Full Text Journal Articles by
Author Zahir Shah

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MYB bi-allelic targeting abrogates primitive clonogenic progenitors while the emergence of primitive blood cells is not affected.

Zahir Shah, Elena S Filonenko, Vasily Ramensky, Chenyu Fan, Cuihua Wang, Hanif Ullah, Baoyun Zhang, Pavel Volchkov, Igor M Samokhvalov,

MYB is a key regulator of definitive hematopoiesis and it is dispensable for the development of primitive hematopoietic cells in vertebrates. To delineate definitive versus primitive hematopoiesis during differentiation of human embryonic stem cells, we have introduced reporters into the MYB locus and inactivated the gene by bi-allelic targeting. To ... Read more >>

Haematologica (Haematologica)
[2020, :]

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Modeling of entropy optimization for hybrid nanofluid MHD flow through a porous annulus involving variation of Bejan number.

Zahir Shah, M Sheikholeslami, Poom Kumam, Ikramullah, Ahmad Shafee,

We numerically investigate the non-Darcy magnetohydrodynamic hybrid nanoparticle migration through a permeable tank using control volume finite element method through entropy generation. The roles of various amounts of Permeability, Lorentz and Rayleigh (Ra) number are investigated upon the various aspects of the hybrid nanofluid flow through contour and 3-D plots. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12821]

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Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage.

Nasir Abbas, Anteneh Getachew, Kai You, Zahir Shah, Yan Chen, Jiawang Tao, Muzammal Hussain, Fan Yang, Yuanqi Zhuang, Yingying Xu, Yin-Xiong Li,

Currently, there is a growing interest in understanding the cellular and molecular events of immune-cell trafficking and recruitment of hepatic stellate cells (HSCs) in liver diseases. Aberrant activation of HSCs is the key event leading to chronic liver fibrosis. However, the underlying mechanisms of the recruitment of HSCs in a ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 529(2):474-479]

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Entropy generation in MHD Casson fluid flow with variable heat conductance and thermal conductivity over non-linear bi-directional stretching surface.

Muhammad Sohail, Zahir Shah, Asifa Tassaddiq, Poom Kumam, Prosun Roy,

This consideration highlights the belongings of momentum, entropy generation, species and thermal dissemination on boundary layer flow (BLF) of Casson liquid over a linearly elongating surface considering radiation and Joule heating effects significant. Transportation of thermal and species are offered by using the temperature-dependent models of thermal conductivity and mass ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12530]

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Non Pharmaceutical Interventions for Optimal Control of COVID-19.

Muhmmad Zamir, Zahir Shah, Fawad Nadeem, Arif Memood, Hussam Alrabaiah, Poom Kumam,

BACKGROUND AND OBJECTIVE:The outbreak of the current pandemic begun from the first individual of a 55-year old from Hubei province in China, the disease instigated by the new coronavirus spreading across the world. Scientists presently speculate this coronavirus, SARS-CoV-2, originated in a bat and by one way or another jumped ... Read more >>

Comput Methods Programs Biomed (Computer methods and programs in biomedicine)
[2020, 196:105642]

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Distinct New York City Aedes albopictus Mosquito Populations Display Differences in Salivary Gland Protein D7 Diversity and Chikungunya Virus Replication.

Maria E Kaczmarek, Nora L Herzog, Maria G Noval, John Zuzworsky, Zahir Shah, Waheed I Bajwa, Kenneth A Stapleford,

In an increasingly interconnected world, the exposure and subsequent spread of emergent viruses has become inevitable. This is particularly true for Aedes (Ae.) mosquito-vectored viruses, whose range has increased over the past decade from tropical to temperate regions. However, it is unclear if all populations of Ae. mosquitoes in temperate ... Read more >>

Viruses (Viruses)
[2020, 12(7):]

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Generation of RUNX1-null reporter human embryonic stem cell line GIBHe008-A.

Hanif Ullah, Hao You, Zahir Shah, Chenyu Fan, Baoyun Zhang, Hao Liu, Jianguang Zhang, Nasir Abbas, Elena S Filonenko, Igor M Samokhvalov,

RUNX1/AML1/CBFA2 (runt-related transcription factor 1/acute myeloid leukemia 1 protein/core-binding factor subunit alpha-2), is a transcription factor that plays a critical role in the development of normal hematopoiesis. RUNX1 is also essential for the development of immune cells and sensory neurons. Chromosomal translocations involving the gene have been associated with several ... Read more >>

Stem Cell Res (Stem cell research)
[2020, 45:101800]

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TALEN-mediated biallelic inactivation of MYB in human embryonic stem cell lines WAe001-A-45 and WAe001-A-46.

Chenyu Fan, Zahir Shah, Hanif Ullah, Elena S Philonenko, Baoyun Zhang, Ying Tan, Cuihua Wang, Jianguang Zhang, Igor M Samokhvalov,

MYB/c-MYB is a proto-oncogene encoding a helix-turn-helix transcription factor that plays a critical role in controlling proliferation and multilineage differentiation of hematopoietic progenitor and stem cells. Deregulation of MYB expression is associated with several types of leukemias and lymphomas. In an attempt to explore the role of the gene in ... Read more >>

Stem Cell Res (Stem Cell Research)
[2020, 46:101854]

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Hopf bifurcation and global dynamics of time delayed Dengue model.

Zain Ul Abadin Zafar, Nigar Ali, Zahir Shah, Gul Zaman, Prosun Roy, Wejdan Deebani,

BACKGROUND AND OBJECTIVE:Dengue viral infections are a standout amongst the supreme critical mosquito-borne illnesses nowadays. They create problems like dengue fever (DF), dengue stun disorder (DSS) and dengue hemorrhagic fever (DHF). Lately, the frequency of DHF has expanded considerably. Dengue may be caused by one of serotypes DEN-1 to DEN-4. ... Read more >>

Comput Methods Programs Biomed (Computer methods and programs in biomedicine)
[2020, 195:105530]

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HIV-1 infection dynamics and optimal control with Crowley-Martin function response.

Muhammad Naeem Jan, Nigar Ali, Gul Zaman, Imtiaz Ahmad, Zahir Shah, Poom Kumam,

BACKGROUND AND OBJECTIVE:As we all know, mathematical models provide very important information for the study of the human immunodeficiency virus type. Mathematical model of human immunodeficiency virus type-1 (HIV-1) infection with contact rate represented by Crowley-Martin function response is taken into account. The aims of this novel study is to ... Read more >>

Comput Methods Programs Biomed (Computer methods and programs in biomedicine)
[2020, 193:105503]

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Radiative MHD Casson Nanofluid Flow with Activation energy and chemical reaction over past nonlinearly stretching surface through Entropy generation.

Zahir Shah, Poom Kumam, Wejdan Deebani,

In the present research analysis we have addressed comparative investigation of radiative electrically conducting Casson nanofluid. Nanofluid Flow is assumed over a nonlinearly stretching sheet. Heat transport analysis is carried via joule dissipation, thermal behavior and convective boundary condition. To employ the radiative effect radiation was involved to show the ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4402]

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Micropolar gold blood nanofluid flow and radiative heat transfer between permeable channels.

Zahir Shah, Arshad Khan, Waris Khan, M Kamran Alam, Saeed Islam, Poom Kumam, Phatiphat Thounthong,

This article characterizes flow and heat transmission of blood that carries the micropolar nanofluid of gold in a permeable channel. The thermal radiations are also present in the channel while its walls are either moving or stationary. The base-fluid is considered as blood while micro polar nanofluid is taken as ... Read more >>

Comput Methods Programs Biomed (Computer methods and programs in biomedicine)
[2020, 186:105197]

Cited: 1 time

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Magnetohydrodynamic nanofluid radiative thermal behavior by means of Darcy law inside a porous media.

Trung Nguyen-Thoi, M Sheikholeslami, Zahir Shah, Poom Kumam, Ahmad Shafee,

Radiative nanomaterial thermal behavior within a permeable closed zone with elliptic hot source is simulated. Darcy law is selected for simulating permeable media in existence of magnetic forces. Contour plots for various buoyancy, Hartmann numbers and radiation parameter were illustrated. Carrier fluid is Al2O3-water with different shapes. Outputs prove that ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12765]

Cited: 2 times

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Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2.

Vikas Malik, Laura V Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A Esteban, Huating Wang, Jiekai Chen, Hans R Schöler, Andrew P Hutchins, Sebastiaan H Meijsing, Sebastian Pott, Ralf Jauch,

Oct4, along with Sox2 and Klf4 (SK), can induce pluripotency but structurally similar factors like Oct6 cannot. To decode why Oct4 has this unique ability, we compare Oct4-binding, accessibility patterns and transcriptional waves with Oct6 and an Oct4 mutant defective in the dimerization with Sox2 (Oct4defSox2). We find that initial ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):3477]

Cited: 3 times

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PEGylated doped- and undoped-TiO2 nanoparticles for photodynamic Therapy of cancers.

Zahir Shah, Samina Nazir, Kehkashan Mazhar, Rashda Abbasi, Igor M Samokhvalov,

Titanium dioxide has been widely known for its phototoxicity in the environmental context, but little is known for its use in the photodynamic therapy of cancers. Previous studides have shown the hazardous effects of undoped-titanium dioxide nanoparticles (undoped-TiO2 NPs) in the ecosystem; however, it remains to explore the effect of ... Read more >>

Photodiagnosis Photodyn Ther (Photodiagnosis and photodynamic therapy)
[2019, 27:173-183]

Cited: 1 time

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Radiative MHD thin film flow of Williamson fluid over an unsteady permeable stretching sheet.

Zahir Shah, Ebenezer Bonyah, Saeed Islam, Waris Khan, Mohammad Ishaq,

In this research work we have examined the flow of Williamson liquid film fluid with heat transmission and having the impact of thermal radiation embedded in a permeable medium over a time dependent stretching surface. The fluid flow of liquid films is assumed in two dimensions. By using suitable similarity ... Read more >>

Heliyon (Heliyon)
[2018, 4(10):e00825]

Cited: 2 times

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Author Correction: Phosphate-Solubilizing Bacteria Nullify the Antagonistic Effect of Soil Calcification on Bioavailability of Phosphorus in Alkaline Soils.

Muhammad Adnan, Zahir Shah, Shah Fahad, Muhamamd Arif, Mukhtar Alam, Imtiaz Ali Khan, Ishaq Ahmad Mian, Abdul Basir, Hidayat Ullah, Muhammad Arshad, Inayat-Ur Rahman, Shah Saud, Muhammad Zahid Ihsan, Yousaf Jamal, Amanullah, Hafiz Mohkum Hammad, Wajid Nasim,

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):4339]

Cited: 1 time

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Liming induces carbon dioxide (CO2) emission in PSB inoculated alkaline soil supplemented with different phosphorus sources.

Muhammad Adnan, Zahir Shah, Muhammad Sharif, Hidayatur Rahman,

Agricultural land is a major sink of global organic carbon (C). Its suitable management is crucial for improving C sequestration and reducing soil CO2 emission. Incubation experiments were performed to assess the impact of phosphate solubilizing bacterial (PSB) inoculation (inoculated and uninoculated) and soil calcification (4.78, 10, 15, and 20% ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2018, 25(10):9501-9509]

Cited: 1 time

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Phosphate-Solubilizing Bacteria Nullify the Antagonistic Effect of Soil Calcification on Bioavailability of Phosphorus in Alkaline Soils.

Muhammad Adnan, Zahir Shah, Shah Fahad, Muhamamd Arif, Mukhtar Alam, Imtiaz Ali Khan, Ishaq Ahmad Mian, Abdul Basir, Hidayat Ullah, Muhammad Arshad, Inayat-Ur Rahman, Shah Saud, Muhammad Zahid Ihsan, Yousaf Jamal, Amanullah, Hafiz Mohkum Hammad, Wajid Nasim,

Phosphate-solubilizing bacteria (PSB) reduce the negative effects of soil calcification on soil phosphorus (P) nutrition. In this incubation study, we explored the ability of PSB (control and inoculated) to release P from different P sources [single super phosphate (SSP), rock phosphate (RP), poultry manure (PM) and farm yard manure (FYM)] ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):16131]

Cited: 7 times

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Physiologic and biochemical effects of electroacupuncture combined with intramuscular administration of dexmedetomidine to provide analgesia in goats.

Zahir Shah, Man L Hu, Zheng Y Qiu, Fei Y Zhou, Jie Zeng, Juan Wan, Shao W Wang, Wei Zhang, Ming X Ding,

To investigate physiologic and biochemical effects of electroacupuncture and dexmedetomidine administration to goats.30 healthy adult goats.Goats were allotted to 5 groups (6 goats/group) and received electroacupuncture, dexmedetomidine (5 or 20 μg/kg, IM), electroacupuncture plus dexmedetomidine (5 μg/kg, IM), or saline (0.9% NaCl) solution (IM [control treatment]). Pain threshold, cardiorespiratory effects, ... Read more >>

Am. J. Vet. Res. (American journal of veterinary research)
[2016, 77(3):252-259]

Cited: 6 times

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Potential drug-drug interactions in medical intensive care unit of a tertiary care hospital in Pakistan.

Mohammad Ismail, Farmanullah Khan, Sidra Noor, Iqbal Haider, Inam-Ul Haq, Zahid Ali, Zahir Shah, Mohsin Hassam,

Background Patients admitted to intensive care unit (ICU) present with severe and life-threatening illnesses. Most of them suffer from various comorbidities. They usually receive complex pharmacotherapy with large number of medicines which increase the risk of drug-drug interactions (DDIs). Objective The present report aimed to investigate prevalence and levels of ... Read more >>

Int J Clin Pharm (International journal of clinical pharmacy)
[2016, 38(5):1052-1056]

Cited: 6 times

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Current approaches to reduce or eliminate mitochondrial DNA mutations.

Liang Yang, Tingfang Mei, Xiaobing Lin, Haite Tang, Yi Wu, Rui Wang, Jinglei Liu, Zahir Shah, Xingguo Liu,

Sci China Life Sci (Science China. Life sciences)
[2016, 59(5):532-535]

Cited: 3 times

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Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy.

Muzammal Hussain, Zahir Shah, Nasir Abbas, Aqeel Javeed, Muhammad Mahmood Mukhtar, Jiancun Zhang,

Despite the tremendous progress in last few years, the cancer immunotherapy has not yet improved disease-free because of the tumor-associated immune suppression being a major barrier. Novel trends to enhance cancer immunotherapy aims at harnessing the therapeutic manipulation of signaling pathways mediating the tumor-associated immune suppression, with the general aims ... Read more >>

Med. Hypotheses (Medical hypotheses)
[2016, 86:56-59]

Cited: 1 time

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TNF/TNFR₁ pathway and endoplasmic reticulum stress are involved in ofloxacin-induced apoptosis of juvenile canine chondrocytes.

Fu-Tao Zhang, Yi Ding, Zahir Shah, Dan Xing, Yuan Gao, Dong Ming Liu, Ming-Xing Ding,

BACKGROUND AND PURPOSE: Quinolones cause obvious cartilaginous lesions in juvenile animals by chondrocyte apoptosis, which results in the restriction of their use in pediatric and adolescent patients. Studies showed that chondrocytes can be induced to produce TNFα, and the cisternae of the endoplasmic reticulum in quinolone-treated chondrocytes become dilated. We ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2014, 276(2):121-128]

Cited: 2 times

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Electroacupuncture-induced dynamic processes of gene expression levels of endogenous opioid Peptide precursors and opioid receptors in the CNS of goats.

Li-Li Cheng, Ming-Xing Ding, Jia Wei, Yi-Qiang Wu, Zheng-Ying Qiu, Jian-Guo Chen, Dong-Ming Liu, Chang-Min Hu, Man-Li Hu, Zahir Shah, Qiong Wang,

In order to investigate the dynamic processes of mRNA levels of proenkephalin, proopiomelanocortin, prodynorphin, and opioid receptors (δ-, μ-, and κ-receptor) induced by electroacupuncture (EA) in the central nerve system, goats were stimulated by EA of 60 Hz for 0.5 h at a set of Baihui, Santai, Ergen, and Sanyangluo points. The ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2013, 2013:257682]

Cited: 9 times

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