Full Text Journal Articles by
Author Yvo Smulders

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[Paraneoplastic syndromes].

Wim Opstelten, Pieter G M van der Valk, Yvo M Smulders,

A paraneoplastic syndrome is a phenomenon or complex of symptoms that can occur with malignancy, without this being the result of tumour cells in the affected area. In this article, we describe the following paraneoplastic syndromes: thrombophlebitis migrans, clubbing, pemphigus, acanthosis nigricans, blue fingers, dermatomyositis, and myasthenia gravis. ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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Hypertension with primary aldosteronism is associated with increased carotid intima-media thickness and endothelial dysfunction.

Ahmet Demirkiran, Henk Everaars, Ali Elitok, Peter M van de Ven, Yvo M Smulders, Koen M Dreijerink, Refik Tanakol, Mustafa Ozcan,

Patients with primary aldosteronism induced hypertension are more likely to experience cardiovascular events compared to patients with essential hypertension. Primary aldosteronism may therefore have distinct adverse effects on cardiovascular structure and function, independent of hypertension. However, current data on such effects of primary aldosteronism are conflicting. The aim of the ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2019, 21(7):932-941]

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Perceived publication pressure in Amsterdam: Survey of all disciplinary fields and academic ranks.

Tamarinde L Haven, Lex M Bouter, Yvo M Smulders, Joeri K Tijdink,

Publications determine to a large extent the possibility to stay in academia ("publish or perish"). While some pressure to publish may incentivise high quality research, too much publication pressure is likely to have detrimental effects on both the scientific enterprise and on individual researchers. Our research question was: What is ... Read more >>

PLoS ONE (PloS one)
[2019, 14(6):e0217931]

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JNK2 in myeloid cells impairs insulin's vasodilator effects in muscle during early obesity development through perivascular adipose tissue dysfunction.

Rick I Meijer, Femke P M Hoevenaars, Erik H Serné, John S Yudkin, Tom J A Kokhuis, Ester M Weijers, Victor W M van Hinsbergh, Yvo M Smulders, Etto C Eringa,

Reduced vasodilator properties of insulin in obesity are caused by changes in perivascular adipose tissue and contribute to microvascular dysfunction in skeletal muscle. The causes of this dysfunction are unknown. The effects of a short-term Western diet on JNK2-expressing cells in perivascular adipose tissue (PVAT) on insulin-induced vasodilation and perfusion ... Read more >>

Am. J. Physiol. Heart Circ. Physiol. (American journal of physiology. Heart and circulatory physiology)
[2019, 317(2):H364-H374]

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Stroboscopic light effects during electronic dance music festivals and photosensitive epilepsy: a cohort study and case report.

Newel Salet, Marieke Visser, Cornelis Stam, Yvo M Smulders,

OBJECTIVES:Electronic dance music (EDM) concerts are becoming increasingly popular. Strong stroboscopic light effects are commonly part of these shows, and may provoke seizures in individuals with photosensitive epilepsy. This study aims to examine the risk of epileptic seizures during EDM concerts. SETTING:28 EDM concerts taking place in The Netherlands. PARTICIPANTS:We ... Read more >>

BMJ Open (BMJ open)
[2019, 9(6):e023442]

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Short-term LPS induces aortic valve thickening in ApoE*3Leiden mice.

Amber van Broekhoven, Paul A J Krijnen, Wessel W Fuijkschot, Martine C Morrison, Ilse P A Zethof, Wessel N van Wieringen, Yvo M Smulders, Hans W M Niessen, Alexander B A Vonk,

BACKGROUND:Recently, it was shown that 12 weeks of lipopolysaccharide (LPS) administration to nonatherosclerotic mice induced thickening of the aortic heart valve (AV). Whether such effects may also occur even earlier is unknown. As most patients with AV stenosis also have atherosclerosis, we studied the short-term effect of LPS on the AVs ... Read more >>

Eur. J. Clin. Invest. (European journal of clinical investigation)
[2019, :e13121]

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[Physicians and lawyers operate in different worlds when it comes to approaching regulatory issues].

Pieter van Eijsden, Yvo Smulders,

Expert panel consultations are heavily regulated. To such an extent that they impede doctors from obtaining expert advice for their patients in practically feasible ways, i.e. by phone call. We argue that this is emblematic of the fact that the legal and the medical domain have increasingly become "non-overlapping magisteria"; ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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Correction to: Association of HIV-infection, antiretroviral treatment and metabolic syndrome with large artery stiffness: a cross-sectional study.

Titus F Msoka, Gary P Van Guilder, Yvo M Smulders, Marceline van Furth, John A Bartlett, Michiel A van Agtmael,

Following publication of the original article [1], the authors reported that they have provided the wrong caption. ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2019, 19(1):187]

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[Lifestyle intervention in the consulting room: high-hanging fruit].

Yvo M Smulders,

The attributable risk of lifestyle factors for the development of diabetes, hypertension, and related disorders is very large. To what extent this attributable risk translates into potential for prevention and treatment in the consulting room in much less clear. Previous trials showing effects of lifestyle interventions have often been characterized ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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Association of HIV-infection, antiretroviral treatment and metabolic syndrome with large artery stiffness: a cross-sectional study.

Titus F Msoka, Gary P Van Guilder, Yvo M Smulders, Marceline van Furth, John A Bartlett, Michiel A van Agtmael,

BACKGROUND:Effective combined antiretroviral therapy (cART) has improved life expectancy among people living with HIV-1 infection. Treated HIV-1infection increases the prevalence of metabolic syndrome (MS). Despite sub-Saharan Africa having among the highest rates of HIV-1 infection, the effects of MS in HIV-1-infected individuals on cardiovascular risk is poorly explored. The aim ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2018, 18(1):708]

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Conflict of interest disclosure slides at the European Society of Cardiology Congress 2016 in Rome: are they displayed long enough to assess their content? A cross-sectional study.

Christianne T van Lieshout, Joeri K Tijdink, Yvo M Smulders,

OBJECTIVES:To assess the duration of display of conflict of interest (COI) disclosure slides of presentations at the European Society of Cardiology (ESC) Congress 2016, and to identify factors associated with the duration of display of the disclosure slide. DESIGN:Cross-sectional observational study. OUTCOME MEASURES:Display duration of the COI disclosure slide and ... Read more >>

BMJ Open (BMJ open)
[2018, 8(11):e023534]

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Improving risk prediction is not easy.

Yvo Smulders,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2018, 25(18):1977-1979]

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Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B2, during infarct-prone early-morning hours.

Cati Racca, Jeske Joanna Katarina van Diemen, Wessel Willem Fuijkschot, Karlinde Spit, Tobias Nicolaas Bonten, Mattijs Everard Numans, Johanna Gerarda van der Bom, Yvo Michiel Smulders, Abel Thijs,

Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the early morning-8.00 AM-in healthy ... Read more >>

Platelets (Platelets)
[2018, :1-7]

Cited: 1 time

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[Valproic acid toxicity due to misinterpretation of plasma levels: increase in unbound fraction caused by hypoalbuminaemia and renal dysfunction].

Roos Ruiter-Visser, Annemieke Dols, Yvo M Smulders, Gabriel E Jacobs, Klaas Jan Nauta,

BACKGROUND:Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy and bipolar disorder. As only the unbound fraction of a medicinal product is pharmacologically active, in some strong protein-bound psychotropic drugs such as valproic acid and phenytoin, a rise in this fraction can lead to ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2018, 162:]

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LPS-Induced Systemic Inflammation Does Not Alter Atherosclerotic Plaque Area or Inflammation in APOE3*LEIDEN Mice in the Early Phase Up to 15 Days.

Wessel W Fuijkschot, Martine C Morrison, Ilse P A Zethof, Paul A J Krijnen, Robert Kleemann, Hans W M Niessen, Yvo M Smulders,

Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intraplaque inflammation. We evaluated whether lipopolysaccharides (LPS)-evoked acute systemic inflammation would induce such detrimental vascular ... Read more >>

Shock (Shock (Augusta, Ga.))
[2018, 50(3):360-365]

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Effects of hyperoxia on vascular tone in animal models: systematic review and meta-analysis.

Bob Smit, Yvo M Smulders, Etto C Eringa, Heleen M Oudemans-van Straaten, Armand R J Girbes, Kimberley E Wever, Carlijn R Hooijmans, Angelique M E Spoelstra-de Man,

BACKGROUND:Arterial hyperoxia may induce vasoconstriction and reduce cardiac output, which is particularly undesirable in patients who already have compromised perfusion of vital organs. Due to the inaccessibility of vital organs in humans, vasoconstrictive effects of hyperoxia have primarily been studied in animal models. However, the results of these studies vary ... Read more >>

Crit Care (Critical care (London, England))
[2018, 22(1):189]

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Variation in minimum desired cardiovascular disease-free longevity benefit from statin and antihypertensive medications: a cross-sectional study of patient and primary care physician perspectives.

Nicole E M Jaspers, Frank L J Visseren, Mattijs E Numans, Yvo M Smulders, Fere A van Loenen Martinet, Yolanda van der Graaf, Jannick A N Dorresteijn,

OBJECTIVE:Expressing therapy benefit from a lifetime perspective, instead of only a 10-year perspective, is both more intuitive and of growing importance in doctor-patient communication. In cardiovascular disease (CVD) prevention, lifetime estimates are increasingly accessible via online decision tools. However, it is unclear what gain in life expectancy is considered meaningful ... Read more >>

BMJ Open (BMJ open)
[2018, 8(5):e021309]

Cited: 1 time

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Estimated individual lifetime benefit from PCSK9 inhibition in statin-treated patients with coronary artery disease.

Lotte Kaasenbrood, Kausik K Ray, S Matthijs Boekholdt, Yvo M Smulders, John C LaRosa, John J P Kastelein, Yolanda van der Graaf, Johannes A N Dorresteijn, Frank L J Visseren,

OBJECTIVE:In statin-treated patients with stable coronary artery disease (CAD), residual risk of cardiovascular events is partly explained by plasma levels of low-density lipoprotein cholesterol (LDL-C). This study aimed to estimate individual benefit of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition in CAD patients already treated with high-dose statin. METHODS:Individual lifetime ... Read more >>

Heart (Heart (British Cardiac Society))
[2018, 104(20):1699-1705]

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Insulin Receptor Substrate 2 Controls Insulin-Mediated Vasoreactivity and Perivascular Adipose Tissue Function in Muscle.

Alexander H Turaihi, Wineke Bakker, Victor W M van Hinsbergh, Erik H Serné, Yvo M Smulders, Hans W M Niessen, Etto C Eringa,

Introduction: Insulin signaling in adipose tissue has been shown to regulate insulin's effects in muscle. In muscle, perivascular adipose tissue (PVAT) and vascular insulin signaling regulate muscle perfusion. Insulin receptor substrate (IRS) 2 has been shown to control adipose tissue function and glucose metabolism, and here we tested the hypothesis ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:245]

Cited: 2 times

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Accuracy of oscillometric blood pressure measurement in atrial fibrillation.

Rudolf K Feenstra, Cor P Allaart, Gijs F N Berkelmans, Berend E Westerhof, Yvo M Smulders,

The primary aim of this study was to assess the accuracy of automated oscillometry (AO) in outpatients with atrial fibrillation (AF). The secondary aim was to explore whether AO accuracy is influenced by beat-to-beat blood pressure (BP) variability or heart frequency (HF).Systolic blood pressure (SBP) and diastolic blood pressure (DBP) ... Read more >>

Blood Press Monit (Blood pressure monitoring)
[2018, 23(2):59-63]

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Hemodynamic effects of acute hyperoxia: systematic review and meta-analysis.

Bob Smit, Yvo M Smulders, Johannes C van der Wouden, Heleen M Oudemans-van Straaten, Angelique M E Spoelstra-de Man,

BACKGROUND:In clinical practice, oxygen is generally administered to patients with the intention of increasing oxygen delivery. Supplemental oxygen may, however, cause arterial hyperoxia, which is associated with hemodynamic alterations. We performed a systematic review and meta-analysis of the literature to determine the effect of hyperoxia on central hemodynamics and oxygen ... Read more >>

Crit Care (Critical care (London, England))
[2018, 22(1):45]

Cited: 2 times

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Hyperoxia does not affect oxygen delivery in healthy volunteers while causing a decrease in sublingual perfusion.

Bob Smit, Yvo M Smulders, Etto C Eringa, Harry P M M Gelissen, Armand R J Girbes, Harm-Jan S de Grooth, Hans H M Schotman, Peter G Scheffer, Heleen M Oudemans-van Straaten, Angelique M E Spoelstra-de Man,

OBJECTIVE:To determine the human dose-response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO2 and sublingual microcirculatory perfusion. METHODS:Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kPa (breathing oxygen). ... Read more >>

Microcirculation (Microcirculation (New York, N.Y. : 1994))
[2018, 25(2):]

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Is HbA1c a good diagnostic test for (pre)diabetes in cardiac rehabilitation patients?

Yvo Smulders, Erik Serné,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2018, 25(5):462-463]

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Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial.

Linda Hartman, Linda A Rasch, Thomas Klausch, Hans W J Bijlsma, Robin Christensen, Yvo M Smulders, Stuart H Ralston, Frank Buttgereit, Maurizio Cutolo, Jose A P Da Silva, Daniela Opris, Jozef Rovenský, Szilvia Szamosi, Leonie M Middelink, Willem F Lems, Maarten Boers,

BACKGROUND:Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints affecting 1% of the world population. It has major impact on patients through disability and associated comorbidities. Current treatment strategies have considerably improved the prognosis, but recent innovations (especially biologic drugs and the new class of so-called "JAK/STAT inhibitors") ... Read more >>

Trials (Trials)
[2018, 19(1):67]

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Hospital-Readmission Risk - Isolating Hospital Effects.

Yvo M Smulders, Prabath W B Nanayakkara,

N. Engl. J. Med. (The New England journal of medicine)
[2017, 377(25):2505]

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