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Antibacterial potential of a novel Lactobacillus casei strain isolated from Chinese northeast sauerkraut and the antibiofilm activity of its exopolysaccharides.

Xiaoqing Xu, Qing Peng, Yuwei Zhang, Dandan Tian, Pengbo Zhang, Ying Huang, Lan Ma, Vermont P Dia, Yu Qiao, Bo Shi,

Lactobacillus spp., as probiotics, have shown efficacy in the inhibition of pathogenic bacteria in the intestinal tract. In this study, we investigated the antibacterial activity of Lactobacillus casei NA-2, which was isolated from northeast sauerkraut in China. The results of co-culture suggested that L. casei NA-2 could inhibit the growth ... Read more >>

Food Funct (Food & function)
[2020, 11(5):4697-4706]

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Initiating polyketide biosynthesis by on-line methyl esterification.

Pengwei Li, Meng Chen, Wei Tang, Zhengyan Guo, Yuwei Zhang, Min Wang, Geoff P Horsman, Jin Zhong, Zhaoxin Lu, Yihua Chen,

Aurantinins (ARTs) are antibacterial polyketides featuring a unique 6/7/8/5-fused tetracyclic ring system and a triene side chain with a carboxyl terminus. Here we identify the art gene cluster and dissect ART's C-methyl incorporation patterns to study its biosynthesis. During this process, an apparently redundant methyltransferase Art28 was characterized as a ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4499]

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Dosimetry study of three-dimensional print template for 125I implantation therapy.

Enli Chen, Yuwei Zhang, Hongtao Zhang, Chenfei Jia, Yansong Liang, Juan Wang,

<h4>Background</h4><sup>125</sup>I seed implantation has been found to show good therapeutic effects on tumors. Recent studies showed that three-dimensional (3D) print template-assisted <sup>125</sup>I seed implantation can optimize radiation dose distribution. This study aimed to compare the dose distribution differences in <sup>125</sup>I seed implantation among 3D print noncoplanar template- (3DPNCT), 3D print ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2021, 16(1):115]

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ncFANs v2.0: an integrative platform for functional annotation of non-coding RNAs.

Yuwei Zhang, Dechao Bu, Peipei Huo, Zhihao Wang, Hao Rong, Yanguo Li, Jingjia Liu, Meng Ye, Yang Wu, Zheng Jiang, Qi Liao, Yi Zhao,

Increasing evidence proves the essential regulatory roles of non-coding RNAs (ncRNAs) in biological processes. However, characterizing the specific functions of ncRNAs remains a challenging task, owing to the intensive consumption of the experimental approaches. Here, we present an online platform ncFANs v2.0 that is a significantly enhanced version of our ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, 49(W1):W459-W468]

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Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device.

Yuwei Zhang, Ayden Malekjahani, Buddhisha N Udugama, Pranav Kadhiresan, Hongmin Chen, Matthew Osborne, Max Franz, Mike Kucera, Simon Plenderleith, Lily Yip, Gary D Bader, Vanessa Tran, Jonathan B Gubbay, Allison McGeer, Samira Mubareka, Warren C W Chan,

The ability to rapidly diagnose, track, and disseminate information for SARS-CoV-2 is critical to minimize its spread. Here, we engineered a portable smartphone-based quantum barcode serological assay device for real-time surveillance of patients infected with SARS-CoV-2. Our device achieved a clinical sensitivity of 90% and specificity of 100% for SARS-CoV-2, ... Read more >>

Nano Lett (Nano letters)
[2021, 21(12):5209-5216]

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Regulatory Network Analysis of Mutated Genes Based on Multi-Omics Data Reveals the Exclusive Features in Tumor Immune Microenvironment Between Left-Sided and Right-Sided Colon Cancer.

Tianfei Yi, Yuwei Zhang, Derry Minyao Ng, Yang Xi, Meng Ye, Lvjun Cen, Jianjiong Li, Xiaoxiang Fan, Yanguo Li, Shiyun Hu, Hao Rong, Yangyang Xie, Guofang Zhao, Leyi Chen, Chen Chen, Shujing Ni, Jiaying Mi, Xiaoyu Dai, Qi Liao,

Left-sided colon cancer (LCC) and right-sided colon cancer (RCC) have distinct characteristics in tumor immune microenvironment (TIME). Although existing studies have shown a strong association between gene mutations and TIME, whether the regulatory mechanisms between gene mutations and TIME are different between RCC and LCC is still unclear. In this ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:685515]

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Microfluidic Streptomyces Cultivation for Whole Lifecycle Characterization and Phenotypic Assays Enabled by Nanogap-stabilized Air-Water Interface

Dongwei Chen, Mengyue Nie, Wei Tang, Yuwei Zhang, Yuxin Qiao, Juanli Yun, Jian Wang, Ying Lan, Liang Ma, Yihua Chen, Wenbin Du,

<h4>ABSTRACT</h4> Streptomyces is a model filamentous prokaryote to study multicellular differentiation and a rich reservoir for antibiotics discovery. In their natural conditions, Streptomyces grows at the interface of porous soil, air, and water. The morphological development of Streptomyces is traditionally performed on agar plates and mostly studied at the population ... Read more >>

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A metabolomics study of Qianliexin capsule treatment of benign prostatic hyperplasia induced by testosterone propionate in the rat model.

Linghe Zang, Yuwei Zhang, Jing Zhao, Yunxia Yuan, Yi Wen, Jiaxin Lian, Shuailong Chen, Yiran Chen, Weiyi Liu, Ze Niu, Xinyue Wang, Chunlin Peng, Wenxin Zhang, Zhaoqing Meng, Jincai Lu,

A metabolomics investigation of the treatment effect of Qianliexin (QLX) capsules was conducted on rats with benign prostatic hyperplasia (BPH) induced by testosterone propionate. Establishment of the BPH model was confirmed using the prostatic index. Hematoxylin and eosin (HE) staining for TGF-β, EGFR, collagen, IL-1 β, TNF-α was performed and ... Read more >>

Anal Biochem (Analytical biochemistry)
[2021, 628:114258]

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SARS-CoV-2 Variant of Concern 202 012/01 (B.1.1.7) in a traveller from the UK to China.

Mingxiao Yao, Fachun Jiang, Yuwei Zhang, Yan Li, Bo Pang, Hao Liang, Zengqiang Kou, Xiaolin Jiang, Hongling Wen, Yifei Xu,

J Travel Med (Journal of travel medicine)
[2021, 28(4):]

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Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-γ-Shh-BDNF pathway.

Ge Wang, Hongyang Zhang, Jiancong Sun, Yuwei Zhang, Fen He, Juntao Zou,

A wealth of evidence indicate that the peripheral immune activation alters brain development. However, it is still largely unclear whether and how peripheral immunosuppression affects neurodevelopment. Here, we found that the immunosuppressant cyclosporin A (CsA) decreased the number of BrdU+, BrdU+/DCX+, BrdU+/NeuN + cells in the hippocampus, impaired learning and memory and ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2021, 96:107744]

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Qianliexin capsule exerts anti-inflammatory activity in chronic non-bacterial prostatitis and benign prostatic hyperplasia via NF-κB and inflammasome.

Linghe Zang, Fangyuan Tian, Yuancheng Yao, Yiran Chen, Yuan Shen, Mingyu Han, Zhaoqing Meng, Shengci Fan, Xinyi Zhang, Tian Cai, Qi Gao, Yuwei Zhang, Jincai Lu,

Qianliexin capsule (QLX) is a standardized traditional Chinese herbal preparation that has long been used to treat chronic non-bacterial prostatitis (CNP) and benign prostatic hyperplasia (BPH). This study investigated the anti-inflammatory activity of QLX in improving lower urinary tract symptoms (LUTS) associated with CNP and BPH. Rat models of CNP ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2021, 25(12):5753-5768]

Cited: 1 time

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Analysis of the efficacy and safety of iodine-125 seeds implantation in the treatment of patients with inoperable early-stage non-small cell lung cancer.

Enli Chen, Juan Wang, Hongtao Zhang, Yuwei Zhang, Chenfei Jia, Xueya Min, Yansong Liang,

<h4>Purpose</h4>To evaluate the efficacy and safety of iodine-125 (<sup>125</sup>I) seeds implantation for inoperable early-stage non-small cell lung cancer (NSCLC).<h4>Material and methods</h4>PubMed, Cochrane Library, Embase, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched from inception until April 2020. Data were collected concerning overall survival, ... Read more >>

J Contemp Brachytherapy (Journal of contemporary brachytherapy)
[2021, 13(3):347-357]

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Henagliflozin as add-on therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin: A multicentre, randomized, double-blind, placebo-controlled, phase 3 trial.

Jianping Weng, Longyi Zeng, Yuwei Zhang, Shen Qu, Xueying Wang, Ping Li, Liujun Fu, Boqing Ma, Shandong Ye, Jiao Sun, Weiping Lu, Zhiwen Liu, Daoxiong Chen, Zhifeng Cheng, Haiyan Liu, Tao Zhang, Jianjun Zou,

<h4>Aim</h4>To evaluate the efficacy and safety of henagliflozin in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin.<h4>Material and methods</h4>This multicentre phase 3 trial included a 24-week randomized, double-blind, placebo-controlled period, followed by a 28-week extension period. Patients with a glycated haemoglobin (HbA1c) level of 7.0% (53 mmol/mol) ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2021, 23(8):1754-1764]

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Different Effects of Leucine Supplementation and/or Exercise on Systemic Insulin Sensitivity in Mice.

Xiaofan Jiang, Yuwei Zhang, Weichao Hu, Yuxiu Liang, Liang Zheng, Juan Zheng, Baozhen Wang, Xin Guo,

<h4>Objective</h4>Obesity-related diseases such as diabetes, hypertension, dyslipidemia, and cardiovascular diseases have increased due to the obesity epidemic. Early intervention for obesity through lifestyle and nutrition plays an important role in preventing obesity-related diseases. Therefore, the purpose of this study is to explore the role of leucine and exercise in adiposity, ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:651303]

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Nanoencapsulation strategy: enabling electrochemiluminescence of thermally activated delayed fluorescence (TADF) emitters in aqueous media.

Zihui Zeng, Ping Huang, Yi Kong, Lianpeng Tong, Baohua Zhang, Yelin Luo, Lijuan Chen, Yuwei Zhang, Dongxue Han, Li Niu,

A nanoencapsulation strategy is introduced to a state-of-the-art thermally activated delayed fluorescence (TADF) molecule, i.e. 4CzIPN, which ensures the achievement of air-stable, water-soluble TADF nanoparticles featuring efficient TADF property without an unsatisfactory oxygen quenching effect. Accordingly, we report here for the first time the electrochemiluminescence of TADF emitters in aqueous ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(43):5262-5265]

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Corrigendum to: Inhibition of Histone Deacetylation by MS-275 Alleviates Colitis by Activating the Vitamin D Receptor.

Chunxiao Li, Yi Chen, Huatuo Zhu, Xiuming Zhang, Lu Han, Zuodong Zhao, Jinghua Wang, Longgui Ning, Weihua Zhou, Chao Lu, Lei Xu, Jianzhong Sang, Zemin Feng, Yuwei Zhang, Xinhe Lou, Xiaochen Bo, Bing Zhu, Chaohui Yu, Min Zheng, Youming Li, Jing Sun, Zhe Shen,

J Crohns Colitis (Journal of Crohn's & colitis)
[2021, 15(5):874]

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The intervening efficacy of health management based on family and organization on elderly diabetic patients.

Xinye Wang, Jinjun Yan, Zhibo Sun, Yuwei Zhang,

<h4>Objective</h4>To study the nursing efficacy of health management based on family and organization on elderly diabetic patients.<h4>Methods</h4>We collected clinical data from 126 elderly diabetic patients treated in our hospital from March 2018 to March 2019. The patients were divided into a control group and a study group by random number ... Read more >>

Am J Transl Res (American journal of translational research)
[2021, 13(4):3549-3554]

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Imaging Biomarkers to Predict and Evaluate the Effectiveness of Immunotherapy in Advanced Non-Small-Cell Lung Cancer.

Ying Liu, Minghao Wu, Yuwei Zhang, Yahong Luo, Shuai He, Yina Wang, Feng Chen, Yulin Liu, Qian Yang, Yanying Li, Hong Wei, Hong Zhang, Chenwang Jin, Nian Lu, Wanhu Li, Sicong Wang, Yan Guo, Zhaoxiang Ye,

<h4>Objective</h4>We aimed to identify imaging biomarkers to assess predictive capacity of radiomics nomogram regarding treatment response status (responder/non-responder) in patients with advanced NSCLC undergoing anti-PD1 immunotherapy.<h4>Methods</h4>197 eligible patients with histologically confirmed NSCLC were retrospectively enrolled from nine hospitals. We carried out a radiomics characterization from target lesions (TL) approach and ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:657615]

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Selective Targeting of Vascular Endothelial YAP Activity Blocks EndMT and Ameliorates Unilateral Ureteral Obstruction-Induced Kidney Fibrosis.

Yafeng Ren, Yuwei Zhang, Lu Wang, Fuqian He, Mengli Yan, Xiaoheng Liu, Yangying Ou, Qinkai Wu, Tao Bi, Shiyuan Wang, Jian Liu, Bi-Sen Ding, Li Wang, Jie Qing,

Kidney fibrosis is accompanied by vascular dysfunction. Discovering new ways to ameliorate dysfunctional angiogenesis may bypass kidney fibrosis. YAP (Yes-associated protein) plays a multifaceted role during angiogenesis. Here, we found that selectively targeting YAP signaling in the endothelium ameliorates unilateral ureteral obstruction (UUO)-induced kidney fibrosis. Genetic deletion of <i>Yap1</i>, encoding ... Read more >>

ACS Pharmacol Transl Sci (ACS pharmacology & translational science)
[2021, 4(3):1066-1074]

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Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

Tomas Raul Wiche Salinas, Yuwei Zhang, Daniele Sarnello, Alexander Zhyvoloup, Laurence Raymond Marchand, Delphine Planas, Manivel Lodha, Debashree Chatterjee, Kasia Karwacz, Sally Oxenford, Jean-Pierre Routy, Heather Amrine-Madsen, Petronela Ancuta, Ariberto Fassati,

Among CD4+ T-cells, T helper 17 (Th17) cells are particularly susceptible to HIV-1 infection and are depleted from mucosal sites, which causes damage to the gut barrier resulting in microbial translocation-induced systemic inflammation, a hallmark of disease progression. Furthermore, a proportion of latently infected Th17 cells persist long-term in the ... Read more >>

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Polymer Electrochemiluminescence Featuring Thermally Activated Delayed Fluorescence.

Ping Huang, Baohua Zhang, Qiong Hu, Bolin Zhao, Yunhui Zhu, Yuwei Zhang, Yi Kong, Zihui Zeng, Yu Bao, Wei Wang, Yanxiang Cheng, Li Niu,

Electrochemiluminescence (ECL) based on conjugated polymers or oligomers is persistently being pursued owing to its huge application scope ranging from ultra-sensitive bioanalysis to ultra-resolution imaging and spectroscopy. Because of the theoretical limit in radiative exciton generation yield (typically ∼25 %) of those polymers or oligomers, the corresponding ECL efficiency is still ... Read more >>

Chemphyschem (Chemphyschem : a European journal of chemical physics and physical chemistry)
[2021, 22(8):726-732]

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Auxiliary Module Promotes the Synthesis of Carboxysomes in E. coli to Achieve High-Efficiency CO2 Assimilation.

Yuwei Zhang, Juan Zhou, Yuchen Zhang, Tiangang Liu, Xiaoyun Lu, Dong Men, Xian-En Zhang,

Carboxysomes (CBs) are protein organelles in cyanobacteria, and they play a central role in assimilation of CO<sub>2</sub>. Heterologous synthesis of CBs in <i>E. coli</i> provides an opportunity for CO<sub>2</sub>-organic compound conversion under controlled conditions but remains challenging; specifically, the CO<sub>2</sub> assimilation efficiency is insufficient. In this study, an auxiliary module ... Read more >>

ACS Synth Biol (ACS synthetic biology)
[2021, 10(4):707-715]

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Combined adaptive evolution and transcriptomic profiles reveal aromatic aldehydes tolerance mechanisms in Yarrowia lipolytica.

Linlin Zhou, Zhaoxian Xu, Zhiqiang Wen, Minrui Lu, Zedi Wang, Yuwei Zhang, Huarong Zhou, Mingjie Jin,

Yarrowia lipolytica is an efficient oleaginous yeast, whereas its activity is typically reduced by inhibitors present in lignocellulosic hydrolysate. Understanding the response mechanism of Y. lipolytica to hydrolysate inhibitors and developing inhibitor tolerant strains are vital to lignocellulose valorization by this promising species. In this study, through adaptive laboratory evolution ... Read more >>

Bioresour Technol (Bioresource technology)
[2021, 329:124910]

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GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration.

Yuwei Zhang, Xuefeng Zhou, Peihao Liu, Xueyang Chen, Jie Zhang, Hong Zhang, Sha Li, Yishu Chen, Xin Song, Jinghua Wang, Hang Zeng, Xiaofen Zhang, Chenxi Tang, Chaohui Yu, Youming Li, Chengfu Xu,

Granulocyte colony stimulating factor (GCSF) is a cytokine with immunomodulation effects. However, little is known about its role in metabolic diseases. In the current study, we aimed to explore the role of GCSF in nonalcoholic fatty liver disease (NAFLD). Male GCSF<i><sup>-/-</sup></i> mice were used to investigate the function of GCSF ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, 320(4):G531-G542]

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Elastic Light Scatter Pattern Analysis for the Expedited Detection of Yersinia Species in Pork Mince: Proof of Concept.

Stephen L W On, Yuwei Zhang, Andrew Gehring, Valery Patsekin, Venkata Chelikani, Steve Flint, Haoran Wang, Craig Billington, Graham C Fletcher, James Lindsay, J Paul Robinson,

Isolation of the pathogens <i>Yersinia enterocolitica</i> and <i>Yersinia pseudotuberculosis</i> from foods typically rely on slow (10-21 day) "cold enrichment" protocols before confirmed results are obtained. We describe an approach that yields results in 39 h that combines an alternative enrichment method with culture on a non-selective medium, and subsequent identification ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:641801]

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