Full Text Journal Articles by
Author Zachary E Stiles

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The utilization and impact of adjuvant therapy following neoadjuvant therapy and resection of pancreatic adenocarcinoma: does more really matter?

Justin A Drake, Zachary E Stiles, Stephen W Behrman, Evan S Glazer, Jeremiah L Deneve, Bradley G Somer, Noam A Vanderwalde, Paxton V Dickson,

BACKGROUND:Although neoadjuvant therapy is increasingly administered to patients with pancreatic ductal adenocarcinoma (PDAC), the impact of additional adjuvant therapy (AT) following resection is not well defined. METHODS:The National Cancer Database (NCDB) was queried for patients who received neoadjuvant therapy followed by R0 or R1 resection for PDAC. Factors influencing survival, ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, :]

Cited: 0 times

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The impact of race and socioeconomic status on the presentation, management and outcomes for gastric cancer patients: Analysis from a metropolitan area in the southeast United States.

Miriam W Tsao, Olivia M Delozier, Zachary E Stiles, Louis J Magnotti, Stephen W Behrman, Jeremiah L Deneve, Evan S Glazer, David Shibata, Danny Yakoub, Paxton V Dickson,

BACKGROUND:Socioeconomic disparities in gastric cancer have been associated with differences in care and inferior outcomes. We evaluated the presentation, treatment, and survival for patients with gastric cancer (GC) in a metropolitan setting with a large African American population. METHODS:Retrospective cohort analysis of patients with GC (2003-2018) across a multi-hospital system ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 121(3):494-502]

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Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.

Zachary E Stiles, Andrew J Murphy, Doralina L Anghelescu, Christina-Lin Brown, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Michael W Bishop, Wayne L Furman, Alberto S Pappo, John T Lucas, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT. METHODS:A retrospective review was performed for ... Read more >>

Ann. Surg. Oncol. (Annals of Surgical Oncology)
[2020, 27(1):171-178]

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Ruptured Appendicitis and a Palpable Mass: Delayed Presentation of Appendiceal Actinomycosis.

Phillip J Link, Zachary E Stiles, Joseph Kaminsky, Drew Dill, Shirin Mazumder, Jeremiah L Deneve,

Am Surg (The American surgeon)
[2019, 85(4):e208-e210]

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Hypervascular lesions of the pancreas: Think before you act.

Susan M Wcislak, Zachary E Stiles, Jeremiah L Deneve, Evan S Glazer, Stephen W Behrman, Farees T Farooq, Paxton V Dickson,

BACKGROUND:The "classic" CT appearance of pancreatic neuroendocrine tumors (PNETs) is a solid, hypervascular lesion; however, non-PNET diagnoses may appear similar. In addition, some PNETs have a "non-classic" appearance. METHODS:Demographic, imaging, endoscopic ultrasound-fine needle aspiration (EUS/FNA) results, and pathology data were analyzed for patients who underwent pancreatectomy for suspected or confirmed ... Read more >>

Am. J. Surg. (American journal of surgery)
[2019, 218(2):362-367]

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Long-Term Implications of Unplanned Conversion During Laparoscopic Liver Resection for Hepatocellular Carcinoma.

Zachary E Stiles, Evan S Glazer, Jeremiah L Deneve, David Shibata, Stephen W Behrman, Paxton V Dickson,

BACKGROUND:Laparoscopic liver resection (LLR) is increasingly utilized for patients with hepatocellular carcinoma (HCC). However, long-term outcomes for patients requiring conversion to an open procedure during LLR have not been examined. METHODS:Patients undergoing attempted LLR for HCC were identified within the National Cancer Database. Patients undergoing successful LLR were compared with ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):282-289]

Cited: 1 time

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Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults.

Doralina L Anghelescu, Christina-Lin Brown, Andrew J Murphy, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Zachary E Stiles, Michael W Bishop, Luke Douthitt, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may improve survival. METHODS:A retrospective review of anesthetic management and postoperative pain control strategies after CRS/HIPEC for DSRCT from 2013 to 2017 was performed. RESULTS:The review analyzed 10 CRS/HIPEC procedures performed ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):131-138]

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Desmoplastic small round cell tumor: A nationwide study of a rare sarcoma.

Zachary E Stiles, Paxton V Dickson, Evan S Glazer, Andrew J Murphy, Andrew M Davidoff, Stephen W Behrman, Michael W Bishop, Michael G Martin, Jeremiah L Deneve,

Desmoplastic small round cell tumor (DSRCT) is a rare peritoneal surface malignancy. Current research is limited by the scarcity of this disease.Patients with DSRCT were identified in the 2004-2014 NCDB. Factors affecting overall survival (OS) were assessed. Additionally, trends were examined based on the volume of cases treated at individual ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2018, 117(8):1759-1767]

Cited: 3 times

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The Impact of Ostomy Creation after Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy in a Newly Established Peritoneal Malignancy Program.

Zachary E Stiles, Nathan M Hinkle, Gitonga Munene, Paxton V Dickson, Andrew M Davidoff, Jeremiah L Deneve,

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) has improved outcomes for selected patients with peritoneal carcinomatosis and often requires ostomy creation. We examined the impact of ostomy creation in a newly established peritoneal malignancy program. A retrospective review was performed of CRS-HIPEC procedures from 2011 to 2016. Those who did ... Read more >>

Am Surg (The American surgeon)
[2018, 84(6):776-782]

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Transmembrane mucin MUC13 distinguishes intraductal papillary mucinous neoplasms from non-mucinous cysts and is associated with high-risk lesions.

Zachary E Stiles, Sheema Khan, Kurt T Patton, Meena Jaggi, Stephen W Behrman, Subhash C Chauhan,

BACKGROUND:Intraductal papillary mucinous neoplasms (IPMN) are currently managed based on imaging characteristics and cyst fluid sampling. This study was designed to determine if MUC13, a glycoprotein aberrantly overexpressed in pancreatic adenocarcinoma, might aid in distinguishing high-risk lesions (high grade dysplasia/invasive disease) from low-grade lesions. METHODS:MUC13 immunohistochemical staining was performed on ... Read more >>

HPB (Oxford) (HPB : The Official Journal of the International Hepato Pancreato Biliary Association)
[2019, 21(1):87-95]

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Outcome and factors associated with aborted cytoreduction for peritoneal carcinomatosis.

Whitney Guerrero, Gitonga Munene, Paxton V Dickson, Zachary E Stiles, Johnathan Mays, Andrew M Davidoff, Evan S Glazer, David Shibata, Jeremiah L Deneve,

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) offers a potential cure for peritoneal carcinomatosis (PC), whereas aborted cytoreduction is associated with a poor outcome. We evaluate factors associated with aborted CRS procedures.An IRB approved retrospective review was performed from 12/2011 to 2/2016. Clinicopathologic variables and outcomes are described.Seventy-four patients underwent ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2018, 9(4):664-673]

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Ampullary adenocarcinoma: Defining predictors of survival and the impact of adjuvant therapy following surgical resection for stage I disease.

Zachary E Stiles, Stephen W Behrman, Jeremiah L Deneve, Evan S Glazer, Lei Dong, Jim Y Wan, Michael G Martin, Paxton V Dickson,

Outcomes and recommendations regarding adjuvant therapy (AT) for stage I ampullary adenocarcinoma (AAC) are inadequately described. We sought to determine factors associated with survival and better define the impact of AT.The NCDB was queried for stage I AAC patients undergoing resection. We evaluated variables influencing the administration of AT and ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2018, 117(7):1500-1508]

Cited: 2 times

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The impact of unplanned conversion to an open procedure during minimally invasive pancreatectomy.

Zachary E Stiles, Paxton V Dickson, Jeremiah L Deneve, Evan S Glazer, Lei Dong, Jim Y Wan, Stephen W Behrman,

BACKGROUND:Minimally invasive pancreatic resection (MIPR) is being increasingly utilized. Outcomes for patients experiencing unplanned conversion to an open procedure during MIPR have been incompletely assessed. We sought to determine the short-term outcomes and factors associated with unplanned conversion during MIPR. METHODS:A retrospective cohort study using the American College of Surgeons ... Read more >>

J. Surg. Res. (The Journal of surgical research)
[2018, 227:168-177]

Cited: 3 times

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Clinical significance of MUC13 in pancreatic ductal adenocarcinoma.

Sheema Khan, Nadeem Zafar, Shabia S Khan, Saini Setua, Stephen W Behrman, Zachary E Stiles, Murali M Yallapu, Peeyush Sahay, Hemendra Ghimire, Tomoko Ise, Satoshi Nagata, Lei Wang, Jim Y Wan, Prabhakar Pradhan, Meena Jaggi, Subhash C Chauhan,

BACKGROUND:Poor prognosis of pancreatic cancer (PanCa) is associated with lack of an effective early diagnostic biomarker. This study elucidates significance of MUC13, as a diagnostic/prognostic marker of PanCa. METHODS:MUC13 was assessed in tissues using our in-house generated anti-MUC13 mouse monoclonal antibody and analyzed for clinical correlation by immunohistochemistry, immunoblotting, RT-PCR, ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2018, 20(6):563-572]

Cited: 1 time

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Predictors and implications of unplanned conversion during minimally invasive hepatectomy: an analysis of the ACS-NSQIP database.

Zachary E Stiles, Stephen W Behrman, Evan S Glazer, Jeremiah L Deneve, Lei Dong, Jim Y Wan, Paxton V Dickson,

Minimally-invasive hepatectomy (MIH) is increasingly utilized; however, predictors and outcomes for patients requiring conversion to an open procedure have not been adequately studied.The 2014-15 ACS-NSQIP database was analyzed. Unplanned conversion was compared to successful MIH and elective open hepatectomy.Among 6918 hepatectomies, 1062 (15.4%) underwent attempted MIH: 989 laparoscopic, 73 robotic. ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2017, 19(11):957-965]

Cited: 3 times

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Neoadjuvant Talimogene Laherparepvec for the Treatment of Metastatic Melanoma.

Zachary E Stiles, Martin D Fleming, Edward A Luce, Jeremiah L Deneve,

Am Surg (The American surgeon)
[2017, 83(7):e266-268]

Cited: 0 times

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Impact of body mass index on the short-term outcomes of resected gastrointestinal stromal tumors.

Zachary E Stiles, Tyler M Rist, Paxton V Dickson, Evan S Glazer, Martin D Fleming, David Shibata, Jeremiah L Deneve,

BACKGROUND:Potentially curative treatment for gastrointestinal stromal tumors (GIST) involves resection with selective utilization of tyrosine kinase inhibitors. A potential association between obesity and GIST has been postulated as GIST is among the most common incidental findings during gastric resection for bariatric procedures. The purpose of this study is to investigate ... Read more >>

J. Surg. Res. (The Journal of surgical research)
[2017, 217:123-130]

Cited: 4 times

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Acute Extremity Compartment Syndrome Secondary to Statin-Induced Myopathy.

Zachary E Stiles, Dorothy A Sparks,

Am Surg (The American surgeon)
[2017, 83(3):e74-75]

Cited: 0 times

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