rai Khalid Farooq, Syed Adnan Ali Shah, Muhammad Nawaz, Zainul Amiruddin Zakaria,

In continuation of our work on enzyme inhibition, the benzofuran-based-thiazoldinone analogues (1-14) were synthesized, characterized by HREI-MS, <sup>1</sup>H and <sup>13</sup>CNMR and evaluated for urease inhibition. Compounds 1-14 exhibited a varying degree of urease inhibitory activity with IC<sub>50</sub> values between 1.2 ± 0.01 to 23.50 ± 0.70 µM when compared with standard drug thiourea having IC<sub>50</sub> ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):10673]

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Complementary alternative medicine use among postpartum mothers in a primary care setting: a cross-sectional study in Malaysia.

Nik Farah Nik Yusof Fuad, Siew Mooi Ching, Dayangku Hayaty Awg Dzulkarnain, Ai Theng Cheong, Zainul Amiruddin Zakaria,

<h4>Background</h4>Complementary alternative medicine (CAM) is widely used among postpartum mothers to maintain their well-being. This study aims to determine the prevalence and factors associated with CAM use among postpartum mothers in a primary-care clinic in Malaysia.<h4>Methods</h4>This is a cross-sectional study of 725 postpartum mothers, aged 18 and above, attending a ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2020, 20(1):197]

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Erratum: Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception.

Rasyidah Ryta Ayumi, Wan Mastura Shaik Mossadeq, Zainul Amiruddin Zakaria, Muhammad Taher Bakhtiar, Nadhirah Kamarudin, Nadia Hisamuddin, Madihah Talib, Aina Mardhiah Sabar,

Planta Med (Planta medica)
[2020, :]

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Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception.

Rasyidah Ryta Ayumi, Wan Mastura Shaik Mossadeq, Zainul Amiruddin Zakaria, Muhammad Taher Bakhtiar, Nadhirah Kamarudin, Nadia Hisamuddin, Madihah Talib, Aina Mardhiah Sabar,

The antinociceptive property of Centella asiatica extracts is known but the analgesic activity of its bioactive constituent asiaticoside has not been reported. We evaluated the antinociceptive activity of orally (p. o.) administered asiaticoside (1, 3, 5, and 10 mg/kg) in mice using the 0.6% acetic acid-induced writhing test, the 2.5% formalin-induced paw ... Read more >>

Planta Med (Planta medica)
[2020, 86(8):548-555]

Cited: 2 times

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Investigation of α-Glucosidase Inhibitory Metabolites from Tetracera scandens Leaves by GC-MS Metabolite Profiling and Docking Studies.

Ahmed Nokhala, Mohammad Jamshed Siddiqui, Qamar Uddin Ahmed, Muhammad Safwan Ahamad Bustamam, And Zainul Amiruddin Zakaria,

Stone leaf (<i>Tetracera scandens</i>) is a Southeast Asian medicinal plant that has been traditionally used for the management of diabetes mellitus. The underlying mechanisms of the antidiabetic activity have not been fully explored yet. Hence, this study aimed to evaluate the α-glucosidase inhibitory potential of the hydromethanolic extracts of <i>T. ... Read more >>

Biomolecules (Biomolecules)
[2020, 10(2):]

Cited: 3 times

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Renal ultrastructural alterations induced by various preparations of mefenamic acid.

Qais Bashir Jarrar, Muhammad Nazrul Hakim, Zainul Amiruddin Zakaria, Manraj Singh Cheema, Said Moshawih,

Mefenamic acid (MFA) treatment is associated with a number of cellular effects that potentiate the incidence of renal toxicity. The aim of this study is to investigate the potential ultrastructural alterations induced by various preparations of MFA (free MFA, MFA-Tween 80 liposomes, and MFA-DDC liposomes) on the renal tissues. Sprague-Dawley ... Read more >>

Ultrastruct Pathol (Ultrastructural pathology)
[2020, 44(1):130-140]

Cited: 1 time

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Aqueous Partition of Methanolic Extract of Dicranopteris linearis Leaves Protects against Liver Damage Induced by Paracetamol.

Zainul Amiruddin Zakaria, Farah Hidayah Kamisan, Nurliana Mohd Nasir, Lay Kek Teh, Mohd Zaki Salleh,

This study aimed to determine the antioxidant and hepatoprotective activities of semi-purified aqueous partition obtained from the methanol extract of Dicranopteris linearis (AQDL) leaves against paracetamol (PCM)-induced liver intoxication in rats. The test solutions, AQDL (50, 250, and 500 mg/kg), were administered orally to rats (n = 6) once daily ... Read more >>

Nutrients (Nutrients)
[2019, 11(12):]

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