Full Text Journal Articles by
Author Zafer Bayraktutan

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Roflumilast as a Potential Therapeutic Agent for Cecal Ligation and Puncture-Induced Septic Lung Injury.

Zafer Bayraktutan, Busra Dincer, Halil Keskin, Duygu Kose, Arzu Bilen, Erdem Toktay, Busra Sirin, Zekai Halici,

<h4>Purpose/aims</h4>This study focused on delineating the possible effects of roflumilast (ROF), a selective phosphodiesterase 4 (PDE4) inhibitor, in rats with cecal ligation and puncture (CLP)-induced polymicrobial sepsis, and investigated whether ROF can act as a protective agent in sepsis-induced lung damage.<h4>Material and methods</h4>Four experimental groups were organized, each comprising eight ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2021, :1-9]

Cited: 0 times

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Protective Effects of Idebenone against Sepsis Induced Acute Lung Damage.

Erol Akpinar, Zerrin Kutlu, Duygu Kose, Pelin Aydin, Taha Tavaci, Zafer Bayraktutan, Tugba Nurcan Yuksel, Serkan Yildirim, Gizem Eser, Busra Dincer,

<h4>Background/aims</h4>Sepsis is an uncontrolled systemic infection, withcomplex pathophysiology that may result in acute lung organ damage and cause multiple organ failure. Although much research has been conducted to illuminate sepsis's complex pathophysiology, sepsis treatment protocols are limited, and sepsis remains an important cause of mortality andmorbidity in intensive care units.Various ... Read more >>

J Invest Surg (Journal of investigative surgery : the official journal of the Academy of Surgical Research)
[2021, :1-9]

Cited: 0 times

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Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells.

Irfan Cinar, Muhammed Yayla, Muhammet Celik, Arzu Bilen, Zafer Bayraktutan,

<h4>Objective</h4>The aim of this study was to explore the role of endothelin 1 (ET-1) in human breast cancer proliferation and migration and antagonism of endothelin receptor A (ETAR) and endothelin receptor B (ETBR) by using the non-selective dual ETA/ETB receptor antagonist bosentan and determine its anti-proliferative, anti-metastatic, and apoptotic effects ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2020, 52(3):277-282]

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Protective effect of luteolin on acute lung injury in a rat model of sepsis.

Demet Celebi, Pelin Aydin, Irfan Cinar, Zerrin Kutlu, Ilknur Calik, Zekai Halici, Dilek Bilici, Zafer Bayraktutan,

We investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). LUT was administered 1 h after CLP surgery. Administration of LUT reduced ... Read more >>

Biotech Histochem (Biotechnic & histochemistry : official publication of the Biological Stain Commission)
[2020, :1-7]

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The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus.

Nihal Efe Atila, Alptug Atila, Zülküf Kaya, Yunus E Bulut, Fatih Oner, Kübra Topal, Zafer Bayraktutan, Ebubekir Bakan,

Elevated levels of heavy metals like cadmium (Cd) and manganese (Mn) are known to lead to oxidative damage-related oto-toxicity and decreased levels of chromium (Cr) and selenium (Se) are known to lead to oto-toxicity due to reduced anti-oxidant activity. The aim of the present study was to evaluate serum levels ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2021, 199(8):2844-2850]

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Determination of Endothelial Nitric Oxide Synthase Gene Polymorphism and Plasma Asymmetric Dimethyl Arginine Concentrations in Patients with Lung Cancer.

Zafer Bayraktutan, Ahmet Kiziltunc, Ebubekir Bakan, Hamit Hakan Alp,

Objective:Genetic factors can contribute to both the occurrence and development of lung cancer. This study aimed to investigate endothelial nitric oxide synthase (eNOS) G894T and T-786C polymorphisms and plasma asymmetric dimethylarginine (ADMA) levels of lung cancer patients in comparison with healthy subjects. Materials and Methods:A total of 200 subjects, 100 ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2020, 52(2):185-190]

Cited: 2 times

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Effect of Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist, on a Rat Model of Acute Bacterial Sinonasal Inflammation.

Zülküf Kaya, Muhammed Yayla, Irfan Cinar, Demet Celebi, Erdem Toktay, Zafer Bayraktutan, Dilek Bilici,

Am J Rhinol Allergy (American journal of rhinology & allergy)
[2019, 33(5):559-566]

Cited: 1 time

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Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model.

Zulkuf Kaya, Muhammed Yayla, Arzu Bilen, Nihal Efe Atilla, Sevilay Ozmen, Irfan Cinar, Zafer Bayraktutan, Vahit Mutlu, Harun Un, Erdem Toktay,

Objective:The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR. Materials and Methods:Twenty-five adult male rats were used and were randomly ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2019, 51(1):75-79]

Cited: 0 times

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Epigallocatechin-3-gallate (EGCG) exert therapeutic effect on acute inflammatory otitis media in rats.

Zulkuf Kaya, Muhammed Yayla, Irfan Cinar, Nihal Efe Atila, Sevilay Ozmen, Zafer Bayraktutan, Dilek Bilici,

<h4>Introduction</h4>That EGCG has strong antioxidant and anti-inflammatory activities as well as antibacterial activity against many streptococcus species suggests that it may be beneficial in the treatment of AOM.<h4>Objective</h4>Aim of the study is to reveal the molecular and biochemical effects of EGCG on LPS induced otitis media in rats.<h4>Methods</h4>Forty-two male albino ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2019, 124:106-110]

Cited: 2 times

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Serum nesfatin-1 levels: a potential new biomarker in patients with subarachnoid hemorrhage.

Murteza Cakir, Cagatay Calikoglu, Atilla Yılmaz, Erol Akpinar, Zafer Bayraktutan, Atilla Topcu,

<h4>Background</h4>Acute subarachnoid hemorrhage (SAH) is a neurological emergency with significant potential for long-term morbidity and mortality. Nesfatin-1 is a polypeptide which is found in various regions of the brain that play role in the feeding and metabolic regulation.<h4>Objective</h4>So this study aimed to investigate if nesfatin-1 levels in patients with SAH, ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2017, 127(2):154-160]

Cited: 0 times

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Serum zinc levels in patients with iron deficiency anemia and its association with symptoms of iron deficiency anemia.

Engin Kelkitli, Nurinnisa Ozturk, Nevin Alayvaz Aslan, Nurcan Kilic-Baygutalp, Zafer Bayraktutan, Nezahat Kurt, Nuri Bakan, Ebubekir Bakan,

Iron deficiency anemia (IDA) is a major public health problem especially in underdeveloped and developing countries. Zinc is the co-factor of several enzymes and plays a role in iron metabolism, so zinc deficiency is associated with IDA. In this study, it was aimed to investigate the relationship of symptoms of ... Read more >>

Ann Hematol (Annals of hematology)
[2016, 95(5):751-756]

Cited: 13 times

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A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine.

Adem Karaman, Busra Diyarbakir, Irmak Durur-Subasi, Duygu Kose, Asli Özbek-Bilgin, Atilla Topcu, Cemal Gundogdu, Afak Durur-Karakaya, Zafer Bayraktutan, Fatih Alper,

<h4>Objective</h4>To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). The drug's action on the antioxidant system and proinflammatory cytokines, superoxide dismutase (SOD) activity, levels of glutathione (GSH) and malondialdehyde (MDA) and the gene expression of interleukin-6 (IL-6), tumour necrosis factor (TNF)-α ... Read more >>

Br J Radiol (The British journal of radiology)
[2016, 89(1061):20150716]

Cited: 5 times

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The Effects of Argan Oil in Second-degree Burn Wound Healing in Rats.

Umit Avsar, Zekai Halici, Erol Akpinar, Muhammed Yayla, Ummu Avsar, Un Harun, Un Harun, Atmaca Hasan Tarik, Zafer Bayraktutan,

Argan oil, produced from the kernels of the argan tree (Argania spinosa), has been shown to have antioxidant properties. To examine the effect of argan oil in second-degree burn wound healing, an in vivo experiment was conducted among 30 adult male Wistar rats divided into 5 equal groups: a sham ... Read more >>

Ostomy Wound Manage (Ostomy/wound management)
[2016, 62(3):26-34]

Cited: 5 times

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Levels of endothelial cell-specific molecule-1 (ESM-1) in overt hypothyroidisim.

Adem Gungor, Saziye Sezin Palabiyik, Zafer Bayraktutan, Hakan Dursun, Naile Gokkaya, Arzu Bilen, Habib Bilen,

<h4>Purpose</h4>Endothelial cell-specific molecule-1, endocan, is a proteoglycan that is expressed by the vascular endothelium. Endocan can be a biomarker of endothelial dysfunction caused by endothelial cell-dependent disorders. Endothelial dysfunction is an early step of atherosclerosis and is developed in hypothyroid patients, which indicates an association between hypothyroidism and atherosclerosis. Therefore, ... Read more >>

Endocr Res (Endocrine research)
[2016, 41(4):275-280]

Cited: 3 times

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Is There a Relationship between Obstructive Sleep Apnea Syndrome Severity and Nesfatin-1?

Omer Araz, Elif Yilmazel Ucar, Emrullah Dorman, Zafer Bayraktutan, Muhammed Yayla, Nafiye Yilmaz, Hamit Acemoglu, Zekai Halici, Metin Akgun,

<h4>Background</h4>Obstructive sleep apnea syndrome (OSAS) and obesity frequently occur together. The relationship between increased appetite and obesity is well known; however, despite existing knowledge about the relationship between OSAS and obesity, it is not fully understood.<h4>Objectives</h4>This study aimed to evaluate the relationship between OSAS and the appetite-suppressing hormone nesfatin-1 independent ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2015, 90(2):105-110]

Cited: 7 times

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Does bosentan protect diabetic brain alterations in rats? The role of endothelin-1 in the diabetic brain.

Recep Demir, Elif Cadirci, Erol Akpinar, Yasemin Cayir, Hasan Tarik Atmaca, Harun Un, Celalettin Semih Kunak, Muhammed Yayla, Zafer Bayraktutan, Ilknur Demir,

Diabetes mellitus (DM) is a major problem all over the world, affecting more people in recent years. Individuals with diabetes are more prone to disease than non-diabetics, especially vascular complications. The aim of this study was to examine the roles of the endothelin (ET)-1 in brain damage formed in a ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2015, 116(3):236-243]

Cited: 3 times

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The ocular endothelin system: a novel target for the treatment of endotoxin-induced uveitis with bosentan.

Sadullah Keles, Zekai Halici, Hasan Tarik Atmaca, Muhammed Yayla, Kenan Yildirim, Metin Ekinci, Erol Akpinar, Durdu Altuner, Ozgur Cakici, Zafer Bayraktutan,

<h4>Purpose</h4>We compared the anti-inflammatory effects of bosentan and dexamethasone in endotoxin-induced uveitis (EIU).<h4>Methods</h4>Endotoxin-induced uveitis was induced by subcutaneous injection of lipopolysaccharide (LPS, 200 μg) in Wistar rats. Rats were divided randomly into 10 groups (n = 6). Bosentan at doses of 50 and 100 mg/kg were administered orally 1 hour ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2014, 55(6):3517-3524]

Cited: 10 times

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Relationship of asymmetrical dimethylarginine, nitric oxide, and sustained attention during attack in patients with major depressive disorder.

Serpil Canpolat, Ismet Kırpınar, Erdem Deveci, Hülya Aksoy, Zafer Bayraktutan, Ibrahim Eren, Recep Demir, Salih Selek, Nazan Aydın,

We investigated the relationship of serum nitric oxide (NO) and asymmetrical dimethylarginine (ADMA) levels with cognitive functioning in patients with major depressive disorder (MDD). 41 MDD patients (Beck depression scale scores>16) and 44 controls were included in the study. Rey verbal learning and memory test, auditory consonant trigram test, digit ... Read more >>

ScientificWorldJournal (TheScientificWorldJournal)
[2014, 2014:624395]

Cited: 7 times

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High serum HTATIP2/TIP30 level in serous ovarian cancer as prognostic or diagnostic marker.

Yakup Kumtepe, Zekai Halici, Ozlem Sengul, Celalettin Semih Kunak, Yasin Bayir, Nergiz Kilic, Elif Cadirci, Alparslan Pulur, Zafer Bayraktutan,

<h4>Background</h4>Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is an evolutionarily conserved gene that is expressed ubiquitously in human tissues and some tumor tissues. This protein has been found to be associated with some gynecological cancers; as such, this study aimed to investigate blood HTATIP2/TIP30 levels in patients with ovarian cancer.<h4>Methods</h4>Twenty-three ... Read more >>

Eur J Med Res (European journal of medical research)
[2013, 18:18]

Cited: 6 times

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