Full Text Journal Articles by
Author Zachary Kon

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Multimodal opioid-sparing pain management after lung transplantation and the impact of liposomal bupivacaine intercostal nerve block.

Tyler C Lewis, Kimberly Sureau, Alyson Katz, Anthony Fargnoli, Melissa Lesko, Darya Rudym, Luis F Angel, Stephanie H Chang, Zachary N Kon,

Opioid analgesics are commonly used post-lung transplant, but have many side effects and are associated with worse outcomes. We conducted a retrospective review of all lung transplant recipients who were treated with a multimodal opioid-sparing pain protocol. The use of liposomal bupivacaine intercostal nerve block was variable due to hospital ... Read more >>

Clin Transplant (Clinical transplantation)
[2021, :e14512]

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Clinical and Financial Implications of 2 Treatment Strategies for Donor-derived Hepatitis C Infections.

Zoe A Stewart, Jeffrey Stern, Nicole M Ali, Harmit S Kalia, Karen Khalil, Srijana Jonchhe, Elaina P Weldon, Rebecca A Dieter, Tyler C Lewis, Nur Funches, Sudara Crosby, Monique Seow, Jonathan C Berger, Nabil N Dagher, Bruce E Gelb, Anthony C Watkins, Nader Moazami, Deane E Smith, Zachary N Kon, Stephanie H Chang, Alex Reyentovich, Luis F Angel, Robert A Montgomery, Bonnie E Lonze,

Transplanting hepatitis C viremic donor organs into hepatitis C virus (HCV)-negative recipients is becoming increasingly common; however, practices for posttransplant direct-acting antiviral (DAA) treatment vary widely. Protracted insurance authorization processes for DAA therapy often lead to treatment delays.<h4>Methods</h4>At our institution, 2 strategies for providing DAA therapy to HCV<sup>-</sup> recipients of ... Read more >>

Transplant Direct (Transplantation direct)
[2021, 7(10):e762]

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A Comparison of Anticoagulation Strategies in Veno-venous Extracorporeal Membrane Oxygenation.

Aakash Shah, Chetan Pasrija, Anthony Kronfli, Eno-Obong Essien, Ya Zhou, Francis Brigante, Gregory Bittle, Jay Menaker, Daniel Herr, Michael A Mazzeffi, Kristopher B Deatrick, Zachary N Kon,

Bleeding remains a major source of morbidity associated with veno-venous extracorporeal membrane oxygenation (VV-ECMO). Moreover, there remains significant controversy, and a paucity of data regarding the ideal anticoagulation strategy for VV-ECMO patients. All patients undergoing isolated, peripheral VV-ECMO between January 2009 and December 2014 at our institution were retrospectively reviewed. ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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Perceptions of Training Pathways from Recent Cardiothoracic Surgery Graduates.

Alison Ward, Neel K Ranganath, Stacey Chen, Tyler Wallen, Amie J Kent, Deane E Smith Iii, Zachary N Kon,

<h4>Background</h4>There are three cardiothoracic surgery (CTS) training pathways-general surgery residency followed by a CTS residency of 2-3 years (traditional), 4 years of general surgery and 3 years of CTS residency (4+3), and an integrated 6-year pathway (I-6). The goal of this study was to survey early career cardiothoracic surgeons regarding ... Read more >>

Heart Surg Forum (The heart surgery forum)
[2021, 24(4):E684-E689]

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Percutaneous Dilational Tracheostomy for Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation.

Luis F Angel, Nancy E Amoroso, Samaan Rafeq, Brian Mitzman, Ronald Goldenberg, Saketh Palasamudram Shekar, Andrea B Troxel, Yan Zhang, Stephanie H Chang, Paul Kwak, Milan R Amin, Kimberly Sureau, Heidi B Nafday, Sarun Thomas, Zachary Kon, Philip M Sommer, Leopoldo N Segal, William H Moore, Robert Cerfolio,

<h4>Objectives</h4>To assess the impact of percutaneous dilational tracheostomy in coronavirus disease 2019 patients requiring mechanical ventilation and the risk for healthcare providers.<h4>Design</h4>Prospective cohort study; patients were enrolled between March 11, and April 29, 2020. The date of final follow-up was July 30, 2020. We used a propensity score matching approach ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1058-1067]

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Safety and Feasibility of an Early Mobilization Protocol for Patients with Femoral Intra-Aortic Balloon Pumps as Bridge to Heart Transplant.

Stacey Chen, Lynette Lester, Greta L Piper, Bridget Toy, Mary Saputo, Wendy Chan, Mary G Fischer, Claudia Gidea, Zachary N Kon, Nader Moazami, Deane E Smith,

Intra-aortic balloon pumps (IABPs) can be used to provide hemodynamic support in patients with end-stage heart failure as a bridge to transplantation (BTT). The IABP is commonly inserted via the common femoral artery, which can limit patients' mobility. The Ramsey protocol, developed by a critical care physical therapist, allows patients ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, :]

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Hemoadsorption for management of patients on veno-venous ECMO support for severe COVID-19 acute respiratory distress syndrome.

Travis C Geraci, Zachary N Kon, Nader Moazami, Stephanie H Chang, Julius Carillo, Stacey Chen, Anthony Fargnoli, Marjan Alimi, Harvey Pass, Aubrey Galloway, Deane E Smith,

<h4>Background and aim</h4>Patients with severe coronavirus disease 2019 (COVID-19) develop a profound cytokine-mediated pro-inflammatory response. This study reports outcomes in 10 patients with COVID-19 supported on veno-venous extracorporeal membrane oxygenation (VV-ECMO) who were selected for the emergency use of a hemoadsorption column integrated in the ECMO circuit.<h4>Materials and methods</h4>Pre and ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2021, 36(11):4256-4264]

Cited: 2 times

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What's in a Name? The Diminishing Value of Quality Designations for Donor Lungs.

Benjamin Wadowski, Matthew G Hartwig, Zachary N Kon,

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

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Inflow Cannula Position Influences Improvement in Mitral Regurgitation After Ventricular Assist Device Implantation.

Chetan Pasrija, Mariem A Sawan, Erik Sorensen, James S Gammie, Ronson Madathil, Douglas Tran, Libin Wang, Van-Khue Ton, Erika Feller, Bartley P Griffith, Zachary N Kon, David J Kaczorowski,

Significant residual mitral regurgitation (MR) after left ventricular assist device (LVAD) implantation has been associated with increased morbidity and mortality. The effect of cannula position on improvement of preexisting MR has yet to be evaluated. Consecutive patients who underwent centrifugal LVAD implantation with >mild preoperative MR and without concomitant mitral ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(4):423-429]

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Neurological complications during veno-venous extracorporeal membrane oxygenation: Does the configuration matter? A retrospective analysis of the ELSO database.

Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M Johnson, Sandro Gelsomino, Daniel Herr,

<h4>Background</h4>Single- (SL) and double-lumen (DL) catheters are used in clinical practice for veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. However, information is lacking regarding the effects of the cannulation on neurological complications.<h4>Methods</h4>A retrospective observational study based on data from the Extracorporeal Life Support Organization (ELSO) registry. All adult patients included ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):107]

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Hemoadsorption for management of Patients on Veno-venous ECMO Support for Severe COVID-19 Acute Respiratory Distress Syndrome

Travis Geraci, Zachary Kon, Nader Moazami, Stephanie Chang, Julius Carillo, Stacey Chen, Anthony Fargnoli, Marjan Alimi, Harvey Pass, Aubrey Galloway, Deane Smith,

<h4>Background: </h4> and aim of the study: Patients with severe coronavirus disease 2019 (COVID-19) develop a profound cytokine-mediated pro-inflammatory response. This study reports outcomes in 10 patients with COVID-19 supported on veno-venous extracorporeal membrane oxygenation (VV-ECMO) who were selected for the emergency use of a hemoadsorption column integrated in the ... Read more >>

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Which one you rather have if you are fifty: TAVR vs. small - incision AVR vs. full sternotomy AVR.

Mehrdad Ghoreishi, Chetan Pasrija, Zachary Kon,

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

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Bedside angiography of distal perfusion catheter for veno-arterial extracorporeal membrane oxygenation.

Aakash Shah, Danielle Arons, Chetan Pasrija, Zachary N Kon, Mehrdad Ghoreishi,

<h4>Background</h4>The aim of this study was to evaluate the ipsilateral lower extremity (ILE) outcomes of patients who underwent bedside angiography via the distal perfusion catheter while on femoral veno-arterial extracorporeal membrane oxygenation (VA ECMO).<h4>Methods</h4>This is a retrospective analysis of all patients placed on VA ECMO at a single center from ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211007017]

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Clinical Outcomes of Pregnant and Postpartum Extracorporeal Membrane Oxygenation Patients.

Allison S Lankford, Jonathan H Chow, Amanda M Jackson, Marianne Wallis, Samuel M Galvagno, Andrew M Malinow, Ozhan M Turan, Jay A Menaker, Sarah D Crimmins, Raymond Rector, David Kaczorowski, Bartley Griffith, Zachary Kon, Daniel Herr, Michael A Mazzeffi,

<h4>Background</h4>The use of extracorporeal membrane oxygenation (ECMO) as a rescue therapy for cardiopulmonary failure is expanding in critical care medicine. In this case series, we describe the clinical outcomes of 21 consecutive pregnant or postpartum patients that required venovenous (VV) or venoarterial (VA) ECMO. Our objective was to characterize maternal ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):777-787]

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Conquer, Not Divide: A Case for Desensitization in Seeking Parity for Sensitized Candidates.

Benjamin J Wadowski, Marcelo Cypel, Zachary N Kon,

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 112(2):681]

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Expert Consensus Paper: Lateral Thoracotomy for Centrifugal Ventricular Assist Device Implant.

Jan D Schmitto, Silvia Mariani, Travis O Abicht, Gregory S Couper, Matthew R Danter, Akinobu Itoh, Zain Khalpey, Zachary N Kon, Simon Maltais, Nahush A Mokadam, Duc Thinh Pham, Aron Frederik Popov, Diyar Saeed, André R Simon, Daniel Zimpfer, Martin Strueber,

<h4>Background</h4>The increasing prevalence of heart failure has led to the expanded use of left ventricle assist devices (VADs) for end-stage heart failure patients worldwide. Technological improvements witnessed the development of miniaturized VADs and their implantation through less traumatic non-full sternotomy approaches using a lateral thoracotomy (LT). Although adoption of the ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, :]

Cited: 1 time

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VA - ECMO for Massive Pulmonary Embolism: When is the Time to Wean?

Mehrdad Ghoreishi, Chetan Pasrija, Zachary Kon,

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, :]

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Safety and Efficacy of Bronchoscopy in Critically Ill Patients With Coronavirus Disease 2019.

Stephanie H Chang, Jeffrey Jiang, Zachary N Kon, David M Williams, Travis C Geraci, Deane E Smith, Robert J Cerfolio, Michael Zervos, Costas Bizekis,

Chest (Chest)
[2021, 159(2):870-872]

Cited: 4 times

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High Lung Transplant Center Volume Is Associated With Increased Survival in Hospitalized Patients.

Neel K Ranganath, Jad Malas, Stacey Chen, Deane E Smith, Stephanie H Chang, Melissa B Lesko, Luis F Angel, Bonnie E Lonze, Zachary N Kon,

<h4>Background</h4>The lung allocation score (LAS) was designed to optimize the use of pulmonary allografts based on anticipated pretransplant survival and posttransplant outcome. Hospital admission status, not included in the LAS, has not been comprehensively investigated with regard to organ allocation. The objective of this study was to determine whether pretransplant ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 111(5):1652-1658]

Cited: 2 times

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Comparison of device-specific adverse event profiles between Impella platforms.

Stacey Chen, Darien Paone, Lilly Spellman, Neel K Ranganath, Julius A Carillo, Claudia G Gidea, Alex Reyentovich, Craig A Thompson, Louai Razzouk, Zachary N Kon, Nader Moazami, Deane E Smith,

<h4>Background</h4>The Impella (Abiomed) ventricular support system is a family of temporary mechanical circulatory support (MCS) devices used to treat patients with cardiogenic shock, acute cardiogenic decompensation, and for high-risk percutaneous or surgical revascularization. These devices include the percutaneously implanted 2.5/cardiac power (CP) and the surgically implanted 5.0/left direct (LD). Despite ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2020, 35(12):3310-3316]

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Outcomes of the Treatment with Glecaprevir/Pibrentasvir following heart transplantation utilizing hepatitis C viremic donors.

Alex Reyentovich, Claudia G Gidea, Deane Smith, Bonnie Lonze, Zachary Kon, Anthony Fargnoli, Jennifer Pavone, Shaline Rao, Tajinderpal Saraon, Tyler Lewis, Yingzhi Qian, Ira Jacobson, Nader Moazami,

<h4>Background</h4>The use of direct-acting antivirals (DAA) has expanded transplantation from hepatitis C viremic donors (HCV-VIR). Our team has conducted an open-label, prospective trial to assess outcomes transplanting HCV viremic hearts. Glecaprevir/pibrentasvir (GLE/PIB) was our sole DAA.<h4>Methods</h4>Serial quantitative hepatitis C virus (HCV) RNA PCR was obtained to assess HCV viral titers. ... Read more >>

Clin Transplant (Clinical transplantation)
[2020, 34(9):e13989]

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Beware the Deus Ex Machina of COVID-19.

Benjamin J Wadowski, Matthew Bacchetta, Zachary N Kon,

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, 110(6):1787-1788]

Cited: 2 times

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Transplant Operative Considerations in Pulmonary Hypertension With Severe Right Heart Failure.

Stephanie H Chang, Deane E Smith, Nader Moazami, Zachary N Kon,

Over the past several decades, the operation of choice for end-stage lung disease secondary to severe pulmonary hypertension (PH) has shifted from heart-lung transplantation (HLT) to bilateral lung transplantation (BLT). This change has maintained excellent long-term outcomes and is appropriate for the majority of patients presenting with end-stage disease in ... Read more >>

Semin Thorac Cardiovasc Surg (Seminars in thoracic and cardiovascular surgery)
[2020, 32(4):1024-1029]

Cited: 1 time

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Less-Invasive Aortic Valve Replacement: Trends and Outcomes From The Society of Thoracic Surgeons Database.

Mehrdad Ghoreishi, Vinod H Thourani, Vinay Badhwar, Malek Massad, Lars Svensson, Bradley S Taylor, Chetan Pasrija, James S Gammie, Jeffery P Jacobs, Morgan Cox, Maria Grau-Sepulveda, Matthew Brennan, Bartley P Griffith, Jeffrey C Milliken, Khaled Abdelhady, Zachary Kon,

<h4>Background</h4>This study compares outcomes of conventional and less-invasive (LI) approaches for aortic valve replacement (AVR) using The Society of Thoracic Surgeons database.<h4>Methods</h4>Between 2011 and 2017, we identified 122,474 patients undergoing isolated primary AVR. Patients were categorized into 3 groups: (1) full sternotomy (FS) (n = 98,549; 78%), (2) partial sternotomy (PS) ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 111(4):1216-1223]

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Lobectomy for Hemorrhagic Lobar Infarction in a Patient With COVID-19.

Travis C Geraci, Navneet Narula, Deane E Smith, Andre L Moreira, Zachary N Kon, Stephanie H Chang,

Patients with severe coronavirus disease 2019 from infection with severe acute respiratory syndrome coronavirus 2 mount a profound inflammatory response and are predisposed to thrombotic complications. Pulmonary vein thrombosis is a rare disease process resulting in pulmonary congestion, infarction, and potential mortality. This report describes a patient with coronavirus disease ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 111(3):e183-e184]

Cited: 1 time

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