Full Text Journal Articles by
Author Zahid Ali

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The response of culturally important plants to experimental warming and clipping in Pakistan Himalayas.

Saira Karimi, Muhammad Ali Nawaz, Saadia Naseem, Ahmed Akrem, Hussain Ali, Olivier Dangles, Zahid Ali,

The relative effects of climate warming with grazing on medicinally important plants are not fully understood in Hindukush-Himalaya (HKH) region. Therefore, we combined the indigenous knowledge about culturally important therapeutic plants and climate change with experimental warming (open-top chambers) and manual clipping (simulated grazing effect) and compared the relative difference ... Read more >>

PLoS One (PloS one)
[2021, 16(5):e0237893]

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Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.

Hui Qiu, Zahid Ali, Andrew Bender, Richard Caldwell, Yi-Ying Chen, Zhizhou Fang, Anna Gardberg, Nina Glaser, Anja Goettsche, Andreas Goutopoulos, Roland Grenningloh, Bettina Hanschke, Jared Head, Theresa Johnson, Christopher Jones, Reinaldo Jones, Shashank Kulkarni, Christine Maurer, Federica Morandi, Constantin Neagu, Sven Poetzsch, Justin Potnick, Ralf Schmidt, Katherine Roe, Ariele Viacava Follis, Carolyn Wing, Xiaohua Zhu, Brian Sherer,

Bruton's tyrosine kinase (BTK) is a cytoplasmic, non-receptor tyrosine kinase member of the TEC family of tyrosine kinases. Pre-clinical and clinical data have shown that targeting BTK can be used for the treatment for B-cell disorders. Here we disclose the discovery of a novel imidazo[4,5-b]pyridine series of potent, selective reversible ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2021, 40:116163]

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COVID-19 vaccination hesitancy in patients with autoimmune diseases: A mystery that needs an immediate solution!

Zahid Ali, Musharraf Sarwar, Sheraz Ansar, Usman Ayub Awan, Haroon Ahmed, Nauman Aftab, Muhammad Sohail Afzal,

J Med Virol (Journal of medical virology)
[2021, 93(9):5216-5218]

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Potential consequences of captivity and environmental pollution in endoparasitic prevalence in different antelopes kept at wildlife parks.

Shabana Naz, Sajida Arooj, Zahid Ali, Zahid Farooq,

Endoparasites are the potential source of substantial health complications in animals; exclusively the endoparasites of zoonotic importance are of great concern to researchers and health authorities for diverse perspectives. A coprological study was conducted to inspect the endoparasitic infestation in antelopes kept at three captive localities, i.e., Safari Park, Jallo ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, 28(13):16308-16313]

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Genetic variability and evolutionary dynamics of atypical Papaya ringspot virus infecting Papaya.

Anam Saleem, Zahid Ali, Shyi-Dong Yeh, Wajeeha Saeed, Amna Imdad, Muhammad Akbar, Saadia Naseem,

The mutation prone RNA genome of Papaya ringspot virus could be a driving force behind its geographical spread and dissemination. Here we present the molecular investigations on atypical PRSV–P strain identified from Pakistan with genome sequence phylogenetic and recombination analysis. The PRSV-P, Pakistan outbreak strain showing a geographic spread across ... Read more >>

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Association of H1-antihistamines with torsade de pointes: a pharmacovigilance study of the food and drug administration adverse event reporting system.

Zahid Ali, Mohammad Ismail, Fahadullah Khan, Hira Sajid,

<b>Background</b>: This study aimed to measure the association of various H1-antihistamines (H1A) with Torsade de Pointes (TdP), and present a comprehensive overview of H1A-induced TdP cases reported to the Food and Drug Administration Adverse Event Reporting System (FAERS). <b>Methods</b>: All H1A-induced TdP cases (n = 406) were retrieved from the FAERS database using ... Read more >>

Expert Opin Drug Saf (Expert opinion on drug safety)
[2021, 20(1):101-107]

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The Response of Culturally Important Plants to Experimental Warming and Grazing in Pakistan Himalayas

Saira Karimi, Muhammad Ali Nawaz, Saadia Naseem, Ahmed Akrem, Olivier Dangles, Zahid Ali,

The response of wild plants towards climate warming is taxa specific, but overgrazing could also be a determining factor for the alpine ecosystems. Overgrazing and climate warming are important drivers of alpine grassland degradation worldwide. Local indigenous peoples will be the first impacted by such degradation due to impacts on ... Read more >>

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Growth and Characterization of Polycrystalline Silicon Thin Films for Photocatalytic Splitting of Water in Oxide-Si Tandem Cells

Ali Zahid, Umer Zahid, Aamir Hasan, Muhammad Khuldoon,

With the decline in fossil fuels, hydrogen-based alternatives provide a reliable and clean source for sustainable energy generation. In these endeavors, photochemical splitting for hydrogen production through tandem cells has been the source of much theoretical and experimental research in science. Much focus has been placed on interfacial band gap ... Read more >>

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Prevalence of QTc interval prolongation and its associated risk factors among psychiatric patients: a prospective observational study.

Zahid Ali, Mohammad Ismail, Zahid Nazar, Fahadullah Khan, Qasim Khan, Sidra Noor,

BACKGROUND:QT interval prolongation is a growing concern worldwide, posing psychiatric patients to life-threatening fatal arrhythmias i.e., torsade de pointes. This study aimed to identify the prevalence of QT interval prolongation, its associated risk factors and prescribing patterns of QT prolonging drugs among psychiatric patients. METHOD:A prospective observational study was conducted ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):277]

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Captivity stress influences the DNA damage of Pavo cristatus under environmental conditions of Faisalabad, Pakistan.

Shabana Naz, Shifa Muazzam, Anila Sagheer, Arnab Tanveer, Nishat Ali Khan, Zahid Ali, Naila Chand, Rifat Ullah Khan,

The surroundings of wild and captive birds are divergent in existence. Wild birds inhabiting their natural environment have unlimited resources availability. They face variety of captivity stresses when moved from wild habitat to caged enclosures. The effect of similar captivity stresses on the DNA of birds living in cages for ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, 27(5):5636-5639]

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Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives?

Sidra Noor, Mohammad Ismail, Zahid Ali,

<h4>Background</h4>Pneumonia patients are usually hospitalized due to severe nature of the disease or for the management of comorbid illnesses or associated symptoms. Such patients are prescribed with multiple medications which increase the likelihood of potential drug-drug interactions (pDDIs). Therefore, in this study the prevalence, levels (severity and documentation), predictors (risk ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2019, 20(1):45]

Cited: 3 times

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Efficient and reproducible somatic embryogenesis and micropropagation in tomato via novel structures - Rhizoid Tubers.

Wajeeha Saeed, Saadia Naseem, Daniyal Gohar, Zahid Ali,

A dual in vitro regeneration system consisting of indirect organogenesis and somatic embryogenesis (SE), applicable to several varieties of tomato-Solanum lycopersicum (cv. Riogrande, cv. Roma, hybrid 17905 and model cv. M82) has been established. This system is both improved and highly reproducible compared to current methods. Callus initiation, plant regeneration ... Read more >>

PLoS One (PloS one)
[2019, 14(5):e0215929]

Cited: 2 times

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The dawn of phage therapy.

Sana Rehman, Zahid Ali, Momna Khan, Nazish Bostan, Saadia Naseem,

Bacteriophages or phages, being the most abundant entities on earth, represent a potential solution to a diverse range of problems. Phages are successful antibacterial agents whose use in therapeutics was hindered by the discovery of antibiotics. Eventually, because of the development and spread of antibiotic resistance among most bacterial species, ... Read more >>

Rev Med Virol (Reviews in medical virology)
[2019, 29(4):e2041]

Cited: 10 times

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Knowledge and Practice of Pharmacists toward Antimicrobial Stewardship in Pakistan.

Inayat Ur Rehman, Malik Muhammad Asad, Allah Bukhsh, Zahid Ali, Humera Ata, Juman Abdulelah Dujaili, Ali Qais Blebil, Tahir Mehmood Khan,

<b>Background:</b> The irrational use, "over the counter supply", and unregulated supply chains of antimicrobials are contributing toward antimicrobial resistance. Antimicrobial stewardship programs regulate antimicrobials usage to prevent resistance and reduce health care burden. <b>Objective:</b> To assess the knowledge and practice of pharmacists' working in various healthcare settings toward antimicrobial stewardship ... Read more >>

Pharmacy (Basel) (Pharmacy (Basel, Switzerland))
[2018, 6(4):]

Cited: 9 times

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Anopheles sundaicus Mosquitoes as Vector for Plasmodium knowlesi, Andaman and Nicobar Islands, India.

Pachalil Thiruvoth Vidhya, Ittoop Pulikkottil Sunish, Anwesh Maile, Ali Khan Zahid,

Using PCR and sequencing, we found Plasmodium knowlesi in the malaria vector Anopheles sundaicus mosquito collected from Katchal Island in the Andaman and Nicobar Islands, India. We cannot rule out natural transmission of this parasite to humans through this mosquito species. An in-depth investigation is needed to prevent disease outbreaks. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2019, 25(4):817-820]

Cited: 3 times

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Computational modeling and functional characterization of a GgChi: A class III chitinase from corms of Gladiolus grandiflorus.

Maria Rafiq, Ashiq Hussain, Kausar Hussain Shah, Qamar Saeed, Muhammad Umair Sial, Zahid Ali, Friedrich Buck, Richard E Goodman, Binish Khaliq, Uzma Ishaq, Mirza Ahsen Baig, Aisha Munawar, Seema Mahmood, Ahmed Akrem,

The present study describes the predicted model and functional characterization of an endochitinase (30 kDa) from corms of Gladiolus grandiflorus. ESI-QTOF-MS generated peptide showed 96% sequence homology with family 18, Class III acidic endochitinase of Gladiolus gandavensis. Purified G. grandiflorus chitinase (GgChi) hydrolyzed 4-methylumbelliferyl β-d-N,N',N''-triacetylchitotriose substrate showing specific endochitinase activity. Since ... Read more >>

Kaohsiung J Med Sci (The Kaohsiung journal of medical sciences)
[2018, 34(12):673-683]

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Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study.

Mohammad Ismail, Sidra Noor, Umme Harram, Inamul Haq, Iqbal Haider, Faiza Khadim, Qasim Khan, Zahid Ali, Tahir Muhammad, Muhammad Asif,

<h4>Background</h4>Potential drug-drug interactions (pDDIs) are one of the preventable drug related problems having the risk of serious adverse events or therapeutic failure. In developing countries like Pakistan, this issue remains poorly addressed. The objective of this study was to explore prevalence of pDDIs in the Outpatient Department (OPD) of a ... Read more >>

BMC Health Serv Res (BMC health services research)
[2018, 18(1):762]

Cited: 4 times

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Efficient and reproducible somatic embryogenesis and micro propagation in tomato via novel structures -Rhizoid Tubers

Wajeeha Saeed, Saadia Naseem, Daniyal Gohar, Zahid Ali,

An improved and highly reproducible system for invitro regeneration via somatic embryogenesis (S.E), applicable to several varieties of tomato (cv. Riogrande , cv. Roma grande , hybrid 17905 and model cv. M82) has been developed. First, we developed a conventional indirect organogenesis for all four varieties used in this study. ... Read more >>

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Moxifloxacin-induced QT interval prolongation and torsades de pointes: a narrative review.

Fahadullah Khan, Mohammad Ismail, Qasim Khan, Zahid Ali,

<h4>Introduction</h4>Moxifloxacin is widely used for the treatment of a number of infectious diseases because of its favorable pharmacological profile and high clinical success rate. However, it is often criticized for its higher risk of QTc interval prolongation (QTIP) and torsades de pointes (TdP).<h4>Areas covered</h4>A review of published literature on moxifloxacin-related ... Read more >>

Expert Opin Drug Saf (Expert opinion on drug safety)
[2018, 17(10):1029-1039]

Cited: 6 times

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Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy.

Aoibhinn McDonnell, Susie Collins, Zahid Ali, Laura Iavarone, Raulin Surujbally, Simon Kirby, Richard P Butt,

The effect of PF-05089771, a selective, peripherally restricted Nav1.7 sodium channel blocker on pain due to diabetic peripheral neuropathy was investigated in a randomised, placebo and active-controlled parallel group clinical trial (NCT02215252). A 1-week placebo-run in the period was followed by a 4-week treatment period and a 1-week placebo run-out/taper-down ... Read more >>

Pain (Pain)
[2018, 159(8):1465-1476]

Cited: 26 times

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Structure-activity relationships of strigolactones via a novel, quantitative in planta bioassay.

Elena Sanchez, Emma Artuso, Chiara Lombardi, Ivan Visentin, Beatrice Lace, Wajeeha Saeed, Marco L Lolli, Piermichele Kobauri, Zahid Ali, Francesca Spyrakis, Pilar Cubas, Francesca Cardinale, Cristina Prandi,

Strigolactones (SLs) are plant hormones with various functions in development, responses to stress, and interactions with (micro)organisms in the rhizosphere, including with seeds of parasitic plants. Their perception for hormonal functions requires an α,β-hydrolase belonging to the D14 clade in higher plants; perception of host-produced SLs by parasitic seeds relies ... Read more >>

J Exp Bot (Journal of experimental botany)
[2018, 69(9):2333-2343]

Cited: 1 time

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Prevalence of the risk factors for QT prolongation and associated drug-drug interactions in a cohort of medical inpatients.

Qasim Khan, Mohammad Ismail, Iqbal Haider, Zahid Ali,

BACKGROUND/PURPOSE:Medical inpatients are at increased risk of QT interval prolongation due to multiple risk actors and QT prolonging drugs. This study aimed to identify the prevalence of risk factors for QT prolongation; QT prolonging medications; associated drug-drug interactions (QT-DDIs); their predictors; and TdP (torsades de pointes) risks of drugs. METHODS:This ... Read more >>

J Formos Med Assoc (Journal of the Formosan Medical Association = Taiwan yi zhi)
[2019, 118(1 Pt 1):109-115]

Cited: 1 time

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Strigolactones Biosynthesis and Their Role in Abiotic Stress Resilience in Plants: A Critical Review.

Wajeeha Saeed, Saadia Naseem, Zahid Ali,

Strigolactones (SLs), being a new class of plant hormones, play regulatory roles against abiotic stresses in plants. There are multiple hormonal response pathways, which are adapted by the plants to overcome these stressful environmental constraints to reduce the negative impact on overall crop plant productivity. Genetic modulation of the SLs ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2017, 8:1487]

Cited: 14 times

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Nickel adsorption onto polyurethane ethylene and vinyl acetate sorbents.

Munawar Iqbal, Zahid Ali, M Afzal Qamar, Abid Ali, Fida Hussain, Mazhar Abbas, Jan Nisar,

The present study was conducted to appraise the efficiencies of polyurethane ethylene sorbent (PES) and vinyl acetate sorbent (VAS) for nickel (Ni) adsorption. Process variables, i.e. Ni(II) ions initial concentration, pH, contact time and adsorbent dosage were optimized by response surface methodology (RSM) approach. The Ni(II) adsorption was fitted to ... Read more >>

Water Sci Technol (Water science and technology : a journal of the International Association on Water Pollution Research)
[2017, 76(1-2):219-235]

Cited: 0 times

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Inherited erythromelalgia due to mutations in SCN9A: natural history, clinical phenotype and somatosensory profile.

Aoibhinn McDonnell, Betsy Schulman, Zahid Ali, Sulayman D Dib-Hajj, Fiona Brock, Sonia Cobain, Tina Mainka, Jan Vollert, Sanela Tarabar, Stephen G Waxman,

Inherited erythromelalgia, the first human pain syndrome linked to voltage-gated sodium channels, is widely regarded as a genetic model of human pain. Because inherited erythromelalgia was linked to gain-of-function changes of sodium channel Na(v)1.7 only a decade ago, the literature has mainly consisted of reports of genetic and/or clinical characterization ... Read more >>

Brain (Brain : a journal of neurology)
[2016, 139(Pt 4):1052-1065]

Cited: 23 times

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