Full Text Journal Articles by
Author Zachary J Brown

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Staging Laparoscopy is Underutilized in the Management of Gastric Adenocarcinoma.

Eric M Groh, Shreya Gupta, Zachary J Brown, Lindsey Enewold, Lauren A Gamble, Jonathan M Hernandez, Jeremy L Davis,

BACKGROUND:Staging laparoscopy (SL) with peritoneal lavage is usually performed on a separate day from the planned resection and is recommended in patients with gastric adenocarcinoma as it can identify radiographically occult metastases and malignant cytology, thus altering prognosis and treatment. SL can be done on the same day as planned ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(5):1473-1479]

Cited: 0 times

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Adjuvant Treatment of Hepatocellular Carcinoma: Prospect of Immunotherapy.

Zachary J Brown, Tim F Greten, Bernd Heinrich,

Although patients undergo procedures with curative intent for early-stage hepatocellular carcinoma (HCC), up to 70% of patients may have disease recurrence in the liver at 5 years. Thus far, no therapy has proven to be effective in the adjuvant setting. Here, we discuss the application of immune-based therapies in the ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2019, 70(4):1437-1442]

Cited: 2 times

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Integrating Osteopathic Philosophy in Cancer Care.

Zachary J Brown, Sean P Martin, Robert Carman,

Recent breakthroughs in the fields of genomics and biology have resulted in a better understanding of diseases and their underlying biology. New targeted and immune-based therapies take advantage of these new discoveries to treat the patient individually. This scientific revolution toward personalized medicine reflects osteopathic medicine's emphasis on patient-centered care ... Read more >>

J Am Osteopath Assoc (The Journal of the American Osteopathic Association)
[2019, 119(6):391-394]

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Laparoscopic Approach to Intrahepatic Cholangiocarcinoma is Associated with an Exacerbation of Inadequate Nodal Staging.

Sean P Martin, Justin Drake, Michael M Wach, Samantha Ruff, Laurence P Diggs, Jim Y Wan, Zachary J Brown, Reed I Ayabe, Evan S Glazer, Paxton V Dickson, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

INTRODUCTION:Laparoscopic approach to liver resection is feasible and safe, though its utilization with intrahepatic cholangiocarcinoma (ICC) remains poorly documented. We sought to evaluate the use laparoscopy for ICC, and to examine adherence to oncologic standards. METHODS:The National Cancer Database was queried for patients who underwent resection for ICC. Patients were ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(6):1851-1857]

Cited: 0 times

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Tumor grade and sex should influence the utilization of portal lymphadenectomy for early stage intrahepatic cholangiocarcinoma.

Sean P Martin, Samantha Ruff, Laurence P Diggs, Justin Drake, Reed I Ayabe, Zachary J Brown, Michael M Wach, Seth M Steinberg, Jeremy L Davis, Jonathan M Hernandez,

BACKGROUND:Portal lymphadenectomy for intrahepatic cholangiocarcinoma (ICC) is encouraged for staging purposes, though it is under-utilized for clinically early-stage tumors. We sought to determine if any factor knowable prior to resection influences rates of portal lymph node metastases. METHODS:The Surveillance, Epidemiology, and End Results (SEER) Program (1973-2014) database was queried to ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2019, 21(4):419-424]

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Indoleamine 2,3-dioxygenase provides adaptive resistance to immune checkpoint inhibitors in hepatocellular carcinoma.

Zachary J Brown, Su Jong Yu, Bernd Heinrich, Chi Ma, Qiong Fu, Milan Sandhu, David Agdashian, Qianfei Zhang, Firouzeh Korangy, Tim F Greten,

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Immune checkpoint blockade with anti-CTLA-4 and anti-PD-1 antibodies has shown promising results in the treatment of patients with advanced HCC. The anti-PD-1 antibody, nivolumab, is now approved for patients who have had progressive disease on the current standard ... Read more >>

Cancer Immunol. Immunother. (Cancer immunology, immunotherapy : CII)
[2018, 67(8):1305-1315]

Cited: 2 times

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Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma.

Su Jong Yu, Chi Ma, Bernd Heinrich, Zachary J Brown, Milan Sandhu, Qianfei Zhang, Qiong Fu, David Agdashian, Umberto Rosato, Firouzeh Korangy, Tim F Greten,

BACKGROUND & AIMS:Cytokine-induced killer (CIK) cell-based immunotherapy is effective as an adjuvant therapy in early stage hepatocellular carcinoma (HCC) but lacks efficacy in advanced HCC. We aimed to investigate immune suppressor mechanisms in HCC, focusing on the role of myeloid-derived suppressor cells (MDSCs) in response to CIK therapy. METHODS:MDSCs were ... Read more >>

J. Hepatol. (Journal of Hepatology)
[2019, 70(3):449-457]

Cited: 4 times

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Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research.

Zachary J Brown, Bernd Heinrich, Tim F Greten,

Mouse models are the basis of preclinical and translational research in hepatocellular carcinoma (HCC). Multiple methods exist to induce tumour formation in mice, including genetically engineered mouse models, chemotoxic agents, intrahepatic or intrasplenic injection of tumour cells and xenograft approaches. Additionally, as HCC generally develops in the context of diseased ... Read more >>

Nat Rev Gastroenterol Hepatol (Nature reviews. Gastroenterology & hepatology)
[2018, 15(9):536-554]

Cited: 10 times

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Promise and pitfalls of immune checkpoint inhibitors in hepato-pancreato-biliary malignancies.

Kaitlin C McLoughlin, Zachary J Brown, Yashvita Shukla, Vivek Shukla,

A growing understanding of the immune system and its anti-tumor functions has been imperative for the comprehension of malignant processes and beneficial in the pursuit of effective cancer treatments. To defend the body, immune cells must be able to differentiate between self and foreign cells using checkpoints, allowing the immune ... Read more >>

Discov Med (Discovery medicine)
[2018, 26(142):85-92]

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Establishment of Orthotopic Liver Tumors by Surgical Intrahepatic Tumor Injection in Mice with Underlying Non-Alcoholic Fatty Liver Disease.

Zachary J Brown, Bernd Heinrich, Tim F Greten,

The prevalence of non-alcoholic fatty liver disease (NAFLD) and its advanced form, nonalcoholic steatohepatitis (NASH), is increasing, and as such its contribution to the development of hepatocellular carcinoma is also rising. NAFLD has been shown to influence the immune tumor microenvironment. Therefore, development of pre-clinical mouse models in the context ... Read more >>

Methods Protoc (Methods and protocols)
[2018, 1(2):]

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Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development.

Zachary J Brown, Qiong Fu, Chi Ma, Michael Kruhlak, Haibo Zhang, Ji Luo, Bernd Heinrich, Su Jong Yu, Qianfei Zhang, Andrew Wilson, Zhen-Dan Shi, Rolf Swenson, Tim F Greten,

Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide. As obesity and diabetes become more prevalent, the contribution of non-alcoholic fatty liver disease (NAFLD) to HCC is rising. Recently, we reported intrahepatic CD4+ T cells are critical for anti-tumor surveillance in NAFLD. Lipid accumulation in the liver is ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(6):620]

Cited: 3 times

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Heated intraperitoneal chemotherapy and gastrectomy for gastric cancer in the U.S.: the time is now.

Zachary J Brown, Jonathan M Hernandez, R Taylor Ripley, Jeremy L Davis,

Peritoneal metastasis is a common final pathway in patients with gastric adenocarcinoma. Microscopic evidence of early peritoneal dissemination of gastric cancer is present in a substantial proportion of patients presumed to have localized disease. Prognosis is poor even for patients with microscopic and low-volume peritoneal carcinomatosis highlighting the need for ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2017, 8(6):1109-1113]

Cited: 0 times

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Development of shellfish allergy after exposure to dual immune checkpoint blockade.

Zachary J Brown, Bernd Heinrich, Tim F Greten,

Hepatocellular carcinoma (HCC) is a major health problem worldwide with limited systemic therapies available. Immunotherapy is a fast-moving field that is quickly evolving as a treatment for HCC with three recent clinical trials published treating HCC with immune checkpoint inhibitors with promising results. Checkpoint inhibition may lead to a unique adverse ... Read more >>

Hepat Oncol (Hepatic oncology)
[2018, 5(1):HEP02]

Cited: 0 times

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A palpable pancreatic duct.

Jonathan M Hernandez, Zachary J Brown, Michael I D'Angelica,

Surgery (Surgery)
[2017, 162(6):1340-1342]

Cited: 0 times

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A mixed dicarboxylate strut approach to enhancing catalytic activity of a de novo urea derivative of metal-organic framework UiO-67.

Paul W Siu, Zachary J Brown, Omar K Farha, Joseph T Hupp, Karl A Scheidt,

A hydrogen-bond donating MOF catalyst based on the framework, containing both urea-functionalized dicarboxylate and biphenyl-4,4'-dicarboxylate struts, was synthesized by a de novo route. The mixed strut framework has larger pore sizes and improved catalytic activity for Henry reactions than the pure strut analogue, which contains only the urea-functionalized dicarboxylate linker. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2013, 49(93):10920-10922]

Cited: 13 times

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Three-dimensional architectures incorporating stereoregular donor-acceptor stacks.

Dennis Cao, Michal Juríček, Zachary J Brown, Andrew C-H Sue, Zhichang Liu, Juying Lei, Anthea K Blackburn, Sergio Grunder, Amy A Sarjeant, Ali Coskun, Cheng Wang, Omar K Farha, Joseph T Hupp, J Fraser Stoddart,

We report the synthesis of two [2]catenane-containing struts that are composed of a tetracationic cyclophane (TC(4+)) encircling a 1,5-dioxynaphthalene (DNP)-based crown ether, which bears two terphenylene arms. The TC(4+) rings comprise either 1) two bipyridinium (BIPY(2+)) units or 2) a BIPY(2+) and a diazapyrenium (DAP(2+)) unit. These degenerate and nondegenerate ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2013, 19(26):8457-8465]

Cited: 4 times

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A facile synthesis of UiO-66, UiO-67 and their derivatives.

Michael J Katz, Zachary J Brown, Yamil J Colón, Paul W Siu, Karl A Scheidt, Randall Q Snurr, Joseph T Hupp, Omar K Farha,

A scalable, reproducible method of synthesizing UiO-66- and UiO-67-type MOFs, entailing the addition of HCl to the reaction mixture, has been investigated. The new protocol requires a fraction of the time of previously reported procedures, yields exceptional porosities, and works with a range of linkers. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2013, 49(82):9449-9451]

Cited: 118 times

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