Full Text Journal Articles by
Author Yvo Smulders

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Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles.

Alexander H Turaihi, Erik H Serné, Carla F M Molthoff, Jasper J Koning, Jaco Knol, Hans W Niessen, Marie Jose T H Goumans, Erik M van Poelgeest, John S Yudkin, Yvo M Smulders, Connie R Jimenez, Victor W M van Hinsbergh, Etto C Eringa,

Insulin-mediated microvascular recruitment (IMVR) regulates delivery of insulin and glucose to insulin-sensitive tissues. We have previously proposed that perivascular adipose tissue (PVAT) controls vascular function through outside-to-inside communication and through vessel-to-vessel, or "vasocrine," signaling. However, direct experimental evidence supporting a role of local PVAT in regulating IMVR and insulin sensitivity ... Read more >>

Diabetes (Diabetes)
[2020, 69(4):603-613]

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The relationship of a Prothrombin G20210A mutation or a factor V Leiden mutation and on-aspirin platelet (re-)activity.

Jeske J K van Diemen, Jeske M Bij de Weg, Arda Arduç, Olivier Veraart, David Mager, Carolien N H Abheiden, Wessel W Fuijkschot, Johanna I P de Vries, Yvo M Smulders, Abel Thijs,

INTRODUCTION:The interplay between platelets and pro-thrombotic factors may have been under-investigated in the identification of aspirin users at high risk for cardiovascular event reoccurrences. There is growing evidence that a Prothrombin G20210A (FII) or a Factor V Leiden (FVL) mutation might increase platelet activity. Subsequently, this study assessed on-aspirin platelet ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2020, 19:127-130]

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Amplified prevalence and incidence of cardiovascular disease in patients with inflammatory arthritis and coexistent autoimmune disorders.

Maaike Heslinga, Mark M J Nielen, Yvo Smulders, Suat Simsek, Mike T Nurmohamed,

OBJECTIVE:This study aims to assess the prevalence proportion and incidence rate of cardiovascular morbidity in patients with inflammatory arthritis compared with that in controls, and to determine whether the co-existence of multiple autoimmune disorders is associated with an amplified risk of cardiovascular disease. METHODS:Data from the Nivel Primary Care Database ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, :]

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Should vascular wall 18F-FDG uptake be adjusted for the extent of atherosclerotic burden?

Karel-Jan D F Lensen, Alexandre E Voskuyl, Emile F I Comans, Conny J van der Laken, Ronald Boellaard, Yvo M Smulders,

Vascular wall 18F-FDG uptake is often used as a surrogate marker of atherosclerotic plaque inflammation. A potential caveat is that vascular wall 18F-FDG uptake is higher simply because more atherosclerosis is present. To determine if the degree of inflammation is high or low relative to the extent of atherosclerosis, vascular ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2020, 36(3):545-551]

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Treatment of hypercholesterolaemia in older adults calls for a patient-centred approach.

Emma Ef Kleipool, Johannes An Dorresteijn, Yvo M Smulders, Frank Lj Visseren, Mike Jl Peters, Majon Muller,

Due to an increasing number of older adults with (risk factors for) cardiovascular disease (CVD), the sum of older adults eligible for lipid-lowering drugs will increase. This has risen questions about benefits and harms of lipid-lowering therapy in older adults with a varying number of (cardiovascular) comorbidities and functional status. ... Read more >>

Heart (Heart (British Cardiac Society))
[2020, 106(4):261-266]

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Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology.

Massimo F Piepoli, Ana Abreu, Christian Albus, Marco Ambrosetti, Carlos Brotons, Alberico L Catapano, Ugo Corra, Bernard Cosyns, Christi Deaton, Ian Graham, Arno Hoes, Maja-Lisa Lochen, Benedetta Matrone, Josep Redon, Naveed Sattar, Yvo Smulders, Monica Tiberi,

European guidelines on cardiovascular prevention in clinical practice were first published in 1994 and have been regularly updated, most recently in 2016, by the Sixth European Joint Task Force. Given the amount of new information that has become available since then, components from the task force and experts from the ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, 27(2):181-205]

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The effects of industry funding and positive outcomes in the interpretation of clinical trial results: a randomized trial among Dutch psychiatrists.

Joeri K Tijdink, Yvo M Smulders, Lex M Bouter, Christiaan H Vinkers,

BACKGROUND:Most studies are inclined to report positive rather than negative or inconclusive results. It is currently unknown how clinicians appraise the results of a randomized clinical trial. For example, how does the study funding source influence the appraisal of an RCT, and do positive findings influence perceived credibility and clinical ... Read more >>

BMC Med Ethics (BMC medical ethics)
[2019, 20(1):64]

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[Use HbA1cas a diagnostic test for type 2 diabetes mellitus].

Yvo Smulders, Erik Serné,

The disease 'diabetes' is based on an agreement and we have nothing to lose by changing that agreement in one based on HbA1c instead of an isolated glucose measurement. We discuss the advantages and disadvantages of this proposal and conclude that the advantages have the upper hand. Clinical chemists are ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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The effect of HIV infection, antiretroviral therapy on carotid intima-media thickness: A systematic review and meta-analysis.

Titus F Msoka, Gary P Van Guilder, Marceline van Furth, Yvo Smulders, Sebastian J Meek, John A Bartlett, Joao Ricardo N Vissoci, Michiel A van Agtmael,

AIMS:We performed a systematic review and meta-analysis on the effect of HIV infection and antiretroviral therapy (ART) on carotid intima-media thickness (cIMT) to elucidate the role of HIV infection and ART. Also, an analysis on the role of ethnicity and gender on cIMT in HIV-infected populations was performed. MAIN METHODS:We ... Read more >>

Life Sci. (Life sciences)
[2019, 235:116851]

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[Paraneoplastic syndromes].

Wim Opstelten, Pieter G M van der Valk, Yvo M Smulders,

A paraneoplastic syndrome is a phenomenon or complex of symptoms that can occur with malignancy, without this being the result of tumour cells in the affected area. In this article, we describe the following paraneoplastic syndromes: thrombophlebitis migrans, clubbing, pemphigus, acanthosis nigricans, blue fingers, dermatomyositis, and myasthenia gravis. ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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Hypertension with primary aldosteronism is associated with increased carotid intima-media thickness and endothelial dysfunction.

Ahmet Demirkiran, Henk Everaars, Ali Elitok, Peter M van de Ven, Yvo M Smulders, Koen M Dreijerink, Refik Tanakol, Mustafa Ozcan,

Patients with primary aldosteronism induced hypertension are more likely to experience cardiovascular events compared to patients with essential hypertension. Primary aldosteronism may therefore have distinct adverse effects on cardiovascular structure and function, independent of hypertension. However, current data on such effects of primary aldosteronism are conflicting. The aim of the ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2019, 21(7):932-941]

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Perceived publication pressure in Amsterdam: Survey of all disciplinary fields and academic ranks.

Tamarinde L Haven, Lex M Bouter, Yvo M Smulders, Joeri K Tijdink,

Publications determine to a large extent the possibility to stay in academia ("publish or perish"). While some pressure to publish may incentivise high quality research, too much publication pressure is likely to have detrimental effects on both the scientific enterprise and on individual researchers. Our research question was: What is ... Read more >>

PLoS ONE (PloS one)
[2019, 14(6):e0217931]

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JNK2 in myeloid cells impairs insulin's vasodilator effects in muscle during early obesity development through perivascular adipose tissue dysfunction.

Rick I Meijer, Femke P M Hoevenaars, Erik H Serné, John S Yudkin, Tom J A Kokhuis, Ester M Weijers, Victor W M van Hinsbergh, Yvo M Smulders, Etto C Eringa,

Reduced vasodilator properties of insulin in obesity are caused by changes in perivascular adipose tissue and contribute to microvascular dysfunction in skeletal muscle. The causes of this dysfunction are unknown. The effects of a short-term Western diet on JNK2-expressing cells in perivascular adipose tissue (PVAT) on insulin-induced vasodilation and perfusion ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2019, 317(2):H364-H374]

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Stroboscopic light effects during electronic dance music festivals and photosensitive epilepsy: a cohort study and case report.

Newel Salet, Marieke Visser, Cornelis Stam, Yvo M Smulders,

OBJECTIVES:Electronic dance music (EDM) concerts are becoming increasingly popular. Strong stroboscopic light effects are commonly part of these shows, and may provoke seizures in individuals with photosensitive epilepsy. This study aims to examine the risk of epileptic seizures during EDM concerts. SETTING:28 EDM concerts taking place in The Netherlands. PARTICIPANTS:We ... Read more >>

BMJ Open (BMJ open)
[2019, 9(6):e023442]

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Cardiovascular Event Risk in Rheumatoid Arthritis Compared with Type 2 Diabetes: A 15-year Longitudinal Study.

Rabia Agca, Luuk H G A Hopman, Koen J C Laan, Vokko P van Halm, Mike J L Peters, Yvo M Smulders, Jacqueline M Dekker, Giel Nijpels, Coen D A Stehouwer, Alexandre E Voskuyl, Maarten Boers, Willem F Lems, Michael T Nurmohamed,

OBJECTIVE:Cardiovascular (CV) disease (CVD) risk is increased in rheumatoid arthritis (RA). However, longterm followup studies investigating this risk are scarce. METHODS:The CARRÉ (CARdiovascular research and RhEumatoid arthritis) study is a prospective cohort study investigating CVD and its risk factors in 353 patients with longstanding RA. CV endpoints were assessed at ... Read more >>

J. Rheumatol. (The Journal of rheumatology)
[2020, 47(3):316-324]

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Short-term LPS induces aortic valve thickening in ApoE*3Leiden mice.

Amber van Broekhoven, Paul A J Krijnen, Wessel W Fuijkschot, Martine C Morrison, Ilse P A Zethof, Wessel N van Wieringen, Yvo M Smulders, Hans W M Niessen, Alexander B A Vonk,

BACKGROUND:Recently, it was shown that 12 weeks of lipopolysaccharide (LPS) administration to nonatherosclerotic mice induced thickening of the aortic heart valve (AV). Whether such effects may also occur even earlier is unknown. As most patients with AV stenosis also have atherosclerosis, we studied the short-term effect of LPS on the AVs ... Read more >>

Eur. J. Clin. Invest. (European journal of clinical investigation)
[2019, 49(7):e13121]

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[Physicians and lawyers operate in different worlds when it comes to approaching regulatory issues].

Pieter van Eijsden, Yvo Smulders,

Expert panel consultations are heavily regulated. To such an extent that they impede doctors from obtaining expert advice for their patients in practically feasible ways, i.e. by phone call. We argue that this is emblematic of the fact that the legal and the medical domain have increasingly become "non-overlapping magisteria"; ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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Correction to: Association of HIV-infection, antiretroviral treatment and metabolic syndrome with large artery stiffness: a cross-sectional study.

Titus F Msoka, Gary P Van Guilder, Yvo M Smulders, Marceline van Furth, John A Bartlett, Michiel A van Agtmael,

Following publication of the original article [1], the authors reported that they have provided the wrong caption. ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2019, 19(1):187]

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[Lifestyle intervention in the consulting room: high-hanging fruit].

Yvo M Smulders,

The attributable risk of lifestyle factors for the development of diabetes, hypertension, and related disorders is very large. To what extent this attributable risk translates into potential for prevention and treatment in the consulting room in much less clear. Previous trials showing effects of lifestyle interventions have often been characterized ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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Association of HIV-infection, antiretroviral treatment and metabolic syndrome with large artery stiffness: a cross-sectional study.

Titus F Msoka, Gary P Van Guilder, Yvo M Smulders, Marceline van Furth, John A Bartlett, Michiel A van Agtmael,

BACKGROUND:Effective combined antiretroviral therapy (cART) has improved life expectancy among people living with HIV-1 infection. Treated HIV-1infection increases the prevalence of metabolic syndrome (MS). Despite sub-Saharan Africa having among the highest rates of HIV-1 infection, the effects of MS in HIV-1-infected individuals on cardiovascular risk is poorly explored. The aim ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2018, 18(1):708]

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Conflict of interest disclosure slides at the European Society of Cardiology Congress 2016 in Rome: are they displayed long enough to assess their content? A cross-sectional study.

Christianne T van Lieshout, Joeri K Tijdink, Yvo M Smulders,

OBJECTIVES:To assess the duration of display of conflict of interest (COI) disclosure slides of presentations at the European Society of Cardiology (ESC) Congress 2016, and to identify factors associated with the duration of display of the disclosure slide. DESIGN:Cross-sectional observational study. OUTCOME MEASURES:Display duration of the COI disclosure slide and ... Read more >>

BMJ Open (BMJ open)
[2018, 8(11):e023534]

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Improving risk prediction is not easy.

Yvo Smulders,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2018, 25(18):1977-1979]

Cited: 1 time

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Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B2, during infarct-prone early-morning hours.

Cati Racca, Jeske Joanna Katarina van Diemen, Wessel Willem Fuijkschot, Karlinde Spit, Tobias Nicolaas Bonten, Mattijs Everard Numans, Johanna Gerarda van der Bom, Yvo Michiel Smulders, Abel Thijs,

Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the early morning-8.00 AM-in healthy ... Read more >>

Platelets (Platelets)
[2019, 30(7):871-877]

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[Valproic acid toxicity due to misinterpretation of plasma levels: increase in unbound fraction caused by hypoalbuminaemia and renal dysfunction].

Roos Ruiter-Visser, Annemieke Dols, Yvo M Smulders, Gabriel E Jacobs, Klaas Jan Nauta,

BACKGROUND:Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy and bipolar disorder. As only the unbound fraction of a medicinal product is pharmacologically active, in some strong protein-bound psychotropic drugs such as valproic acid and phenytoin, a rise in this fraction can lead to ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2018, 162:]

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LPS-Induced Systemic Inflammation Does Not Alter Atherosclerotic Plaque Area or Inflammation in APOE3*LEIDEN Mice in the Early Phase Up to 15 Days.

Wessel W Fuijkschot, Martine C Morrison, Ilse P A Zethof, Paul A J Krijnen, Robert Kleemann, Hans W M Niessen, Yvo M Smulders,

BACKGROUND AND AIMS:Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intraplaque inflammation. We evaluated whether lipopolysaccharides (LPS)-evoked acute systemic inflammation would induce such ... Read more >>

Shock (Shock (Augusta, Ga.))
[2018, 50(3):360-365]

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